{"id":"https://openalex.org/W2531887134","doi":"https://doi.org/10.1111/bjh.14393","title":"Regular automated red cell exchange transfusion in the management of stuttering priapism complicating sickle cell disease","display_name":"Regular automated red cell exchange transfusion in the management of stuttering priapism complicating sickle cell disease","publication_year":2016,"publication_date":"2016-10-10","ids":{"openalex":"https://openalex.org/W2531887134","doi":"https://doi.org/10.1111/bjh.14393","mag":"2531887134","pmid":"https://pubmed.ncbi.nlm.nih.gov/27723091"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.14393","doi":"https://doi.org/10.1111/bjh.14393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.14393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14393","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14393","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Anietie Ekong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I4210098291","display_name":"Homerton University Hospital","ror":"https://ror.org/00x444s43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210098291","https://openalex.org/I4210112187"]},{"id":"https://openalex.org/I4210112187","display_name":"Homerton University Hospital NHS Foundation Trust","ror":"https://ror.org/01zpp3d44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210112187"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Anietie Ekong","raw_affiliation_strings":["Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I4210098291","https://openalex.org/I4210112187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071239876","display_name":"Lauren Berg","orcid":"https://orcid.org/0000-0002-6617-3065","observed_orcids":["https://orcid.org/0000-0002-6617-3065"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I4210098291","display_name":"Homerton University Hospital","ror":"https://ror.org/00x444s43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210098291","https://openalex.org/I4210112187"]},{"id":"https://openalex.org/I4210112187","display_name":"Homerton University Hospital NHS Foundation Trust","ror":"https://ror.org/01zpp3d44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210112187"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lauren Berg","raw_affiliation_strings":["Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I4210098291","https://openalex.org/I4210112187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111885246","display_name":"Roger J. Amos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I4210098291","display_name":"Homerton University Hospital","ror":"https://ror.org/00x444s43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210098291","https://openalex.org/I4210112187"]},{"id":"https://openalex.org/I4210112187","display_name":"Homerton University Hospital NHS Foundation Trust","ror":"https://ror.org/01zpp3d44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210112187"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roger J. Amos","raw_affiliation_strings":["Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I4210098291","https://openalex.org/I4210112187"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049353540","display_name":"Dimitris A. Tsitsikas","orcid":"https://orcid.org/0000-0003-3468-049X","observed_orcids":["https://orcid.org/0000-0003-3468-049X"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I4210098291","display_name":"Homerton University Hospital","ror":"https://ror.org/00x444s43","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210098291","https://openalex.org/I4210112187"]},{"id":"https://openalex.org/I4210112187","display_name":"Homerton University Hospital NHS Foundation Trust","ror":"https://ror.org/01zpp3d44","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210112187"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dimitris A. Tsitsikas","raw_affiliation_strings":["Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Haemoglobinopathy Service, Department of Haematology, Homerton University Hospital NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I4210098291","https://openalex.org/I4210112187"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049353540"],"corresponding_institution_ids":["https://openalex.org/I125671874","https://openalex.org/I4210098291","https://openalex.org/I4210112187"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.5467,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82905334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"180","issue":"4","first_page":"585","last_page":"588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stuttering-priapism","display_name":"stuttering