{"id":"https://openalex.org/W2532010263","doi":null,"title":"Characteristics of 547 pedigrees from the Prostate Cancer Risk Assessment Program over a 10-year period","display_name":"Characteristics of 547 pedigrees from the Prostate Cancer Risk Assessment Program over a 10-year period","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2532010263","mag":"2532010263"},"language":"en","primary_location":{"id":"mag:2532010263","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/16/12_Supplement/A70","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075831823","display_name":"Veda N. Giri","orcid":"https://orcid.org/0000-0002-7268-5913","observed_orcids":["https://orcid.org/0000-0002-7268-5913"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veda N. Giri","raw_affiliation_strings":["Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-7268-5913","affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001714656","display_name":"Asha George","orcid":"https://orcid.org/0000-0002-3490-7984","observed_orcids":["https://orcid.org/0000-0002-3490-7984"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asha George","raw_affiliation_strings":["Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-3490-7984","affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021755146","display_name":"Susan L Raysor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Raysor","raw_affiliation_strings":["Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112414330","display_name":"Karen J Ruth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Ruth","raw_affiliation_strings":["Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074209350","display_name":"Agnes B. Baffoe\u2010Bonnie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agnes Baffoe\u2010Bonnie","raw_affiliation_strings":["Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Ctr., Philadelphia, PA, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44294832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.7829999923706055},{"id":"https://openalex.org/keywords/pedigree","display_name":"pedigree","score":0.7059999704360962},{"id":"https://openalex.org/keywords/familial-risk","display_name":"familial risk","score":0.5370000004768372},{"id":"https://openalex.org/keywords/african-american-men","display_name":"African American men","score":0.9580000042915344},{"id":"https://openalex.org/keywords/high-risk-screening","display_name":"high-risk screening","score":0.5519999861717224},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cancer-detection-rate","display_name":"cancer detection rate","score":0.597000002861023},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.4869999885559082},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cancer-risk-assessment","display_name":"cancer risk assessment","score":0.4050000011920929},{"id":"https://openalex.org/keywords/first-degree-relatives","display_name":"first-degree relatives","score":0.5329999923706055},{"id":"https://openalex.org/keywords/second-degree-relatives","display_name":"second-degree relatives","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.48899999260902405},{"id":"https://openalex.org/keywords/psa-screening","display_name":"PSA screening","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C22593422","wikidata":"https://www.wikidata.org/wiki/Q3242583","display_name":"Pedigree chart","level":3,"score":0.7329835891723633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6916193962097168},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5461905002593994},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.5456973314285278},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4525545835494995},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.4439485967159271},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4296434223651886},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.41330093145370483},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3288741409778595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.272663950920105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15365147590637207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0874079167842865},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2532010263","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/16/12_Supplement/A70","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889772055","https://openalex.org/W2084228321","https://openalex.org/W2314567907","https