{"id":"https://openalex.org/W2531723309","doi":"https://doi.org/10.1182/blood.v108.11.2877.2877","title":"Chemokine Profiling in Patients with Graft Versus Host Disease (GVHD) Following Allogeneic Blood Stem Cell Transplantation.","display_name":"Chemokine Profiling in Patients with Graft Versus Host Disease (GVHD) Following Allogeneic Blood Stem Cell Transplantation.","publication_year":2006,"publication_date":"2006-11-16","ids":{"openalex":"https://openalex.org/W2531723309","doi":"https://doi.org/10.1182/blood.v108.11.2877.2877","mag":"2531723309"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v108.11.2877.2877","doi":"https://doi.org/10.1182/blood.v108.11.2877.2877","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.2877.2877","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110150803","display_name":"Judy A. Ziegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judy A. Ziegler","raw_affiliation_strings":["Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071827985","display_name":"Anna E Lokshin","orcid":"https://orcid.org/0000-0001-8171-220X","observed_orcids":["https://orcid.org/0000-0001-8171-220X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna Lokshin","raw_affiliation_strings":["Luminex Facility, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luminex Facility, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031344736","display_name":"Suzanne Lentzsch","orcid":"https://orcid.org/0000-0003-1708-7344","observed_orcids":["https://orcid.org/0000-0003-1708-7344"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Lentzsch","raw_affiliation_strings":["Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022228597","display_name":"Mounzer Agha","orcid":"https://orcid.org/0000-0002-2275-7544","observed_orcids":["https://orcid.org/0000-0002-2275-7544"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mounzer Agha","raw_affiliation_strings":["Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110938637","display_name":"Renate Arnold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Renate Arnold","raw_affiliation_strings":["Hematology and Oncology, University Medical Center Charite, Humboldt University, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Oncology, University Medical Center Charite, Humboldt University, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002240997","display_name":"Markus Y. Mapara","orcid":"https://orcid.org/0000-0002-8547-8905","observed_orcids":["https://orcid.org/0000-0002-8547-8905"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Y. Mapara","raw_affiliation_strings":["Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071827985","https://openalex.org/A5110150803","https://openalex.org/A5110938637"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I39343248","https://openalex.org/I4210128526","https://openalex.org/I7877124"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33804791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"108","issue":"11","first_page":"2877","last_page":"2877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9610000252723694},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ccl3","display_name":"CCL3","score":0.871999979019165},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.859000027179718},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.5849999785423279},{"id":"https://openalex.org/keywords/chronic-graft-versus-host-disease","display_name":"chronic graft-versus-host disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.43299999833106995},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.43799999356269836},{"id":"https://openalex.org/keywords/hla-matched-unrelated-donor","display_name":"HLA-matched unrelated donor","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.737305223941803},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6990652680397034},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.6225355267524719},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5742620825767517},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.5728172659873962},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5551224946975708},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.48966363072395325},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46549925208091736},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.42602774500846863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4191626012325287},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.41448336839675903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37641268968582153},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2541848421096802},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09516879916191101},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v108.11.2877.2877","doi":"https://doi.org/10.1182/blood.v108.11.2877.2877","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v108.11.2877.2877","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985931779","https://openalex.org/W2490