{"id":"https://openalex.org/W2531539980","doi":null,"title":"Understanding specific functions of PARP-2: new lessons for cancer therapy.","display_name":"Understanding specific functions of PARP-2: new lessons for cancer therapy.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2531539980","mag":"2531539980","pmid":"https://pubmed.ncbi.nlm.nih.gov/27725894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5043098"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5043098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5043098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5043098","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029410531","display_name":"Syed O. Ali","orcid":"https://orcid.org/0000-0002-9073-0415","observed_orcids":["https://orcid.org/0000-0002-9073-0415"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Syed O Ali","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045147676","display_name":"Farhaan A. Khan","orcid":"https://orcid.org/0000-0003-2308-414X","observed_orcids":["https://orcid.org/0000-0003-2308-414X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Farhaan A Khan","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003717320","display_name":"Miguel Alejandro Galindo-Campos","orcid":"https://orcid.org/0000-0002-0650-8660","observed_orcids":["https://orcid.org/0000-0002-0650-8660"]},"institutions":[{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel A Galindo-Campos","raw_affiliation_strings":["Department of Immunology, Cancer Research Program, Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Cancer Research Program, Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM) Barcelona, Spain","institution_ids":["https://openalex.org/I4210156109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041717462","display_name":"Jos\u00e9 Y\u00e9lamos","orcid":"https://orcid.org/0000-0003-1195-1496","observed_orcids":["https://orcid.org/0000-0003-1195-1496"]},"institutions":[{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Y\u00e9lamos","raw_affiliation_strings":["Department of Immunology, Cancer Research Program, Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM)Barcelona, Spain; CIBERehdSpain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Cancer Research Program, Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM)Barcelona, Spain; CIBERehdSpain","institution_ids":["https://openalex.org/I4210156109"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3482,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90100151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":"9","first_page":"1842","last_page":"1863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp2","display_name":"PARP2","score":1.0},{"id":"https://openalex.org/keywords/poly-adp-ribosyl-ation","display_name":"poly(ADP-ribosyl)ation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/isoform-selective-inhibition","display_name":"isoform-selective inhibition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8949999809265137},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8159999847412109},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.7760000228881836},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/parp3","display_name":"PARP3","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.7290204167366028},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7191053628921509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6140631437301636},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5469064116477966},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5049362778663635},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48809707164764404},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4833106994628906},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45421233773231506},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.44017478823661804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.411693274974823},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.2472597062587738},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24496063590049744},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23109054565429688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11981326341629028}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5043098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5043098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:27725894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27725894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Review"},{"id":"pmh:oai:repositori.upf.edu:10230/28225","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/28225","pdf_url":"http://hdl.handle.net/10230/28225","source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2531539980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27725894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5043098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5043098","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310701","display_name":"Fundaci\u00f3 