{"id":"https://openalex.org/W2531753870","doi":"https://doi.org/10.1038/cddis.2016.232","title":"A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas","display_name":"A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas","publication_year":2016,"publication_date":"2016-10-13","ids":{"openalex":"https://openalex.org/W2531753870","doi":"https://doi.org/10.1038/cddis.2016.232","mag":"2531753870","pmid":"https://pubmed.ncbi.nlm.nih.gov/27735949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133958"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2016.232","doi":"https://doi.org/10.1038/cddis.2016.232","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.232","pdf_url":"https://www.nature.com/articles/cddis2016232.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2016232.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004516087","display_name":"Gregory R. Bean","orcid":"https://orcid.org/0000-0003-2866-8283","observed_orcids":["https://orcid.org/0000-0003-2866-8283"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory R Bean","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035134233","display_name":"Jeff C. Kremer","orcid":"https://orcid.org/0009-0003-1841-640X","observed_orcids":["https://orcid.org/0009-0003-1841-640X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff C Kremer","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049583085","display_name":"Bethany Cheree Prudner","orcid":"https://orcid.org/0000-0002-3522-9820","observed_orcids":["https://orcid.org/0000-0002-3522-9820"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany C Prudner","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052444901","display_name":"Aaron D. Schenone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron D Schenone","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058953758","display_name":"Juo-Chin Yao","orcid":"https://orcid.org/0000-0002-2041-9867","observed_orcids":["https://orcid.org/0000-0002-2041-9867"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juo-Chin Yao","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009037373","display_name":"Matthew Schultze","orcid":"https://orcid.org/0009-0003-4850-6967","observed_orcids":["https://orcid.org/0009-0003-4850-6967"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew B Schultze","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002111756","display_name":"David Y. Chen","orcid":"https://orcid.org/0000-0002-3681-6576","observed_orcids":["https://orcid.org/0000-0002-3681-6576","https://orcid.org/0009-0007-5537-9096"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Y Chen","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035007884","display_name":"Munir R. Tanas","orcid":"https://orcid.org/0000-0002-6779-2642","observed_orcids":["https://orcid.org/0000-0002-6779-2642"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Munir R Tanas","raw_affiliation_strings":["Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064319129","display_name":"Douglas R. Adkins","orcid":"https://orcid.org/0000-0003-3207-8227","observed_orcids":["https://orcid.org/0000-0003-3207-8227"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas R Adkins","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007808102","display_name":"John S. Bomalaski","orcid":"https://orcid.org/0000-0002-9454-7271","observed_orcids":["https://orcid.org/0000-0002-9454-7271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Bomalaski","raw_affiliation_strings":["Polaris Group, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polaris Group, San Diego, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001267176","display_name":"Brian P. Rubin","orcid":"https://orcid.org/0000-0002-0657-3024","observed_orcids":["https://orcid.org/0000-0002-0657-3024"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P Rubin","raw_affiliation_strings":["Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110538055","display_name":"Loren Scott Michel","orcid":"https://orcid.org/0009-0000-1865-3315","observed_orcids":["https://orcid.org/0009-0000-1865-3315"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loren S Michel","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091098703","display_name":"Brian Andrew Van Tine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian A Van Tine","raw_affiliation_strings":["Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Siteman Cancer Center, Washington University in St. Louis School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091098703"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":6.5155,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.98061727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"7","issue":"10","first_page":"e2406","last_page":"e2406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.07050000131130219,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/arginine-deprivation","display_name":"arginine deprivation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/arginine-auxotrophy","display_name":"arginine auxotrophy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/argininosuccinate-synthetase-1","display_name":"argininosuccinate synthetase 1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pegylated-arginine-deiminase","display_name":"pegylated arginine deiminase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/adi-peg20","display_name":"ADI-PEG20","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.753000020980835},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/arginine-starvation","display_name":"arginine starvation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C188610204","wikidata":"https://www.wikidata.org/wiki/Q24741403","display_name":"Argininosuccinate synthase","level":5,"score":0.7539154291152954},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.6389138102531433},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5961881875991821},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5847674608230591},{"id":"https://openalex.org/C2777186326","wikidata":"https://www.wikidata.org/wiki/Q24722788","display_name":"Arginine