{"id":"https://openalex.org/W2531854908","doi":"https://doi.org/10.21767/2476-1974.100008","title":"NF-kB Regulation in T-cells in Pregnancy is Mediated via Fas/FasL Interactions: The Signal for which is Derived from Exosomes Present in Maternal Plasma","display_name":"NF-kB Regulation in T-cells in Pregnancy is Mediated via Fas/FasL Interactions: The Signal for which is Derived from Exosomes Present in Maternal Plasma","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2531854908","doi":"https://doi.org/10.21767/2476-1974.100008","mag":"2531854908"},"language":"en","primary_location":{"id":"doi:10.21767/2476-1974.100008","doi":"https://doi.org/10.21767/2476-1974.100008","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2476-1974.100008","pdf_url":"https://reproductive-immunology.imedpub.com/nfb-regulation-in-tcells-in-pregnancy-is-mediated-via-fasfasl-interactions-the-signal-for-which-is-derived-from-exosomes-present-i.pdf","source":{"id":"https://openalex.org/S4210211115","display_name":"Reproductive Immunology Open Access","issn_l":"2476-1974","issn":["2476-1974"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Immunology: Open Access","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://reproductive-immunology.imedpub.com/nfb-regulation-in-tcells-in-pregnancy-is-mediated-via-fasfasl-interactions-the-signal-for-which-is-derived-from-exosomes-present-i.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008646377","display_name":"Sharon A. McCracken","orcid":"https://orcid.org/0000-0002-7700-6123","observed_orcids":["https://orcid.org/0000-0002-7700-6123"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sharon A McCracken","raw_affiliation_strings":["Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059210850","display_name":"Katrina A. Hadfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katrina A Hadfield","raw_affiliation_strings":["Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018909921","display_name":"Vanessa M. Yenson","orcid":"https://orcid.org/0000-0002-7112-0785","observed_orcids":["https://orcid.org/0000-0002-7112-0785"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vanessa M Yenson","raw_affiliation_strings":["Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089880737","display_name":"Gaayathri Ariyakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gaayathri Ariyakumar","raw_affiliation_strings":["Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006228270","display_name":"Kelly J. McKelvey","orcid":"https://orcid.org/0000-0002-4923-791X","observed_orcids":["https://orcid.org/0000-0002-4923-791X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kelly J McKelvey","raw_affiliation_strings":["Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066830476","display_name":"Narelle Woodland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114017466","display_name":"University of Technology Sydney","ror":"https://ror.org/03f0f6041","country_code":"AU","type":"education","lineage":["https://openalex.org/I114017466"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Narelle Woodland","raw_affiliation_strings":["School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I114017466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007862294","display_name":"Anthony W. Ashton","orcid":"https://orcid.org/0000-0001-6063-1566","observed_orcids":["https://orcid.org/0000-0001-6063-1566"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony W Ashton","raw_affiliation_strings":["Division of Perinatal Research , Kolling Institute of Medical Research , Royal North Shore Hospital , Reserve Rd , St Leonards , NSW 2065 , Australia,","Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Research , Kolling Institute of Medical Research , Royal North Shore Hospital , Reserve Rd , St Leonards , NSW 2065 , Australia,","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101566179","display_name":"Jonathan M Morris","orcid":"https://orcid.org/0000-0002-5640-4923","observed_orcids":["https://orcid.org/0000-0002-5640-4923"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]},{"id":"https://openalex.org/I4210119033","display_name":"Northern Sydney Local Health District","ror":"https://ror.org/02hmf0879","country_code":"AU","type":"government","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2801351115","https://openalex.org/I4210119033"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jonathan M