{"id":"https://openalex.org/W2530716009","doi":"https://doi.org/10.1182/blood.v120.21.197.197","title":"Combining Proteomics and Gene Expression Profiling Identifies Proteins/Genes Associated with Short Overall Survival in Multiple Myeloma","display_name":"Combining Proteomics and Gene Expression Profiling Identifies Proteins/Genes Associated with Short Overall Survival in Multiple Myeloma","publication_year":2012,"publication_date":"2012-11-16","ids":{"openalex":"https://openalex.org/W2530716009","doi":"https://doi.org/10.1182/blood.v120.21.197.197","mag":"2530716009"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v120.21.197.197","doi":"https://doi.org/10.1182/blood.v120.21.197.197","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.197.197","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003180228","display_name":"Ricky D. Edmondson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricky D Edmondson","raw_affiliation_strings":["Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077766447","display_name":"Shweta S. Chavan","orcid":"https://orcid.org/0000-0001-9433-6936","observed_orcids":["https://orcid.org/0000-0001-9433-6936"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shweta S. Chavan","raw_affiliation_strings":["Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085020317","display_name":"Christoph Johann Heuck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christoph Heuck","raw_affiliation_strings":["Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000879635","display_name":"Bart Barlogie","orcid":"https://orcid.org/0000-0001-6116-1017","observed_orcids":["https://orcid.org/0000-0001-6116-1017"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bart Barlogie","raw_affiliation_strings":["Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79620101"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.2117,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63575393,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"120","issue":"21","first_page":"197","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9470000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6690000295639038},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peptide-expression","display_name":"peptide expression","score":0.5979999899864197},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.6060000061988831},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5920000076293945},{"id":"https://openalex.org/keywords/newly-diagnosed-multiple-myeloma","display_name":"newly diagnosed multiple myeloma","score":0.7409999966621399},{"id":"https://openalex.org/keywords/survival-prediction-model","display_name":"survival prediction model","score":0.4860000014305115},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.33500000834465027},{"id":"https://openalex.org/keywords/mrna-protein-correlation","display_name":"mRNA-protein correlation","score":0.3840000033378601},{"id":"https://openalex.org/keywords/prognostic-biomarker-validation","display_name":"prognostic biomarker validation","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.7049787640571594},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.680214524269104},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6473424434661865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238135457038879},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.5144486427307129},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4901498258113861},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.472896009683609},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.46374377608299255},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.45808330178260803},{"id":"https://openalex.org/C77360908","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Significance analysis of microarrays","level":5,"score":0.4317856431007385},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.41510075330734253},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39662742614746094},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3859386444091797},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36844342947006226},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3515845537185669},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27753591537475586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26868143677711487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2130793035030365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v120.21.197.197","doi":"https://doi.org/10.1182/blood.v120.21.197.197","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v120.21.197.197","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2560424447","https://openalex.org/W2014656587","https://openalex.org/W2979321854","https://openalex.org/W4385644639","https://openalex.org/W2575095000","https://openalex.org/W4230542662","https://openalex.org/W2594327109","https://openalex.org/W2560648839","https://openalex.org/W2589576710","https://openalex.org/W4405041593"],"abstract_inverted_index":{"Abstract":[0,1],"197":[2],"We":[3,456,529],"and":[4,17,28,121,155,166,237,255,273,336,396,428,430,505,534,546,554],"others":[5],"have":[6],"used":[7,72,291,352],"gene":[8,381,569],"expression