{"id":"https://openalex.org/W2532182121","doi":"https://doi.org/10.1111/pedi.12453","title":"Congenital Hypoglycemia Disorders: New Aspects of Etiology, Diagnosis, Treatment and Outcomes","display_name":"Congenital Hypoglycemia Disorders: New Aspects of Etiology, Diagnosis, Treatment and Outcomes","publication_year":2016,"publication_date":"2016-10-18","ids":{"openalex":"https://openalex.org/W2532182121","doi":"https://doi.org/10.1111/pedi.12453","mag":"2532182121","pmid":"https://pubmed.ncbi.nlm.nih.gov/27753189","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5473026"},"language":"en","primary_location":{"id":"doi:10.1111/pedi.12453","doi":"https://doi.org/10.1111/pedi.12453","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pedi.12453","pdf_url":null,"source":{"id":"https://openalex.org/S118758356","display_name":"Pediatric Diabetes","issn_l":"1399-543X","issn":["1399-543X","1399-5448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5473026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051617679","display_name":"Diva D. De Le\u00f3n","orcid":"https://orcid.org/0000-0003-1225-8087","observed_orcids":["https://orcid.org/0000-0003-1225-8087"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diva D. De Leon","raw_affiliation_strings":["The Children's Hospital of Philadelphia Congenital Hyperinsulinism Center and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia Congenital Hyperinsulinism Center and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073631988","display_name":"Charles A. Stanley","orcid":"https://orcid.org/0000-0003-4881-9392","observed_orcids":["https://orcid.org/0000-0003-4881-9392"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Stanley","raw_affiliation_strings":["The Children's Hospital of Philadelphia Congenital Hyperinsulinism Center and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Children's Hospital of Philadelphia Congenital Hyperinsulinism Center and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051617679"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"],"apc_list":{"value":2740,"currency":"USD","value_usd":2740},"apc_paid":null,"fwci":5.4664,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.9651761,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"3","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-hyperinsulinism","display_name":"congenital hyperinsulinism","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neonatal-hypoglycemia","display_name":"neonatal hypoglycemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.4830000102519989},{"id":"https://openalex.org/keywords/genetic-diagnosis","display_name":"genetic diagnosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hypoglycemia-management","display_name":"hypoglycemia management","score":0.8769999742507935},{"id":"https://openalex.org/keywords/novel-therapies","display_name":"new drugs","score":0.6430000066757202},{"id":"https://openalex.org/keywords/brain-injury-prevention","display_name":"brain injury prevention","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8801447153091431},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.877484917640686},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6635997295379639},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.620231032371521},{"id":"https://openalex.org/C2777643638","wikidata":"https://www.wikidata.org/wiki/Q5160437","display_name":"Congenital hyperinsulinism","level":5,"score":0.6063231825828552},{"id":"https://openalex.org/C2775858560","wikidata":"https://www.wikidata.org/wiki/Q11612732","display_name":"Hyperinsulinemic hypoglycemia","level":4,"score":0.5561211109161377},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.521476149559021},{"id":"https://openalex.org/C2777368190","wikidata":"https://www.wikidata.org/wiki/Q477390","display_name":"Hyperinsulinism","level":4,"score":0.4004688262939453},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19164687395095825},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.17554524540901184},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1490749716758728},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":true},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D015143","descriptor_name":"Philadelphia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044903","descriptor_name":"Congenital Hyperinsulinism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D044903","descriptor_name":"Congenital