Morris","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, NSW, Australia","Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, NSW, Australia","institution_ids":["https://openalex.org/I2800079252","https://openalex.org/I4210119033"]},{"raw_affiliation_string":"Division of Perinatal Research, Kolling Institute of Medical Research, Royal North Shore Hospital, University of Sydney, Reserve Rd, St Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008646377"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"],"apc_list":null,"apc_paid":null,"fwci":0.4828,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65151279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"01","issue":"02","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-fasl-signaling","display_name":"Fas/FasL signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/maternal-plasma","display_name":"maternal plasma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9869999885559082},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.7049999833106995},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.753000020980835},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.6539999842643738},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.8046742081642151},{"id":"https://openalex.org/C2776989580","wikidata":"https://www.wikidata.org/wiki/Q421320","display_name":"Ionomycin","level":3,"score":0.7633997201919556},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7612141370773315},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.7258885502815247},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.665493369102478},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6376460194587708},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4940855801105499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4727749824523926},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4690715968608856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4520454704761505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4415853023529053},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.4290293753147125},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.38691839575767517},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3644983172416687},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3039581775665283},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2844069302082062},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2652185261249542},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.16698694229125977},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.09077346324920654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21767/2476-1974.100008","doi":"https://doi.org/10.21767/2476-1974.100008","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2476-1974.100008","pdf_url":"https://reproductive-immunology.imedpub.com/nfb-regulation-in-tcells-in-pregnancy-is-mediated-via-fasfasl-interactions-the-signal-for-which-is-derived-from-exosomes-present-i.pdf","source":{"id":"https://openalex.org/S4210211115","display_name":"Reproductive Immunology Open Access","issn_l":"2476-1974","issn":["2476-1974"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Immunology: Open Access","raw_type":"journal-article"},{"id":"pmh:oai:opus.lib.uts.edu.au:10453/50885","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10453/50885","pdf_url":null,"source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21767/2476-1974.100008","doi":"https://doi.org/10.21767/2476-1974.100008","is_oa":true,"landing_page_url":"https://doi.org/10.21767/2476-1974.100008","pdf_url":"https://reproductive-immunology.imedpub.com/nfb-regulation-in-tcells-in-pregnancy-is-mediated-via-fasfasl-interactions-the-signal-for-which-is-derived-from-exosomes-present-i.pdf","source":{"id":"https://openalex.org/S4210211115","display_name":"Reproductive Immunology Open Access","issn_l":"2476-1974","issn":["2476-1974"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Immunology: Open Access","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329014","display_name":"Ramsay Health Care","ror":"https://ror.org/01b05bn14"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531854908.pdf","grobid_xml":"https://content.openalex.org/works/W2531854908.