{"id":"https://openalex.org/W2532440299","doi":null,"title":"Critical determinants of the risk-benefit assessment of antidepressants in pregnancy : pharmacokinetic, safety and economic considerations.","display_name":"Critical determinants of the risk-benefit assessment of antidepressants in pregnancy : pharmacokinetic, safety and economic considerations.","publication_year":2010,"publication_date":"2010-07-19","ids":{"openalex":"https://openalex.org/W2532440299","mag":"2532440299"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/24518","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/24518","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0ba88d79-ea03-4031-8b10-b4c3568807b5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/0ba88d79-ea03-4031-8b10-b4c3568807b5/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005801700","display_name":"Lisa O\u2019Brien","orcid":"https://orcid.org/0000-0003-4733-9864","observed_orcids":["https://orcid.org/0000-0003-4733-9864"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa O\u2019Brien","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4733-9864","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5005801700"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressant-use-in-pregnancy","display_name":"antidepressant use in pregnancy","score":0.921999990940094},{"id":"https://openalex.org/keywords/maternal-depression","display_name":"maternal depression","score":0.9789999723434448},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7039999961853027},{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":0.8299999833106995},{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.9929999709129333},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cardiac-abnormalities","display_name":"cardiac anomalies","score":0.843999981880188},{"id":"https://openalex.org/keywords/fetal-safety","display_name":"fetal safety","score":0.6470000147819519},{"id":"https://openalex.org/keywords/maternal-safety","display_name":"maternal safety","score":0.5809999704360962},{"id":"https://openalex.org/keywords/hair-analysis","display_name":"hair analysis","score":0.5220000147819519},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5580000281333923},{"id":"https://openalex.org/keywords/nausea-and-vomiting-of-pregnancy","display_name":"nausea and vomiting of pregnancy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.49000000953674316},{"id":"https://openalex.org/keywords/untreated-depression","display_name":"untreated depression","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5456609725952148},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4935559034347534},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.45602887868881226},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4155164361000061},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.35982775688171387},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33310142159461975},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3090946078300476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18063831329345703},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0878419280052185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/24518","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/24518","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0ba88d79-ea03-4031-8b10-b4c3568807b5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/24518","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/24518","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2532440299","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/24518/8/O%27Brien_Lisa_200903_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/24518","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/24518","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0ba88d79-ea03-4031-8b10-b4c3568807b5/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2532440299.pdf","grobid_xml":"https://content.openalex.org/works/W2532440299.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W4584757","https://openalex.org/W5301038","https://openalex.org/W1562849972","https://openalex.org/W1592471647","https://openalex.org/W1596870307","https://openalex.org/W1711341365","https://openalex.org/W1747295370","https://openalex.org/W1754726403","https://openalex.org/W1909234973","https://openalex.org/W1944976733","https://openalex.org/W1947455821","https://openalex.org/W1964435302","https://openalex.org/W1971318678","https://openalex.org/W1972617787","https://openalex.org/W1976327254","https://openalex.org/W1977989261","https://openalex.org/W1978522713","https://openalex.org/W1978801067","https://openalex.org/W1982720679","https://openalex.org/W1983734682","https://openalex.org/W1985220666","https://openalex.org/W1988643756","https://openalex.org/W1990553277","https://openalex.org/W1991147318","https://openalex.org/W1991702239","https://openalex.org/W1992853570","https://openalex.org/W1994306639","https://openalex.org/W1996299251","https://openalex.org/W1999449749","https://openalex.org/W1999989918","https://openalex.org/W2000846240","https://openalex.org/W2002098693","https://openalex.org/W2006546769","https://openalex.org/W2010162103","https://openalex.org/W2011658133","https://openalex.org/W2012517517","https://openalex.org/W2013822799","https://openalex.org/W2016238793","https://openalex.org/W2019890777","https://openalex.org/W2019939591","https://openalex.org/W2021269109","https://openalex.org/W2021816296","https://openalex.org/W2024132854","https://openalex.org/W2026135238","https://openalex.org/W2027277232","https://openalex.org/W2027369712","https://openalex.org/W2027747918","https://openalex.org/W2028194357","https://openalex.org/W2029958153","https://openalex.org/W2031314736","https://openalex.org/W2033757879","https://openalex.org/W2042751011","https://openalex.org/W2043907269","https://openalex.org/W2046178543","https://openalex.org/W2047622237","https://openalex.org/W2048118364","https://openalex.org/W2048817337","https://openalex.org/W2049534897","https://openalex.org/W2051082022","https://openalex.org