Hyperinsulinism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D044903","descriptor_name":"Congenital Hyperinsulinism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/pedi.12453","doi":"https://doi.org/10.1111/pedi.12453","is_oa":false,"landing_page_url":"https://doi.org/10.1111/pedi.12453","pdf_url":null,"source":{"id":"https://openalex.org/S118758356","display_name":"Pediatric Diabetes","issn_l":"1399-543X","issn":["1399-543X","1399-5448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Diabetes","raw_type":"journal-article"},{"id":"pmid:27753189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27753189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric diabetes","raw_type":"Conference Proceedings"},{"id":"pmh:oai:europepmc.org:4321906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5473026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5473026","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5473026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Diabetes","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4321906","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5473026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4710995538","display_name":"Congenital Hypoglycemia Disorders: Hyperinsulinism and Glycogen Storage Diseases","funder_award_id":"R13DK112408","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G78998978","display_name":"Islet Dysregulation in Infants with Congenital Hyperinsulinism","funder_award_id":"R37DK056268","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1585861318","https://openalex.org/W1718583305","https://openalex.org/W1986381180","https://openalex.org/W1988775252","https://openalex.org/W1991865729","https://openalex.org/W2015230257","https://openalex.org/W2016657294","https://openalex.org/W2059774448","https://openalex.org/W2063092778","https://openalex.org/W2063247572","https://openalex.org/W2076523697","https://openalex.org/W2083700606","https://openalex.org/W2091862985","https://openalex.org/W2098176814","https://openalex.org/W2107040844","https://openalex.org/W2115515282","https://openalex.org/W2119164190","https://openalex.org/W2120854249","https://openalex.org/W2123053518","https://openalex.org/W2123427895","https://openalex.org/W2127882901","https://openalex.org/W2131874671","https://openalex.org/W2147281552","https://openalex.org/W2153705755","https://openalex.org/W2168895815","https://openalex.org/W2170463064","https://openalex.org/W2263491684","https://openalex.org/W2277559429","https://openalex.org/W2407707716","https://openalex.org/W2429820528","https://openalex.org/W3023173633"],"related_works":["https://openalex.org/W3008061677","https://openalex.org/W3048295897","https://openalex.org/W2277086769","https://openalex.org/W2277559429","https://openalex.org/W4235038439","https://openalex.org/W2967551410","https://openalex.org/W3200988331","https://openalex.org/W2730575593","https://openalex.org/W4220907907","https://openalex.org/W2893122299"],"abstract_inverted_index":{"Hypoglycemia":[0],"continues":[1],"to":[2,79,85,115],"be":[3],"an":[4],"important":[5],"cause":[6,40],"of":[7,17,41,50,54,60,72,93],"morbidity":[8],"in":[9,44,109],"neonates":[10,45],"and":[11,15,28,38,46,68,76,121],"children.":[12,47],"Prompt":[13],"diagnosis":[14],"management":[16,65],"the":[18,35,51,61,70,81,86],"underlying":[19],"hypoglycemia":[20,43,100],"disorder":[21],"is":[22,34,66],"critical":[23],"for":[24],"preventing":[25],"brain":[26],"damage":[27],"improving":[29],"outcomes.":[30,123],"Congenital":[31],"hyperinsulinism":[32],"(HI)":[33],"most":[36],"common":[37],"severe":[39],"persistent":[42],"Recent":[48],"discoveries":[49],"genetic":[52,111],"causes":[53],"HI":[55],"have":[56],"improved":[57],"our":[58],"understanding":[59],"pathophysiology,":[62],"but":[63],"its":[64],"complex":[67],"requires":[69],"integration":[71],"clinical,":[73],"biochemical,":[74],"molecular,":[75],"imaging":[77],"findings":[78],"establish":[80],"appropriate":[82],"treatment":[83],"according":[84],"subtype.":[87],"Here":[88],"we":[89],"present":[90],"a":[91,94],"summary":[92],"recent":[95],"international":[96],"symposium":[97],"on":[98,104],"congenital":[99],"disorders":[101],"with":[102],"emphasis":[103],"novel":[105,117],"molecular":[106],"mechanisms":[107],"resulting":[108],"HI,":[110],"diagnosis,":[112],"overall":[113],"approach":[114],"management,":[116],"therapies":[118],"under":[119],"development,":[120],"current":[122]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-28T00:00:00"}