priapism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/etilefrine","display_name":"etilefrine","score":0.6970000267028809},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.5590000152587891},{"id":"https://openalex.org/keywords/recurrent-priapism","display_name":"recurrent priapism","score":0.6579999923706055},{"id":"https://openalex.org/keywords/priapism-management","display_name":"priapism management","score":0.48899999260902405},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2780345856","wikidata":"https://www.wikidata.org/wiki/Q156590","display_name":"Priapism","level":2,"score":0.9604678750038147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8703888654708862},{"id":"https://openalex.org/C2779042277","wikidata":"https://www.wikidata.org/wiki/Q886468","display_name":"Exchange transfusion","level":2,"score":0.5129889845848083},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.4781245291233063},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4541638493537903},{"id":"https://openalex.org/C2779817106","wikidata":"https://www.wikidata.org/wiki/Q7834210","display_name":"Transfusion therapy","level":3,"score":0.4259144067764282},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.3984343409538269},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3704994022846222},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30329474806785583}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011317","descriptor_name":"Priapism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017707","descriptor_name":"Erythrocyte Transfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/bjh.14393","doi":"https://doi.org/10.1111/bjh.14393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.14393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14393","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:27723091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27723091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1111/bjh.14393","doi":"https://doi.org/10.1111/bjh.14393","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.14393","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.14393","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531887134.pdf","grobid_xml":"https://content.openalex.org/works/W2531887134.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1935071313","https://openalex.org/W1962164169","https://openalex.org/W1984412875","https://openalex.org/W2041536638","https://openalex.org/W2070434673","https://openalex.org/W2078448849","https://openalex.org/W2113495643","https://openalex.org/W2281630631","https://openalex.org/W2407396318"],"related_works":["https://openalex.org/W3197168928","https://openalex.org/W4226347945","https://openalex.org/W1962164169","https://openalex.org/W3202778523","https://openalex.org/W2063942878","https://openalex.org/W2462538517","https://openalex.org/W2553568404","https://openalex.org/W7097792314","https://openalex.org/W1935071313","https://openalex.org/W4243525936"],"abstract_inverted_index":{"Stuttering":[0],"priapism":[1,92,138],"(SP)":[2],"is":[3,126,151,833,953,1053],"a":[4,29,74,100,340,469,834,876,909,1001,1026],"painful,":[5],"unwanted":[6],"erection":[7],"lasting":[8],"up":[9,17,679],"to":[10,18,192,369,393,578,680,709,955,1097],"3":[11,536],"h":[12],"(Broderick,":[13],"2012).":[14],"It":[15],"affects":[16,1025],"30\u201345%":[19],"of":[20,31,66,80,103,123,132,162,242,247,292,301,351,360,391,420,427,445,455,517,524,540,550,599,608,624,631,634,668,678,689,739,750,774,781,828,850,879,889,892,904,926,930,939,947,958,1015,1029,1039,1089,1095],"male":[21],"patients":[22,166,229,720,839,852,863,932,963,1030,1046],"with":[23,28,63,167,230,250,255,339,464,532,559,676,718,754,804,806,812,840,846,894,964,1031,1033,1047],"Sickle":[24],"Cell":[25],"Disease":[26],"(SCD)":[27],"prevalence":[30],"75\u201389%":[32],"(Adeyoju":[33,94],"et":[34,38,83,95,233,968,983],"al,":[35,39,84,96,234,969,984],"2002;":[36],"Nolan":[37],"2005).":[40,85],"Management":[41],"measures":[42],"include":[43],"urination,":[44],"analgesia,":[45],"exercise":[46],"and":[47,70,125,169,174,252,290,299,355,372,397,408,422,491,493,502,519,569,586,603,613,687,711,759,770