{"id":"https://openalex.org/W2530833279","doi":"https://doi.org/10.1111/acer.13239","title":"Genetic Loss of Immunoglobulin A Does Not Influence Development of Alcoholic Steatohepatitis in Mice","display_name":"Genetic Loss of Immunoglobulin A Does Not Influence Development of Alcoholic Steatohepatitis in Mice","publication_year":2016,"publication_date":"2016-10-14","ids":{"openalex":"https://openalex.org/W2530833279","doi":"https://doi.org/10.1111/acer.13239","mag":"2530833279","pmid":"https://pubmed.ncbi.nlm.nih.gov/27739086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5133156"},"language":"en","primary_location":{"id":"doi:10.1111/acer.13239","doi":"https://doi.org/10.1111/acer.13239","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13239","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133156/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058083558","display_name":"Tatsuo Inamine","orcid":"https://orcid.org/0000-0001-5160-2325","observed_orcids":["https://orcid.org/0000-0001-5160-2325"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tatsuo Inamine","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California","Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103389462","display_name":"An\u2010Ming Yang","orcid":"https://orcid.org/0000-0002-3627-7920","observed_orcids":["https://orcid.org/0000-0002-3627-7920"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"An\u2010Ming Yang","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007415599","display_name":"Lirui Wang","orcid":"https://orcid.org/0000-0001-9285-7084","observed_orcids":["https://orcid.org/0000-0001-9285-7084"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lirui Wang","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California","Department of Medicine, VA San Diego Healthcare System, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Medicine, VA San Diego Healthcare System, San Diego, California","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019010782","display_name":"Kuei\u2010Chuan Lee","orcid":"https://orcid.org/0000-0003-4318-5511","observed_orcids":["https://orcid.org/0000-0003-4318-5511","https://orcid.org/0000-0001-8088-6320"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuei\u2010Chuan Lee","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074186613","display_name":"Cristina Llorente","orcid":"https://orcid.org/0000-0001-8135-9186","observed_orcids":["https://orcid.org/0000-0001-8135-9186"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Llorente","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California","Department of Medicine, VA San Diego Healthcare System, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Medicine, VA San Diego Healthcare System, San Diego, California","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001918029","display_name":"Bernd Schnabl","orcid":"https://orcid.org/0000-0002-6281-825X","observed_orcids":["https://orcid.org/0000-0002-6281-825X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernd Schnabl","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, California","Department of Medicine, VA San Diego Healthcare System, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Medicine, VA San Diego Healthcare System, San Diego, California","institution_ids":["https://openalex.org/I4210099595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001918029"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":3.6789,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.93093548,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"40","issue":"12","first_page":"2604","last_page":"2613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9559999704360962},{"id":"https://openalex.org/keywords/iga-deficiency","display_name":"IgA deficiency","score":0.8529999852180481},{"id":"https://openalex.org/keywords/alcoholic-steatohepatitis","display_name":"alcoholic steatohepatitis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.7400000095367432},{"id":"https://openalex.org/keywords/chronic-ethanol-feeding","display_name":"chronic ethanol feeding","score":0.718999981880188},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mesenteric-lymph-nodes","display_name":"mesenteric lymph nodes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/intestinal-immunity","display_name":"intestinal immunity","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7117219567298889},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.6348024606704712},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.633084237575531},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6178637146949768},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6130754947662354},{"id":"https://openalex.org/C2779102806","wikidata":"https://www.wikidata.org/wiki/Q79453","display_name":"Immunoglobulin A","level":4,"score":0.6101086735725403},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.5364606380462646},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4841935932636261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45084643363952637},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.44251933693885803},{"id":"https://openalex.org/C2780999109","wikidata":"https://www.wikidata.org/wiki/Q1271831","display_name":"Small intestinal bacterial overgrowth","level":3,"score":0.4267141819000244},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40147674083709717},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3806627094745636},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.31567519903182983},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3086853623390198},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.2741384506225586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2645399570465088},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2594267427921295},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18737825751304626},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.12659791111946106}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005235","descriptor_name":"Fatty