{"id":"https://openalex.org/W2531711944","doi":"https://doi.org/10.1182/blood.v112.11.1430.1430","title":"Safety and Efficacy of High Dose Intravenous Desferoxamine for Reduction of Iron Overload Due to Chronic Transfusion in Sickle Cell Patients.","display_name":"Safety and Efficacy of High Dose Intravenous Desferoxamine for Reduction of Iron Overload Due to Chronic Transfusion in Sickle Cell Patients.","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W2531711944","doi":"https://doi.org/10.1182/blood.v112.11.1430.1430","mag":"2531711944"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.1430.1430","doi":"https://doi.org/10.1182/blood.v112.11.1430.1430","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1430.1430","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087767536","display_name":"Ram V. Kalpatthi","orcid":"https://orcid.org/0000-0002-2135-2801","observed_orcids":["https://orcid.org/0000-0002-2135-2801"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Kalpatthi","raw_affiliation_strings":["Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044877485","display_name":"Brittany Peters","orcid":"https://orcid.org/0000-0001-5145-2929","observed_orcids":["https://orcid.org/0000-0001-5145-2929"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Peters","raw_affiliation_strings":["Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079293297","display_name":"David Holloman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Holloman","raw_affiliation_strings":["Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054930231","display_name":"Elizabeth Rackoffe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Rackoffe","raw_affiliation_strings":["Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087019590","display_name":"Deborah Disco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Disco","raw_affiliation_strings":["Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112692174","display_name":"Sherron M. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherron Jackson","raw_affiliation_strings":["Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Hematology Oncology, Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073625002","display_name":"Miguel Raul Abboud","orcid":"https://orcid.org/0000-0001-8469-6823","observed_orcids":["https://orcid.org/0000-0001-8469-6823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel Abboud","raw_affiliation_strings":["Children\u2019s Cancer Center of Lebanon, Beirut, Lebanon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Center of Lebanon, Beirut, Lebanon","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.236,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63528315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"1430","last_page":"1430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9620000123977661},{"id":"https://openalex.org/keywords/chronic-transfusion-therapy","display_name":"chronic transfusion","score":0.9330000281333923},{"id":"https://openalex.org/keywords/iron-chelation-therapy","display_name":"iron chelation therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/non-compliant-patients","display_name":"non-compliant patients","score":0.6790000200271606},{"id":"https://openalex.org/keywords/liver-iron-concentration","display_name":"liver iron concentration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.46299999952316284},{"id":"https://openalex.org/keywords/deferasirox","display_name":"deferasirox","score":0.6769999861717224},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5730000138282776},{"id":"https://openalex.org/keywords/audiometric-hearing-loss","display_name":"audiometric hearing loss","score":0.4359999895095825},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.6029999852180481},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.4059999883174896},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.41499999165534973},{"id":"https://openalex.org/keywords/portal-vein-thrombosis","display_name":"portal vein