{"id":"https://openalex.org/W2531699720","doi":"https://doi.org/10.3390/md14100181","title":"New Metabolites and Bioactive Actinomycins from Marine-Derived Streptomyces sp. ZZ338","display_name":"New Metabolites and Bioactive Actinomycins from Marine-Derived Streptomyces sp. ZZ338","publication_year":2016,"publication_date":"2016-10-11","ids":{"openalex":"https://openalex.org/W2531699720","doi":"https://doi.org/10.3390/md14100181","mag":"2531699720","pmid":"https://pubmed.ncbi.nlm.nih.gov/27727167"},"language":"en","primary_location":{"id":"doi:10.3390/md14100181","doi":"https://doi.org/10.3390/md14100181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md14100181","pdf_url":"https://www.mdpi.com/1660-3397/14/10/181/pdf?version=1476174408","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1660-3397/14/10/181/pdf?version=1476174408","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002116089","display_name":"Xiufang Zhang","orcid":"https://orcid.org/0000-0002-5270-8153","observed_orcids":["https://orcid.org/0000-0002-5270-8153"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiufang Zhang","raw_affiliation_strings":["Ocean College, Zhejiang University, Zhoushan 316021, China"],"raw_orcid":"https://orcid.org/0000-0002-5270-8153","affiliations":[{"raw_affiliation_string":"Ocean College, Zhejiang University, Zhoushan 316021, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025032366","display_name":"Xuewei Ye","orcid":"https://orcid.org/0000-0002-5077-2055","observed_orcids":["https://orcid.org/0000-0002-5077-2055"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuewei Ye","raw_affiliation_strings":["Ocean College, Zhejiang University, Zhoushan 316021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocean College, Zhejiang University, Zhoushan 316021, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064232977","display_name":"Weiyun Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyun Chai","raw_affiliation_strings":["Ocean College, Zhejiang University, Zhoushan 316021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocean College, Zhejiang University, Zhoushan 316021, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058365389","display_name":"Xiao\u2010Yuan Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Yuan Lian","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101821858","display_name":"Zhizhen Zhang","orcid":"https://orcid.org/0000-0002-8290-3507","observed_orcids":["https://orcid.org/0000-0002-8290-3507"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhizhen Zhang","raw_affiliation_strings":["Ocean College, Zhejiang University, Zhoushan 316021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocean College, Zhejiang University, Zhoushan 316021, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058365389","https://openalex.org/A5101821858"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":3.8759,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93214531,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"10","first_page":"181","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinomycin","display_name":"actinomycin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/marine-actinomycetes","display_name":"marine actinomycetes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dactinomycin","display_name":"actinomycin D","score":0.9100000262260437},{"id":"https://openalex.org/keywords/new-natural-products","display_name":"new natural products","score":0.7009999752044678},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9309999942779541},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.5979999899864197},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glutaminolysis","display_name":"glutaminolysis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6559143662452698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5350967645645142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47604918479919434},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.42227011919021606},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4200670123100281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3744013011455536},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.36062493920326233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009792","descriptor_name":"Oceans and Seas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009792","descriptor_name":"Oceans and Seas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009792","descriptor_name":"Oceans and Seas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/md14100181","doi":"https://doi.org/10.3390/md14100181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md14100181","pdf_url":"https://www.mdpi.com/1660-3397/14/10/181/pdf?version=1476174408","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},{"id":"pmid:27727167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27727167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine drugs","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4031839","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5082329","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5082329","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5082329","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mar Drugs","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a2d1581e347e4c67a46511520ea438a5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a2d1581e347e4c67a46511520ea438a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Marine Drugs, Vol 14, Iss 10, p 181 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/md14100181","doi":"https://doi.org/10.3390/md14100181","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md14100181","pdf_url":"https://www.mdpi.com/1660-3397/14/10/181/pdf?version=1476174408","source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8799999952316284,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531699720.pdf","grobid_xml":"https://content.openalex.org/works/W2531699720.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W629269523","https://openalex.org/W1543790510","https://openalex.org/W1909500234","https://openalex.org/W1964504447","https://openalex.org/W1969528530","https://openalex.org/W1992084711","https://openalex.org/W1993038196","https://openalex.org/W1995815175","https://openalex.org/W2030424138","https://openalex.org/W2035158433","https://openalex.org/W2051761222","https://openalex.org/W2065188354","https://openalex.org/W2065310517","https://openalex.org/W2079176468","https://openalex.org/W2085531694","https://openalex.org/W2087726825","https://openalex.org/W2102424000","https://openalex.org/W2102564718","https://openalex.org/W2102729115","https://openalex.org/W2122197684","https://openalex.org/W2122816851","https://openalex.org/W2131719921","https://openalex.org/W2135462171","https://openalex.org/W2148156107","https://openalex.org/W2153178365","https://openalex.org/W2166129831","https://openalex.org/W2225764644","https://openalex.org/W2334615011","https://openalex.org/W2365384404","https://openalex.org/W2405467164","https://openalex.org/W2465806199","https://openalex.org/W2921720775","https://openalex.org/W2950053773"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2331760418","https://openalex.org/W4281790352","https://openalex.org/W4243501567","https://openalex.org/W276237299","https://openalex.org/W2384305430","https://openalex.org/W2342726987","https://openalex.org/W2317186008","https://openalex.org/W2093770231","https://openalex.org/W1997216672"],"abstract_inverted_index":{"An":[0],"extract":[1,28],"prepared":[2],"from":[3,104],"the":[4,31,49,115,121,136,139,177,186],"culture":[5],"of":[6,25,33,48,95,117,123,138,154,172,180,188],"a":[7,105,168,182],"marine-derived":[8],"actinomycete":[9],"Streptomyces":[10],"sp.":[11],"ZZ338":[12],"was":[13,145],"found":[14,103,147],"to":[15,148],"have":[16],"significant":[17],"antimicrobial":[18],"and":[19,39,44,67,78,120,129,132,157],"antiproliferative":[20],"activities.":[21],"A":[22],"chemical":[23],"investigation":[24],"this":[26],"active":[27],"resulted":[29],"in":[30,113],"isolation":[32],"three":[34],"known":[35,109],"bioactive":[36],"actinomycins":[37,55,110],"(1\u20133)":[38],"two":[40],"new":[41,96,169],"metabolites":[42],"(4":[43],"5).":[45],"The":[46],"structures":[47],"isolated":[50],"compounds":[51],"were":[52],"identified":[53],"as":[54,87,89],"D":[56,143],"(1),":[57],"V":[58],"(2),":[59],"X0\u03b2":[60],"(3),":[61],"2-acetylamino-3-hydroxyl-4-methyl-benzoic":[62],"acid":[63],"methyl":[64],"ester":[65],"(4),":[66],"N-1S-(4-methylaminophenylmethyl)-2-oxo-propyl":[68],"acetamide":[69],"(5)":[70],"based":[71],"on":[72],"their":[73,90],"nuclear":[74],"magnetic":[75],"resonance":[76],"(NMR)":[77],"high":[79],"resolution":[80],"electrospray":[81],"ionization":[82],"mass":[83],"spectroscopy":[84],"(HRESIMS)":[85],"data":[86],"well":[88],"optical":[91],"rotation.":[92],"This":[93,175],"class":[94,187],"compound":[97],"5":[98],"had":[99],"never":[100],"before":[101],"been":[102],"natural":[106],"resource.":[107],"Three":[108],"showed":[111],"activities":[112],"inhibiting":[114],"proliferation":[116],"glioma":[118,151],"cells":[119],"growth":[122],"methicillin-resistant":[124],"Staphylococcus":[125],"aureus,":[126],"Escherichia":[127],"coli,":[128],"Candida":[130],"albicans":[131],"are":[133],"responsible":[134],"for":[135,185],"activity":[137],"crude":[140],"extract.":[141],"Actinomycin":[142],"(1)":[144],"also":[146],"downregulate":[149],"several":[150],"metabolic":[152,164],"enzymes":[153],"glycolysis,":[155],"glutaminolysis,":[156],"lipogenesis,":[158],"suggesting":[159],"that":[160],"targeting":[161],"multiple":[162],"tumor":[163],"regulators":[165],"might":[166],"be":[167],"anti-glioma":[170],"mechanism":[171,184],"actinomycin":[173],"D.":[174],"is":[176],"first":[178],"report":[179],"such":[181],"possible":[183],"actinomycins.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
