{"id":"https://openalex.org/W2531292978","doi":null,"title":"Beneficial Effects of a Protein Rich Diet on Coping Neurotrans-mitter Levels During Ampicillin-Induced Neurotoxicity Compared to Propionic-Acid Induced Autistic Biochemical Features.","display_name":"Beneficial Effects of a Protein Rich Diet on Coping Neurotrans-mitter Levels During Ampicillin-Induced Neurotoxicity Compared to Propionic-Acid Induced Autistic Biochemical Features.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2531292978","mag":"2531292978","pmid":"https://pubmed.ncbi.nlm.nih.gov/27942501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125367"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5125367","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Cell Med","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115600505","display_name":"Ramesa Shafi Bhat","orcid":"https://orcid.org/0000-0003-2149-6239","observed_orcids":["https://orcid.org/0000-0003-2149-6239"]},"institutions":[{"id":"https://openalex.org/I15517640","display_name":"Shri Venkateshwara University","ror":"https://ror.org/00xh8va68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15517640"]},{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["IN","SA"],"is_corresponding":false,"raw_author_name":"Ramesa Shafi Bhat","raw_affiliation_strings":["Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia.; Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India","institution_ids":["https://openalex.org/I15517640","https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112789345","display_name":"Kaushal K. Chandrul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15517640","display_name":"Shri Venkateshwara University","ror":"https://ror.org/00xh8va68","country_code":"IN","type":"education","lineage":["https://openalex.org/I15517640"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kaushal Kishore Chandrul","raw_affiliation_strings":["Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula, Amroha, Uttar Pradesh, India","institution_ids":["https://openalex.org/I15517640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011705440","display_name":"Afaf K El-Ansary","orcid":"https://orcid.org/0000-0002-1404-5248","observed_orcids":["https://orcid.org/0000-0002-1404-5248","https://orcid.org/0000-0003-1411-7683"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Afaf El-Ansary","raw_affiliation_strings":["Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia.; Central Laboratory, Female Center for \u00a0Medical Studies and Scientific Section, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Science College, King Saud University, Riyadh, Saudi Arabia.; Central Laboratory, Female Center for \u00a0Medical Studies and Scientific Section, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"5","issue":"3","first_page":"149","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-protein-diet","display_name":"high-protein diet","score":0.9729999899864197},{"id":"https://openalex.org/keywords/propionic-acid","display_name":"propionic acid","score":0.8529999852180481},{"id":"https://openalex.org/keywords/autism-model","display_name":"autism model","score":0.8299999833106995},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.8450000286102295},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":1.0},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.996999979019165},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.8045344948768616},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5742679238319397},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5571987628936768},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5118245482444763},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.48414498567581177},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.47318267822265625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46537110209465027},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4417819082736969},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4234752655029297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42224475741386414},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.4158018231391907},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.41106724739074707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3265608251094818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3073452413082123},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1913977861404419},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.16907256841659546},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.16883674263954163},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15469521284103394},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14649814367294312},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5125367","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Cell Med","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4085892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5125367","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27942501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27942501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular and cellular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d7f398164af544da8fb6a98bdcfea80e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d7f398164af544da8fb6a98bdcfea80e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular and Cellular Medicine, Vol 5, Iss 3, Pp 149-159 (2016)","raw_type":"article"},{"id":"mag:2531292978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27942501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5125367","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5125367/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Cell Med","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2531292978.pdf","grobid_xml":"https://content.openalex.org/works/W2531292978.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1825066541","https://openalex.org/W1970304160","https://openalex.org/W1979375518","https://openalex.org/W1982693223","https://openalex.org/W1992353280","https://openalex.org/W1996087940","https://openalex.org/W2010724711","https://openalex.org/W2013700693","https://openalex.org/W2029296787","https://openalex.org/W2055607877","https://openalex.org/W2060785552","https://openalex.org/W2061631433","https://openalex.org/W2064355322","https://openalex.org/W2100404177","https://openalex.org/W2101147266","https://openalex.org/W2101586468","https://openalex.org/W2101680415","https://openalex.org/W2115334373","https://openalex.org/W2128767692","https://openalex.org/W2133501876","https://openalex.org/W2141857876","https://openalex.org/W2153537282","https://openalex.org/W2165429615","https://openalex.org/W2167066956","https://openalex.org/W2312518075","https://openalex.org/W4247665917"],"related_works":["https://openalex.org/W4380082108","https://openalex.org/W7096876686","https://openalex.org/W2061631433","https://openalex.org/W2526460334","https://openalex.org/W2165429615","https://openalex.org/W1975948108","https://openalex.org/W3033155329","https://openalex.org/W1935427544","https://openalex.org/W2101147266","https://openalex.org/W4400985469"],"abstract_inverted_index":{"This":[0],"study":[1],"examined":[2],"the":[3,51,72,78,88,92,117,194,207],"effects":[4,182],"of":[5,26,63,81,95,120,126,165,183],"a":[6,174,199,215,221],"protein":[7,102,200,211],"rich":[8,103,201],"diet":[9],"on":[10,185,198],"coping":[11],"neurotransmitter":[12,225],"levels":[13,137,145],"in":[14,116,150,159,169,177,227],"orally":[15],"administered":[16],"ampicillin-induced":[17],"neurotoxic":[18,79],"rats":[19,33,195],"compared":[20,139],"with":[21,60,77,100,173,206],"propionic":[22],"acid":[23],"(PA)":[24],"models":[25],"autism.":[27,231],"40":[28],"young":[29],"male":[30],"western":[31],"albino":[32],"were":[34,114,146,188,196],"divided":[35],"into":[36],"four":[37],"groups.":[38,123],"The":[39,181],"first":[40],"group":[41,53,74,90,153,172],"served":[42],"as":[43,55],"control":[44],"and":[45,97,110,128,135],"received":[46,91],"phosphate":[47],"buffered":[48],"saline":[49],"orally;":[50],"second":[52],"serving":[54],"autistic":[56],"model":[57],"was":[58,75,98,157,167],"treated":[59,76,152,161,171,179],"oral":[61],"dose":[62,80,94],"PA":[64,127,151,170],"(250":[65],"mg/kg":[66,84],"body":[67],"weight/day":[68],"for":[69,85],"3":[70],"days);":[71],"third":[73],"ampicillin":[82,96,129,160,178,184],"(50":[83],"three":[86],"weeks);":[87],"fourth":[89],"same":[93],"fed":[99,197],"special":[101],"diets.":[104],"Noradrenaline,":[105],"dopamine,":[106,134],"serotonin":[107,136],"glutamate,":[108,143],"glutamine":[109,166],"interleukin":[111],"6":[112],"(IL-6)":[113],"measured":[115],"brain":[118],"homogenate":[119],"all":[121],"tested":[122],"Specified":[124],"doses":[125],"significantly":[130,147],"(P<0.001)":[131,148],"decreased":[132],"noradrenaline,":[133],"when":[138,193],"to":[140,190,218,223],"control.":[141],"Also":[142],"IL-6":[144],"increased":[149],"while":[154],"non-significant":[155],"increase":[156,164,176],"found":[158,168,189],"group.":[162,180],"Non-significant":[163],"significant":[175],"these":[186],"parameters":[187],"be":[191,214],"potentiated":[192],"diet.":[202],"Our":[203],"results":[204],"end":[205],"conclusion":[208],"that":[209],"dietary":[210],"level":[212],"may":[213],"useful":[216],"tool":[217],"find":[219],"out":[220],"path":[222],"restrict":[224],"alterations":[226],"neurodevelopmental":[228],"disorders":[229],"like":[230]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-10-21T00:00:00"}