305351","https://openalex.org/W1970215136","https://openalex.org/W2554430617","https://openalex.org/W2035050419","https://openalex.org/W159075832","https://openalex.org/W2166731160","https://openalex.org/W2578769340","https://openalex.org/W2025489606","https://openalex.org/W4247449416"],"abstract_inverted_index":{"Abstract":[0],"Development":[1],"of":[2,55,83,122,128,148,154,164,189,257,270,296,320,351,378,408,418,430],"GVHD":[3,56,155,172,176,269,276,284,291,319,342],"following":[4,42],"allogeneic":[5,200],"blood":[6,195],"stem":[7,196],"cell":[8],"or":[9,204,340,416,422],"bone":[10],"marrow":[11],"transplantation":[12,197],"(BMT)":[13],"is":[14,45,66,177],"dependent":[15],"on":[16],"the":[17,27,52,69,120,126,143,151,161,187,212,220,254,271,321,368,376,390,428],"immunogenetic":[18],"disparity":[19],"between":[20],"donor":[21,207],"and":[22,26,65,92,100,138,145,173,250,264,280,305,354,392,410],"host,":[23],"subsequent":[24,53],"alloactivation":[25],"inflammatory":[28,38],"reaction":[29],"occurring":[30,40],"secondary":[31],"to":[32,47,62,80,103,210,219,311,345,361,366,372,401,411],"conditioning":[33,43,136],"regimen-induced":[34],"tissue":[35,63,107,144],"damage.":[36],"The":[37],"response":[39,61],"early":[41,152],"therapy":[44],"thought":[46,102],"be":[48,104,367,373],"particularly":[49],"crucial":[50],"for":[51,427],"development":[54],"as":[57],"it":[58],"occurs":[59],"in":[60,97,106,125,156,174,208,375,385,405],"damage":[64],"amplified":[67],"by":[68],"alloresponse.":[70],"Chemokines":[71],"are":[72,101,359,399],"predominantly":[73],"small":[74],"molecules":[75],"(8\u201314":[76],"kd)":[77],"that":[78,135,363],"bind":[79],"a":[81,88],"family":[82],"heterotrimeric":[84],"G-protein-coupled":[85],"receptors":[86,224],"with":[87,267,282,289,317,338,380],"seven-transmembrane-spanning":[89],"serpentine":[90],"structure":[91],"play":[93],"an":[94,199],"important":[95],"role":[96],"leukocyte":[98],"trafficking":[99],"involved":[105],"infiltration":[108],"during":[109,150,171,215],"GVHD.":[110,129,216,315,431],"Reports":[111],"from":[112,198],"several":[113],"investigators":[114],"using":[115],"murine":[116],"model":[117],"have":[118,132,346],"demonstrated":[119,134],"relevance":[121,163],"distinct":[123],"chemokines":[124,149,165],"pathogenesis":[127],"Furthermore,":[130],"we":[131,185,252,358],"recently":[133],"intensity":[137],"genetic":[139],"host":[140],"factors":[141],"influence":[142],"systemic":[146],"expression":[147,166,256],"course":[153],"rodent":[157],"BMT":[158,387],"models.":[159,388],"However,":[160],"pathobiologic":[162],"at":[167],"later":[168],"time":[169],"points":[170],"human":[175],"so":[178],"far":[179],"unclear.":[180],"Using":[181],"luminex":[182],"multiplex":[183],"assays":[184],"studied":[186],"sera":[188],"patients,":[190],"who":[191],"had":[192,292,323],"undergone":[193],"peripheral":[194],"HLA":[201],"matched":[202,205],"sibling":[203],"unrelated":[206],"order":[209],"determine":[211],"chemokine":[213,371],"profiles":[214],"In":[217,335,356],"addition":[218],"most":[221,369],"relevant":[222],"cytokines/cytokine":[223],"(IL-1a,":[225],"IL-2,":[226],"IL-4,":[227],"IL-5,":[228],"IL-6,":[229],"IL-7,":[230],"IL-8,":[231],"IL-10,":[232],"IFN-a,":[233],"IFN-g,":[234],"GM-CSF,":[235],"IL-12":[236],"(p40),":[237],"IL-13,":[238],"IL-15,":[239],"IL17,":[240],"TNF-alpha,":[241],"TNF-RI,":[242],"TNF-RII,":[243],"DR5,":[244],"FGF-b,":[245],"VEGF,":[246],"HGF,":[247,352],"IL-1Ra,":[248,353],"sIL-2R":[249],"sIL-6R),":[251],"analyzed":[253],"serum":[255,349,377],"CCL2,":[258],"CCL3,":[259],"CCL4,":[260],"CCL5,":[261],"CCL11,":[262],"CXCL9,":[263],"CXCL10.":[265],"Patients":[266,288,316],"acute":[268,318,339],"gut":[272,322],"(n=8),":[273],"patients":[274,281,313,337,379,409],"without":[275,314],"(n":[277],"=":[278],"4)":[279],"chronic":[283,341],"(n=4)":[285],"were":[286,343],"studied.":[287],"acute/chronic":[290],"significantly":[293,347],"elevated":[294,326,348,374],"levels":[295,329,350],"CCL3":[297,364,415],"(90":[298],"pg/ml":[299],"vs.":[300,308],"58":[301],"pg/ml,":[302],"p=":[303],"0.004)":[304],"CCL11":[306],"(167pg/ml":[307],"93pg/ml)":[309],"compared":[310],"controls":[312],"also":[324],"markedly":[325],"CXCL10,":[327],"CCL4":[328],"although":[330],"not":[331],"reaching":[332],"statistical":[333],"significance.":[334],"addition,":[336],"found":[344],"TNF-RI.":[355],"conclusion":[357],"able":[360],"demonstrate":[362],"appears":[365],"prominent":[370],"a/cGVHD":[381],"supporting":[382],"results":[383],"obtained":[384],"preclinical":[386,395],"Given":[389],"complex":[391],"frequently":[393],"contradictory":[394],"results,":[396],"further":[397],"studies":[398],"warranted":[400],"confirm":[402],"our":[403],"findings":[404],"larger":[406],"cohorts":[407],"delineate":[412],"whether":[413],"targeting":[414],"one":[417],"its":[419],"receptor":[420],"(CCR1":[421],"CCR5)":[423],"might":[424],"prove":[425],"beneficial":[426],"treatment":[429]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-10-21T00:00:00"}
