{"id":"https://openalex.org/W2531943239","doi":null,"title":"A Novel Approach to Assay DNA Methylation in Prostate Cancer","display_name":"A Novel Approach to Assay DNA Methylation in Prostate Cancer","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2531943239","mag":"2531943239"},"language":"en","primary_location":{"id":"mag:2531943239","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1005093.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026756753","display_name":"Jindan Yu","orcid":"https://orcid.org/0000-0002-2326-0409","observed_orcids":["https://orcid.org/0000-0002-2326-0409","https://orcid.org/0009-0002-2082-5141"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jindan Yu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2326-0409","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026756753"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18622532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/5-hydroxymethylcytosine","display_name":"5-hydroxymethylcytosine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tet-enzymes","display_name":"TET enzymes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.7549999952316284},{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.953000009059906},{"id":"https://openalex.org/keywords/enhancer-activation","display_name":"enhancer activation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/methylation-markers","display_name":"methylation biomarkers","score":0.8629999756813049},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8289999961853027},{"id":"https://openalex.org/keywords/genome-wide-methylation-mapping","display_name":"genome-wide methylation mapping","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.8111491799354553},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6811104416847229},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6141070127487183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5107691287994385},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4995095729827881},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.498319149017334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45920851826667786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41583770513534546},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3273715376853943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23795393109321594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23453760147094727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1768685281276703}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2531943239","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1005093.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:3146614561","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1024725.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4306412026","https://openalex.org/W2898530667","https://openalex.org/W2752330677","https://openalex.org/W7018724483","https://openalex.org/W2735883211","https://openalex.org/W3134785045","https://openalex.org/W7172509065","https://openalex.org/W2887974597","https://openalex.org/W2726569180","https://openalex.org/W2315745732"],"abstract_inverted_index":{"Abstract":[0],":":[1],"Previous":[2],"studies":[3,39],"of":[4,9,17,28,74,92,104,144,166],"DNA":[5,44,157],"methylation":[6,19,45,76,93],"at":[7],"5-position":[8],"cytosine":[10],"(5mC)":[11,46],"have":[12,40,100,185],"led":[13],"to":[14,132,137,151,155,179],"the":[15,51,90,141],"discovery":[16],"useful":[18],"biomarkers":[20],"for":[21],"prostate":[22,115,119,125],"cancer":[23,120,126],"diagnosis":[24],"and":[25,84,106,122,139,173],"prognosis,":[26],"some":[27],"which":[29,58],"are":[30,129],"being":[31],"developed":[32],"into":[33],"clinical":[34],"tests.":[35],"However,":[36],"several":[37],"seminal":[38],"recently":[41],"reported":[42],"that":[43,81,161],"can":[47],"be":[48],"de-methylated":[49],"by":[50,71],"TET":[52],"proteins":[53],"resulting":[54],"in":[55,108,148],"5-hydroxylmethylation":[56],"(5hmC),":[57],"plays":[59],"functional":[60],"roles":[61],"distinct":[62],"from":[63,69],"5mC":[64,70,83,105],"but":[65],"yet":[66],"is":[67],"indistinguishable":[68],"a":[72,134,153,163],"majority":[73],"existing":[75],"assays.":[77],"Developing":[78],"enabling":[79],"assays":[80],"measure":[82],"5hmC":[85,107],"specifically":[86],"might":[87],"significantly":[88],"improve":[89],"performance":[91],"biomarkers.":[94],"During":[95],"this":[96],"reporting":[97],"period,":[98],"we":[99,159],"performed":[101],"genome-wide":[102],"mapping":[103],"33":[109],"samples,":[110],"including":[111],"11":[112,117],"primary":[113],"benign":[114],"tissue,":[116],"localized":[118],"tissue":[121],"6":[123],"castration-resistant":[124],"tissue.":[127],"We":[128],"working":[130],"on":[131],"establish":[133,152],"bioinformatics":[135],"system":[136,154],"handle":[138],"analyze":[140],"large":[142],"amount":[143],"sequencing":[145],"data.":[146],"Further,":[147],"an":[149],"effort":[150],"manipulate":[156],"methylation,":[158],"found":[160],"FOXA1,":[162],"pioneer":[164],"factor":[165],"androgen":[167],"receptor,":[168],"directly":[169],"induces":[170],"TET1":[171,176],"expression":[172],"interacts":[174],"with":[175],"protein,":[177],"leading":[178],"lineage-specific":[180],"enhancer":[181],"activation.":[182],"Several":[183],"manuscripts":[184],"been":[186],"either":[187],"published":[188],"or":[189],"under":[190],"submission.":[191]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-10-21T00:00:00"}