{"id":"https://openalex.org/W2530675933","doi":null,"title":"Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery","display_name":"Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2530675933","mag":"2530675933"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-133794","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079511753","display_name":"Jakob Regberg","orcid":"https://orcid.org/0000-0002-4604-6413","observed_orcids":["https://orcid.org/0000-0002-4604-6413"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jakob Regberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4604-6413","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079511753"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oligonucleotide-delivery","display_name":"oligonucleotide delivery","score":0.9070000052452087},{"id":"https://openalex.org/keywords/endocytic-uptake","display_name":"endocytic uptake","score":0.7310000061988831},{"id":"https://openalex.org/keywords/scavenger-receptor-a","display_name":"scavenger receptor A","score":0.9269999861717224},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/transfection-agents","display_name":"transfection agents","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6080896258354187},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6075849533081055},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.536160409450531},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.44112300872802734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4356229603290558},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4204164743423462},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3278639316558838},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27013227343559265},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.21873310208320618},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19242966175079346},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1614680290222168},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1558939516544342}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:su-133794","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2530675933","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/record.jsf?pid=diva2:971282","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-133794","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-133794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":126,"referenced_works":["https://openalex.org/W334122155","https://openalex.org/W994255587","https://openalex.org/W1510227107","https://openalex.org/W1515068677","https://openalex.org/W1574601702","https://openalex.org/W1584683177","https://openalex.org/W1647075334","https://openalex.org/W1799444595","https://openalex.org/W1849819493","https://openalex.org/W1963662573","https://openalex.org/W1964561645","https://openalex.org/W1968695777","https://openalex.org/W1968922381","https://openalex.org/W1969117282","https://openalex.org/W1971409649","https://openalex.org/W1972440560","https://openalex.org/W1972711580","https://openalex.org/W1975875150","https://openalex.org/W1976223354","https://openalex.org/W1979582699","https://openalex.org/W1982519048","https://openalex.org/W1983327991","https://openalex.org/W1985222229","https://openalex.org/W1990804768","https://openalex.org/W1991720510","https://openalex.org/W1992044364","https://openalex.org/W1992095148","https://openalex.org/W1992366573","https://openalex.org/W2002934128","https://openalex.org/W2005993715","https://openalex.org/W2006359896","https://openalex.org/W2007318225","https://openalex.org/W2007445917","https://openalex.org/W2008502150","https://openalex.org/W2008718396","https://openalex.org/W2011920499","https://openalex.org/W2019818589","https://openalex.org/W2021713080","https://openalex.org/W2022823589","https://openalex.org/W2023455126","https://openalex.org/W2025938842","https://openalex.org/W2026691184","https://openalex.org/W2027954222","https://openalex.org/W2029788925","https://openalex.org/W2030765885","https://openalex.org/W2035050992","https://openalex.org/W2036408851","https://openalex.org/W2038720675","https://openalex.org/W2040135588","https://openalex.org/W2041646961","https://openalex.org/W2041771455","https://openalex.org/W2042143995","https://openalex.org/W2044296969","https://openalex.org/W2047909810","https://openalex.org/W2051319112","https://openalex.org/W2052530916","https://openalex.org/W2052706007","https://openalex.org/W2055449190","https://openalex.org/W2055777720","https://openalex.org/W2055944585","https://openalex.org/W2058907087","https://openalex.org/W2062072646","https://openalex.org/W2064215841","https://openalex.org/W2064487427","https://openalex.org/W2067783340","https://openalex.org/W2068506297","https://openalex.org/W2069444054","https://openalex.org/W2070468167","https://openalex.org/W2070573684","https://openalex.org/W2072203964","https://openalex.org/W2072472077","https://openalex.org/W2073183478","https://openalex.org/W2076859770","https://openalex.org/W2077112895","https://openalex.org/W2079335891","https://openalex.org/W2079445254","https://openalex.org/W2080823739","https://openalex.org/W2080971086","https://openalex.org/W2089657872","https://openalex.org/W2092482435","https://openalex.org/W2094895270","https://openalex.org/W2097134015","https://openalex.org/W2097812689","https://openalex.org/W2098777190","https://openalex.org/W2102125805","https://openalex.org/W2103262726","https://openalex.org/W2104629568","https://openalex.org/W2107354145","https://openalex.org/W2108224709","https://openalex.org/W2108907335","https://openalex.org/W2110921202","https://openalex.org/W2111994795","https://openalex.org/W2114609224","https://openalex.org/W2120820989","https://openalex.org/W2126510623","https://openalex.org/W2127677388","https://openalex.org/W2128873134","https://openalex.org/W2134500769","https://openalex.org/W2135837360","https://openalex.org/W2143376609","https://openalex.org/W2144593277","https://openalex.org/W2148405034","https://openalex.org/W2149587981","https://openalex.org/W2152617351","https://openalex.org/W2153940274","https://openalex.org/W2156077095","https://openalex.org/W2157963288","https://openalex.org/W2159821105","https://openalex.org/W2160863389","https://openalex.org/W2167739272","https://openalex.org/W2168639488","https://openalex.org/W2170932434","https://openalex.org/W2220780917","https://openalex.org/W2251045241","https://openalex.org/W2313221601","https://openalex.org/W2320556745","https://openalex.org/W2341405505","https://openalex.org/W2344644350","https://openalex.org/W2402834822","https://openalex.org/W2411634967","https://openalex.org/W2414781026","https://openalex.org/W2434872344","https://openalex.org/W2462330271","https://openalex.org/W2494748207","https://openalex.org/W2501239489","https://openalex.org/W3148913165"],"related_works":["https://openalex.org/W7042501918","https://openalex.org/W7046297887","https://openalex.org/W2801513916","https://openalex.org/W1701330199","https://openalex.org/W2161620823","https://openalex.org/W2020763460","https://openalex.org/W188018140","https://openalex.org/W245867117","https://openalex.org/W2082175825","https://openalex.org/W7034595506"],"abstract_inverted_index":{"Oligonucleotide-based":[0],"drugs":[1,58],"hold":[2],"great":[3],"promise":[4],"for":[5,34,62,180],"the":[6,29,66,73,85,138,146,154,183,191,198,212,233,240],"treatment":[7],"of":[8,11,53,87,90,100,127,141,148,157,177,200,206,214,217,235,243],"many":[9,112],"types":[10,115],"diseases,":[12],"ranging":[13],"from":[14,222],"genetic":[15],"disorders":[16],"to":[17,36,47,72,136,196,210],"viral":[18],"infections":[19],"and":[20,116,120,131,165,186,226,230],"cancer.":[21],"The":[22,203],"problem":[23],"is":[24,32,82,209],"that":[25],"efficient":[26],"delivery":[27,181,216,237],"across":[28,182],"cell":[30,114],"membrane":[31],"required":[33],"oligonucleotides":[35,218],"have":[37,123,173],"their":[38],"desired":[39],"effect.":[40],"Cell-penetrating":[41],"peptides":[42,91,94,130,179,221],"(CPPs)":[43],"provide":[44],"a":[45,88,125,132,175,187,224,227],"solution":[46],"this":[48,207,236],"problem.":[49],"CPPs":[50,164],"are":[51,108,117],"capable":[52,99],"transporting":[54],"cargoes":[55],"such":[56],"as":[57,160,162],"or":[59,75],"nucleic":[60],"acids":[61],"gene":[63],"therapy":[64],"into":[65],"cell,":[67],"either":[68],"by":[69,76,111],"covalent":[70],"conjugation":[71],"cargo":[74],"non-covalent":[77],"complex":[78],"formation.":[79],"This":[80],"thesis":[81,208],"focused":[83],"on":[84],"development":[86],"class":[89,151],"called":[92],"PepFects,":[93],"with":[95,104,219,239],"fatty":[96],"acid":[97],"modifications":[98],"forming":[101],"nanoparticle-sized":[102],"complexes":[103,107,159],"oligonucleotides.":[105],"These":[106],"efficiently":[109],"internalized":[110],"different":[113],"generally":[118],"non-toxic":[119],"non-immunogenic.":[121],"We":[122],"developed":[124,174],"number":[126],"novel":[128],"PepFect":[129,158,178,220],"quantitative":[133],"structure-activity":[134],"model":[135,188],"predict":[137],"biological":[139,228],"effect":[140],"our":[142],"peptides.":[143,202],"In":[144],"addition,":[145],"involvement":[147],"scavenger":[149],"receptors":[150],"A":[152],"in":[153,194,247],"endocytic":[155],"uptake":[156],"well":[161],"other":[163],"polymeric":[166],"transfection":[167],"agents":[168],"was":[169],"studied.":[170],"Lastly,":[171],"we":[172],"series":[176],"blood-brain":[184,192],"barrier":[185,193],"system":[189,238],"mimicking":[190],"order":[195],"evaluate":[197],"passage":[199],"these":[201],"general":[204],"aim":[205],"improve":[211,232],"understanding":[213],"intracellular":[215],"both":[223],"chemical":[225],"viewpoint,":[229],"further":[231],"efficacy":[234],"long-term":[241],"goal":[242],"making":[244],"it":[245],"useful":[246],"clinical":[248],"settings.":[249]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-10-21T00:00:00"}