{"id":"https://openalex.org/W2530767985","doi":null,"title":"Abnormal development c lymphocytes in Atm mut","display_name":"Abnormal development c lymphocytes in Atm mut","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2530767985","mag":"2530767985"},"language":"en","primary_location":{"id":"mag:2530767985","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/121893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022555433","display_name":"Paul R. Borghesani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul R. Borghesani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033821931","display_name":"Frederick W. Alt","orcid":"https://orcid.org/0000-0002-0583-1271","observed_orcids":["https://orcid.org/0000-0002-0583-1271"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederick W. Alt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0583-1271","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053356330","display_name":"Andrea Bo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Bo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029245218","display_name":"Thomas M. Roberts","orcid":"https://orcid.org/0000-0001-6453-3955","observed_orcids":["https://orcid.org/0000-0001-6453-3955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Roberts","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6453-3955","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020581774","display_name":"Wojciech Swat","orcid":"https://orcid.org/0009-0007-9311-5163","observed_orcids":["https://orcid.org/0009-0007-9311-5163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wojciech Swat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023801509","display_name":"Rosalind A. Seg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalind A. Seg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Laurie A. Davidson","orcid":"https://orcid.org/0000-0002-4159-4680","observed_orcids":["https://orcid.org/0000-0002-4159-4680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie A. Davidson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4159-4680","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011666146","display_name":"Saime Aksoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saime Aksoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012096690","display_name":"Gary A. Rathbunlll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary A. Rathbunlll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07835427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.08160000294446945,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atm-gene","display_name":"ATM gene","score":0.9300000071525574},{"id":"https://openalex.org/keywords/thymic-lymphoma","display_name":"thymic lymphoma","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cd4-8-thymocytes","display_name":"CD4+8+ thymocytes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cerebellar-dysfunction","display_name":"cerebellar dysfunction","score":0.9819999933242798},{"id":"https://openalex.org/keywords/motor-incoordination","display_name":"motor incoordination","score":0.8259999752044678},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.6262128353118896},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6174824237823486},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6075388193130493},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5351643562316895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5162762999534607},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5032839179039001},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4530869722366333},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.43713468313217163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41206708550453186},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.41197487711906433},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41180577874183655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.370807945728302},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36662232875823975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35082656145095825},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3051660656929016},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.2653478980064392},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25266793370246887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2081069052219391},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.10286527872085571},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2530767985","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/121893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2031863792","https://openalex.org/W2418349810"],"related_works":["https://openalex.org/W2071674290","https://openalex.org/W3199732263","https://openalex.org/W1866398330","https://openalex.org/W2122405873","https://openalex.org/W2046589688","https://openalex.org/W2106087857","https://openalex.org/W2054011395","https://openalex.org/W2141530672","https://openalex.org/W3204002534","https://openalex.org/W1973969831","https://openalex.org/W2033200608","https://openalex.org/W2046568492","https://openalex.org/W3146928157","https://openalex.org/W2034239110","https://openalex.org/W2098041458","https://openalex.org/W2979031794","https://openalex.org/W1975026872","https://openalex.org/W338609365","https://openalex.org/W2289508011","https://openalex.org/W2579599467"],"abstract_inverted_index":{"Motor":[0],"incoordination,":[1],"immune":[2],"deficiencies,":[3],"and":[4,87,151],"an":[5],"increased":[6],"of":[7,13,53,61,71,97,125,133,142,148,157],"cancer":[8],"are":[9],"the":[10,14,143,155],"characteristic":[11],"features":[12],"hereditary":[15],"disE":[16],"ataxia-telangiectasia":[17],"(A-T),":[18],"which":[19],"is":[20],"caused":[21],"by":[22],"mutations":[23],"in":[24,67,82,94,108,113,140],"ATM":[25],"gene.":[26],"Through":[27],"gene":[28],"targeting,":[29],"we":[30,76,119],"have":[31],"generated":[32],"a":[33,50,58,121],"lina":[34],"Atm":[35,44,114,126],"mutant":[36,95,115],"mice,":[37,46],"AtmY/Y":[38,63],"mice.":[39,116],"In":[40,117],"contrast":[41],"to":[42,154],"other":[43],"mul":[45],"AtmY/v":[47],"mice":[48,64,96],"show":[49],"lower":[51],"incidence":[52],"thymic":[54],"lymphoma":[55],"survive":[56],"beyond":[57],"few":[59],"months":[60],"age.":[62],"exhibit":[65],"def":[66],"motor":[68],"learning":[69],"indicative":[70],"cerebellar":[72,80],"dysfunction.":[73],"Even":[74],"tho":[75],"found":[77],"no":[78],"gross":[79],"degeneration":[81],"older":[83],"AtmYY":[84],"anirr":[85],"ectopic":[86],"abnormally":[88],"differentiated":[89],"Purkinje":[90],"cells":[91,150],"were":[92],"appal":[93],"all":[98],"ages.":[99],"These":[100],"findings":[101,139],"establish":[102],"that":[103,145],"sc":[104],"neuropathological":[105],"abnormalities":[106],"seen":[107],"A-T":[109,158],"patients":[110],"also":[111],"present":[112],"addition,":[118],"report":[120],"previo":[122],"unrecognized":[123],"effect":[124],"deficiency":[127],"on":[128],"development":[129,147],"or":[130],"m":[131],"tenance":[132],"CD4+8+":[134],"thymocytes.":[135],"We":[136],"discuss":[137],"these":[138],"context":[141],"hypothesis":[144],"abnormal":[146],"Purk":[149],"lymphocytes":[152],"contributes":[153],"pathogenesis":[156]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}