,776,823,842,869,914,928,945,993,1062,1069,1078,1083],"sympathomimetic":[48],"agents,":[49],"such":[50],"as":[51,186,223,574,614,896,949,1000],"etilefrine":[52],"hydrochloride":[53],"(EH).":[54],"SP":[55,86,150,243,293,302,392,421,446,518,541,600,625,635,649,675,702,726,751,766,844,868,893,913,927,1024],"usually":[56],"occurs":[57],"in":[58,120,149,164,179,346,365,382,389,447,457,473,509,514,542,552,566,591,636,662,666,697,725,772,961,1004,1009,1020],"the":[59,121,129,160,194,218,240,245,425,522,525,582,606,609,743,765,779,782,826,853,897,902,905,915,921,956,975,1010,1060,1064,1071,1076,1081,1086,1090],"early":[60,638],"morning":[61],"hours":[62],"consequent":[64],"loss":[65],"sleep,":[67],"daytime":[68],"somnolence":[69],"anxiety,":[71],"which":[72,98,477],"have":[73,579,1092],"negative":[75],"impact":[76,1035],"on":[77,146,159,262,335,375,462,480,505,557,572,656,695,837,1036],"patient":[78,791],"quality":[79,688,1038],"life":[81],"(Karsenty":[82],"can":[87],"evolve":[88],"into":[89],"acute":[90,137,500],"major":[91],"(MP)":[93],"2002),":[97],"carries":[99],"considerable":[101],"risk":[102],"erectile":[104,489],"dysfunction":[105,490],"(ED)":[106],"(Ballas":[107,141],"&":[108,142,278],"Lyon,":[109,143],"2015).":[110,144],"Automated":[111],"red":[112],"cell":[113,213],"exchange":[114],"transfusion":[115],"(ARCET)":[116],"has":[117],"been":[118,260,334,693],"used":[119],"management":[122,350,738],"MP":[124,456,471,551],"recognized":[127],"by":[128,189,217,729,867],"American":[130],"Society":[131],"Apharesis":[133],"(ASFA)":[134],"for":[135,228,349,411,507,589,658,700,731,737,856,979,991,1013,1045],"managing":[136],"(category":[139],"III)":[140],"Data":[145],"its":[147,1016],"use":[148,193,1017],"more":[152],"limited.":[153],"Here,":[154],"we":[155,734],"report":[156,836,997],"our":[157,716],"experience":[158,717],"effect":[161,786],"ARCET":[163,345,364,410,430,506,588,602,657,730,736,753,822,830,857,884,906,944,999,1041],"five":[165,237,838,862],"SCD":[168,231,841,962,1005,1032],"recurrent":[170,659,843,980],"SP.":[171,670,741,860],"Patient":[172],"characteristics":[173],"haematological":[175],"parameters":[176],"are":[177,1018],"summarised":[178],"Table":[180],"1.":[181],"All":[182,236,257,861],"procedures":[183],"were":[184,215,864,886],"performed":[185],"day":[187],"cases":[188],"nurses":[190],"trained":[191],"Spectra":[195],"Optia":[196],"Apheresis":[197],"System":[198],"(TerumoBCT":[199],"Europe":[200],"NV,":[201],"Zaventem,":[202],"Belgium).":[203],"The":[204,432,527,986],"target":[205],"post-transfusion":[206],"HbS":[207,616,898,916,950],"was":[208,269,373,380,435,460,494,503,530,555,570,576,641,654,706,787,802,858],"less":[209,788],"than":[210],"10%.":[211],"Red":[212],"units":[214],"provided":[216],"UK":[219,225,988,1011],"National":[220,989],"Blood":[221],"Service":[222],"per":[224],"national":[226],"standards":[227],"(Milkins":[232],"2013).":[235],"subjects":[238,258],"reported":[239,417,596,629,747,795],"onset":[241],"between":[244,756,912],"ages":[246],"10\u201325":[248],"years":[249],"duration":[251,291,300,396,677],"frequency":[253,289,298,775],"worsening":[254,630,701],"time.":[256,583],"had":[259,333,692,792],"trialled":[261],"EH":[263,281,285,336,463,558,640,696],"at":[264,581,618,713],"varying":[265],"doses":[266],"but":[267,644,703,784,810,971],"this":[268,379,785],"not":[270,859],"always":[271],"effective":[272,381,643],"or":[273,1056],"tolerated":[274,1055],"(Table":[275],"2).":[276],"Exercise":[277,284],"warm":[279],"bath":[280],"(25\u2013125":[282],"mg)":[283,287],"(50\u201380":[286],"\u2193":[288,297],"Effects":[294,303],"short":[295,304],"lived":[296,305],"Immediate":[306,312,318,324],"cessation":[307,313,319,325,359,419,516,598,667,749],"Recurrence":[308,314,320,326],"6":[309,315,321],"weeks":[310,316,322,757],"post-ARCET":[311,317,323,330,769],"from":[327,974],"week":[328],"4":[329,628,758],"Subject":[331,440,535,627,671],"1":[332],"since":[337],"2004":[338,544],"suboptimal":[341],"response.":[342],"He":[343,362,416,459,467,497,554,562,584,594,653,691,801],"started":[344,442,461,504,537,571,647,655,694],"June":[347,592],"2011":[348,448,568,699],"frequent":[352],"painful":[353,385],"crises":[354],"noticed":[356,722],"an":[357,404,452,499,547,564],"immediate":[358,418,515,597,748,940],"symptoms.":[361],"discontinued":[363],"February":[366],"2014":[367],"due":[368,708],"personal":[370],"reasons":[371],"commenced":[374,479,587