{"id":"https://openalex.org/W2530178321","doi":"https://doi.org/10.1212/con.0000000000000373","title":"Imaging of Central Nervous System Demyelinating Disorders","display_name":"Imaging of Central Nervous System Demyelinating Disorders","publication_year":2016,"publication_date":"2016-10-01","ids":{"openalex":"https://openalex.org/W2530178321","doi":"https://doi.org/10.1212/con.0000000000000373","mag":"2530178321","pmid":"https://pubmed.ncbi.nlm.nih.gov/27740991"},"language":"en","primary_location":{"id":"doi:10.1212/con.0000000000000373","doi":"https://doi.org/10.1212/con.0000000000000373","is_oa":false,"landing_page_url":"https://doi.org/10.1212/con.0000000000000373","pdf_url":null,"source":{"id":"https://openalex.org/S4210206818","display_name":"CONTINUUM Lifelong Learning in Neurology","issn_l":"1080-2371","issn":["1080-2371","1538-6899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Continuum","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037742305","display_name":"Konstantin E. Balashov","orcid":"https://orcid.org/0000-0003-3409-8731","observed_orcids":["https://orcid.org/0000-0003-3409-8731"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Konstantin Balashov","raw_affiliation_strings":["Robert Wood Johnson Medical School (RWJMS), Neurology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert Wood Johnson Medical School (RWJMS), Neurology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037742305"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6059,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.73319279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"5","first_page":"1613","last_page":"1635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.746999979019165},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.6230000257492065},{"id":"https://openalex.org/keywords/ultra-high-field-mri","display_name":"ultra-high field MRI","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cortical-lesions","display_name":"cortical lesions","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuromyelitis-optica-spectrum-disorder","display_name":"neuromyelitis optica spectrum disorder","score":0.8980000019073486},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.800000011920929},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.8537046909332275},{"id":"https://openalex.org/C2908708501","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating Disorder","level":3,"score":0.8187762498855591},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8186949491500854},{"id":"https://openalex.org/C2781137167","wikidata":"https://www.wikidata.org/wiki/Q611458","display_name":"Neuromyelitis optica","level":3,"score":0.7559391856193542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6718831658363342},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.5832923650741577},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5625466108322144},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.5412386059761047},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5191470980644226},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4519410729408264},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.44159799814224243},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.41011911630630493},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41009238362312317},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2628026604652405},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15286484360694885},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13234537839889526}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004673","descriptor_name":"Encephalomyelitis, Acute Disseminated","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D004673","descriptor_name":"Encephalomyelitis, Acute Disseminated","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009471","descriptor_name":"Neuromyelitis Optica","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009471","descriptor_name":"Neuromyelitis Optica","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/con.0000000000000373","doi":"https://doi.org/10.1212/con.0000000000000373","is_oa":false,"landing_page_url":"https://doi.org/10.1212/con.0000000000000373","pdf_url":null,"source":{"id":"https://openalex.org/S4210206818","display_name":"CONTINUUM Lifelong Learning in Neurology","issn_l":"1080-2371","issn":["1080-2371","1538-6899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Continuum","raw_type":"journal-article"},{"id":"pmid:27740991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27740991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Continuum (Minneapolis, Minn.)","raw_type":"Case Reports"},{"id":"pmh:oai:alma.01RUT_INST:11665198670004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Imaging-of-Central-Nervous-System-Demyelinating/991031665990304646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1148982456","https://openalex.org/W1572639874","https://openalex.org/W1763205699","https://openalex.org/W1828579964","https://openalex.org/W1939031061","https://openalex.org/W1943838624","https://openalex.org/W1966515383","https://openalex.org/W1970702615","https://openalex.org/W1973550674","https://openalex.org/W1990591009","https://openalex.org/W1991526672","https://openalex.org/W2004101346","https://openalex.org/W2005889577","https://openalex.org/W2030113529","https://openalex.org/W2043676066","https://openalex.org/W2047049772","https://openalex.org/W2074644637","https://openalex.org/W2084534504","https://openalex.org/W2090829353","https://openalex.org/W2093210280","https://openalex.org/W2096847489","https://openalex.org/W2098344611","https://openalex.org/W2105206040","https://openalex.org/W2105419237","https://openalex.org/W2106359604","https://openalex.org/W2108780874","https://openalex.org/W2117882647","https://openalex.org/W2122545833","https://openalex.org/W2128346633","https://openalex.org/W2128879265","https://openalex.org/W2129229339","https://openalex.org/W2129412982","https://openalex.org/W2132304833","https://openalex.org/W2135277857","https://openalex.org/W2148333046","https://openalex.org/W2148991512","https://openalex.org/W2151423278","https://openalex.org/W2158227195","https://openalex.org/W2164984683","https://openalex.org/W2169159041","https://openalex.org/W2169262628","https://openalex.org/W2317774179","https://openalex.org/W2336172696","https://openalex.org/W2531342489","https://openalex.org/W4247429833"],"related_works":["https://openalex.org/W2887142772","https://openalex.org/W4254262850","https://openalex.org/W4391488892","https://openalex.org/W2322591522","https://openalex.org/W306983655","https://openalex.org/W3018001787","https://openalex.org/W4396533794","https://openalex.org/W3135307753","https://openalex.org/W7214080001","https://openalex.org/W1580068662"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"article":[4],"focuses":[5],"on":[6,105],"neuroimaging":[7,53,67,156],"in":[8,40,52,68,88],"multiple":[9],"sclerosis":[10],"(MS),":[11],"the":[12,41,56,64,73,79,100,106,125],"most":[13,74],"common":[14,26],"central":[15],"nervous":[16],"system":[17],"(CNS)":[18],"demyelinating":[19,28,70,134],"disorder":[20],"encountered":[21],"by":[22],"practicing":[23,97],"neurologists.":[24],"Less":[25],"adult":[27],"disorders":[29],"and":[30,84,111,130,136,144,150],"incidental":[31],"subclinical":[32],"white":[33],"matter":[34],"abnormalities":[35],"that":[36],"are":[37,46,61,158],"often":[38],"considered":[39],"differential":[42],"diagnosis":[43],"of":[44,58,66,81,91,103,124,147,164],"MS":[45,110,129],"also":[47],"reviewed.":[48],"RECENT":[49],"FINDINGS:":[50],"Advancements":[51],"techniques,":[54],"eg,":[55],"application":[57],"ultrahigh-field":[59],"MRI,":[60],"rapidly":[62,154],"expanding":[63],"use":[65],"CNS":[69,85,133],"disorders.":[71,116],"Probably":[72],"important":[75,122],"recent":[76],"findings":[77],"include":[78],"detection":[80],"cortical":[82],"lesions":[83],"atrophy":[86],"even":[87],"early":[89],"stages":[90],"MS.":[92],"The":[93],"key":[94],"development":[95],"for":[96,109,128],"neurologists":[98],"is":[99],"growing":[101],"impact":[102],"MRI":[104,118],"diagnostic":[107,126],"criteria":[108,127],"neuromyelitis":[112],"optica":[113],"(NMO)":[114],"spectrum":[115],"SUMMARY:":[117],"serves":[119],"as":[120,141],"an":[121],"component":[123],"other":[131],"major":[132],"disorders,":[135],"it":[137],"has":[138],"been":[139],"established":[140],"a":[142],"reliable":[143],"sensitive":[145],"indicator":[146],"disease":[148,165],"activity":[149],"progression.":[151],"In":[152],"addition,":[153],"advancing":[155],"techniques":[157],"helping":[159],"to":[160],"improve":[161],"our":[162],"understanding":[163],"pathogenesis.":[166]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-21T00:00:00"}