{"id":"https://openalex.org/W2531720369","doi":"https://doi.org/10.1182/blood.v112.11.1181.1181","title":"Adoptive Transfer and Consequential Selective Reconstitution of Streptamer-Selected Cytomegalovirus-Specific CD8+ T Cells Leads to Enduring Virus Clearance in Patients after Allogeneic Stem Cell Transplantation","display_name":"Adoptive Transfer and Consequential Selective Reconstitution of Streptamer-Selected Cytomegalovirus-Specific CD8+ T Cells Leads to Enduring Virus Clearance in Patients after Allogeneic Stem Cell Transplantation","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2531720369","doi":"https://doi.org/10.1182/blood.v112.11.1181.1181","mag":"2531720369"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.1181.1181","doi":"https://doi.org/10.1182/blood.v112.11.1181.1181","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1181.1181","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111818788","display_name":"Anita Schmitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anita Schmitt","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050893255","display_name":"Torsten Tonn","orcid":"https://orcid.org/0000-0001-9580-2193","observed_orcids":["https://orcid.org/0000-0001-9580-2193"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Tonn","raw_affiliation_strings":["Institute for Transfusion Medicine and Immunohematology, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine and Immunohematology, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062895290","display_name":"Dirk Hans Busch","orcid":"https://orcid.org/0000-0001-8713-093X","observed_orcids":["https://orcid.org/0000-0001-8713-093X","https://orcid.org/0000-0002-0685-4483"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Busch","raw_affiliation_strings":["Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073587250","display_name":"G\u00f6tz Ulrich Grigoleit","orcid":"https://orcid.org/0000-0003-0847-8124","observed_orcids":["https://orcid.org/0000-0003-0847-8124"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Go\u0308tz Grigoleit","raw_affiliation_strings":["Dept. of Hematooncology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Hematooncology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016360607","display_name":"Hermann Einsele","orcid":"https://orcid.org/0000-0002-7680-0819","observed_orcids":["https://orcid.org/0000-0002-7680-0819"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hermann Einsele","raw_affiliation_strings":["Dept. of Hematooncology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Hematooncology, University of Wu\u0308rzburg, Wu\u0308rzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083419667","display_name":"Marcus Odendahl","orcid":"https://orcid.org/0000-0002-5821-6328","observed_orcids":["https://orcid.org/0000-0002-5821-6328"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Odendahl","raw_affiliation_strings":["Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091804848","display_name":"Lothar Germeroth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lothar Germeroth","raw_affiliation_strings":["Stage Pharmaceuticals Ltd., Go\u0308ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stage Pharmaceuticals Ltd., Go\u0308ttingen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013435653","display_name":"Mark Ringhoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mark Ringhoffer","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061467389","display_name":"Simone Ringhoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone Ringhoffer","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022113021","display_name":"Markus Wiesneth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Wiesneth","raw_affiliation_strings":["Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102725381","display_name":"Detlef Michel","orcid":"https://orcid.org/0000-0003-2188-1815","observed_orcids":["https://orcid.org/0000-0003-2188-1815"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Detlef Michel","raw_affiliation_strings":["Dept. of Virology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Virology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109004887","display_name":"Thomas Mertens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Mertens","raw_affiliation_strings":["Dept. of Virology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Virology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007372145","display_name":"Markus Rojewski","orcid":"https://orcid.org/0000-0003-4265-0442","observed_orcids":["https://orcid.org/0000-0003-4265-0442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Rojewski","raw_affiliation_strings":["Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Martin Marx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Marx","raw_affiliation_strings":["Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Transfusion Medicine and Immunogenetics gemeinnu\u0308tzige GmbH, Ulm, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005122036","display_name":"Stephanie von