{"id":"https://openalex.org/W2533748764","doi":"https://doi.org/10.1177/2040622316665350","title":"Sacubitril/valsartan in heart failure: latest evidence and place in therapy","display_name":"Sacubitril/valsartan in heart failure: latest evidence and place in therapy","publication_year":2016,"publication_date":"2016-10-19","ids":{"openalex":"https://openalex.org/W2533748764","doi":"https://doi.org/10.1177/2040622316665350","mag":"2533748764","pmid":"https://pubmed.ncbi.nlm.nih.gov/27803793","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5076745"},"language":"en","primary_location":{"id":"doi:10.1177/2040622316665350","doi":"https://doi.org/10.1177/2040622316665350","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2040622316665350","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2040622316665350","source":{"id":"https://openalex.org/S101854828","display_name":"Therapeutic Advances in Chronic Disease","issn_l":"2040-6223","issn":["2040-6223","2040-6231"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Chronic Disease","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/2040622316665350","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081929932","display_name":"Edgardo Kaplinsky","orcid":"https://orcid.org/0000-0002-6399-6736","observed_orcids":["https://orcid.org/0000-0002-6399-6736"]},"institutions":[{"id":"https://openalex.org/I4210153095","display_name":"Hospital Municipal de Badalona","ror":"https://ror.org/0495vrm88","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153095"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Edgardo Kaplinsky","raw_affiliation_strings":["Cardiology Unit, Medicine Department, Hospital Municipal de Badalona, Via Augusta Av. 9\u201313, 08911 Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Unit, Medicine Department, Hospital Municipal de Badalona, Via Augusta Av. 9\u201313, 08911 Badalona, Spain","institution_ids":["https://openalex.org/I4210153095"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081929932"],"corresponding_institution_ids":["https://openalex.org/I4210153095"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.637,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.56886228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"6","first_page":"278","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":1.0},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neprilysin-inhibition","display_name":"neprilysin inhibition","score":0.9089999794960022},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9020000100135803},{"id":"https://openalex.org/keywords/natriuretic-peptides","display_name":"natriuretic peptides","score":0.9129999876022339},{"id":"https://openalex.org/keywords/paradigm-hf","display_name":"PARADIGM-HF","score":0.9179999828338623},{"id":"https://openalex.org/keywords/reduced-ejection-fraction","display_name":"reduced ejection fraction","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.7770000100135803},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.9279999732971191},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2776754050","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril","level":4,"score":0.9169789552688599},{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.8664858341217041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7668397426605225},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7297816276550293},{"id":"https://openalex.org/C2775999527","wikidata":"https://www.wikidata.org/wiki/Q17811448","display_name":"Sacubitril, Valsartan","level":4,"score":0.6983860731124878},{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.6790851354598999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6044319868087769},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5405904054641724},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.5382267236709595},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4821779131889343},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.47832512855529785},{"id":"https://openalex.org/C174459258","wikidata":"https://www.wikidata.org/wiki/Q6980232","display_name":"Natriuresis","level":3,"score":0.4531288146972656},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.424453467130661},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3640667498111725},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3538249731063843},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19142553210258484},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17346328496932983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.058315545320510864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1177/2040622316665350","doi":"https://doi.org/10.1177/2040622316665350","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2040622316665350","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2040622316665350","source":{"id":"https://openalex.org/S101854828","display_name":"Therapeutic Advances in Chronic Disease","issn_l":"2040-6223","issn":["2040-6223","2040-6231"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Chronic Disease","raw_type":"journal-article"},{"id":"pmid:27803793","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27803793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic advances in chronic disease","raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:5076745","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5076745/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Adv