{"id":"https://openalex.org/W2532004191","doi":"https://doi.org/10.3389/fmolb.2016.00068","title":"Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides","display_name":"Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides","publication_year":2016,"publication_date":"2016-10-25","ids":{"openalex":"https://openalex.org/W2532004191","doi":"https://doi.org/10.3389/fmolb.2016.00068","mag":"2532004191","pmid":"https://pubmed.ncbi.nlm.nih.gov/27826550","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5078471"},"language":"en","primary_location":{"id":"doi:10.3389/fmolb.2016.00068","doi":"https://doi.org/10.3389/fmolb.2016.00068","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2016.00068","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmolb.2016.00068/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmolb.2016.00068/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038709548","display_name":"Zehra Kevser Timur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zehra Kevser Timur","raw_affiliation_strings":["Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075591548","display_name":"Secil Akyildiz Demir","orcid":"https://orcid.org/0000-0002-8528-4801","observed_orcids":["https://orcid.org/0000-0002-8528-4801"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Secil Akyildiz Demir","raw_affiliation_strings":["Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014700133","display_name":"Volkan Seyrantepe","orcid":"https://orcid.org/0000-0002-0243-5011","observed_orcids":["https://orcid.org/0000-0002-0243-5011"]},"institutions":[{"id":"https://openalex.org/I120217413","display_name":"Izmir Institute of Technology","ror":"https://ror.org/03stptj97","country_code":"TR","type":"education","lineage":["https://openalex.org/I120217413"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Volkan Seyrantepe","raw_affiliation_strings":["Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Izmir Institute of Technology, Molecular Biology and Genetics, Izmir, Turkey","institution_ids":["https://openalex.org/I120217413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014700133"],"corresponding_institution_ids":["https://openalex.org/I120217413"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.8163,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.86357197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":null,"first_page":"68","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.22419999539852142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-a","display_name":"cathepsin A","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":1.0},{"id":"https://openalex.org/keywords/angiotensin-i","display_name":"angiotensin I","score":1.0},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/c-terminal-cleavage","display_name":"C-terminal cleavage","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C78553746","wikidata":"https://www.wikidata.org/wiki/Q423561","display_name":"Cathepsin A","level":4,"score":0.800950288772583},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.6462531089782715},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.5556944608688354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5215606689453125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5160000324249268},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.49070775508880615},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.44407689571380615},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4288749694824219},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.42538541555404663},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.42387181520462036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27471017837524414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2733917534351349},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16255420446395874}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fmolb.2016.00068","doi":"https://doi.org/10.3389/fmolb.2016.00068","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2016.00068","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmolb.2016.00068/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5078471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5078471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Mol Biosci","raw_type":"Text"},{"id":"pmid:27826550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27826550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in molecular biosciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:90b4e83fadd04f7ab8c1867cbe4ee31b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/90b4e83fadd04f7ab8c1867cbe4ee31b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Molecular