{"id":"https://openalex.org/W2530515744","doi":"https://doi.org/10.1182/blood-2016-05-715961","title":"Caspase-3\u2013dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells","display_name":"Caspase-3\u2013dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells","publication_year":2016,"publication_date":"2016-10-14","ids":{"openalex":"https://openalex.org/W2530515744","doi":"https://doi.org/10.1182/blood-2016-05-715961","mag":"2530515744","pmid":"https://pubmed.ncbi.nlm.nih.gov/27742710"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2016-05-715961","doi":"https://doi.org/10.1182/blood-2016-05-715961","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2016-05-715961","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003950817","display_name":"Ioulia Vardaki","orcid":"https://orcid.org/0000-0002-0333-6496","observed_orcids":["https://orcid.org/0000-0002-0333-6496"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ioulia Vardaki","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050978284","display_name":"Claire Sanchez","orcid":"https://orcid.org/0000-0003-0982-1051","observed_orcids":["https://orcid.org/0000-0003-0982-1051"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Claire Sanchez","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101907440","display_name":"Pedro Fonseca","orcid":"https://orcid.org/0000-0001-9685-8092","observed_orcids":["https://orcid.org/0000-0001-9685-8092"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Pedro Fonseca","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045155025","display_name":"Magnus Olsson","orcid":"https://orcid.org/0000-0002-6370-8423","observed_orcids":["https://orcid.org/0000-0002-6370-8423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magnus Olsson","raw_affiliation_strings":["Department of Environmental Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021116358","display_name":"Dimitrios Chioureas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Dimitrios Chioureas","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017699382","display_name":"George Z. Rassidakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"George Rassidakis","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088582666","display_name":"Anders Ull\u00e9n","orcid":"https://orcid.org/0000-0002-9023-3259","observed_orcids":["https://orcid.org/0000-0002-9023-3259"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Ull\u00e9n","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080920861","display_name":"Boris Zhivotovsky","orcid":"https://orcid.org/0000-0002-2238-3482","observed_orcids":["https://orcid.org/0000-0002-2238-3482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris Zhivotovsky","raw_affiliation_strings":["Department of Environmental Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046644939","display_name":"Magnus Bj\u00f6rkholm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Magnus Bj\u00f6rkholm","raw_affiliation_strings":["Department of Medicine, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037435178","display_name":"Theocharis Panaretakis","orcid":"https://orcid.org/0000-0001-5754-6950","observed_orcids":["https://orcid.org/0000-0001-5754-6950","https://orcid.org/0009-0008-3265-5040"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Theocharis Panaretakis","raw_affiliation_strings":["Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and"],"raw_orcid":"https://orcid.org/0000-0001-5754-6950","affiliations":[{"raw_affiliation_string":"Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.5364,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.82581278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"128","issue":"23","first_page":"2655","last_page":"2665"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9779999852180481},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8069999814033508},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.8029999732971191},{"id":"https://openalex.org/keywords/exosome-uptake","display_name":"exosome uptake","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9169999957084656},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9110000133514404},{"id":"https://openalex.org/keywords/abt-737","display_name":"ABT-737","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9453364610671997},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.7185564041137695},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5644593238830566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5092624425888062},{"id":"https://openalex.org/C2776789625","wikidata":"https://www.wikidata.org/wiki/Q4875408","display_name":"Bcl-xL","level":4,"score":0.46921172738075256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4508150517940521},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.42242926359176636},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.38574767112731934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3607128858566284},