{"id":"https://openalex.org/W2534422312","doi":"https://doi.org/10.1242/bio.019729","title":"Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases","display_name":"Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases","publication_year":2016,"publication_date":"2016-10-15","ids":{"openalex":"https://openalex.org/W2534422312","doi":"https://doi.org/10.1242/bio.019729","mag":"2534422312","pmid":"https://pubmed.ncbi.nlm.nih.gov/27744293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5087680"},"language":"en","primary_location":{"id":"doi:10.1242/bio.019729","doi":"https://doi.org/10.1242/bio.019729","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.019729","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1242/bio.019729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087766294","display_name":"Fei Lu","orcid":"https://orcid.org/0000-0001-5086-1157","observed_orcids":["https://orcid.org/0000-0001-5086-1157","https://orcid.org/0009-0007-8572-2465"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Lu","raw_affiliation_strings":["Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487140","display_name":"Xiaojun Wu","orcid":"https://orcid.org/0000-0001-7085-4720","observed_orcids":["https://orcid.org/0000-0001-7085-4720"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Wu","raw_affiliation_strings":["Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101648965","display_name":"Feng Yin","orcid":"https://orcid.org/0000-0001-7407-9047","observed_orcids":["https://orcid.org/0000-0001-7407-9047","https://orcid.org/0000-0003-1655-3542"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Yin","raw_affiliation_strings":["Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042517995","display_name":"Christina Chia-Fang Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christina Chia-Fang Lee","raw_affiliation_strings":["Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721745","display_name":"Min Yu","orcid":"https://orcid.org/0000-0001-7208-2197","observed_orcids":["https://orcid.org/0000-0001-7208-2197"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yu","raw_affiliation_strings":["Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011732517","display_name":"Ivailo S. Mihaylov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivailo S. Mihaylov","raw_affiliation_strings":["Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045439640","display_name":"Jiekai Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiekai Yu","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769312","display_name":"Hong Sun","orcid":"https://orcid.org/0000-0003-2100-1451","observed_orcids":["https://orcid.org/0000-0003-2100-1451"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Sun","raw_affiliation_strings":["Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA","institution_ids":["https://openalex.org/I133999245"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100323333","display_name":"Hui Zhang","orcid":"https://orcid.org/0000-0001-6028-2554","observed_orcids":["https://orcid.org/0000-0001-6028-2554"]},"institutions":[{"id":"https://openalex.org/I133999245","display_name":"University of Nevada, Las Vegas","ror":"https://ror.org/0406gha72","country_code":"US","type":"education","lineage":["https://openalex.org/I133999245"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hui Zhang","raw_affiliation_strings":["Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA"],"raw_orcid":"https://orcid.org/0000-0001-6028-2554","affiliations":[{"raw_affiliation_string":"Basic Science Division, Nevada Cancer Institute, Las Vegas, NV 89135, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, NV 89154, USA","institution_ids":["https://openalex.org/I133999245"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100323333"],"corresponding_institution_ids":["https://openalex.org/I133999245"],"apc_list":{"value":1995,"currency":"USD","value_usd":1995},"apc_paid":{"value":1995,"currency":"USD","value_usd":1995},"fwci":1.0389,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77765222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"5","issue":"10","first_page":"1449","last_page":"1460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5443999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-replication-licensing","display_name":"DNA replication licensing","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dna-re-replication","display_name":"DNA re-replication","score":0.8859999775886536},{"id":"https://openalex.org/keywords/histone-h3k4-methylation","display_name":"histone H3 lysine 4 methylation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/wdr5","display_name":"WDR5","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rbbp5","display_name":"RBBP5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/geminin","display_name":"geminin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cdt1","display_name":"Cdt1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"origin recognition complex","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mcm2-7-helicase","display_name":"MCM2-7 helicase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/replication-origins","display_name":"origin of replication","score":0.7099999785423279},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9372777938842773},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.8330596685409546},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6066957712173462},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.573371171951294},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5340368151664734},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.49797511100769043},{"id":"https://openalex.org/C2776626444","wikidata":"https://www.wikidata.org/wiki/Q213410","display_name":"Polyploid","level":4,"score":0.42204049229621887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3875076472759247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.341804563999176},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.30890968441963196},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.22689688205718994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18768110871315002},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0816507339477539}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1242/bio.019729","doi":"https://doi.org/10.1242/bio.019729","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.019729","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5087680","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5087680","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biol