deiminase","level":4,"score":0.5704367160797119},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5681231021881104},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.5118852853775024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5072014331817627},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.44421109557151794},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.4400051236152649},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3787541389465332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35017526149749756},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.21144437789916992},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21110489964485168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1430264413356781},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001124","descriptor_name":"Argininosuccinate Synthase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D001124","descriptor_name":"Argininosuccinate Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002738","descriptor_name":"Chloroquine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006867","descriptor_name":"Hydrolases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/cddis.2016.232","doi":"https://doi.org/10.1038/cddis.2016.232","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.232","pdf_url":"https://www.nature.com/articles/cddis2016232.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4094434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27735949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27735949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5133958","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133958/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/cddis.2016.232","doi":"https://doi.org/10.1038/cddis.2016.232","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2016.232","pdf_url":"https://www.nature.com/articles/cddis2016232.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death &amp; Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000874578","display_name":"Molecular Oncology Training Grant","funder_award_id":"T32CA113275","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531753870.pdf","grobid_xml":"https://content.openalex.org/works/W2531753870.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W45211868","https://openalex.org/W106686669","https://openalex.org/W1966242225","https://openalex.org/W1974313449","https://openalex.org/W1982253551","https://openalex.org/W1984040233","https://openalex.org/W1985124617","https://openalex.org/W1986978728","https://openalex.org/W1988968354","https://openalex.org/W1989634299","https://openalex.org/W2011698659","https://openalex.org/W2013206354","https://openalex.org/W2018204131","https://openalex.org/W2027169351","https://openalex.org/W2027449497","https://openalex.org/W2028387032","https://openalex.org/W2028897202","https://openalex.org/W2031315726","https://openalex.org/W2033556277","https://openalex.org/W2036204029","https://openalex.org/W2037323859","https://openalex.org/W2041076445","https://openalex.org/W2043600567","https://openalex.org/W2046864536","https://openalex.org/W2055426891","https://openalex.org/W2059738518","https://openalex.org/W2071146934","https://openalex.org/W2072028737","https://openalex.org/W2075806787","https://openalex.org/W2079286948","https://openalex.org/W2080915191","https://openalex.org/W2102690338","https://openalex.org/W2103030360","https://openalex.org/W2110195508","https://openalex.org/W2116284113","https://openalex.org/W2119097025","https://openalex.org/W2119785831","https://openalex.org/W2123003943","https://openalex.org/W2134972696","https://openalex.org/W2139206468","https://openalex.org/W2147998910","https://openalex.org/W2152021740","https://openalex.org/W2170554156"],"related_works":["https://openalex.org/W2051510657","https://openalex.org/W4296130471","https://openalex.org/W2965171919","https://openalex.org/W2789682006","https://openalex.org/W2688756118","https://openalex.org/W2739533050","https://openalex.org/W2969296956","https://openalex.org/W2521758670","https://openalex.org/W2885308266","https://openalex.org/W4381435871"],"abstract_inverted_index":{"Sarcomas":[0],"comprise":[1],"a":[2,68,146,183,194],"large":[3],"heterogeneous":[4],"group":[5],"of":[6,38,71,102,149,205,209],"mesenchymal":[7],"cancers":[8],"with":[9,15,140],"limited":[10],"therapeutic":[11],"options.":[12],"When":[13],"treated":[14],"standard":[16],"cytotoxic":[17],"chemotherapies,":[18],"many":[19],"sarcomas":[20,39,188],"fail":[21],"to":[22,67,78,115,120,124,201,203],"respond":[23],"completely":[24],"and":[25,36,73,122,177,189],"rapidly":[26],"become":[27],"treatment":[28,37,197],"resistant.":[29],"A":[30],"major":[31],"problem":[32],"in":[33,135,187],"the":[34,41,54,79,100,167,191,206],"investigation":[35],"is":[40],"fact":[42],"that":[43,64,93],"no":[44],"single":[45],"gene":[46],"mutation":[47],"or":[48,108,127],"alteration":[49],"has":[50],"been":[51],"identified":[52],"among":[53],"diverse":[55],"histologic":[56],"subtypes.":[57],"We":[58,91,132],"searched":[59],"for":[60,193],"therapeutically":[61],"druggable":[62],"targets":[63],"are":[65],"common":[66],"wide":[69],"range":[70],"histologies":[72,88],"hence":[74],"could":[75],"provide":[76],"alternatives":[77],"conventional":[80],"chemotherapy.":[81],"Seven":[82],"hundred":[83],"samples":[84],"comprising":[85],"45":[86],"separate":[87],"were":[89,96],"examined.":[90],"found":[92],"almost":[94],"90%":[95,204],"arginine":[97,116,137,142,150],"auxotrophs,":[98],"as":[99],"expression":[101],"argininosuccinate":[103],"synthetase":[104],"1":[105],"was":[106,159],"lost":[107],"significantly":[109],"reduced.":[110],"Arginine":[111],"auxotrophy":[112],"confers":[113],"sensitivity":[114],"deprivation,":[117],"leading":[118],"temporarily":[119],"starvation":[121,151,158],"ultimately":[123],"cell":[125,154],"survival":[126],"death":[128],"under":[129],"different":[130],"circumstances.":[131],"showed":[133],"that,":[134],"sarcoma,":[136],"deprivation":[138],"therapy":[139],"pegylated":[141],"deiminase":[143],"(ADI-PEG20)":[144],"maintains":[145],"prolonged":[147,161],"state":[148],"without":[152],"causing":[153],"death.":[155],"However,":[156],"when":[157],"simultaneously":[160],"by":[162,166],"ADI-PEG20":[163],"while":[164],"inhibited":[165],"clinically":[168],"available":[169],"drug":[170],"chloroquine,":[171],"sarcoma":[172],"cells":[173],"died":[174],"via":[175],"necroptosis":[176],"apoptosis.":[178],"These":[179],"results":[180],"have":[181],"revealed":[182],"novel":[184],"metabolic":[185],"vulnerability":[186],"provided":[190],"basis":[192],"well-tolerated":[195],"alternative":[196],"strategy,":[198],"potentially":[199],"applicable":[200],"up":[202],"tumors,":[207],"regardless":[208],"histology.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-21T00:00:00"}
