{"id":"https://openalex.org/W2530615698","doi":null,"title":"Formulation preparation and in vitro evaluation of Simvastatin self- nanoemulsifying systems","display_name":"Formulation preparation and in vitro evaluation of Simvastatin self- nanoemulsifying systems","publication_year":2015,"publication_date":"2015-04-20","ids":{"openalex":"https://openalex.org/W2530615698","mag":"2530615698"},"language":"en","primary_location":{"id":"mag:2530615698","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/2153-2435/2153-2435.S1.016-011.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764521035","display_name":"Pharmaceutica Analytica Acta","issn_l":"2153-2435","issn":["2153-2435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutica Analytica Acta","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025028594","display_name":"Hanaa Abdelmonem Mahmoud Elsaghir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hanaa Abdelmonem Mahmoud Elsaghir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025028594"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20054376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/self-nanoemulsifying-drug-delivery-system","display_name":"self-nanoemulsifying drug delivery system","score":0.9739999771118164},{"id":"https://openalex.org/keywords/liquisolid-tablets","display_name":"liquisolid tablets","score":0.9629999995231628},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dissolution-enhancement","display_name":"dissolution enhancement","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pseudo-ternary-phase-diagram","display_name":"pseudo-ternary phase diagram","score":0.9120000004768372},{"id":"https://openalex.org/keywords/loading-factor","display_name":"loading factor","score":0.6230000257492065},{"id":"https://openalex.org/keywords/simulated-gastric-fluid","display_name":"simulated gastric fluid","score":0.7670000195503235},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.7438767552375793},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.7000811100006104},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6814278960227966},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.6593762636184692},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6212902665138245},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.5983163118362427},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.54085373878479},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.4904424846172333},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.43764230608940125},{"id":"https://openalex.org/C3018292220","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric fluid","level":2,"score":0.411129355430603},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3828124701976776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32593652606010437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11600291728973389},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10597953200340271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08003762364387512},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2530615698","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/2153-2435/2153-2435.S1.016-011.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764521035","display_name":"Pharmaceutica Analytica Acta","issn_l":"2153-2435","issn":["2153-2435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutica Analytica Acta","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119768665","https://openalex.org/W2590400071","https://openalex.org/W2803567073","https://openalex.org/W1975404927","https://openalex.org/W7217482543","https://openalex.org/W7083033259","https://openalex.org/W2807297139","https://openalex.org/W4366742525","https://openalex.org/W4280507388","https://openalex.org/W4384621007"],"abstract_inverted_index":{"T":[0],"aim":[1],"of":[2,10,34,43,52,65,84,139,155,190,232],"this":[3],"work":[4],"was":[5,88,166,202,239],"to":[6,77,111,160,180,214,228,247],"improve":[7],"the":[8,32,63,82,85,153,186,191,218,230,245],"dissolution":[9,211],"poorly":[11],"water-soluble":[12],"drug,":[13],"simvastatin,":[14],"through":[15],"its":[16,26],"formulation":[17],"as":[18],"selfnanoemulsifying":[19],"drug":[20],"delivery":[21],"system":[22,95],"(SNEDDS)":[23],"and":[24,39,57,72,81,97,119,185,222,226],"then":[25],"incorporation":[27],"into":[28],"liquisolid":[29,145,183,193,206,248],"tablets":[30,194,215],"combining":[31],"advantages":[33],"SNEDDS":[35],"(i.e.":[36],"enhanced":[37],"solubility":[38],"bioavailability)":[40],"with":[41,130,174],"those":[42],"solid":[44],"dosage":[45],"forms":[46],"(e.g.":[47],"low":[48],"production":[49],"cost,":[50],"convenience":[51],"process":[53],"control,":[54],"high":[55],"stability,":[56],"better":[58],"patient":[59],"compliance)":[60],"thus":[61],"overcoming":[62],"drawbacks":[64],"liquid":[66],"formulations.":[67,171],"Various":[68],"modified":[69],"oils,":[70],"surfactant":[71,106],"cosurfactant":[73],"mixtures":[74],"were":[75,142,178],"used":[76],"prepare":[78],"different":[79,148],"systems":[80],"composition":[83],"formed":[86],"SNEDDSs":[87,102,246],"optimized":[89],"using":[90,147],"drug-solubility,":[91],"pseudo-ternary":[92],"phase":[93],"diagram,":[94],"stability":[96,115],"particle":[98,121],"size":[99,122,235],"studies.":[100],"Furthermore,":[101],"that":[103],"have":[104],"acceptable":[105,114,175],"ratio":[107,154],"(ranging":[108],"from":[109],"30%":[110],"60%":[112],"w/w),":[113],"(minimum":[116],"two":[117],"hours)":[118],"show":[120],"in":[123,169,187,195],"nano-range":[124],"(<":[125],"100":[126],"nm)":[127],"upon":[128,236],"dilution":[129,238],"simulated":[131,196],"gastric":[132,197],"fluid":[133,198],"(SGF,":[134,199],"pH":[135,200],"1.2)":[136,201],"under":[137],"conditions":[138],"gentle":[140],"agitation":[141],"loaded":[143],"onto":[144],"powders":[146,173],"loading":[149],"factors":[150],"(Lf),":[151],"where":[152],"Vivapur\u00ae":[156],"PH":[157],"102":[158],"(carrier)":[159],"Aerosil\u00ae":[161],"200":[162],"(coating":[163],"powder":[164],"material)":[165],"kept":[167],"constant":[168],"all":[170],"Liquisolid":[172],"physical":[176],"properties":[177],"compressed":[179],"form":[181],"self-nanoemulsifying":[182,205],"tablet":[184,207,224,237],"vitro":[188],"performance":[189],"prepared":[192,216],"investigated.":[203],"Prepared":[204],"demonstrated":[208],"significantly":[209,241],"higher":[210],"rates,":[212],"compared":[213],"by":[217,243],"direct":[219],"compression":[220],"method":[221],"conventional":[223],"(Zocor\u00ae)":[225],"expected":[227],"increase":[229],"bioavailability":[231],"simvastatin.":[233],"Particle":[234],"not":[240],"affected":[242],"converting":[244],"tablets.":[249]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-10-21T00:00:00"}