":[9,51,213,382],"profiling":[10],"to":[11,73,79,162,195,264,282,377,394,400,439,485,584],"classify":[12],"multiple":[13],"myeloma":[14,70],"into":[15,324],"high":[16],"low":[18],"risk":[19],"groups;":[20,228],"here,":[21],"we":[22,258,290,494],"report":[23],"the":[24,107,131,139,174,182,196,207,226,243,250,276,287,299,309,315,328,333,341,344,367,373,388,405,409,419,424,451,467,474,482,512,517,521,532,538,551,557,567],"first":[25],"combined":[26],"GEP":[27,256,292],"proteomics":[29,92,197,254],"study":[30],"of":[31,35,39,64,95,110,124,253,270,298,314,332,340,372,418,426,481,574,582],"a":[32,61,295,304,431,444,496],"large":[33],"number":[34],"baseline":[36],"samples":[37],"(n=85)":[38],"highly":[40],"enriched":[41],"tumor":[42],"cells":[43,59],"from":[44,53,60,286,294,387],"patients":[45,66],"with":[46,67,151,176,184,192,206,245,267,466,511],"newly":[47,68],"diagnosed":[48,69],"myeloma.":[49],"Peptide":[50,113],"levels":[52,172,236,241,269],"MS":[54],"data":[55,293],"on":[56,366,436,473,537],"CD138-selected":[57],"plasma":[58],"discovery":[62,288],"set":[63,306,330,338,357,369,390,541],"85":[65],"were":[71,77,115,168,222,232,391,548],"identify":[74,479],"proteins":[75],"that":[76,221],"linked":[78],"short":[80,277],"survival":[81,179,402,417,449],"(OS":[82,142],"<":[83,143],"3":[84,89,144,149],"years":[85,145],"vs":[86,146],"OS":[87,147],"\u2265":[88,148],"years).":[90],"The":[91,158,384,415],"dataset":[93],"consisted":[94],"intensity":[96,105],"values":[97],"for":[98,307,312,327,370,404,412],"11,006":[99],"peptides":[100,134,160],"(representing":[101],"2,155":[102],"proteins),":[103],"where":[104,542],"is":[106],"quantitative":[108],"measure":[109],"peptide":[111],"abundance;":[112],"intensities":[114],"normalized":[116],"by":[117,408,550,571],"Z":[118],"score":[119],"transformation":[120],"significance":[122,508],"analysis":[123,191,198,216,460],"microarray":[125,210],"(SAM)":[126],"was":[127,204,322,351,364,421,433,443,566],"applied":[128,393],"resulting":[129],"in":[130,173,181,242,275,448,516],"identification":[132],"24":[133,159],"as":[135,303,353,471],"differentially":[136,223],"expressed":[137,224],"between":[138,225,450],"two":[140,227,325,452],"groups":[141,406,420,453],"years),":[150],"fold":[152],"change":[153,200],"\u22651.5":[154],"FDR":[156,202],"<5%.":[157],"mapped":[161],"19":[163],"unique":[164],"proteins,":[165],"all":[167],"present":[169,233],"at":[170,234,239],"higher":[171,235],"group":[175,183,244],"shorter":[177,246],"overall":[178,186,247,416],"than":[180],"longer":[185],"survival.":[187,248],"An":[188],"independent":[189,491],"SAM":[190,251],"parameters":[193],"identical":[194],"(fold":[199],"\u22651.5;":[201],"<5%)":[203],"performed":[205,365,457,495,531],"Affymetrix":[208],"U133Plus2":[209],"chip":[211],"based":[212],"data.":[214],"This":[215],"identified":[217,259],"151":[218],"probe":[219,230,261,317,375,469,514],"sets":[220,231,376,399,470,515],"144":[229],"seven":[238,265],"lower":[240],"Comparing":[249],"analyses":[252,536,573],"data,":[257],"nine":[260,316,374,468,487],"sets,":[262],"corresponding":[263,484],"genes,":[266],"increased":[268],"both":[271,575],"protein":[272],"mRNA":[274],"lived":[278],"group.":[279],"In":[280],"order":[281],"validate":[283],"these":[284,486],"findings":[285],"experiment":[289],"randomized":[296,323],"subset":[297],"TT3":[300,320,395,475],"patient":[301,349],"population":[302,321,350],"training":[305,329,368,389],"determining":[308],"optimal":[310,380,410],"cut-points":[311,385],"each":[313,371,413],"sets.":[318,577],"Thus,":[319],"sub-populations":[326],"(two-thirds":[331],"population;":[334,342],"n=294)":[335],"test":[337,356,363,398,476,540,576],"(one-third":[339],"n=147);":[343],"Total":[345],"Therapy":[346],"2":[347],"(TT2)":[348],"an":[354,490],"additional":[355],"(n=441).":[358],"A":[359],"running":[360],"log":[361],"rank":[362],"determine":[378,440],"its":[379],"cut-point.":[383],"derived":[386],"then":[392,530],"TT2":[397,539],"investigate":[401],"differences":[403],"separated":[407],"cutpoint":[411],"probe.":[414],"visualized":[422],"using":[423,461],"method":[425],"Kaplan":[427],"Meier,":[429],"P-value":[432,527,563],"calculated":[434],"(based":[435],"log-rank":[437],"test)":[438],"whether":[441],"there":[442],"statistically":[445],"significant":[446],"difference":[447],"(P":[454],"\u22640.05).":[455],"univariate":[458,533],"regression":[459,500],"Cox":[462,499],"proportional":[463],"hazard":[464,523,559],"model":[465],"variables":[472],"set.":[477],"To":[478],"which":[480],"genes":[483],"probes":[488],"had":[489,520,556],"prognostic":[492],"value,":[493],"multivariate":[497,535,552,572],"stepwise":[498],"analysis.":[501,518],"wherein":[502],"CACYBP,":[503,543],"FABP5,":[504],"IQGAP2":[506],"retained":[507],"after":[509],"competing":[510],"remaining":[513],"CACYBP":[519,555,565],"highest":[522,558],"ratio":[524,560],"(HR":[525,561],"2.70,":[526],"0.01).":[528],"CORO1A,":[544],"ENO1,":[545],"STMN1":[547],"selected":[549,570],"analysis,":[553],"1.93,":[562],"0.004).":[564],"only":[568],"Disclosures:":[578],"No":[579],"relevant":[580],"conflicts":[581],"interest":[583],"declare.":[585]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-10-21T00:00:00"}