Biosciences, Vol 3 (2016)","raw_type":"article"},{"id":"pmh:oai:gcris.iyte.edu.tr:11147/9355","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2016.00068","pdf_url":null,"source":{"id":"https://openalex.org/S4306400894","display_name":"\u0130YTE (\u0130ZM\u0130R Y\u00dcKSEK TEKNOLOJ\u0130 ENST\u0130T\u00dcS\u00dc)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:openaccess.iyte.edu.tr:11147/9355","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11147/9355","pdf_url":null,"source":{"id":"https://openalex.org/S4377196445","display_name":"IYTE GCRIS Database (Izmir Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120217413","host_organization_name":"Izmir Institute of Technology","host_organization_lineage":["https://openalex.org/I120217413"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmolb.2016.00068","doi":"https://doi.org/10.3389/fmolb.2016.00068","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmolb.2016.00068","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmolb.2016.00068/pdf","source":{"id":"https://openalex.org/S2595797843","display_name":"Frontiers in Molecular Biosciences","issn_l":"2296-889X","issn":["2296-889X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-140","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Molecular Biosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6348258756","display_name":null,"funder_award_id":"111T896","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2532004191.pdf","grobid_xml":"https://content.openalex.org/works/W2532004191.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1515556278","https://openalex.org/W1538944936","https://openalex.org/W1578946246","https://openalex.org/W1585032009","https://openalex.org/W1942364642","https://openalex.org/W1975008822","https://openalex.org/W1978331190","https://openalex.org/W1986839466","https://openalex.org/W1993283661","https://openalex.org/W1994697562","https://openalex.org/W2014071799","https://openalex.org/W2015502058","https://openalex.org/W2019687681","https://openalex.org/W2024118722","https://openalex.org/W2067188727","https://openalex.org/W2069707706","https://openalex.org/W2075493559","https://openalex.org/W2081424390","https://openalex.org/W2095554947","https://openalex.org/W2105605379","https://openalex.org/W2131796001","https://openalex.org/W2159986416","https://openalex.org/W2166139320","https://openalex.org/W2168161193","https://openalex.org/W2169337884","https://openalex.org/W2328431040","https://openalex.org/W4247936073","https://openalex.org/W4255410319","https://openalex.org/W6653824980"],"related_works":["https://openalex.org/W2019687681","https://openalex.org/W2108868457","https://openalex.org/W2081424390","https://openalex.org/W2096745826","https://openalex.org/W2589599634","https://openalex.org/W1985939984","https://openalex.org/W3174052823","https://openalex.org/W2042615489","https://openalex.org/W625082954","https://openalex.org/W2079024462"],"abstract_inverted_index":{"Lysosomal":[0],"serine":[1],"carboxypeptidase":[2],"Cathepsin":[3],"A":[4],"(CTSA)":[5],"is":[6,18],"a":[7,40,85],"multifunctional":[8],"enzyme":[9],"with":[10],"distinct":[11],"protective":[12],"and":[13,30,34,55,102,110,119],"catalytic":[14],"function.":[15],"CTSA":[16,38,80,127],"that":[17,126],"present":[19],"in":[20,42,84,104,136],"the":[21,43,66,76,93,105,113,131],"lysosomal":[22,27],"multienzyme":[23],"complex":[24],"facilitates":[25],"correct":[26],"routing,":[28],"stability":[29],"activation":[31],"of":[32,45,59,79,89,95,112,121,133,139,145],"beta\uf02dgalactosidase":[33],"alpha-neuraminidase.":[35],"In":[36,69],"addition,":[37],"plays":[39],"role":[41,78],"inactivation":[44],"bioactive":[46,82,134],"peptides":[47,83,135],"including":[48],"bradykinin,":[49,96],"substances":[50,97],"P,":[51,98],"oxytocin,":[52,99],"angiotensin":[53,100],"I":[54,101],"endothelin-I":[56,103],"by":[57],"cleavage":[58],"one":[60],"or":[61],"two":[62],"amino":[63],"acid(s)":[64],"from":[65],"C-terminal":[67],"ends.":[68],"this":[70],"study,":[71],"we":[72],"aimed":[73],"to":[74,130,143],"elucidate":[75],"regulatory":[77],"on":[81],"knock-in":[86],"mouse":[87,115],"model":[88,116],"CTSAS190A.":[90],"We":[91],"evaluated":[92],"levels":[94],"kidney,":[106],"liver,":[107],"lung,":[108],"brain":[109],"serum":[111],"CTSAS190A":[114,140],"at":[117],"three-":[118],"six-months":[120],"age.":[122],"Our":[123],"results":[124],"suggest":[125],"selectively":[128],"contributes":[129],"processing":[132],"different":[137],"tissues":[138],"mice":[141],"compared":[142],"those":[144],"age-matched":[146],"wild-type":[147],"mice.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-10-28T00:00:00"}