Harsdorf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Harsdorf","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395073","display_name":"Hartmut D\u00f6hner","orcid":"https://orcid.org/0000-0003-2116-5536","observed_orcids":["https://orcid.org/0000-0003-2116-5536"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Do\u0308hner","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088797832","display_name":"Erhard Seifried","orcid":"https://orcid.org/0000-0002-5777-9225","observed_orcids":["https://orcid.org/0000-0002-5777-9225"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erhard Seifried","raw_affiliation_strings":["Institute for Transfusion Medicine and Immunohematology, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Transfusion Medicine and Immunohematology, Johann Wolfgang Goethe University Clinics, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002578778","display_name":"Donald Werner Bunjes","orcid":"https://orcid.org/0000-0002-1952-5443","observed_orcids":["https://orcid.org/0000-0002-1952-5443"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Donald Bunjes","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017514499","display_name":"Michael W. Schmitt","orcid":"https://orcid.org/0000-0002-1579-1509","observed_orcids":["https://orcid.org/0000-0002-1579-1509"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schmitt","raw_affiliation_strings":["Dept. of Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.2261,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.81331371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"1181","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytomegalovirus-reactivation","display_name":"cytomegalovirus reactivation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.703000009059906},{"id":"https://openalex.org/keywords/cmv-antigenemia","display_name":"CMV antigenemia","score":0.6840000152587891},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.5559999942779541},{"id":"https://openalex.org/keywords/magnetic-activated-cell-sorting","display_name":"magnetic cell separation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6827218532562256},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6009380221366882},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5733389854431152},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5458316206932068},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5335227847099304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5208938121795654},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.48780396580696106},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.47770169377326965},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4761773943901062},{"id":"https://openalex.org/C2776738589","wikidata":"https://www.wikidata.org/wiki/Q618446","display_name":"Apheresis","level":3,"score":0.4313659369945526},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3240726590156555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28535735607147217},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2812029719352722},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21294242143630981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18151360750198364},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09464138746261597},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07700765132904053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.1181.1181","doi":"https://doi.org/10.1182/blood.v112.11.1181.1181","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1181.1181","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1834144979","https://openalex.org/W2555643994","https://openalex.org/W2123440147","https://openalex.org/W1976058260","https://openalex.org/W2559398249","https://openalex.org/W2565455624","https://openalex.org/W2586224685","https://openalex.org/W2532059005","https://openalex.org/W2578687163","https://openalex.org/W2557998390"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Cytomegalovirus":[2],"(CMV)":[3],"disease":[4,323],"constitutes":[5],"a":[6,169,178,218,271,275,375,434,446,571],"serious":[7],"complication":[8],"after":[9,28,138,267,303,521],"allogeneic":[10,268],"peripheral":[11,141,456],"blood":[12,142],"stem":[13,151],"cell":[14,85,108,144,152,379,439,525,536,561,567,584],"transplantation":[15],"(allo-PBSCT).":[16],"For":[17],"the":[18,78,92,96,114,149,231,234,293,333,344,406,425,482,491,515,522,531,546,588],"clearance":[19],"of":[20,44,54,61,80,95,123,154,161,245,277,305,321,332,336,346,363,385,400,424,448,462,493,538,548,574,601],"CMV,":[21],"CD8+":[22,83,338,356,430,465,476,552,576,582],"T":[23,39,57,64,84,98,107,126,235,252,339,348,357,378,387,403,431,438,466,477,495,507,512,524,535,553,560,566,577,583],"cells":[24,65,99,127,210,253,283,340,349,358,388,432,478,508,513,554,578],"are":[25],"pivotal.":[26],"Patients":[27],"allo-PBSCT":[29],"with":[30,133,157,193,211,227,274,286,343,389,481],"recurrent":[31,134],"CMV":[32,37,45,55,62,124,136,162,201,294,463,473,533,550],"reactivation":[33,46,600],"usually":[34],"lack":[35],"such":[36],"specific":[38,56,63,82,125,163,202,240,251,464,511,534,551,565],"cells.":[40,58,236,467,496],"Conventional":[41],"antiviral":[42,593],"therapy":[43,307,595],"characteristically":[47],"results":[48],"in":[49,260,308,341,426,514,570],"myelosuppression":[50],"and":[51,100,104,111,284,289,298,329,486,509,579],"further":[52,597],"suppression":[53],"Adoptive":[59],"transfer":[60,122],"may":[66],"help":[67],"to":[68,87,196,229,351,590],"overcome":[69],"this":[70],"problem.":[71],"A":[72,238,327],"novel":[73,115],"technology":[74,117,544],"designated":[75],"\u201cstreptamers\u201d":[76],"allows":[77],"selection":[79,175],"CMVpp65":[81,250,272,281,394,510,564],"up":[86,350],"98%":[88],"purity":[89],"without":[90,101,596],"altering":[91],"functional":[93],"properties":[94],"selected":[97],"requiring":[102],"cumbersome":[103],"time":[105,519],"consuming":[106],"cultures.":[109],"Materials":[110],"Methods:":[112],"Here,":[113],"streptamer":[116],"was":[118,146,166,224,258,296,325,353,417,479,502],"used":[119],"for":[120,184,188,372,490,504,558],"adoptive":[121,523,559],"into":[128],"two":[129,155,450],"acute":[130,158,312],"leukemia":[131],"patients":[132,156,516,589],"high":[135,598],"antigenemia":[137,273,295],"allo-PBSCT.":[139],"Standard":[140],"mononuclear":[143,209],"apheresis":[145],"performed":[147,167,259],"on":[148,177,217],"former":[150],"donors":[153],"leukemia.":[159],"Isolation":[160],"donor":[164,241,436,506,540],"lymphocytes":[165],"using":[168],"Good":[170],"Manufacturing":[171],"Product":[172],"(GMP)-grade":[173],"Streptamer":[174,543],"kit":[176],"CliniMacs\u2122":[179,219],"device.":[180,220],"Briefly,":[181],"MHC-Streptamers":[182],"(CMVpp65/HLA-B7":[183],"patient":[185,189,265],"1;":[186],"CMVpp65/HLA-A2":[187],"2)":[190],"were":[191,204,215,537],"labeled":[192,206],"beads":[194],"overnight":[195],"obtain":[197],"MHC-streptamer-bead":[198],"complexes.":[199,213],"Subsequently":[200],"T-lymphocytes":[203],"immunomagnetically":[205],"by":[207],"incubating":[208],"MHC-Streptamer-bead":[212],"Cells":[214],"run":[216],"The":[221,421,497],"positive":[222,371],"fraction":[223],"then":[225],"incubated":[226],"biotin":[228],"detach":[230],"steptamers":[232],"from":[233,382,470],"Results:":[237],"single":[239],"lymphocyte":[242],"infusion":[243],"(sDLI)":[244],"0.4":[246],"or":[247,263,279,313,366],"2.2":[248],"\u00d7105":[249],"per":[254],"kg":[255],"body":[256],"weight":[257],"an":[261],"AML":[262],"ALL":[264],"respectively,":[266],"PBSCT":[269],"developing":[270],"maximum":[276],"959":[278],"716":[280],"positive/500,000":[282],"treatment":[285],"foscarnet,":[287],"ganciclovir":[288],"valganciclovir.":[290],"After":[291],"sDLI,":[292],"cleared":[297],"remained":[299],"persistently":[300],"controlled":[301],"even":[302],"discontinuation":[304],"valganciclovir":[306],"both":[309,505],"patients.":[310],"No":[311],"chronic":[314],"toxic":[315,592],"side":[316],"effect,":[317],"particularly":[318],"no":[319,360],"aggravation":[320],"graft-versus-host":[322],"(GvHD)":[324],"observed.":[326],"strong":[328],"sustained":[330],"increase":[331,345,573],"absolute":[334],"count":[335],"CMV-specific":[337,355,402,410,429,575],"concordance":[342],"CD3+CD8+":[347],"440/\u03bcl":[352],"detected.":[354],"showed":[359],"significant":[361],"expression":[362],"CCR7,":[364],"CD62L":[365],"CD107,":[367],"but":[368],"stained":[369],"increasingly":[370],"CD45RA,":[373],"indicating":[374,455,529],"preferential":[376],"effector":[377],"phenotype.":[380],"Results":[381],"stimulation":[383],"experiments":[384],"CD3+":[386],"HLA-B7":[390],"versus":[391],"HLA-A2":[392],"restricted":[393],"derived":[395],"peptides":[396],"demonstrate":[397],"late":[398],"reconstitution":[399],"HLA-A2-restricted":[401],"cells,":[404],"whereas":[405],"adoptively":[407],"transferred":[408],"HLA-B7-restricted":[409],"T-cell":[411],"response":[412],"augmented":[413],"very":[414],"early":[415],"und":[416],"maintained":[418],"over":[419],"time.":[420],"chimerism":[422],"analysis":[423,444],"vivo":[427],"expanded":[428,532],"demonstrated":[433],"100%":[435],"chimerism.":[437],"receptor":[440],"excision":[441],"circle":[442],"(sjTRECs)":[443],"revealed":[445],"frequency":[447],"sjTRECs":[449],"logs":[451],"lower":[452],"than":[453,459],"expected,":[454],"expansion":[457],"rather":[458],"thymic":[460],"proliferation":[461],"cDNA":[468],"generated":[469],"FACS-purified":[471],"donor-derived":[472],"B7":[474],"pp65-specific":[475],"probed":[480],"indicated":[483],"5\u2032":[484],"V\u00df14-specific":[485],"3\u2032":[487],"CDR3-specific":[488],"primers":[489],"presence":[492],"clonotypic":[494],"respective":[498],"CDR3":[499],"region":[500],"sequence":[501],"identical":[503],"at":[517,555],"different":[518],"points":[520],"transfer,":[526],"thus":[527],"clearly":[528],"that":[530],"clonogenic":[539],"origin.":[541],"Conclusion:":[542],"offers":[545],"advantage":[547],"selecting":[549],"GMP":[556],"level":[557,599],"transfer.":[562],"Two":[563],"transfers":[568],"resulted":[569],"marked":[572],"induced":[580],"long-lasting":[581],"responses,":[585],"which":[586],"allowed":[587],"discontinue":[591],"drug":[594],"CMV.":[602]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-10-21T00:00:00"}