{"id":"https://openalex.org/W2531710836","doi":null,"title":"RGS2 and Human Adipogenesis","display_name":"RGS2 and Human Adipogenesis","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2531710836","mag":"2531710836"},"language":"en","primary_location":{"id":"pmh:oai:digitalscholarship.unlv.edu:jhdrp-1546","doi":null,"is_oa":true,"landing_page_url":"https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/16","pdf_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1546&context=jhdrp","source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Health Disparities Research and Practice","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1546&context=jhdrp","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008354287","display_name":"Kaia Partlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaia Partlow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050738450","display_name":"Alma Madrigal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alma Madrigal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004078781","display_name":"Yuanxiang Zhao","orcid":"https://orcid.org/0000-0003-1611-4590","observed_orcids":["https://orcid.org/0000-0003-1611-4590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanxiang Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1611-4590","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13343459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"5","first_page":"16","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgs2","display_name":"RGS2","score":1.0},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/human-mesenchymal-stem-cells","display_name":"human mesenchymal stem cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gtpase-regulators","display_name":"GTPase regulators","score":0.6669999957084656},{"id":"https://openalex.org/keywords/regulators-of-g-protein-signaling","display_name":"regulator of G protein signaling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8320000171661377},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.9758632183074951},{"id":"https://openalex.org/C4963665","wikidata":"https://www.wikidata.org/wiki/Q18031115","display_name":"RGS2","level":5,"score":0.8258278369903564},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7214381694793701},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5748786926269531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.512117862701416},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.45701056718826294},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.41184112429618835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3395771384239197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3284154236316681},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2040172815322876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1432093381881714},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.0728820264339447},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalscholarship.unlv.edu:jhdrp-1546","doi":null,"is_oa":true,"landing_page_url":"https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/16","pdf_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1546&context=jhdrp","source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Health Disparities Research and Practice","raw_type":"text"},{"id":"pmh:oai:oasis.library.unlv.edu:jhdrp-1546","doi":null,"is_oa":false,"landing_page_url":"https://oasis.library.unlv.edu/jhdrp/vol9/iss5/16","pdf_url":null,"source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Health Disparities Research and Practice","raw_type":"text"},{"id":"mag:2531710836","doi":null,"is_oa":false,"landing_page_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1546&context=jhdrp","pdf_url":null,"source":{"id":"https://openalex.org/S2764566294","display_name":"Journal of health disparities research and practice","issn_l":"2166-5222","issn":["2166-5222"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320281","host_organization_name":"American Speech\u2013Language\u2013Hearing Association","host_organization_lineage":["https://openalex.org/P4310320281"],"host_organization_lineage_names":["American Speech\u2013Language\u2013Hearing Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of health disparities research and practice","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalscholarship.unlv.edu:jhdrp-1546","doi":null,"is_oa":true,"landing_page_url":"https://digitalscholarship.unlv.edu/jhdrp/vol9/iss5/16","pdf_url":"https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1546&context=jhdrp","source":{"id":"https://openalex.org/S4377196371","display_name":"Digital Scholarship - UNLV (University of Nevada Reno)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134113660","host_organization_name":"University of Nevada, Reno","host_organization_lineage":["https://openalex.org/I134113660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Health Disparities Research and Practice","raw_type":"text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531710836.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2778656946","https://openalex.org/W1994293323","https://openalex.org/W2155203478","https://openalex.org/W3048641608","https://openalex.org/W2121503076","https://openalex.org/W4205990284","https://openalex.org/W2356734514","https://openalex.org/W2936677272","https://openalex.org/W3134069497","https://openalex.org/W7052431750"],"abstract_inverted_index":{"Obesity":[0],"is":[1,8,157,162],"characterized":[2],"by":[3,203],"excess":[4],"adipose":[5,21],"tissue":[6,22],"and":[7,62,69,72,161],"one":[9],"of":[10,15,20,27,39,54,85,104,114,130,147,150,178,185,196,223,233],"the":[11,16,67,148,176,181,219,231],"leading":[12],"public-health":[13],"issues":[14],"industrialized":[17],"world.":[18],"Gain":[19],"can":[23,109],"result":[24],"from":[25],"accumulation":[26],"fat":[28],"in":[29,92,180,218],"existing":[30],"adipocytes":[31,44,119],"(fat":[32],"cells),":[33],"as":[34,36,49,60,201],"well":[35,65],"increased":[37],"commitment":[38,184,221],"stem":[40,98,106],"cells":[41,99,107],"into":[42],"new":[43],"through":[45],"a":[46,52,102,112,125,128,145,158,215],"process":[47,222],"known":[48],"adipogenesis.":[50,237],"Although":[51],"number":[53,113,129],"key":[55],"adipogenic":[56,167,182,206,220],"transcription":[57],"factors":[58,153],"such":[59],"PPARgamma2":[61],"CEBPalpha":[63],"are":[64,79,101],"characterized,":[66],"temporal":[68],"spatial":[70],"molecular":[71],"cellular":[73],"events":[74,87],"that":[75,108,193,212],"occur":[76],"during":[77,139,205,236],"adipogenesis":[78,140],"still":[80],"largely":[81],"unknown.":[82],"Better":[83],"understanding":[84,175],"these":[86],"could":[88],"have":[89],"important":[90],"implications":[91],"finding":[93],"treatments":[94],"for":[95],"obesity.\\nHuman":[96],"mesenchymal":[97],"(hMSCs)":[100],"type":[103],"adult":[105],"commit":[110],"to":[111],"mature":[115],"cell":[116],"types":[117],"including":[118,143],"upon":[120,166],"receiving":[121],"appropriate":[122],"stimuli.":[123],"Through":[124],"microarray":[126],"study,":[127,171],"genes":[131],"whose":[132],"expression":[133],"was":[134],"significantly":[135,163,208],"up-":[136],"or":[137],"down-regulated":[138],"were":[141],"uncovered,":[142],"RGS2,":[144],"member":[146],"Regulators":[149],"G-protein":[151],"signaling":[152],"(RGS)":[154],"family.":[155],"RGS2":[156,179,197,213,234],"GTPase":[159],"regulator":[160],"up":[164],"regulated":[165],"stimulation.":[168],"In":[169],"this":[170],"we":[172],"focus":[173,228],"on":[174,229],"role":[177,217],"lineage":[183],"adipose-derived":[186],"hMSCs":[187],"(ad-hMSCs).\\nOur":[188],"results":[189],"so":[190],"far":[191],"demonstrated":[192],"down":[194],"regulation":[195],"at":[198],"40-50%":[199],"level":[200],"induced":[202],"siRGS2":[204],"initiation":[207],"inhibited":[209],"adipogenesis,":[210],"suggesting":[211],"plays":[214],"positive":[216],"ad-hMSCs.":[224],"Future":[225],"studies":[226],"will":[227],"examining":[230],"effect":[232],"overexpression":[235]},"counts_by_year":[],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2016-10-21T00:00:00"}
