{"id":"https://openalex.org/W2529948435","doi":"https://doi.org/10.5772/63637","title":"The Role of MicroRNAs in Impaired Diabetic Wound Healing","display_name":"The Role of MicroRNAs in Impaired Diabetic Wound Healing","publication_year":2016,"publication_date":"2016-10-12","ids":{"openalex":"https://openalex.org/W2529948435","doi":"https://doi.org/10.5772/63637","mag":"2529948435"},"language":"en","primary_location":{"id":"doi:10.5772/63637","doi":"https://doi.org/10.5772/63637","is_oa":true,"landing_page_url":"https://doi.org/10.5772/63637","pdf_url":"https://www.intechopen.com/citation-pdf-url/51215","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Healing - New insights into Ancient Challenges","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2531357390","display_name":"Wound Healing - New insights into Ancient Challenges"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.intechopen.com/citation-pdf-url/51215","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009823177","display_name":"Maggie M. Hodges","orcid":"https://orcid.org/0000-0001-5814-6932","observed_orcids":["https://orcid.org/0000-0001-5814-6932"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maggie M. Hodges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021392303","display_name":"Carlos Zgheib","orcid":"https://orcid.org/0000-0001-9977-8055","observed_orcids":["https://orcid.org/0000-0001-9977-8055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Zgheib","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737479","display_name":"Junwang Xu","orcid":"https://orcid.org/0000-0001-7905-8915","observed_orcids":["https://orcid.org/0000-0001-7905-8915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junwang Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101442154","display_name":"Kenneth W. Liechty","orcid":"https://orcid.org/0000-0001-8084-5342","observed_orcids":["https://orcid.org/0000-0001-8084-5342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth W. Liechty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009823177"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.6940000057220459},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.906000018119812},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lower-extremity-amputation","display_name":"lower limb amputation","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8637576103210449},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7995305061340332},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6209110021591187},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6106135845184326},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5560568571090698},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5453949570655823},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.509082019329071},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4795365333557129},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.47333770990371704},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42292749881744385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3259669244289398},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24954348802566528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14628973603248596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07035201787948608},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06919863820075989},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5772/63637","doi":"https://doi.org/10.5772/63637","is_oa":true,"landing_page_url":"https://doi.org/10.5772/63637","pdf_url":"https://www.intechopen.com/citation-pdf-url/51215","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Healing - New insights into Ancient Challenges","raw_type":"book-chapter"},{"id":"pmh:oai:biblioboard.com:d1e5a92e-c4e2-441e-9405-680ed5976f43","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/d1e5a92e-c4e2-441e-9405-680ed5976f43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-6d55e02e354:IntechOpen","raw_type":"CHAPTER"},{"id":"pmh:oai:intechopen.com:51215","doi":null,"is_oa":true,"landing_page_url":"http://www.intechopen.com/articles/show/title/the-role-of-micrornas-in-impaired-diabetic-wound-healing","pdf_url":null,"source":{"id":"https://openalex.org/S4306401291","display_name":"Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210154139","host_organization_name":"Intech (Slovakia)","host_organization_lineage":["https://openalex.org/I4210154139"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intechopen.com/download/pdf/pdfs_id/51215","raw_type":"01"}],"best_oa_location":{"id":"doi:10.5772/63637","doi":"https://doi.org/10.5772/63637","is_oa":true,"landing_page_url":"https://doi.org/10.5772/63637","pdf_url":"https://www.intechopen.com/citation-pdf-url/51215","source":{"id":"https://openalex.org/S4306463447","display_name":"InTech eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wound Healing - New insights into Ancient Challenges","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2529948435.pdf","grobid_xml":"https://content.openalex.org/works/W2529948435.