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3556879162788391},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3211378753185272},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27164626121520996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20523366332054138},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.1983220875263214},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.18706801533699036},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019169","descriptor_name":"Jurkat Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051020","descriptor_name":"bcl-X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2016-05-715961","doi":"https://doi.org/10.1182/blood-2016-05-715961","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2016-05-715961","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:27742710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27742710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1492051324","https://openalex.org/W1638318949","https://openalex.org/W1690731028","https://openalex.org/W1861245238","https://openalex.org/W1902243229","https://openalex.org/W1968162870","https://openalex.org/W1980879721","https://openalex.org/W1981037583","https://openalex.org/W2003343932","https://openalex.org/W2015994724","https://openalex.org/W2016540525","https://openalex.org/W2019732053","https://openalex.org/W2026450889","https://openalex.org/W2039047382","https://openalex.org/W2047135607","https://openalex.org/W2064495417","https://openalex.org/W2067130864","https://openalex.org/W2068701997","https://openalex.org/W2069075668","https://openalex.org/W2084770914","https://openalex.org/W2089540661","https://openalex.org/W2095932809","https://openalex.org/W2098160574","https://openalex.org/W2105202319","https://openalex.org/W2116619860","https://openalex.org/W2141290510","https://openalex.org/W2150180451","https://openalex.org/W2161891609","https://openalex.org/W2165983675","https://openalex.org/W2300876204","https://openalex.org/W2409527434","https://openalex.org/W3195431600","https://openalex.org/W4252175385","https://openalex.org/W6681200718"],"related_works":["https://openalex.org/W1964632582","https://openalex.org/W2047364887","https://openalex.org/W2910896051","https://openalex.org/W1638318949","https://openalex.org/W2532567175","https://openalex.org/W2593746547","https://openalex.org/W3198452179","https://openalex.org/W3041669837","https://openalex.org/W2594109417","https://openalex.org/W2160275670"],"abstract_inverted_index":{"The":[0,83],"intercellular":[1],"crosstalk":[2],"between":[3],"hematological":[4],"malignancies":[5],"and":[6,15,71,93,97,160,194,217],"the":[7,21,29,35,39,75,79,101,105,110,117,121,143,158,170,182,188,207,224],"tumor":[8],"microenvironment":[9],"is":[10,24,28,62,86,98,185,212,221],"mediated":[11],"by":[12,156,174,192,228],"cell-to-cell":[13],"interactions":[14],"soluble":[16],"factors.":[17],"One":[18],"component":[19],"of":[20,43,74,91,104,109,123,140,145,149,172,190,226],"secretome":[22],"that":[23,60,129,181,210,218],"gaining":[25],"increasing":[26],"attention":[27],"extracellular":[30],"vesicles":[31],"and,":[32],"in":[33,64,88,134,169],"particular,":[34],"exosomes.":[36],"Apart":[37],"from":[38],"role":[40],"as":[41],"vectors":[42],"molecular":[44,154],"information,":[45],"exosomes":[46,70,96,111,128,173,191,227],"have":[47],"been":[48],"shown":[49],"to":[50,77,165,198],"possess":[51],"intrinsic":[52],"biological":[53],"activity.":[54],"In":[55,202],"this":[56,219],"study,":[57],"we":[58,204],"found":[59,87],"caspase-3":[61,114,141,215],"activated":[63],"L88":[65],"bone":[66],"marrow":[67],"stroma":[68],"cell-derived":[69,95,127],"identified":[72],"1":[73],"substrates":[76],"be":[78],"antiapoptotic":[80],"protein":[81],"Bcl-xL.":[82,124,146],"cleaved":[84,183],"Bcl-xL":[85,150,162,184,211],"a":[89,113,166],"panel":[90],"normal":[92],"cancer":[94],"localized":[99],"on":[100],"outer":[102],"leaflet":[103],"exosomal":[106,214],"membrane.":[107],"Incubation":[108],"with":[112,151],"inhibitor":[115,119],"or":[116,153],"pan-caspase":[118],"prevents":[120],"cleavage":[122,144],"Importantly,":[125],"MCF-7":[126],"are":[130,132],"caspase-3-deficient":[131],"enriched":[133],"full-length":[135],"Bcl-xL,":[136],"whereas":[137],"ectopic":[138],"expression":[139],"restores":[142],"Chemical":[147],"inhibition":[148,155],"ABT737":[152],"using":[157],"D61A":[159],"D76A":[161],"mutant":[163],"leads":[164],"significant":[167],"decrease":[168],"uptake":[171,189,225],"hematopoietic":[175],"malignant":[176],"cells.":[177,230],"These":[178],"data":[179],"indicate":[180],"required":[186,222],"for":[187,206,223],"myeloma":[193],"lymphoma":[195],"cells,":[196],"leading":[197],"their":[199],"increased":[200],"proliferation.":[201],"summary,":[203],"demonstrate":[205],"first":[208],"time":[209],"an":[213],"substrate":[216],"processing":[220],"recipient":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-10-21T00:00:00"}
