{"id":"https://openalex.org/W2534252146","doi":"https://doi.org/10.1182/blood.v112.11.3501.3501","title":"Induced CD4+CD25+ FOXP-3+ and CD8+CD25+ FOXP-3+t Cells Exhibit a Concurrent Expression of Effector and Selective Suppressive Capacities","display_name":"Induced CD4+CD25+ FOXP-3+ and CD8+CD25+ FOXP-3+t Cells Exhibit a Concurrent Expression of Effector and Selective Suppressive Capacities","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2534252146","doi":"https://doi.org/10.1182/blood.v112.11.3501.3501","mag":"2534252146"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.3501.3501","doi":"https://doi.org/10.1182/blood.v112.11.3501.3501","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3501.3501","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079688295","display_name":"Irit Mazza Avivi","orcid":"https://orcid.org/0000-0001-8663-444X","observed_orcids":["https://orcid.org/0000-0001-8663-444X"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Irit Avivi","raw_affiliation_strings":["Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102834605","display_name":"Dina Stroopinsky","orcid":"https://orcid.org/0000-0002-9749-2704","observed_orcids":["https://orcid.org/0000-0002-9749-2704"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Dina Stroopinsky","raw_affiliation_strings":["Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869658","display_name":"Jacob M. Rowe","orcid":"https://orcid.org/0000-0002-2016-2918","observed_orcids":["https://orcid.org/0000-0002-2016-2918"]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Jacob Rowe","raw_affiliation_strings":["Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel","institution_ids":["https://openalex.org/I2801301638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052641327","display_name":"David Avigan","orcid":"https://orcid.org/0000-0003-4624-6017","observed_orcids":["https://orcid.org/0000-0003-4624-6017"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Avigan","raw_affiliation_strings":["Beth Israel Deaconess Med. Ctr., Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Med. Ctr., Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103583325","display_name":"Tami Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Tami Katz","raw_affiliation_strings":["Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel","institution_ids":["https://openalex.org/I2801301638"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079688295","https://openalex.org/A5102834605","https://openalex.org/A5103583325"],"corresponding_institution_ids":["https://openalex.org/I2801301638"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34237108,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"3501","last_page":"3501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-regulatory-t-cells","display_name":"induced regulatory T cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cd8-cd25-t-cells","display_name":"CD8+CD25+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/selective-immunosuppression","display_name":"selective immunosuppression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6990000009536743},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.8716951012611389},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7049399018287659},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6414427757263184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5788025259971619},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.562818169593811},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5078890919685364},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.48717209696769714},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43248093128204346},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4149465560913086},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.37703922390937805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3435991406440735},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17794263362884521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05046546459197998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.3501.3501","doi":"https://doi.org/10.1182/blood.v112.11.3501.3501","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.3501.3501","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031494927","https://openalex.org/W2119173517","https://openalex.org/W2105239353","https://openalex.org/W1899852997","https://openalex.org/W2583821351","https://openalex.org/W2573031606","https://openalex.org/W2131161