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W99601214","https://openalex.org/W1483732515","https://openalex.org/W1516645486","https://openalex.org/W1522825861","https://openalex.org/W1529544531","https://openalex.org/W1538504824","https://openalex.org/W1848733318","https://openalex.org/W1893364625","https://openalex.org/W1976173775","https://openalex.org/W1982062664","https://openalex.org/W1984058847","https://openalex.org/W1992549746","https://openalex.org/W1993199753","https://openalex.org/W1993986867","https://openalex.org/W1996214390","https://openalex.org/W1998358627","https://openalex.org/W2000612438","https://openalex.org/W2003126748","https://openalex.org/W2012209476","https://openalex.org/W2020076884","https://openalex.org/W2024178516","https://openalex.org/W2028671682","https://openalex.org/W2029870127","https://openalex.org/W2034295054","https://openalex.org/W2041001602","https://openalex.org/W2060076119","https://openalex.org/W2074798933","https://openalex.org/W2089564896","https://openalex.org/W2092382469","https://openalex.org/W2093203195","https://openalex.org/W2096185404","https://openalex.org/W2099703022","https://openalex.org/W2100592302","https://openalex.org/W2104538381","https://openalex.org/W2128727471","https://openalex.org/W2130776611","https://openalex.org/W2135238509","https://openalex.org/W2138751320","https://openalex.org/W2140684477","https://openalex.org/W2152093499"],"related_works":["https://openalex.org/W7011780203","https://openalex.org/W3209963090","https://openalex.org/W3011453278","https://openalex.org/W1992549746","https://openalex.org/W2020076884","https://openalex.org/W2152523607","https://openalex.org/W2074798933","https://openalex.org/W2057017726","https://openalex.org/W2313083914","https://openalex.org/W1992841547"],"abstract_inverted_index":{"Background:":[0],"Regulated":[1],"suppression":[2,32,104,143,164,195,199,265],"of":[3,33,37,111,159,165,189,218,251,263,269,280,295],"maternal":[4,40,190,238],"Th1":[5,14,211],"immunity":[6],"is":[7,214,291],"necessary":[8],"for":[9,81],"normal":[10,224],"pregnancy":[11,19,233,296],"since":[12,198],"inappropriate":[13],"responses":[15],"results":[16],"in":[17,39,45,73,102,108,138,141,150,161,167,196,237,243,272,282,293],"increased":[18,130,173],"loss":[20],"and":[21,59,69,76,83,91,147,175,255,266],"complications":[22,294],"including":[23,297],"intrauterine":[24],"growth":[25],"restriction":[26],"(IUGR).":[27],"We":[28],"have":[29],"shown":[30],"that":[31,54,66,232,290],"the":[34,77,86,109,112,186,261,267],"p65":[35,56,68,103,125,142,166,194,241,264],"subunit":[36],"NF-\u03baB":[38],"T-cells":[41,75,128,245,254],"underlies":[42],"this":[43],"change":[44],"T-cell":[46,71],"responses.":[47],"This":[48],"study":[49],"aimed":[50],"to":[51,133,152,169,172,223,274],"determine":[52],"mechanism(s)":[53],"control":[55],"suppression.":[57],"Methods":[58],"findings:":[60],"Maternal":[61,127],"plasma":[62,191,239],"contained":[63],"particulate":[64,187],"factor\u2019s":[65,78],"suppress":[67,124],"induce":[70],"apoptosis":[72],"Jurkat":[74,96],"was":[79,106,200,220],"positive":[80],"FasL":[82,219,256,281],"TRAIL.":[84],"Both":[85],"Fas":[87,99,113,131,136,160,247,252],"activating":[88],"antibody":[89,115],"CH11":[90],"recombinant":[92,120],"human":[93],"TRAIL":[94,121],"induced":[95,193],"apoptosis.":[97],"Specific":[98],"activation":[100,137],"resulted":[101,140],"which":[105],"reversed":[107,202],"presence":[110],"inactivating":[114],"ZB4.":[116,204],"Despite":[117],"inducing":[118],"apoptosis,":[119],"did":[122],"not":[123],"expression.":[126],"expressed":[129],"relative":[132],"non-pregnant":[134],"controls.":[135,225],"Jurkats":[139,162,197],"thus":[144],"limited":[145],"IL-2":[146,174],"IFN\u00c3\u00af\u00c2\u0081\u00c2\u00a7":[148,176],"transcription":[149],"response":[151,168,273],"PMA/ionomycin":[153],"stimulation.":[154],"In":[155,205],"contrast,":[156],"partial":[157],"knockdown":[158],"prevented":[163],"CH11,":[170],"leading":[171],"production":[177,213,271],"when":[178],"stimulated":[179],"with":[180,203,208],"PMA/ionomycin.":[181],"FasL+":[182,235],"Exosomes":[183],"isolated":[184],"from":[185],"fraction":[188],"specifically":[192],"completely":[201],"pregnancies":[206],"complicated":[207],"IUGR":[209],"where":[210],"cytokine":[212,270],"increased,":[215],"placental":[216,283],"expression":[217,250,279],"reduced":[221],"compared":[222],"Conclusion:":[226],"Taken":[227],"together":[228],"these":[229],"data":[230],"suggest":[231],"derived":[234,284],"exosomes":[236,258,285],"regulate":[240],"levels":[242],"circulating":[244],"through":[246],"activation.":[248],"The":[249],"on":[253,257],"both":[259],"dictate":[260],"level":[262,268],"stimulation":[275],"throughout":[276],"pregnancy.":[277],"Inappropriate":[278],"may":[286],"underlie":[287],"one":[288],"mechanism":[289],"abnormal":[292],"IUGR.":[298]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-21T00:00:00"}