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W42284190","https://openalex.org/W177963378","https://openalex.org/W1555423999","https://openalex.org/W1963143659","https://openalex.org/W1967162280","https://openalex.org/W1969806743","https://openalex.org/W1979043688","https://openalex.org/W1982861439","https://openalex.org/W2000292756","https://openalex.org/W2013888190","https://openalex.org/W2019507287","https://openalex.org/W2027991714","https://openalex.org/W2031484324","https://openalex.org/W2039486440","https://openalex.org/W2040922710","https://openalex.org/W2049051295","https://openalex.org/W2049660591","https://openalex.org/W2055199717","https://openalex.org/W2055670245","https://openalex.org/W2057933885","https://openalex.org/W2075860675","https://openalex.org/W2089196685","https://openalex.org/W2089606621","https://openalex.org/W2093114427","https://openalex.org/W2098199767","https://openalex.org/W2098468251","https://openalex.org/W2100430314","https://openalex.org/W2101004085","https://openalex.org/W2101930328","https://openalex.org/W2113167876","https://openalex.org/W2118152091","https://openalex.org/W2120472250","https://openalex.org/W2132075120","https://openalex.org/W2132554143","https://openalex.org/W2133613657","https://openalex.org/W2134161094","https://openalex.org/W2135378032","https://openalex.org/W2136114846","https://openalex.org/W2139556098","https://openalex.org/W2143723758","https://openalex.org/W2148694583","https://openalex.org/W2152476796","https://openalex.org/W2159793493","https://openalex.org/W2161068194","https://openalex.org/W2162674813","https://openalex.org/W2168156883","https://openalex.org/W2235008829","https://openalex.org/W2257505506","https://openalex.org/W2305067011"],"related_works":["https://openalex.org/W3023862939","https://openalex.org/W2408025807","https://openalex.org/W2885026326","https://openalex.org/W4405680509","https://openalex.org/W7220615720","https://openalex.org/W3090331431","https://openalex.org/W2418909714","https://openalex.org/W7097492079","https://openalex.org/W4386517427","https://openalex.org/W4327979079"],"abstract_inverted_index":{"Diabetes":[0],"mellitus":[1],"is":[2,34,109],"a":[3,38],"worldwide":[4],"pandemic,":[5],"affecting":[6],"29":[7],"million":[8],"Americans,":[9],"resulting":[10],"in":[11,26,64],"substantial":[12],"morbidity":[13],"and":[14,16,45,59,73,94,105,121,139],"mortality,":[15],"accounting":[17],"for":[18],"an":[19],"annual":[20],"healthcare":[21],"expenditure":[22],"exceeding":[23],"$176":[24],"billion":[25],"the":[27,35,46,53,97,102,128,141],"US":[28],"alone.":[29],"This":[30],"burden":[31],"of":[32,37,48,56,84,96,101,113,133],"disease":[33,40],"result":[36],"progressive":[39],"associated":[41,110],"with":[42,77,111],"numerous":[43],"complications":[44],"development":[47],"chronic":[49,86],"wounds,":[50],"which":[51],"remain":[52,81],"leading":[54],"cause":[55],"hospital":[57],"admissions":[58],"nontraumatic":[60],"lower":[61],"extremity":[62],"amputations":[63],"diabetic":[65,87,98,103,142],"patients.":[66],"Despite":[67],"clinical":[68],"strategies":[69],"aimed":[70],"at":[71,82],"prevention":[72],"early":[74],"detection,":[75],"patients":[76],"diabetes":[78],"continue":[79],"to":[80,90],"risk":[83],"developing":[85],"wounds":[88],"due":[89],"poor":[91],"patient":[92],"compliance":[93],"progression":[95],"phenotype.":[99,144],"Development":[100],"phenotype":[104],"wound":[106,137],"healing":[107,138],"impairment":[108],"dysregulation":[112,135],"microRNAs":[114],"that":[115,130],"regulate":[116],"inflammation,":[117],"extracellular":[118],"matrix":[119],"composition,":[120],"angiogenesis;":[122],"here":[123],"we":[124],"present":[125],"evidence":[126],"from":[127],"studies":[129],"demonstrate":[131],"correction":[132],"microRNA":[134],"expedites":[136],"reverses":[140],"skin":[143]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-10-21T00:00:00"}