la Marat\u00f3 de TV3","ror":"https://ror.org/00t5xc355"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531539980.pdf","grobid_xml":"https://content.openalex.org/works/W2531539980.grobid-xml"},"referenced_works_count":169,"referenced_works":["https://openalex.org/W1487669901","https://openalex.org/W1532086012","https://openalex.org/W1535628640","https://openalex.org/W1543500873","https://openalex.org/W1601923831","https://openalex.org/W1800636867","https://openalex.org/W1801843862","https://openalex.org/W1848063234","https://openalex.org/W1914336093","https://openalex.org/W1923855798","https://openalex.org/W1926646823","https://openalex.org/W1945295084","https://openalex.org/W1946287926","https://openalex.org/W1963711485","https://openalex.org/W1970891016","https://openalex.org/W1975445106","https://openalex.org/W1976164429","https://openalex.org/W1976886432","https://openalex.org/W1977546802","https://openalex.org/W1983550104","https://openalex.org/W1983566327","https://openalex.org/W1983622721","https://openalex.org/W1984542357","https://openalex.org/W1989540020","https://openalex.org/W1993180847","https://openalex.org/W2001431040","https://openalex.org/W2002638727","https://openalex.org/W2002962154","https://openalex.org/W2003308339","https://openalex.org/W2005560019","https://openalex.org/W2009979784","https://openalex.org/W2012650343","https://openalex.org/W2012790791","https://openalex.org/W2015037479","https://openalex.org/W2015414930","https://openalex.org/W2018329608","https://openalex.org/W2019775979","https://openalex.org/W2020304127","https://openalex.org/W2021250240","https://openalex.org/W2021980639","https://openalex.org/W2024522890","https://openalex.org/W2027379868","https://openalex.org/W2027931017","https://openalex.org/W2028392042","https://openalex.org/W2030475136","https://openalex.org/W2031050244","https://openalex.org/W2032347891","https://openalex.org/W2032407757","https://openalex.org/W2033289868","https://openalex.org/W2033761616","https://openalex.org/W2034058449","https://openalex.org/W2034773856","https://openalex.org/W2037316481","https://openalex.org/W2038657349","https://openalex.org/W2039171346","https://openalex.org/W2039855253","https://openalex.org/W2040971700","https://openalex.org/W2041156660","https://openalex.org/W2041862154","https://openalex.org/W2043251251","https://openalex.org/W2047259732","https://openalex.org/W2047330128","https://openalex.org/W2049216034","https://openalex.org/W2049378557","https://openalex.org/W2050164541","https://openalex.org/W2050302428","https://openalex.org/W2051063130","https://openalex.org/W2051193631","https://openalex.org/W2056848326","https://openalex.org/W2057706543","https://openalex.org/W2064830796","https://openalex.org/W2065388657","https://openalex.org/W2066490621","https://openalex.org/W2066851999","https://openalex.org/W2067724937","https://openalex.org/W2069972055","https://openalex.org/W2070758111","https://openalex.org/W2072528578","https://openalex.org/W2072709416","https://openalex.org/W2073551059","https://openalex.org/W2076434586","https://openalex.org/W2077436902","https://openalex.org/W2077994677","https://openalex.org/W2083158919","https://openalex.org/W2083456009","https://openalex.org/W2085215116","https://openalex.org/W2085407032","https://openalex.org/W2087949216","https://openalex.org/W2094170505","https://openalex.org/W2096330673","https://openalex.org/W2098495967","https://openalex.org/W2098748492","https://openalex.org/W2099904057","https://openalex.org/W2100475250","https://openalex.org/W2101988823","https://openalex.org/W2103225674","https://openalex.org/W2104198050","https://openalex.org/W2104425537","https://openalex.org/W2104509411","https://openalex.org/W2104676795","https://openalex.org/W2105664288","https://openalex.org/W2106109160","https://openalex.org/W2106390123","https://openalex.org/W2106440131","https://openalex.org/W2106996266","https://openalex.org/W2107632586","https://openalex.org/W2110017381","https://openalex.org/W2110471374","https://openalex.org/W2110576677","https://openalex.org/W2110616862","https://openalex.org/W2111365327","https://openalex.org/W2111667552","https://openalex.org/W2114342948","https://openalex.org/W2116005493","https://openalex.org/W2116804853","https://openalex.org/W2117692326","https://openalex.org/W2118542406","https://openalex.org/W2119609556","https://openalex.org/W2120396502","https://openalex.org/W2121272379","https://openalex.org/W2121328270","https://openalex.org/W2121371748","https