thrombosis","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8556378483772278},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.5155637264251709},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.47701001167297363},{"id":"https://openalex.org/C2781053155","wikidata":"https://www.wikidata.org/wiki/Q5251502","display_name":"Deferasirox","level":3,"score":0.471329927444458},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.46284979581832886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4397856593132019},{"id":"https://openalex.org/C2780622394","wikidata":"https://www.wikidata.org/wiki/Q2089854","display_name":"Hemosiderosis","level":2,"score":0.42605969309806824},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.37388700246810913},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3446654975414276},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33358994126319885}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.1430.1430","doi":"https://doi.org/10.1182/blood.v112.11.1430.1430","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1430.1430","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068667017","https://openalex.org/W190357846","https://openalex.org/W3215073121","https://openalex.org/W2594652814","https://openalex.org/W4255257391","https://openalex.org/W2567717486","https://openalex.org/W1747646164","https://openalex.org/W2338844233","https://openalex.org/W75313515","https://openalex.org/W2554055446"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Patients":[2,562],"with":[3,24,45,63,87,95,149,248,489,517,527,537,584],"sickle":[4,549],"cell":[5,230,550],"disease":[6],"(SCD)":[7],"receiving":[8],"chronic":[9,122,405],"blood":[10,229],"transfusions":[11,231],"are":[12,92],"at":[13,273,327],"risk":[14],"of":[15,51,75,84,102,118,143,202,275,288,331,335,344,477,524,533,548,561,600,613,616,619,637,640,650],"developing":[16],"iron":[17,39,65,89,126,136,170,346,487,519,529,539,598,611,630,652],"overload":[18,40,66,90,127,540],"and":[19,37,113,146,159,179,217,265,325,508,541,553],"organ":[20,542],"toxicity.":[21,503],"Chelation":[22],"therapy":[23,498],"either":[25],"subcutaneous":[26],"(SQ)":[27],"desferoxamine":[28],"(DFO)":[29],"or":[30,239,399,402,404],"oral":[31,528],"deferasirox":[32],"is":[33,506],"effective":[34],"in":[35,59,67,80,108,307,319,341,365,376,415,425,455,462,465,485,575],"preventing":[36],"reducing":[38],"but":[41,382,420],"poses":[42],"significant":[43,88,125,363,460,483,518,538,585],"challenges":[44],"patient":[46,429,441,470],"compliance.":[47],"Intravenous":[48],"(IV)":[49],"infusions":[50],"high":[52,76,276,431,490,555],"dose":[53,77,277,491,556],"DFO":[54,79,249,558],"(HDD)":[55],"have":[56],"been":[57],"utilized":[58],"non":[60,93],"compliant":[61,94,515],"patients":[62,86,104,153,190,196,298,320,349,390,417,479,495,516,536,551],"heavy":[64],"small":[68],"case":[69],"series.":[70],"We":[71],"review":[72],"our":[73,109,466,475],"experience":[74],"IV":[78,252,492,557],"a":[81,339,374,482],"large":[82],"cohort":[83,476],"SCD":[85,103,478],"who":[91,105,321],"SQ":[96,150],"DFO.":[97,151,493],"Methods:":[98],"The":[99,270,285],"medical":[100],"records":[101],"received":[106,326],"HDD":[107,289,358,381,392,419,567,570,617,638],"center":[110],"between":[111],"1993":[112],"2004":[114],"were":[115,120,147,184,188,197,245,309,408],"reviewed.":[116],"All":[117,152,223,389],"them":[119],"on":[121,198],"transfusion,":[123],"had":[124,299,322,350,430,442],"defined":[128],"by":[129,302],"serum":[130,166,426,432,463],"ferritin":[131,167,378],">":[132],"1500":[133],"and/or":[134],"liver":[135,144,169,173,303,336,345,366,486,601,620,641,651],"concentration":[137,171],"(LIC)":[138],"more":[139,317],"than":[140],"10":[141],"\u03bcg/g":[142],"tissue":[145,602,621],"non-compliant":[148],"underwent":[154],"annual":[155],"ophthalmologic,":[156],"hearing,":[157],"pulmonary":[158,406],"cardiac":[160],"evaluation.":[161],"Demographic":[162],"data,":[163],"treatment":[164,290],"details,":[165],"levels,":[168],"(LIC),":[172],"enzymes,":[174],"renal":[175],"function":[176],"tests,":[177],"audiogram":[178],"other":[180],"relevant":[181],"clinical":[182],"data":[183],"collected.":[185],"Results:":[186],"There":[187,372,457],"27":[189,663,672,681,691],"(19":[191],"males,":[192],"8":[193,623],"females),":[194],"19":[195],"transfusion":[199],"for":[200,206,213,219,253,452,513],"history":[201],"cerebrovascular":[203],"accident,":[204],"5":[205],"abnormal":[207],"transcranial":[208],"Doppler":[209],"flow":[210],"velocity,":[211],"2":[212,257],"transient":[214],"ischemic":[215],"attack":[216],"one":[218],"recurrent":[220],"pain":[221],"crises.":[222],"continued":[224],"to":[225,233,535,566],"receive":[226],"packed":[227],"red":[228],"aimed":[232],"keep":[234],"HbS":[235],"levels":[236,379,577],"below":[237],"30":[238],"50%":[240],"during":[241],"this":[242,383,469,525],"time.":[243],"They":[244],"treated":[246],"in-hospital":[247],"15":[250],"mg/kg/hr":[251],"48":[254],"hrs":[255],"every":[256],"weeks":[258,262,267],"(20":[259],"patients),":[260],"3":[261],"(4":[263],"patients)":[264],"4":[266],"(3":[268],"patients).":[269],"mean":[271,286,576],"age":[272],"start":[274],"regimen":[278,505,526],"was":[279,291,316,362,373,422,447,458,471],"14.6":[280],"years":[281],"(range":[282,294],"9\u201327":[283],"years).":[284],"duration":[287],"8.9":[292,692],"months":[293,330,615,636],"3\u201349":[295],"months).":[296],"Fourteen":[297],"LIC":[300,308,324],"determined":[301],"biopsy.":[304],"Significant":[305],"reductions":[306],"observed":[310,481],"after":[311,356,370,380,418,436,554],"HD":[312],"(table":[313],"I).":[314],"This":[315,440,504],"pronounced":[318],"higher":[323],"least":[328],"6":[329,614,635],"HDD.":[332,371,439],"Histological":[333],"examination":[334],"biopsies":[337],"revealed":[338],"decrease":[340,484],"the":[342,450,453,497],"grade":[343],"storage.":[347],"Four":[348],"portal":[351],"triaditis":[352],"initially":[353],"which":[354,446],"resolved":[355],"starting":[357],"therapy.":[359],"Also":[360],"there":[361,421],"improvement":[364],"enzymes":[367],"(ALT,":[368],"AST)":[369],"trend":[375],"decreasing":[377],"did":[384],"not":[385],"achieve":[386],"statistical":[387],"significance.":[388],"tolerated":[391,496],"without":[393,500],"any":[394,501],"major":[395,502],"reactions.":[396],"No":[397],"audiologic":[398],"ophthalmologic":[400],"toxicity":[401],"acute":[403],"complications":[407],"observed.":[409],"Blood":[410,687],"urea":[411,688],"nitrogen":[412,689],"remained":[413],"normal":[414],"all":[416],"mild":[423],"increase":[424,461],"creatinine.":[427,456],"One":[428],"creatinine":[433,464],"(1.2":[434],"mg/dL)":[435],"two":[437],"doses":[438],"focal":[443],"segmental":[444],"glomeurosclerosis":[445],"most":[448],"probably":[449],"cause":[451],"rise":[454],"no":[459],"series":[467],"when":[468],"excluded.":[472],"Conclusions:":[473],"In":[474,521],"we":[480],"burden":[488],"Our":[494],"well":[499],"safe":[507],"may":[509,531],"be":[510,532],"an":[511],"option":[512],"poorly":[514],"overload.":[520],"addition,":[522],"combination":[523],"chelators":[530],"benefit":[534],"dysfunction.":[543],"Table":[544],"1:":[545],"Laboratory":[546],"characteristics":[547],"before":[552],"Parameter":[559],"No.":[560],"Mean":[563,568],"(SD)":[564],"prior":[565],"(SD)after":[569],"p":[571,586],"Value*":[572],"*":[573],"Changes":[574],"analyzed":[578],"using":[579],"two-tailed":[580],"Paired":[581],"T":[582],"Test":[583],"value":[587],"\u2264":[588],"0.05.":[589],"SD":[590],"\u2013":[591],"Standard":[592],"deviation":[593],"+":[594],"See":[595],"text":[596],"Liver":[597,610,629],"(\u03bcg/g":[599,618,639],")":[603,622],"14":[604,654],"16864":[605],"(10903)":[606],"12681":[607],"(8298)":[608],"0.04":[609,677],"min":[612],"18677":[624],"(8319)":[625],"9362":[626],"(4521)":[627],"0.01":[628,648,686],">10":[631],"mg":[632],"&":[633],"minimum":[634],"tissue)":[642],"7":[643],"21181":[644],"(7054)":[645],"10092":[646],"(4443)":[647],"Grade":[649],"storage":[653],"3.57":[655],"(0.9)":[656],"3.07":[657],"(1)":[658],"0.05":[659],"Serum":[660,669,678,697],"Ferritin":[661],"(ng/mL)":[662],"3842":[664],"(2619)":[665],"3238":[666],"(1780)":[667],"0.06":[668],"AST":[670],"(IU/L)":[671,680],"54.1":[673],"(27.2)":[674],"44.6":[675],"(17.6)":[676],"ALT":[679],"39.2":[682],"(36)":[683],"27.5":[684],"(14.2)":[685],"(mg/dL)":[690],"(2.9)":[693],"9.5":[694],"(4.3)":[695],"0.20":[696],"Creatinine":[698],"(mg/dL)+":[699],"26":[700],"0.50":[701],"(0.1)":[702],"0.55":[703],"(0.2)":[704],"0.07":[705]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-21T00:00:00"}