Open","raw_type":"Text"},{"id":"pmid:27744293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27744293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a62c43d44443474fbfbcd4aed8124bff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a62c43d44443474fbfbcd4aed8124bff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Open, Vol 5, Iss 10, Pp 1449-1460 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1242/bio.019729","doi":"https://doi.org/10.1242/bio.019729","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.019729","pdf_url":null,"source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G235852614","display_name":null,"funder_award_id":"NSFC21133002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2449601139","display_name":"Control of Epigenetic Inheritance By Proteolysis","funder_award_id":"R15GM116087","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3517361031","display_name":"\u8fd0\u7528\u86cb\u767d\u8d28\u7ec4\u5b66\u65b9\u6cd5\u63a2\u8ba8\u7ec4\u86cb\u767d\u8868\u89c2\u9057\u4f20\u5b66\u5bf9\u7ec6\u80de\u91cd\u7f16\u7a0b\u8c03\u63a7\u7684\u65b0\u673a\u5236","funder_award_id":"30971616","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4337467711","display_name":null,"funder_award_id":"2014A030313779","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G8908572505","display_name":null,"funder_award_id":"JC201104210125A","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1965666412","https://openalex.org/W1968574736","https://openalex.org/W1968920794","https://openalex.org/W1974370722","https://openalex.org/W1979239647","https://openalex.org/W1980838744","https://openalex.org/W1985180051","https://openalex.org/W1985874860","https://openalex.org/W1993925474","https://openalex.org/W1995667706","https://openalex.org/W1996868531","https://openalex.org/W2006932105","https://openalex.org/W2009093325","https://openalex.org/W2009858080","https://openalex.org/W2013407554","https://openalex.org/W2014069479","https://openalex.org/W2029925140","https://openalex.org/W2032735361","https://openalex.org/W2044090970","https://openalex.org/W2048464448","https://openalex.org/W2049868369","https://openalex.org/W2057896961","https://openalex.org/W2058104615","https://openalex.org/W2062114156","https://openalex.org/W2068784898","https://openalex.org/W2072472133","https://openalex.org/W2074637369","https://openalex.org/W2086645776","https://openalex.org/W2095934571","https://openalex.org/W2099487576","https://openalex.org/W2103625519","https://openalex.org/W2109470020","https://openalex.org/W2111964212","https://openalex.org/W2121291166","https://openalex.org/W2125695802","https://openalex.org/W2134629510","https://openalex.org/W2135138200","https://openalex.org/W2142732735","https://openalex.org/W2161369834","https://openalex.org/W2165372706","https://openalex.org/W2168970170"],"related_works":["https://openalex.org/W2036247984","https://openalex.org/W1979042611","https://openalex.org/W2012346714","https://openalex.org/W7033531298","https://openalex.org/W2095907362","https://openalex.org/W4389498210","https://openalex.org/W7095314072","https://openalex.org/W2444103466","https://openalex.org/W7145665806","https://openalex.org/W2139613313"],"abstract_inverted_index":{"DNA":[0,34,84,169,174],"replication":[1,14,46,128,154,170],"licensing":[2,47],"occurs":[3],"on":[4],"chromatin,":[5],"but":[6,102,171],"how":[7],"the":[8,22,33,38,51,65,94,110,117,132,143,148,160],"chromatin":[9],"template":[10],"is":[11],"regulated":[12],"for":[13,27,168,173],"remains":[15],"mostly":[16],"unclear.":[17],"Here,":[18],"we":[19],"have":[20],"analyzed":[21],"requirement":[23],"of":[24,31,40,45,61,64,90,96,112,134,138,150],"histone":[25,78],"methyltransferases":[26],"a":[28],"specific":[29],"type":[30],"replication:":[32],"re-replication":[35,85],"induced":[36],"by":[37,100,104],"downregulation":[39],"either":[41],"Geminin,":[42],"an":[43],"inhibitor":[44],"protein":[48],"CDT1,":[49],"or":[50,71,106,140],"CRL4CDT2":[52],"ubiquitin":[53],"E3":[54],"ligase.":[55],"We":[56],"found":[57],"that":[58,159],"siRNA-mediated":[59],"reduction":[60],"essential":[62],"components":[63,111],"MLL-WDR5-RBBP5":[66],"methyltransferase":[67],"complexes":[68,114,126,152,162],"including":[69],"WDR5":[70,139],"RBBP5,":[72],"which":[73],"transfer":[74],"methyl":[75],"groups":[76],"to":[77,130],"H3":[79],"at":[80,127],"K4":[81],"(H3K4),":[82],"suppressed":[83,147],"and":[86,109,122,146,163],"chromosomal":[87],"polyploidy.":[88],"Reduction":[89],"WDR5/RBBP5":[91],"also":[92],"prevented":[93],"activation":[95],"H2AX":[97],"checkpoint":[98],"caused":[99],"re-replication,":[101],"not":[103,172],"ultraviolet":[105],"X-ray":[107],"irradiation;":[108],"MLL":[113,161],"co-localized":[115],"with":[116],"origin":[118],"recognition":[119],"complex":[120],"(ORC)":[121],"MCM2-7":[123,151],"replicative":[124],"helicase":[125],"origins":[129],"control":[131],"levels":[133],"methylated":[135,144],"H3K4.":[136],"Downregulation":[137],"RBBP5":[141],"reduced":[142],"H3K4":[145,164],"recruitment":[149],"onto":[153],"origins.":[155],"Our":[156],"studies":[157],"indicate":[158],"methylation":[165],"are":[166],"required":[167],"damage":[175],"repair.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-10-28T00:00:00"}