://openalex.org/W7135070778","https://openalex.org/W2563176431","https://openalex.org/W2891504040","https://openalex.org/W2048647174","https://openalex.org/W7160635566","https://openalex.org/W1895591853","https://openalex.org/W2597651605"],"abstract_inverted_index":{"A70":[0],"Background:":[2],"Men":[3],"with":[4,78,145,152,161,181,320,333,349,361],"a":[5,182,206,281,317,381],"family":[6],"history":[7],"(FH)":[8],"and":[9,61,66,95,227,253,275,289,310,353,363],"African":[10],"American":[11],"(AA)":[12],"men":[13,55,131,248,387,398],"are":[14,338,351,367,408],"at":[15,41,56,91,147,155,388,399],"increased":[16],"risk":[17,58,119,284,405],"for":[18,24,54,59,117,137,209,235,285,390,411],"prostate":[19,362],"cancer":[20,81],"(PCA).":[21],"Risk":[22,37],"assessment":[23,406],"PCA":[25,60,72,87,112,162,271,286,350,393,404,415],"is":[26,76,373,394],"challenging":[27],"due":[28],"to":[29,51,105,204,259,416],"lack":[30],"of":[31,69,86,111,130,167,175,214,246,265,277,296,301,313,325,335,358,368,377,386,414],"genetic":[32,67],"testing.":[33],"The":[34,340],"Prostate":[35],"Cancer":[36,44],"Assessment":[38],"Program":[39],"(PRAP)":[40],"Fox":[42],"Chase":[43],"Center":[45],"(FCCC)":[46],"was":[47,190,217,242],"established":[48],"in":[49,74,113,132,202,223,272,346,380,397,419],"1996":[50],"provide":[52],"screening":[53],"high":[57],"gain":[62,106],"insight":[63,107],"into":[64,108],"familial":[65,109,283,308,321,378],"patterns":[68,110],"this":[70,420],"risk.":[71],"incidence":[73],"PRAP":[75,138,247,303,327,347,359],"9%":[77],"an":[79],"11%":[80],"detection":[82,413],"rate.":[83],"Twenty":[84],"percent":[85,300,357],"have":[88,270,280,305,329],"been":[89],"found":[90,345],"low":[92],"PSA":[93],"values":[94],"were":[96,196,233,257],"Gleason":[97],"7":[98],"or":[99,177,185],"higher,":[100],"pointing":[101],"out":[102],"the":[103,124,164,168,220,278,293,297,374],"need":[104],"these":[114,273],"high-risk":[115,389,421],"families":[116,348],"effective":[118],"assessment.":[120],"Here,":[121],"we":[122],"report":[123,316,376],"prospective":[125],"data":[126,199,237],"on":[127,163,292],"547":[128,250],"pedigrees":[129,306,360],"PRAP.":[133],"Methods:":[134],"Eligibility":[135],"criteria":[136],"include":[139],"any":[140,171,179,210,364],"man":[141,173,180],"between":[142],"35-69":[143],"years":[144,269],"(1)":[146],"least":[148,156],"1":[149],"first-degree":[150],"(FDR)":[151],"PCA,":[153,309,334],"(2)":[154],"2":[157,186],"second-degree":[158],"relatives":[159],"(SDR)":[160],"same":[165,294],"side":[166,295],"family,":[169],"(3)":[170],"AA":[172,314,369,402],"regardless":[174],"FH,":[176],"(4)":[178],"known":[183],"BRCA1":[184],"mutation.":[187],"FH":[188,240,318],"information":[189,241],"self-reported":[191],"by":[192,198,244],"participants.":[193],"Imputed":[194],"individuals":[195],"added":[197],"management":[200],"staff":[201],"order":[203],"complete":[205],"mother-father":[207],"link":[208],"child":[211],"reported.":[212],"Description":[213],"relationships":[215],"captured":[216],"performed":[218,258],"using":[219],"FCOR":[221],"program":[222],"S.A.G.E.":[224],"3.1.":[225],"Frequency":[226],"univariate":[228],"methods":[229],"(SAS":[230],"version":[231],"9.1)":[232],"used":[234],"other":[236,343,365],"analyses.":[238],"Results:":[239],"provided":[243],"88.7%":[245],"representing":[249],"unique":[251],"pedigrees,":[252],"6.96%":[254],"mother/father":[255],"imputations":[256],"maintain":[260],"pedigree":[261],"structure.":[262],"Approximately":[263],"14.8%":[264],"males":[266],">":[267],"18":[268],"families,":[274],"12.6%":[276],"probands":[279,304,315,328],"strong":[282],"(1":[287],"FDR":[288],">2":[290],"SDR":[291],"family).":[298],"Twelve":[299],"unaffected":[302,326],"demonstrating":[307],"almost":[311],"6%":[312],"consistent":[319],"PCA.":[322,391],"Furthermore,":[323],"20%":[324],">1":[330],"brother":[331],"affected":[332],"which":[336],"33%":[337],"AA.":[339],"most":[341],"common":[342],"cancers":[344,366],"breast":[352],"colon":[354],"cancer.":[355],"Eleven":[356],"ethnicity.":[370],"Conclusions:":[371],"This":[372],"first":[375],"characteristics":[379],"large,":[382],"prospectively":[383],"screened":[384],"population":[385],"Familial":[392],"quite":[395],"prevalent":[396],"high-risk,":[400],"including":[401],"men.":[403],"measures":[407],"greatly":[409],"needed":[410],"early":[412],"reduce":[417],"mortality":[418],"population.":[422]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-10-28T00:00:00"}