{"id":"https://openalex.org/W2532332344","doi":"https://doi.org/10.5740/jaoacint.16-0166","title":"LC-MS/MS Validation of a Residue Analysis Method for Penicillin G and Its Metabolites in Commercial Orange Juice","display_name":"LC-MS/MS Validation of a Residue Analysis Method for Penicillin G and Its Metabolites in Commercial Orange Juice","publication_year":2016,"publication_date":"2016-10-17","ids":{"openalex":"https://openalex.org/W2532332344","doi":"https://doi.org/10.5740/jaoacint.16-0166","mag":"2532332344","pmid":"https://pubmed.ncbi.nlm.nih.gov/27751203"},"language":"en","primary_location":{"id":"doi:10.5740/jaoacint.16-0166","doi":"https://doi.org/10.5740/jaoacint.16-0166","is_oa":false,"landing_page_url":"https://doi.org/10.5740/jaoacint.16-0166","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023139060","display_name":"Fadi Aldeek","orcid":"https://orcid.org/0000-0002-1652-3952","observed_orcids":["https://orcid.org/0000-0002-1652-3952","https://orcid.org/0009-0003-5350-0420"]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fadi Aldeek","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038899945","display_name":"Daniele Canzani","orcid":"https://orcid.org/0000-0002-9390-0571","observed_orcids":["https://orcid.org/0000-0002-9390-0571"]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniele Canzani","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001238612","display_name":"Matthew Standland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Standland","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087727407","display_name":"Walter Hammack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter Hammack","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075985200","display_name":"Jo Marie Cook","orcid":"https://orcid.org/0000-0002-7319-1253","observed_orcids":["https://orcid.org/0000-0002-7319-1253"]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo-Marie Cook","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008985924","display_name":"Mark R. Crosswhite","orcid":"https://orcid.org/0000-0002-0478-8267","observed_orcids":["https://orcid.org/0000-0002-0478-8267"]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R Crosswhite","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056074841","display_name":"Ghislain Gerard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1308724467","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57","country_code":"US","type":"government","lineage":["https://openalex.org/I1308724467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ghislain Gerard","raw_affiliation_strings":["Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florida Department of Agriculture and Consumer Services, Division of Food Safety, 3125 Conner Blvd, Tallahassee, FL 32399-1650, USA","institution_ids":["https://openalex.org/I1308724467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023139060"],"corresponding_institution_ids":["https://openalex.org/I1308724467"],"apc_list":{"value":1868,"currency":"USD","value_usd":1868},"apc_paid":null,"fwci":0.2979,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.60840722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"100","issue":"1","first_page":"189","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillin-g","display_name":"penicillin G","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antibiotic-residues","display_name":"antibiotic residues","score":0.8840000033378601},{"id":"https://openalex.org/keywords/orange-juice","display_name":"orange juice","score":0.7850000262260437},{"id":"https://openalex.org/keywords/huanglongbing","display_name":"citrus greening","score":0.9300000071525574},{"id":"https://openalex.org/keywords/residue-analysis-method-validation","display_name":"residue analysis method validation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/lc-ms-ms","display_name":"LC-MS/MS","score":0.7839999794960022},{"id":"https://openalex.org/keywords/recovery","display_name":"recovery","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8321430683135986},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.7881758213043213},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7271618843078613},{"id":"https://openalex.org/C2992423453","wikidata":"https://www.wikidata.org/wiki/Q219059","display_name":"Orange juice","level":2,"score":0.7125416994094849},{"id":"https://openalex.org/C83082669","wikidata":"https://www.wikidata.org/wiki/Q39338","display_name":"Orange (colour)","level":2,"score":0.7100030779838562},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.6380615234375},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.5737516283988953},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4670492708683014},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.4136161506175995},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3522583842277527},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.34714171290397644},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.273654580116272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1590462625026703}],"mesh":[{"descriptor_ui":"D000067030","descriptor_name":"Fruit and Vegetable Juices","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010400","descriptor_name":"Penicillin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D032084","descriptor_name":"Citrus sinensis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5740/jaoacint.16-0166","doi":"https://doi.org/10.5740/jaoacint.16-0166","is_oa":false,"landing_page_url":"https://doi.org/10.5740/jaoacint.16-0166","pdf_url":null,"source":{"id":"https://openalex.org/S103486911","display_name":"Journal of AOAC International","issn_l":"1060-3271","issn":["1060-3271","1944-7922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC INTERNATIONAL","raw_type":"journal-article"},{"id":"pmid:27751203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27751203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AOAC International","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"},{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312834","display_name":"Florida Department of Agriculture and Consumer Services","ror":"https://ror.org/058nbms57"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416719431","https://openalex.org/W2575478569","https://openalex.org/W2349424274","https://openalex.org/W2890709168","https://openalex.org/W4400092772","https://openalex.org/W7120654406","https://openalex.org/W2747552076","https://openalex.org/W2389542845","https://openalex.org/W2360991955","https://openalex.org/W2425968359"],"abstract_inverted_index":{"Florida":[0,38],"citrus":[1,10],"depends":[2],"on":[3,98],"a":[4,129],"breakthrough":[5],"in":[6,34,86],"the":[7,14,27,35,67,99],"fight":[8],"against":[9],"greening":[11],"disease.":[12],"Of":[13],"antibiotics":[15],"used":[16,41],"to":[17,42,54,128],"treat":[18],"this":[19,74],"disease,":[20],"penicillin":[21,57,106],"G":[22,58,107],"has":[23],"been":[24],"one":[25],"of":[26,37,105,132],"most":[28],"effective.":[29],"Because":[30],"orange":[31,44],"fruit":[32],"grown":[33],"state":[36],"are":[39],"mainly":[40],"produce":[43],"juice,":[45],"we":[46],"have":[47],"validated":[48],"an":[49,109],"ultra-HPLC":[50],"tandem":[51],"MS":[52],"method":[53],"screen":[55],"for":[56,90,124],"and":[59,63,81,92],"its":[60],"metabolites":[61],"(penillic":[62],"penilloic":[64,93],"acids)":[65],"at":[66],"chemical":[68],"residue":[69],"level":[70],"after":[71],"treatment.":[72],"In":[73],"method,":[75],"three":[76],"spike":[77],"levels":[78],"(0.25,":[79],"1,":[80],"20":[82],"ng/g)":[83],"were":[84,95,114,122],"tested":[85],"triplicate.":[87],"Absolute":[88],"recoveries":[89,104],"penillic":[91],"acids":[94],"60-75%":[96],"depending":[97],"matrix":[100],"used,":[101],"whereas":[102],"corrected":[103],"using":[108],"isotopically":[110],"labeled":[111],"internal":[112],"standard":[113],"~100%.":[115],"Two":[116],"product":[117],"ion":[118],"transitions":[119],"per":[120],"analyte":[121],"required":[123],"identification,":[125],"which":[126],"contributes":[127],"high":[130],"degree":[131],"selectivity.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-10-28T00:00:00"}