{"id":"https://openalex.org/W2530360334","doi":"https://doi.org/10.1186/s12938-016-0235-5","title":"Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging","display_name":"Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging","publication_year":2016,"publication_date":"2016-10-12","ids":{"openalex":"https://openalex.org/W2530360334","doi":"https://doi.org/10.1186/s12938-016-0235-5","mag":"2530360334","pmid":"https://pubmed.ncbi.nlm.nih.gov/27733170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5062945"},"language":"en","primary_location":{"id":"doi:10.1186/s12938-016-0235-5","doi":"https://doi.org/10.1186/s12938-016-0235-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12938-016-0235-5","pdf_url":"https://biomedical-engineering-online.biomedcentral.com/track/pdf/10.1186/s12938-016-0235-5","source":{"id":"https://openalex.org/S162176842","display_name":"BioMedical Engineering OnLine","issn_l":"1475-925X","issn":["1475-925X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMedical Engineering OnLine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biomedical-engineering-online.biomedcentral.com/track/pdf/10.1186/s12938-016-0235-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089557360","display_name":"Chung-Wein Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Wein Lee","raw_affiliation_strings":["School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010543493","display_name":"Keith M. Stantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Keith M. Stantz","raw_affiliation_strings":["School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA. kstantz@purdue.edu","School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA. kstantz@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"School of Health Science, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN, 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010543493"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.4693,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67358637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.15080000460147858,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.08470000326633453,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-oxygenation","display_name":"tumor oxygenation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7630000114440918},{"id":"https://openalex.org/keywords/blood-perfusion","display_name":"blood perfusion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hemoglobin-levels","display_name":"hemoglobin levels","score":0.7820000052452087},{"id":"https://openalex.org/keywords/metabolic-rate","display_name":"metabolic rate","score":0.5979999899864197},{"id":"https://openalex.org/keywords/measurement-error","display_name":"measurement error","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cancer-therapy-response","display_name":"cancer therapy response","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6860811114311218},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.574569821357727},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5042117834091187},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.4985208511352539},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4365333914756775},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4356253147125244},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.43109598755836487},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4304257929325104},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.4249313771724701},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.42305225133895874},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.4102882742881775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30150845646858215},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.28631073236465454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2671177387237549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2656599283218384},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25270015001296997},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19399818778038025},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.17993870377540588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15870243310928345},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15645760297775269},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D057054","descriptor_name":"Molecular Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12938-016-0235-5","doi":"https://doi.org/10.1186/s12938-016-0235-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12938-016-0235-5","pdf_url":"https://biomedical-engineering-online.biomedcentral.com/track/pdf/10.1186/s12938-016-0235-5","source":{"id":"https://openalex.org/S162176842","display_name":"BioMedical Engineering OnLine","issn_l":"1475-925X","issn":["1475-925X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMedical Engineering OnLine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4024682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5062945","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5062945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5062945","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomed Eng Online","raw_type":"Text"},{"id":"pmid:27733170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27733170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical engineering online","raw_type":"Journal Article"},{"id":"pmh:oai:docs.lib.purdue.edu:hscipubs-1002","doi":null,"is_oa":true,"landing_page_url":"https://docs.lib.purdue.edu/hscipubs/3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196310","display_name":"Purdue e-Pubs (Purdue University System)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801333002","host_organization_name":"Purdue University System","host_organization_lineage":["https://openalex.org/I2801333002"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"School of Health Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/s12938-016-0235-5","doi":"https://doi.org/10.1186/s12938-016-0235-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12938-016-0235-5","pdf_url":"https://biomedical-engineering-online.biomedcentral.com/track/pdf/10.1186/s12938-016-0235-5","source":{"id":"https://openalex.org/S162176842","display_name":"BioMedical Engineering OnLine","issn_l":"1475-925X","issn":["1475-925X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioMedical Engineering OnLine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2530360334.pdf","grobid_xml":"https://content.openalex.org/works/W2530360334.