{"id":"https://openalex.org/W253443366","doi":null,"title":"Damage to hyphal forms of fungi by human leukocytes in vitro. A possible host defense mechanism in aspergillosis and mucormycosis.","display_name":"Damage to hyphal forms of fungi by human leukocytes in vitro. A possible host defense mechanism in aspergillosis and mucormycosis.","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W253443366","mag":"253443366","pmid":"https://pubmed.ncbi.nlm.nih.gov/347942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018207"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2018207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018207","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108502875","display_name":"Richard D. Diamond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R D Diamond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078618033","display_name":"RAYMOND F. KRZESICKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Krzesicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B Epstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Epstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108590388","display_name":"Jao W","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Jao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9708,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.92708718,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"91","issue":"2","first_page":"313","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.04659999907016754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hyphae","display_name":"fungal hyphae","score":0.8379999995231628},{"id":"https://openalex.org/keywords/aspergillosis","display_name":"aspergillosis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mucormycosis","display_name":"mucormycosis","score":1.0},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.9390000104904175},{"id":"https://openalex.org/keywords/rhizopus-arrhizus","display_name":"Rhizopus oryzae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/host-defense-against-fungal-infection","display_name":"host defense against fungi","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.8541096448898315},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7139503359794617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.668434202671051},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.6507841944694519},{"id":"https://openalex.org/C2778541762","wikidata":"https://www.wikidata.org/wiki/Q3024179","display_name":"Rhizopus oryzae","level":3,"score":0.4953280985355377},{"id":"https://openalex.org/C2776391196","wikidata":"https://www.wikidata.org/wiki/Q259626","display_name":"Aspergillosis","level":2,"score":0.48497891426086426},{"id":"https://openalex.org/C2778753027","wikidata":"https://www.wikidata.org/wiki/Q134258","display_name":"Rhizopus","level":3,"score":0.43460026383399963},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.42786192893981934},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41778290271759033},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.41199082136154175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32072675228118896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16328641772270203},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001232","descriptor_name":"Aspergillus fumigatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009091","descriptor_name":"Mucormycosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012233","descriptor_name":"Rhizopus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012233","descriptor_name":"Rhizopus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2018207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:347942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/347942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:253443366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/347942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2018207","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018207","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W63490885","https://openalex.org/W81032753","https://openalex.org/W87082738","https://openalex.org/W123024795","https://openalex.org/W1449964103","https://openalex.org/W1546679115","https://openalex.org/W1561780216","https://openalex.org/W1929503553","https://openalex.org/W1969158315","https://openalex.org/W1970480024","https://openalex.org/W1972824411","https://openalex.org/W1976325235","https://openalex.org/W1978498634","https://openalex.org/W1991236622","https://openalex.org/W1996152805","https://openalex.org/W2025804022","https://openalex.org/W2029090265","https://openalex.org/W2030764175","https://openalex.org/W2036361338","https://openalex.org/W2047202043","https://openalex.org/W2047953635","https://openalex.org/W2049059366","https://openalex.org/W2049291162","https://openalex.org/W2068350209","https://openalex.org/W2073635661","https://openalex.org/W2080883399","https://openalex.org/W2082076412","https://openalex.org/W2090879136","https://openalex.org/W2095029703","https://openalex.org/W2095139195","https://openalex.org/W2165271448","https://openalex.org/W2182038113","https://openalex.org/W2271741392","https://openalex.org/W2307348679","https://openalex.org/W2346629900","https://openalex.org/W4290155823"],"related_works":["https://openalex.org/W2171595787","https://openalex.org/W2099043151","https://openalex.org/W1490210760","https://openalex.org/W7100743743","https://openalex.org/W2263789901","https://openalex.org/W1979878015","https://openalex.org/W2036903343","https://openalex.org/W2066110878","https://openalex.org/W7098279438","https://openalex.org/W1967781603"],"abstract_inverted_index":{"Evidence":[0],"suggests":[1],"that":[2,46,158],"neutrophils":[3,27,47,97,130],"are":[4,19,112],"important":[5,178],"in":[6,16,38,58,138,165,180],"host":[7,181],"defenses":[8,182],"against":[9,169,183],"invasive":[10],"aspergillosis":[11],"and":[12,33,41,50,74,120,185],"mucormycosis,":[13],"although":[14],"hyphae":[15,29,103,154],"these":[17,136,184],"lesions":[18],"too":[20],"large":[21],"to":[22,49,90,93,102,114,140,150,153],"be":[23],"phagocytized.":[24],"Interactions":[25],"of":[26,30,55,61,77,81,84,86,109,123,125,129,135,143,189],"with":[28],"Aspergillus":[31],"fumigatus":[32],"Rhizopus":[34],"oryzae":[35],"were":[36],"studed":[37],"vitro.":[39],"Light":[40],"electron":[42],"microscopic":[43],"observations":[44],"indicated":[45,131],"attached":[48],"spread":[51],"over":[52],"the":[53,59,94,132,166],"surfaces":[54],"hyphae,":[56],"even":[57],"absence":[60],"serum.":[62],"This":[63,171],"was":[64,88,104],"followed":[65],"by":[66,96,106,155],"dramatic":[67],"morphologic":[68],"changes":[69],"which":[70,111],"suggested":[71,157],"severe":[72],"damage":[73,92,139,148],"probably":[75],"death":[76],"hyphae.":[78,141],"An":[79],"assay":[80],"neutrophil-induced":[82],"reduction":[83],"uptake":[85],"radioisotopes":[87],"used":[89],"quantitate":[91],"fungi":[95],"from":[98],"normal":[99],"subjects.":[100],"Damage":[101,152],"inhibited":[105],"a":[107,162],"variety":[108],"compounds":[110],"known":[113],"affect":[115],"neutrophil":[116,144],"surface":[117],"functions,":[118],"motility,":[119],"metabolism.":[121],"Use":[122],"inhibitors":[124],"oxidative":[126],"microbicidal":[127],"mechanisms":[128,137],"central":[133],"importance":[134],"Inhibitors":[142],"cationic":[145],"proteins":[146],"altered":[147],"only":[149],"Rhizopus.":[151],"lysozyme":[156],"it":[159],"may":[160,175],"play":[161,176],"secondary":[163],"role":[164,179],"neutrophil,":[167],"primarily":[168],"Aspergillus.":[170],"new":[172],"nonphagocytic":[173],"mechanism":[174],"an":[177],"other":[186],"hyphal":[187],"forms":[188],"fungi.":[190]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