Liver, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063425","descriptor_name":"Binge Drinking","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/acer.13239","doi":"https://doi.org/10.1111/acer.13239","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13239","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:27739086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27739086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5133156","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133156/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5133156","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5133156/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1125931216","display_name":"Microbiome and intestinal innate immune response in alcoholic liver disease","funder_award_id":"R01AA020703","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G1371943267","display_name":null,"funder_award_id":"I01BX002213","funder_id":"https://openalex.org/F4320309842","funder_display_name":"Biomedical Laboratory Research and Development, VA Office of Research and Development"},{"id":"https://openalex.org/G2971162200","display_name":null,"funder_award_id":"I01BX002213","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6644058654","display_name":"Microbiome as Therapeutic Target in Alcoholic Hepatitis","funder_award_id":"U01AA021856","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309842","display_name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1547925037","https://openalex.org/W1548367056","https://openalex.org/W1969579498","https://openalex.org/W1973067432","https://openalex.org/W1975691929","https://openalex.org/W1983778185","https://openalex.org/W1985357860","https://openalex.org/W2011848880","https://openalex.org/W2018620221","https://openalex.org/W2024933805","https://openalex.org/W2028799613","https://openalex.org/W2031315847","https://openalex.org/W2037652424","https://openalex.org/W2040391599","https://openalex.org/W2048180954","https://openalex.org/W2063800686","https://openalex.org/W2068734008","https://openalex.org/W2079960787","https://openalex.org/W2086224292","https://openalex.org/W2086227179","https://openalex.org/W2094834014","https://openalex.org/W2103456695","https://openalex.org/W2123831499","https://openalex.org/W2125065061","https://openalex.org/W2136211803","https://openalex.org/W2141759041","https://openalex.org/W2154308078","https://openalex.org/W2164995080","https://openalex.org/W2171836054","https://openalex.org/W2267180887","https://openalex.org/W2328023807","https://openalex.org/W2343596424","https://openalex.org/W2777302266"],"related_works":["https://openalex.org/W4317801823","https://openalex.org/W7222814729","https://openalex.org/W2027968599","https://openalex.org/W2098799791","https://openalex.org/W2113785871","https://openalex.org/W2516003588","https://openalex.org/W4321435561","https://openalex.org/W2259551399","https://openalex.org/W7211911388","https://openalex.org/W2619680342"],"abstract_inverted_index":{"Background":[0],"Chronic":[1,77],"alcohol":[2],"abuse":[3],"is":[4,234],"associated":[5,198],"with":[6,131,155,199],"intestinal":[7,123,134,142,195,201,232,240],"dysbiosis":[8],"and":[9,29,53,64,69,95,104,114,202],"bacterial":[10,31,165,245],"translocation.":[11,32],"Translocated":[12],"commensal":[13],"bacteria":[14,28],"contribute":[15],"to":[16,57,167,188],"alcoholic":[17,225],"liver":[18,44,101,152,226],"disease.":[19],"Secretory":[20],"immunoglobulin":[21],"A":[22],"(IgA)":[23],"in":[24,41,46,90,136,173,205,228],"the":[25,36,65,182,222],"intestine":[26],"binds":[27],"prevents":[30],"Methods":[33],"To":[34],"investigate":[35],"functional":[37],"role":[38],"of":[39,60,67,83,109,128,151,161,194,217,224,231,239],"IgA":[40,87,118,135,196,218,233],"ethanol":[42],"(EtOH)\u2010induced":[43],"disease":[45,153,227],"mice,":[47],"we":[48],"subjected":[49],"wild":[50],"type":[51],"(WT)":[52],"IgA\u2010deficient":[54],"littermate":[55,97,138,145,190],"mice":[56,98,146,157,175,207],"Lieber\u2013DeCarli":[58],"models":[59],"chronic":[61,68,113,248],"EtOH":[62,71,78,110,116,162,185,209,249],"administration":[63],"model":[66],"binge":[70,115],"feeding":[72,79,111,186],"(the":[73],"NIAAA":[74],"model).":[75],"Results":[76],"increased":[80,141,172,200,237],"systemic":[81],"levels":[82,238],"IgA,":[84,143],"while":[85],"fecal":[86],"was":[88,171,181,197],"reduced":[89],"C57BL/6":[91],"WT":[92,94,137,144,189],"mice.":[93,139,191,229],"Iga\u2212/\u2212":[96,156,174,206],"showed":[99],"similar":[100,149],"injury,":[102],"steatosis,":[103],"inflammation":[105],"following":[106],"4":[107],"weeks":[108,160],"or":[112,125],"feeding.":[117,163,210],"deficiency":[119],"did":[120],"not":[121,220],"affect":[122,221],"absorption":[124],"hepatic":[126],"metabolism":[127],"EtOH.":[129],"Pretreatment":[130],"ampicillin":[132],"elevated":[133],"Despite":[140],"exhibited":[147],"a":[148],"degree":[150],"compared":[154],"after":[158,184,208,247],"7":[159],"Interestingly,":[164],"translocation":[166,246],"mesenteric":[168],"lymph":[169],"nodes":[170],"fed":[176],"an":[177],"isocaloric":[178],"diet,":[179],"but":[180],"same":[183],"relative":[187],"The":[192],"absence":[193,216],"plasma":[203],"IgM":[204],"Conclusions":[211],"Our":[212],"findings":[213],"indicate":[214],"that":[215],"does":[219],"development":[223],"Loss":[230],"compensated":[235],"by":[236],"IgM,":[241],"which":[242],"likely":[243],"limits":[244],"administration.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-21T00:00:00"}