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W120172290","https://openalex.org/W156950869","https://openalex.org/W1551145590","https://openalex.org/W1586108416","https://openalex.org/W1964128680","https://openalex.org/W1970243835","https://openalex.org/W1978963385","https://openalex.org/W1979022019","https://openalex.org/W1981563126","https://openalex.org/W1983765832","https://openalex.org/W1984742768","https://openalex.org/W1988557543","https://openalex.org/W1994134155","https://openalex.org/W1994652225","https://openalex.org/W1997299298","https://openalex.org/W2006202974","https://openalex.org/W2010638294","https://openalex.org/W2011123504","https://openalex.org/W2016550302","https://openalex.org/W2019182285","https://openalex.org/W2023036763","https://openalex.org/W2023153057","https://openalex.org/W2024903578","https://openalex.org/W2025034737","https://openalex.org/W2029602209","https://openalex.org/W2035527703","https://openalex.org/W2038175013","https://openalex.org/W2047922146","https://openalex.org/W2050204129","https://openalex.org/W2050765432","https://openalex.org/W2051123582","https://openalex.org/W2053847699","https://openalex.org/W2054635658","https://openalex.org/W2057960412","https://openalex.org/W2060532763","https://openalex.org/W2065520133","https://openalex.org/W2073844962","https://openalex.org/W2088010486","https://openalex.org/W2090559362","https://openalex.org/W2094146747","https://openalex.org/W2096980055","https://openalex.org/W2101327682","https://openalex.org/W2102418913","https://openalex.org/W2109393326","https://openalex.org/W2112543105","https://openalex.org/W2115485662","https://openalex.org/W2118458775","https://openalex.org/W2118655588","https://openalex.org/W2123392379","https://openalex.org/W2123872323","https://openalex.org/W2131783235","https://openalex.org/W2131937454","https://openalex.org/W2137311703","https://openalex.org/W2140741294","https://openalex.org/W2140741923","https://openalex.org/W2142081209","https://openalex.org/W2142147155","https://openalex.org/W2146628652","https://openalex.org/W2147216681","https://openalex.org/W2155105887","https://openalex.org/W2155725425","https://openalex.org/W2162018845","https://openalex.org/W2164249457","https://openalex.org/W2169401034","https://openalex.org/W2585015296","https://openalex.org/W2753068189"],"related_works":["https://openalex.org/W1673030604","https://openalex.org/W7138260042","https://openalex.org/W7205241914","https://openalex.org/W2044784870","https://openalex.org/W2010895480","https://openalex.org/W7096967595","https://openalex.org/W2039945538","https://openalex.org/W2345130404","https://openalex.org/W1578077707","https://openalex.org/W7220730233"],"abstract_inverted_index":{"Tumor":[0],"hypoxia":[1,19,23,33,45,277],"is":[2,35,47],"involved":[3],"in":[4,21,67,91,206,251,278,300],"every":[5,132],"stage":[6],"of":[7,18,74,97,135,211,215,236,260,276,292],"solid":[8],"tumor":[9,139,143],"development:":[10],"formation,":[11],"progression,":[12],"metastasis,":[13],"and":[14,24,40,84,166,200,222,284,297],"apoptosis.":[15],"Two":[16],"types":[17],"exist":[20],"tumors\u2014chronic":[22],"acute":[25,298],"hypoxia.":[26],"Recent":[27],"studies":[28,102],"indicate":[29,256],"that":[30,194,257],"the":[31,58,63,72,95,106,113,120,129,158,173,177,195,212,219,258,265,272,285],"regional":[32,44],"kinetics":[34,46],"closely":[36],"linked":[37],"to":[38,49,56,87,119,141,157,218,233,245,287,302],"metastasis":[39],"therapeutic":[41],"responses,":[42],"but":[43],"hard":[48],"measure.":[50],"We":[51],"propose":[52],"a":[53,75],"novel":[54],"approach":[55,154],"determine":[57],"local":[59,107],"pO2":[60,122,149,160,220],"by":[61,124,181],"fusing":[62],"parameters":[64],"obtained":[65],"from":[66,112,131,151],"vivo":[68,92],"functional":[69,182,216],"imaging":[70,99,183,217,282],"through":[71,94,264],"use":[73,96],"modified":[76],"multivariate":[77,115],"Krogh":[78],"model.":[79],"To":[80],"test":[81],"our":[82,152],"idea":[83],"its":[85],"potential":[86,286],"translate":[88],"into":[89],"an":[90,136,167],"setting":[93],"existing":[98,281],"techniques,":[100],"simulation":[101,191,254],"were":[103,155,203],"performed":[104],"comparing":[105],"partial":[108],"oxygen":[109,144],"pressure":[110],"(pO2)":[111],"proposed":[114],"image":[116],"fusion":[117,153,259],"model":[118],"referenced":[121,159],"derived":[123,150,267],"Green\u2019s":[125],"function,":[126],"which":[127],"considers":[128],"contribution":[130],"vessel":[133],"segment":[134],"entire":[137],"three-dimensional":[138],"vasculature":[140],"profile":[142],"with":[145,161,230,280],"high":[146],"spatial":[147,178,274],"resolution.":[148],"close":[156],"regression":[162],"slope":[163],"near":[164],"1.0":[165],"r2":[168],"higher":[169],"than":[170,187],"0.8":[171],"if":[172],"voxel":[174],"size":[175],"(or":[176],"resolution":[179],"set":[180],"modality)":[184],"was":[185,224],"less":[186],"200":[188],"\u03bcm.":[189],"The":[190,209,253],"also":[192],"showed":[193],"metabolic":[196],"rate,":[197],"blood":[198,237],"perfusion,":[199],"hemoglobin":[201],"concentration":[202],"dominant":[204],"factors":[205],"tissue":[207],"oxygenation.":[208],"impact":[210],"measurement":[213,243],"error":[214,228,250],"precision":[221],"accuracy":[223],"simulated.":[225],"A":[226],"Gaussian":[227],"function":[229],"FWHM":[231],"equal":[232],"20":[234],"%":[235,248],"perfusion":[238],"or":[239],"fractional":[240],"vascular":[241],"volume":[242],"contributed":[244],"average":[246],"7":[247],"statistical":[249],"pO2.":[252],"results":[255],"multiple":[261],"parametric":[262],"maps":[263],"biophysically":[266],"mathematical":[268],"models":[269],"can":[270],"monitor":[271],"intra-tumor":[273],"variations":[275],"tumors":[279],"methods,":[283],"further":[288],"investigate":[289],"different":[290],"forms":[291],"hypoxia,":[293,299],"such":[294],"as":[295],"chronic":[296],"response":[301],"cancer":[303],"therapies.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-21T00:00:00"}