/W2051806203","https://openalex.org/W2053048310","https://openalex.org/W2054663967","https://openalex.org/W2056523980","https://openalex.org/W2059200362","https://openalex.org/W2059525140","https://openalex.org/W2059666008","https://openalex.org/W2062240933","https://openalex.org/W2063638540","https://openalex.org/W2064195543","https://openalex.org/W2066454117","https://openalex.org/W2067495470","https://openalex.org/W2068406604","https://openalex.org/W2069261330","https://openalex.org/W2069838467","https://openalex.org/W2072314080","https://openalex.org/W2078385758","https://openalex.org/W2081644697","https://openalex.org/W2082032843","https://openalex.org/W2083334529","https://openalex.org/W2083777407","https://openalex.org/W2101485714","https://openalex.org/W2103545352","https://openalex.org/W2104128554","https://openalex.org/W2104302525","https://openalex.org/W2105780964","https://openalex.org/W2108167688","https://openalex.org/W2112778345","https://openalex.org/W2114200126","https://openalex.org/W2114552474","https://openalex.org/W2120877170","https://openalex.org/W2121074897","https://openalex.org/W2121390454","https://openalex.org/W2122004959","https://openalex.org/W2122985395","https://openalex.org/W2124906668","https://openalex.org/W2127101811","https://openalex.org/W2130941553","https://openalex.org/W2135119205","https://openalex.org/W2137027390","https://openalex.org/W2140437986","https://openalex.org/W2142492706","https://openalex.org/W2146329783","https://openalex.org/W2148535867","https://openalex.org/W2149264570","https://openalex.org/W2150087029","https://openalex.org/W2154912010","https://openalex.org/W2156836608","https://openalex.org/W2159601567","https://openalex.org/W2160473344","https://openalex.org/W2163433021","https://openalex.org/W2168408572","https://openalex.org/W2171166215","https://openalex.org/W2202478075","https://openalex.org/W2235575201","https://openalex.org/W2243749545","https://openalex.org/W2298420059","https://openalex.org/W2309010963","https://openalex.org/W2332931762","https://openalex.org/W2335578979","https://openalex.org/W2399023748","https://openalex.org/W2401253661","https://openalex.org/W2410337299","https://openalex.org/W2413621638","https://openalex.org/W2415612263","https://openalex.org/W2909396081","https://openalex.org/W4387923542","https://openalex.org/W4415404129"],"related_works":["https://openalex.org/W2035932982","https://openalex.org/W3210398881","https://openalex.org/W2525095533","https://openalex.org/W2498770329","https://openalex.org/W4412305235","https://openalex.org/W4407302275","https://openalex.org/W2236050166","https://openalex.org/W1964263738","https://openalex.org/W4238943722","https://openalex.org/W2791085253"],"abstract_inverted_index":{"Untreated":[0],"depression":[1,80,194,290],"in":[2,6,56,66,86,99,114,166,198,220,254,279,291],"pregnancy":[3,67,100,116,121,167,191,222,280,292],"may":[4,205],"result":[5],"adverse":[7],"health":[8],"outcomes":[9],"to":[10,32,46,84,119,144,170,208,274,283],"both":[11],"the":[12,22,30,48,60,89,92,105,133,139,145,149,171,199,270,304],"mother":[13],"and":[14,62,68,71,95,211,298],"her":[15],"unborn":[16],"child.":[17],"Pharmacotherapy":[18],"with":[19,34,293,318],"antidepressants":[20,65,93,152],"is":[21,81,295],"most":[23],"common":[24],"treatment":[25,49],"option":[26],"for":[27,129,135,174,230,311],"depression;":[28],"however,":[29],"decision":[31],"treat":[33],"medication":[35],"becomes":[36],"complicated":[37],"by":[38,269],"pregnancy.":[39,214],"Risk":[40],"benefit":[41,309],"assessments":[42,310],"are":[43],"critical":[44],"tools":[45],"guide":[47],"decision.":[50],"Factors":[51],"that":[52,104,161,193,224],"should":[53],"be":[54,206],"included":[55],"these":[57,136],"analyses":[58],"include":[59],"pharmacokinetics":[61,90],"pharmacodynamics":[63],"of":[64,77,91,110,151,187,202,213,217,239,250,276,289,306],"their":[69],"maternal":[70,79],"fetal":[72],"safety.":[73],"The":[74,264,287],"economic":[75],"cost":[76],"untreated":[78],"also":[82],"important":[83,297],"keep":[85],"mind.":[87],"When":[88,148],"venlafaxine":[94,181],"bupropion":[96,111],"were":[97,196],"studied":[98],"it":[101,158],"was":[102,112,126,142,153,159,163,226,252,281],"found":[103,160,253],"apparent":[106],"oral":[107],"clearance":[108],"rate":[109],"increased":[113,164,228],"late":[115],"when":[117,138,168],"compared":[118,143,169],"early":[120,221],"(p":[122,176,182],"=":[123,177,183,262],"0.03).":[124],"There":[125],"a":[127,246],"trend":[128],"lower":[130],"area":[131],"under":[132],"curve":[134],"medications":[137,278],"third":[140],"trimester":[141,201],"first":[146,200],"trimester.":[147],"metabolism":[150,165],"investigated":[154],"using":[155],"hair":[156],"analysis":[157],"there":[162,225],"postpartum":[172],"period":[173],"citalopram":[175],"0.02)":[178],"but":[179],"not":[180],"0.77).":[184],"Follow":[185],"up":[186],"depressive":[188],"symptoms":[189],"throughout":[190],"identified":[192],"scores":[195],"highest":[197],"pregnancy,":[203],"which":[204],"due":[207,273],"concurrent":[209],"nausea":[210],"vomiting":[212],"A":[215],"meta-analysis":[216],"paroxetine":[218],"use":[219],"demonstrated":[223],"no":[227],"risk":[229,308],"cardiac":[231],"malformations;":[232],"case-control":[233,255],"studies":[234,256],"had":[235],"an":[236,296],"odds":[237],"ratio":[238],"1.18":[240],"(CI95:":[241,257],"0.88":[242],"\u2013":[243,259],"1.59)":[244],"while":[245],"weighted":[247],"average":[248],"difference":[249],"0.3%":[251],"-0.1":[258],"0.7%,":[260],"p":[261],"0.19)":[263],"direct":[265],"medical":[266],"costs":[267],"incurred":[268],"Ontario":[271],"government":[272],"discontinuation":[275],"antidepressant":[277],"estimated":[282],"exceed":[284],"$20,000,000":[285],"CAD.":[286],"management":[288],"pharmacotherapy":[294],"complex":[299],"issue.":[300],"My":[301],"study":[302],"documents":[303],"advantages":[305],"conducting":[307],"vulnerable":[312],"populations":[313],"such":[314],"as":[315],"pregnant":[316],"women":[317],"depression.":[319]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-10-28T00:00:00"}
