{"id":"https://openalex.org/W2530300960","doi":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","title":"EP2 Receptor Blockade Protects Against Intestinal Barrier Breakdown in Experimental Peritonitis","display_name":"EP2 Receptor Blockade Protects Against Intestinal Barrier Breakdown in Experimental Peritonitis","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2530300960","doi":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","mag":"2530300960"},"language":"en","primary_location":{"id":"doi:10.1016/j.jamcollsurg.2016.06.362","doi":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031359568","display_name":"Jamie M. Golden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Golden","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005171277","display_name":"Laura Illingworth","orcid":"https://orcid.org/0000-0002-2747-2046","observed_orcids":["https://orcid.org/0000-0002-2747-2046"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Illingworth","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicole Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Jones","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060911982","display_name":"Jordan D. Bowling","orcid":"https://orcid.org/0000-0001-7024-8691","observed_orcids":["https://orcid.org/0000-0001-7024-8691"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan D. Bowling","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070886590","display_name":"Oswaldo H. Escobar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oswaldo H. Escobar","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108691276","display_name":"Brandon A. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Bell","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017577947","display_name":"Mubina A. Isani","orcid":"https://orcid.org/0000-0001-5448-5996","observed_orcids":["https://orcid.org/0000-0001-5448-5996"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mubina Isani","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012727802","display_name":"Christopher P. Gayer","orcid":"https://orcid.org/0000-0002-5351-553X","observed_orcids":["https://orcid.org/0000-0002-5351-553X"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher P. Gayer","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039038490","display_name":"Anatoly Grishin","orcid":"https://orcid.org/0000-0002-6170-6926","observed_orcids":["https://orcid.org/0000-0002-6170-6926"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anatoly V. Grishin","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041497800","display_name":"Henri R. Ford","orcid":"https://orcid.org/0000-0001-9118-9512","observed_orcids":["https://orcid.org/0000-0001-9118-9512"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henri R. Ford","raw_affiliation_strings":["s Hospital, Los Angeles, CA","Children\u2019s Hospital, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"s Hospital, Los Angeles, CA","institution_ids":[]},{"raw_affiliation_string":"Children\u2019s Hospital, Los Angeles, CA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336910626"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"223","issue":"4","first_page":"S54","last_page":"S54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7348999977111816,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":0.890999972820282},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.7319999933242798},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8420000076293945},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/experimental-peritonitis","display_name":"experimental peritonitis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/receptor-antagonism","display_name":"receptor antagonism","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9207534790039062},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.780576229095459},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.5082723498344421},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39159566164016724},{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.365992933511734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28068608045578003},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jamcollsurg.2016.06.362","doi":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jamcollsurg.2016.06.362","pdf_url":null,"source":{"id":"https://openalex.org/S134316426","display_name":"Journal of the American College of Surgeons","issn_l":"1072-7515","issn":["1072-7515","1879-1190"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Surgeons","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035924037","https://openalex.org/W1992007744","https://openalex.org/W2110833630","https://openalex.org/W2128736999","https://openalex.org/W2018492310","https://openalex.org/W2030391277","https://openalex.org/W2056621175","https://openalex.org/W2040542666","https://openalex.org/W2001326844","https://openalex.org/W2898171584"],"abstract_inverted_index":{"Golden,":[0],"Jamie":[1],"MD;":[2,10,18],"Illingworth,":[3],"Laura;":[4],"Jones,":[5],"Nicole;":[6],"Bowling,":[7],"Jordan":[8],"D.":[9],"Escobar,":[11],"Oswaldo":[12],"H.;":[13],"Bell,":[14],"Brandon;":[15],"Isani,":[16],"Mubina":[17],"Gayer,":[19],"Christopher":[20],"P.":[21],"MD,":[22,32],"PhD,":[23],"FACS;":[24],"Grishin,":[25],"Anatoly":[26],"V.":[27],"PhD;":[28],"Ford,":[29],"Henri":[30],"R.":[31],"FACS":[33],"Author":[34],"Information":[35]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-10-21T00:00:00"}