://openalex.org/W2121618450","https://openalex.org/W2124577886","https://openalex.org/W2125663719","https://openalex.org/W2127686099","https://openalex.org/W2127957276","https://openalex.org/W2131670056","https://openalex.org/W2131786456","https://openalex.org/W2132324298","https://openalex.org/W2134630150","https://openalex.org/W2136306650","https://openalex.org/W2137023032","https://openalex.org/W2139727963","https://openalex.org/W2140236604","https://openalex.org/W2142125232","https://openalex.org/W2146221477","https://openalex.org/W2150490516","https://openalex.org/W2153216034","https://openalex.org/W2156109602","https://openalex.org/W2158389792","https://openalex.org/W2163294504","https://openalex.org/W2165912346","https://openalex.org/W2168891239","https://openalex.org/W2173456459","https://openalex.org/W2177072498","https://openalex.org/W2198119276","https://openalex.org/W2210184605","https://openalex.org/W2214404849","https://openalex.org/W2217722934","https://openalex.org/W2226165420","https://openalex.org/W2232592265","https://openalex.org/W2234443850","https://openalex.org/W2253016623","https://openalex.org/W2256722979","https://openalex.org/W2279561773","https://openalex.org/W2281629727","https://openalex.org/W2325021350","https://openalex.org/W2332817318","https://openalex.org/W2342788383","https://openalex.org/W2416703957","https://openalex.org/W2418610767","https://openalex.org/W2444594224","https://openalex.org/W2476568892","https://openalex.org/W2500066130","https://openalex.org/W3093265161","https://openalex.org/W4242932535","https://openalex.org/W4297852118","https://openalex.org/W7074201630"],"related_works":["https://openalex.org/W2560078451","https://openalex.org/W2005560019","https://openalex.org/W4396619622","https://openalex.org/W162528498","https://openalex.org/W2169569938","https://openalex.org/W2088880249","https://openalex.org/W2166571825","https://openalex.org/W4376140894","https://openalex.org/W4200469408","https://openalex.org/W2059177130"],"abstract_inverted_index":{"Poly(ADP-ribosyl)ation":[0],"(PARylation)":[1],"is":[2,85,91],"a":[3,12,215],"widespread":[4],"and":[5,33,36,89,105,114,125,136,147,152,187],"highly":[6],"conserved":[7],"post-translational":[8],"modification":[9],"catalysed":[10],"by":[11],"large":[13],"family":[14,100],"of":[15,30,53,82,98,157,165,185,194,203,208],"enzymes":[16],"called":[17],"poly(ADP-ribose)":[18],"polymerases":[19],"(PARPs).":[20],"PARylation":[21],"plays":[22,134],"an":[23],"essential":[24],"role":[25],"in":[26,43,50,118,140,168,174,182,197],"various":[27],"cardinal":[28],"processes":[29,171],"cellular":[31,141,170],"physiology":[32],"recent":[34],"approvals":[35],"breakthrough":[37],"therapy":[38,45],"designations":[39],"for":[40,191],"PARP":[41,54,58,70,99],"inhibitors":[42,59,196],"cancer":[44,186,220],"have":[46,60],"sparked":[47],"great":[48],"interest":[49],"pharmacological":[51],"targeting":[52],"proteins.":[55],"Although,":[56],"many":[57,169],"been":[61],"developed,":[62],"existing":[63],"compounds":[64],"display":[65],"promiscuous":[66],"inhibition":[67,84,213],"across":[68],"the":[69,80,108,119,166,183,189,192,201,206],"superfamily":[71],"which":[72],"could":[73],"lead":[74],"to":[75,149],"unwanted":[76],"off-target":[77],"effects.":[78],"Thus":[79],"prospect":[81],"isoform-selective":[83,195],"being":[86],"increasingly":[87],"explored":[88],"research":[90],"now":[92],"focusing":[93],"on":[94,219],"understanding":[95],"specific":[96,135],"roles":[97,117,139,202],"members.":[101],"PARP-2,":[102],"alongside":[103],"PARP-1":[104],"PARP-3":[106],"are":[107],"only":[109],"known":[110],"DNA":[111,120,123],"damage-dependent":[112],"PARPs":[113],"play":[115],"critical":[116],"damage":[121],"response,":[122],"metabolism":[124],"chromatin":[126],"architecture.":[127],"However,":[128],"growing":[129],"evidence":[130],"shows":[131],"that":[132],"PARP-2":[133,158,204],"diverse":[137],"regulatory":[138],"physiology,":[142],"ranging":[143],"from":[144],"genomic":[145],"stability":[146],"epigenetics":[148],"proliferative":[150],"signalling":[151],"inflammation.":[153],"The":[154],"emerging":[155],"network":[156],"target":[159],"proteins":[160],"has":[161],"uncovered":[162],"wide-ranging":[163],"functions":[164,181],"molecule":[167],"commonly":[172],"dysregulated":[173],"carcinogenesis.":[175],"Here,":[176],"we":[177,210],"review":[178],"novel":[179],"PARP-2-specific":[180],"hallmarks":[184],"consider":[188],"implications":[190],"development":[193],"chemotherapy.":[198],"By":[199],"considering":[200],"through":[205],"lens":[207],"tumorigenesis,":[209],"propose":[211],"PARP-2-selective":[212],"as":[214],"potentially":[216],"multipronged":[217],"attack":[218],"physiology.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-21T00:00:00"}