334","https://openalex.org/W1989449514","https://openalex.org/W2979323966","https://openalex.org/W2550634542"],"abstract_inverted_index":{"Abstract":[0],"Naturally":[1],"occurring":[2,248,267,294],"regulatory":[3,233],"T":[4,20,68,103,187,259],"cells":[5,69,80,104,135,188,196,224,298,301],"(Tregs),":[6],"identified":[7],"as":[8,236,238,383],"CD4+CD25+FoxP-3+":[9],"cells,":[10],"are":[11],"known":[12],"to":[13,55,87,98,213,246,265,352,362],"modulate":[14],"immunologic":[15],"tolerance":[16],"and":[17,23,50,61,81,90,138,161,174,206,217,243,253,358,370,374],"inhibit":[18,73],"primary":[19],"cell":[21,170,260],"activation,":[22],"therefore,":[24,375],"may":[25,43],"protect":[26],"against":[27,78,276],"graft-versus-host":[28],"disease":[29,62],"(GvHD)":[30],"following":[31,41,219],"allograft.":[32],"However,":[33,262],"having":[34],"a":[35,110,113,201,226,364],"non-selective":[36],"suppressive":[37,67,372],"effect,":[38,53],"Tregs":[39],"administration":[40],"transplantation":[42],"also":[44],"result":[45],"in":[46,130,263],"delayed":[47],"immunological":[48],"reconstitution":[49],"diminished":[51],"graft-versus-tumor":[52],"leading":[54],"an":[56],"increased":[57],"risk":[58],"of":[59,66,94,102,117,123,133,185,200,204,231,289,367],"infections":[60],"relapse.":[63],"The":[64,92,150,178,222],"generation":[65,199],"that":[70,183],"could":[71],"selectively":[72],"GvHD":[74,88,385],"whilst":[75],"preserving":[76],"immunity":[77],"malignant":[79],"infection":[82],"would":[83],"promote":[84],"significant":[85],"contribution":[86],"prevention":[89],"therapy.":[91],"aim":[93],"this":[95],"study":[96,180],"was":[97,211],"investigate":[99],"the":[100,131,232,239,250,269,277,381],"characteristics":[101],"undergoing":[105],"allogeneic":[106,146,190,322],"stimulation,":[107],"looking":[108],"for":[109,148,163,285,380],"subpopulation":[111],"with":[112,125,145,158,189],"more":[114,215,286],"specific":[115],"inhibition":[116,288],"host":[118,290],"immunity.":[119,291],"A":[120],"negative":[121],"selection":[122],"PBMCs":[124,141],"anti-CD25":[126],"magnetic":[127,159],"beads":[128,160],"resulted":[129],"production":[132],"CD25+":[134],"(-Naturally":[136],"occurring)":[137],"CD25\u2212PBMCs.":[139],"CD25\u2212":[140,186,355],"were":[142,156],"than":[143],"stimulated":[144],"DC":[147],"5\u20136.":[149],"resultant":[151,223],"CD4+CD25+":[152,205,252],"or":[153,194],"CD8+CD25+":[154,207,254,359],"populations":[155],"isolated":[157],"investigated":[162],"immunophenotypical":[164],"markers,":[165],"cytokine":[166],"expression":[167,230,335,366],"profile":[168],"(FACS),":[169],"proliferation,":[171],"inhibitory":[172],"capacity":[173,345],"anti-viral":[175],"response":[176],"(INF-gamma).":[177],"current":[179],"has":[181],"shown":[182],"stimulation":[184],"peripheral":[191],"blood":[192],"mononuclear":[193],"dendritic":[195],"(DCs)":[197],"induces":[198],"large":[202],"fraction":[203],"T-cells.":[208],"This":[209],"process":[210],"found":[212],"be":[214,377],"rapid":[216],"prominent":[218],"DCs":[220],"stimulation.":[221],"exhibit":[225],"mixed":[227],"phenotype,":[228],"demonstrating":[229],"marker,":[234],"FoxP3,":[235],"well":[237],"inflammatory":[240],"cytokines,":[241],"IL-2":[242,336],"IFN\u03b3.":[244],"Similar":[245],"naturally":[247,266,293],"Tregs,":[249,268],"induced":[251,270],"have":[255,363],"markedly":[256],"inhibited":[257],"alloreactive":[258],"expansion.":[261],"contrast":[264],"populations,":[271],"did":[272],"not":[273],"suppress":[274],"proliferation":[275],"cytomegalovirus":[278],"(CMV)":[279],"recombinant":[280],"protein,":[281],"suggesting":[282],"their":[283],"potential":[284],"selective":[287,371],"Expanded":[292],"CD4+CD25+T":[295,297],"Induced":[296,299],"CD8+CD25+T":[300],"GITR":[302],"+":[303,308,312,324,331,338,339,350],"++":[304,305,309,310,313,314,325,326,342,343],"Immunophenotype":[306],"CTLA-4":[307],"FoxP-3":[311],"Self-proliferation":[315],"\u2212":[316,317,318,332,333,337,341,348,349],"Suppression":[319],"rate":[320],"Primary":[321],"stimuli":[323,330],"CMV":[327],"recall":[328],"antigen":[329],"Cytokine":[334],"IFN-\u03b3":[340],"Cytotoxic":[344],"(granzyme":[346],"B)":[347],"According":[351],"these":[353],"data,":[354],"derived":[356],"CD4+CD25+FOXP-3+":[357],"FOXP-3,":[360],"appear":[361],"dual":[365],"both":[368],"effector":[369],"capacities,":[373],"might":[376],"potentially":[378],"ideal":[379],"use":[382],"post-transplant":[384],"prophylaxis.":[386]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-10-28T00:00:00"}
