{"id":"https://openalex.org/W2530788862","doi":null,"title":"Lactoferrin. Antiviral activity of lactoferrin.","display_name":"Lactoferrin. Antiviral activity of lactoferrin.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2530788862","mag":"2530788862","pmid":"https://pubmed.ncbi.nlm.nih.gov/9781360"},"language":"en","primary_location":{"id":"pmid:9781360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9781360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"P J Swart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P J Swart","raw_affiliation_strings":["Department of Pharmacology, University of Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012302147","display_name":"E. Mirjam Kuipers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E M Kuipers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009841685","display_name":"Catharina Smit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Smit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108535517","display_name":"Barry W. A. van der Strate","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B W Van Der Strate","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031487758","display_name":"Martin C. Harmsen","orcid":"https://orcid.org/0000-0002-7128-2741","observed_orcids":["https://orcid.org/0000-0002-7128-2741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Harmsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057782919","display_name":"D. K. F. Meijer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D K Meijer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2744,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.87276697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"443","issue":null,"first_page":"205","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":1.0},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.8489999771118164},{"id":"https://openalex.org/keywords/colostrum","display_name":"colostrum","score":0.7440000176429749},{"id":"https://openalex.org/keywords/milk","display_name":"milk","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lysine-acylation","display_name":"lysine acylation","score":0.871999979019165},{"id":"https://openalex.org/keywords/charge-distribution","display_name":"charge distribution","score":0.42500001192092896},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.46700000762939453},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.6549999713897705},{"id":"https://openalex.org/keywords/mt-4-cells","display_name":"MT-4 cells","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.7670142650604248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7029731273651123},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5991198420524597},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5725314021110535},{"id":"https://openalex.org/C2775996393","wikidata":"https://www.wikidata.org/wiki/Q1149147","display_name":"Cytopathic effect","level":3,"score":0.5027554035186768},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4167725443840027},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41217103600502014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3844282031059265},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37726259231567383},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.26024937629699707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22121593356132507}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:9781360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9781360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/8d5fa989-d391-4a52-81c5-d1af8b3c07eb","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/8d5fa989-d391-4a52-81c5-d1af8b3c07eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swart, P J, Kuipers, E M, Smit, C, Van Der Strate, B W, Harmsen, M C & Meijer, D K 1998, 'Lactoferrin. Antiviral activity of lactoferrin', Advances in experimental medicine and biology, vol. 443, pp. 205-213.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/61b0dce0-a7bd-42f9-9731-ac391055acaa","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/lactoferrin--antiviral-activity-of-lactoferrin(61b0dce0-a7bd-42f9-9731-ac391055acaa).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ADVANCES IN LACTOFERRIN RESEARCH, 205 - 213","raw_type":"info:eu-repo/semantics/conferencepaper"},{"id":"pmh:rug:oai:pure.rug.nl:publications/8d5fa989-d391-4a52-81c5-d1af8b3c07eb","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/8d5fa989-d391-4a52-81c5-d1af8b3c07eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in experimental medicine and biology, 443, 205 - 213","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2530788862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9781360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1950650831","https://openalex.org/W2003601107","https://openalex.org/W2036533336","https://openalex.org/W2066178760","https://openalex.org/W2085338361","https://openalex.org/W2168734495","https://openalex.org/W2413918464"],"related_works":["https://openalex.org/W4231336021","https://openalex.org/W2158124451","https://openalex.org/W350270460","https://openalex.org/W1986032666","https://openalex.org/W2060666201","https://openalex.org/W2777696444","https://openalex.org/W2049828708","https://openalex.org/W6884300587","https://openalex.org/W2016828201","https://openalex.org/W2356347055"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,56,60,68,131,152,158,164,181,188,200,216,227],"native":[3,118],"and":[4,12,21,27,34,162,197,229,244],"chemically":[5],"derivatized":[6],"lactoferrins":[7],"(Lfs)":[8],"purified":[9],"from":[10,32],"milk":[11,36],"colostrum":[13,38],"were":[14,39,78],"assayed":[15],"in":[16,24,64,90,140,147,156,167,192,207,233,240],"vitro":[17,148],"for":[18],"their":[19],"anti-HIV":[20,176,201,243],"anti-HCMV-cytopathic":[22],"effects":[23],"MT4":[25,168],"cells":[26,169],"fibroblasts":[28],"respectively.":[29],"All":[30],"Lfs":[31],"bovine":[33],"human":[35],"or":[37,71],"able":[40],"to":[41,127,184,220,237],"completely":[42],"block":[43],"HCMV":[44,109],"replication":[45],"as":[46,48,120,122,145],"well":[47,121],"inhibited":[49],"HIV-1":[50,89,100],"induced":[51],"cytopathic":[52],"effects.":[53,246],"Through":[54],"acylation":[55],"the":[57,61,88,102,106,117,128,132,141,146,159,165,171,175,189,208,234,242],"amino":[58],"function":[59],"lysine":[62],"residues":[63],"Lf,":[65],"using":[66],"anhydrides":[67],"succinic":[69],"acid":[70],"cis-aconitic":[72],"acid,":[73],"negatively":[74,230],"charged":[75,231],"Lf":[76,119,124,185],"derivatives":[77],"obtained":[79],"that":[80,116],"all":[81],"showed":[82],"a":[83,94,198],"strong":[84],"antiviral":[85,97],"activity":[86,107,196],"against":[87],"vitro.":[91],"Acylated-Lf":[92],"exhibited":[93],"4-fold":[95],"stronger":[96],"effect":[98],"on":[99,108],"than":[101],"parent":[103],"compound":[104],"but":[105],"was":[110],"abolished.":[111],"Peptide":[112],"scanning":[113],"studies":[114],"indicated":[115],"acylated":[123],"strongly":[125],"bind":[126],"V3":[129],"domain":[130],"HIV":[133],"envelope":[134],"protein":[135],"gp120,":[136],"with":[137,203],"Kd":[138],"values":[139,206],"same":[142],"concentration":[143,211],"range":[144],"IC50.":[149],"Therefore,":[150],"shielding":[151],"this":[153,221],"domain,":[154],"resulting":[155],"inhibition":[157],"virus-cell":[160],"fusion":[161],"entry":[163],"virus":[166],"is":[170],"likely":[172],"mechanism":[173],"underlying":[174],"activity.":[177],"In":[178],"contrast,":[179],"addition":[180],"positive":[182],"charges":[183],"through":[186],"amination":[187],"proteins":[190],"resulted":[191],"an":[193],"increased":[194],"anti-HCMV":[195,204,222,245],"loss":[199],"activity,":[202],"IC50":[205],"low":[209],"micromolar":[210],"range.":[212],"The":[213,224],"N-terminal":[214],"portion":[215],"LF":[217],"appeared":[218],"essential":[219],"effect.":[223],"specific":[225],"distribution":[226],"positively":[228],"domains":[232],"molecule":[235],"appears":[236],"be":[238],"important":[239],"both":[241]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-21T00:00:00"}