Chronic Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1177/2040622316665350","doi":"https://doi.org/10.1177/2040622316665350","is_oa":true,"landing_page_url":"https://doi.org/10.1177/2040622316665350","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/2040622316665350","source":{"id":"https://openalex.org/S101854828","display_name":"Therapeutic Advances in Chronic Disease","issn_l":"2040-6223","issn":["2040-6223","2040-6231"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Advances in Chronic Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2533748764.pdf"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W52877415","https://openalex.org/W163500002","https://openalex.org/W1525658879","https://openalex.org/W1536076490","https://openalex.org/W1545907965","https://openalex.org/W1862226808","https://openalex.org/W1964952529","https://openalex.org/W1970636330","https://openalex.org/W1983279085","https://openalex.org/W1987269847","https://openalex.org/W1994035387","https://openalex.org/W1998245427","https://openalex.org/W2001498167","https://openalex.org/W2021894572","https://openalex.org/W2032130572","https://openalex.org/W2034557166","https://openalex.org/W2044591445","https://openalex.org/W2048664109","https://openalex.org/W2056893352","https://openalex.org/W2061143322","https://openalex.org/W2067941974","https://openalex.org/W2094713640","https://openalex.org/W2095835518","https://openalex.org/W2097123331","https://openalex.org/W2105138814","https://openalex.org/W2105157791","https://openalex.org/W2111856132","https://openalex.org/W2113698123","https://openalex.org/W2124664054","https://openalex.org/W2129330037","https://openalex.org/W2135038122","https://openalex.org/W2136642260","https://openalex.org/W2143094666","https://openalex.org/W2155400583","https://openalex.org/W2157574602","https://openalex.org/W2164145340","https://openalex.org/W2167760816","https://openalex.org/W2172025889","https://openalex.org/W2183542050","https://openalex.org/W2274091016","https://openalex.org/W2285606889","https://openalex.org/W2296998040","https://openalex.org/W2312388685","https://openalex.org/W2323458614","https://openalex.org/W2326354230","https://openalex.org/W2340731691","https://openalex.org/W2397911846","https://openalex.org/W2401853487","https://openalex.org/W2404989232","https://openalex.org/W2427094903","https://openalex.org/W2475261460","https://openalex.org/W2585382523","https://openalex.org/W3023400402","https://openalex.org/W4229508205","https://openalex.org/W4229755335","https://openalex.org/W4245244523"],"related_works":["https://openalex.org/W4235179588","https://openalex.org/W2590112465","https://openalex.org/W2560910557","https://openalex.org/W2918872672","https://openalex.org/W7061863627","https://openalex.org/W7015096194","https://openalex.org/W2217644778","https://openalex.org/W2342277773","https://openalex.org/W2591831185","https://openalex.org/W7043064402"],"abstract_inverted_index":{"Despite":[0],"significant":[1],"therapeutic":[2],"advances,":[3],"patients":[4,101],"with":[5,102,115],"chronic":[6],"heart":[7],"failure":[8],"(HF)":[9],"remain":[10],"at":[11],"high":[12],"risk":[13,126,143,154],"for":[14],"HF":[15,136,170],"progression":[16],"and":[17,35,56,73,75,89,110],"death.":[18],"Sacubitril/valsartan":[19],"(previously":[20],"known":[21],"as":[22,189,191],"LCZ696)":[23],"is":[24,44],"a":[25,30,152,177],"first-in-class":[26],"medicine":[27],"that":[28,47],"contains":[29],"neprilysin":[31],"(NEP)":[32],"inhibitor":[33],"(sacubitril)":[34],"an":[36,45],"angiotensin":[37,83],"II":[38],"(Ang-II)":[39],"receptor":[40,84],"blocker":[41],"(valsartan).":[42],"NEP":[43],"endopeptidase":[46],"metabolizes":[48],"different":[49],"vasoactive":[50],"peptides":[51,69],"including":[52,198],"natriuretic":[53,68],"peptides,":[54],"bradykinin":[55],"Ang-II.":[57],"In":[58],"consequence,":[59],"its":[60],"inhibition":[61],"increases":[62],"mainly":[63],"the":[64,82,94,120,125,142,157,192,204],"levels":[65],"of":[66,124,127,135,141,144,162,181,187,196],"both,":[67],"(promoting":[70],"diuresis,":[71],"natriuresis":[72],"vasodilatation)":[74],"Ang-II":[76],"whose":[77],"effects":[78],"are":[79,201],"blocked":[80],"by":[81,132,138,147],"blocker,":[85],"valsartan":[86],"(reducing":[87],"vasoconstriction":[88],"aldosterone":[90],"release).":[91],"Results":[92],"from":[93,129],"8442":[95],"patient":[96],"PARADIGM-HF":[97,172,188],"study":[98],"showed":[99],"in":[100,194,203],"New":[103],"York":[104],"Heart":[105],"Association":[106],"(NYHA)":[107],"class":[108],"II\u2013IV":[109],"reduced":[111],"ejection":[112],"fraction":[113],"treated":[114],"LCZ696":[116],"(":[117],"versus":[118],"enalapril),":[119],"following":[121],"benefits:":[122],"reduction":[123,134,140,155],"death":[128,165],"cardiovascular":[130,163],"causes":[131],"20%;":[133],"hospitalizations":[137],"21%;":[139],"all-cause":[145],"mortality":[146],"16%.":[148],"Overall":[149],"there":[150],"was":[151,173],"20%":[153],"on":[156],"primary":[158],"endpoint,":[159],"composite":[160],"measure":[161],"(CV)":[164],"or":[166],"time":[167],"to":[168],"first":[169],"hospitalization.":[171],"stopped":[174],"early":[175],"after":[176],"median":[178],"follow":[179],"up":[180],"27":[182],"months.":[183],"Post":[184],"hoc":[185],"analyses":[186],"well":[190],"place":[193],"therapy":[195],"sacubitril/valsartan,":[197],"future":[199],"directions,":[200],"included":[202],"present":[205],"review.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-28T00:00:00"}