],"hydroxycarbamide.":[376],"Even":[377,484],"though":[378,485],"preventing":[383],"his":[384,428,615,632,637,669,685,704,740,816,829],"crises,":[386],"it":[387,487],"resulted":[388,513,665],"recurrence":[390,423,520,604,755,895,946],"pre-ARCET":[394],"frequency,":[395],"severity.":[398],"In":[399],"March":[400],"2015":[401],"he":[402,478,575,621,645,746],"suffered":[403,451,498,546,563],"ischaemic":[405],"stroke":[406,413],"(IS)":[407],"re-commenced":[409],"secondary":[412],"prevention":[414],"(SSP).":[415],"towards":[424,521,605,778,825,901],"end":[426,523,607,780,827,903],"8-weekly":[429],"cycle.":[431,526,610,831],"same":[433,528],"pattern":[434,529,878,938,957],"observed":[436,531,960,978],"after":[437,449,476,601,752,821,882,943],"subsequent":[438,533,763,919],"cycles.":[439,534],"2":[441,681],"experiencing":[443,538],"episodes":[444,539,633,650,767,891],"having":[450,545,648],"isolated":[453,548],"episode":[454,472,549],"2001.":[458],"no":[465],"effect.":[466],"sustained":[468],"second":[470],"January":[474,543],"2012":[475],"cyproterone":[481],"acetate":[482],"(CA).":[483],"effective,":[486],"induced":[488],"gynaecomastia":[492],"subsequently":[495],"stopped.":[496],"IS":[501,565],"SSP":[508,590],"October":[510],"2012.":[511],"This":[512,664,790,832,937],"1985.":[553],"tried":[556],"little":[560],"benefit.":[561],"May":[567],"hydroxycarbamide":[573],"unwilling":[577],"transfusions":[580],"re-considered":[585],"2015.":[593],"too,":[595],"With":[611,762,918],"time,":[612],"stabilised":[617],"low":[619],"levels,":[620],"remained":[622,923],"free":[623,888,925],"throughout.":[626],"twenties.":[639],"initially":[642],"soon":[646],"despite":[651],"treatment.":[652],"leg":[660],"ulceration":[661],"2011.":[663],"5":[672,760],"experienced":[673,872],"daily":[674],"hs,":[682],"greatly":[683],"affecting":[684,798],"sleep":[686],"life.":[690],"July":[698],"compliance":[705],"poor":[707],"palpitations":[710],"headaches":[712],"night.":[714],"Given":[715],"previous":[719],"who":[721],"great":[723],"improvement":[724],"when":[727],"treated":[728,803,845],"other":[732,744],"indications,":[733],"recommended":[735],"Like":[742],"patients,":[745],"post-ARCET.":[761],"cycles":[764],"ceased":[768,820],"worsened":[771],"terms":[773],"severity":[777],"cycle":[783],"prominent.":[789],"also":[793,819],"previously":[794],"neuropathic":[796,817],"pain":[797,818,981],"both":[799],"shins.":[800],"pregabalin":[805],"good":[807],"clinical":[808,941],"response":[809,942,959,977],"associated":[811],"significant":[813,873,1034],"somnolence.":[814],"Interestingly,":[815],"recurred":[824],"single-centre":[835],"ARCET.":[847],"For":[848],"four":[849],"these":[851,931],"primary":[854],"indication":[855],"severely":[865],"affected":[866],"they":[870,885],"all":[871],"improvement,":[874],"demonstrating":[875],"similar":[877,954],"response:":[880],"immediately":[881],"undergoing":[883],"completely":[887],"any":[890,934,1093],"percentage":[899],"increased":[900],"cycle,":[907],"suggesting":[908],"direct":[910],"correlation":[911],"level.":[917],"cycles,":[920],"majority":[922],"essentially":[924],"none":[929],"required":[933],"pharmacological":[935],"intervention.":[936],"symptoms":[948],"levels":[951],"rise":[952],"pulmonary":[965],"hypertension":[966],"(Tsitsikas":[967,982],"2014)":[970],"distinctly":[972],"different":[973],"gradual":[976],"2016).":[985],"2016":[987],"Institute":[990],"Health":[992],"Care":[994],"Excellence":[995],"(NICE)":[996],"recommends":[998],"cost-effective":[1002],"intervention":[1003],"(NICE":[1006],"2016)":[1007],"while":[1008],"incentives":[1012],"expansion":[1014],"already":[1019],"place":[1021],"(https://www.england.nhs.uk/wp-content/uploads/2016/03/bi3-auto-exchng-transfsn-sickle-cell.pdf).":[1022],"As":[1023],"large":[1027],"number":[1028],"their":[1037],"life,":[1040],"should":[1042],"be":[1043],"considered":[1044],"severe":[1048],"SP,":[1049],"especially":[1050],"if":[1051],"pharmacotherapy":[1052],"poorly":[1054],"ineffective.":[1057],"AE":[1058],"designed":[1059,1080],"project":[1061,1082],"wrote":[1063],"paper,":[1065,1072],"LB":[1066],"collected":[1067],"data":[1068],"co-authored":[1070],"RJA":[1073],"critically":[1074,1084],"reviewed":[1075,1085],"paper":[1077],"DAT":[1079],"paper.":[1087],"None":[1088],"authors":[1091],"conflict":[1094],"interest":[1096],"declare.":[1098]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-10-21T00:00:00"}