{"id":"https://openalex.org/W2529614161","doi":"https://doi.org/10.1182/blood.v124.21.513.513","title":"BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1-Driven Leukemia","display_name":"BACH2 promotes Lineage-Specific Fate Decisions in BCR-ABL1-Driven Leukemia","publication_year":2014,"publication_date":"2014-12-06","ids":{"openalex":"https://openalex.org/W2529614161","doi":"https://doi.org/10.1182/blood.v124.21.513.513","mag":"2529614161"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v124.21.513.513","doi":"https://doi.org/10.1182/blood.v124.21.513.513","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.513.513","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101617358","display_name":"Eugene Park","orcid":"https://orcid.org/0000-0001-8432-5168","observed_orcids":["https://orcid.org/0000-0001-8432-5168"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Eugene Park","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA","University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103176539","display_name":"Srividya Swaminathan","orcid":"https://orcid.org/0000-0002-3459-7488","observed_orcids":["https://orcid.org/0000-0002-3459-7488"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srividya Swaminathan","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035417581","display_name":"Firas Sadiyah","orcid":"https://orcid.org/0000-0002-6067-3800","observed_orcids":["https://orcid.org/0000-0002-6067-3800"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammed Firas Sadiyah","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376003","display_name":"Kazuhiko Igarashi","orcid":"https://orcid.org/0000-0002-2470-2475","observed_orcids":["https://orcid.org/0000-0002-2470-2475"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiko Igarashi","raw_affiliation_strings":["Japan Science and Technology, Sendai, Japan","Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Science and Technology, Sendai, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770989","display_name":"Ari M. Melnick","orcid":"https://orcid.org/0000-0002-8074-2287","observed_orcids":["https://orcid.org/0000-0002-8074-2287"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ari Melnick","raw_affiliation_strings":["Weill Cornell Medical College, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103112288","display_name":"Markus M\u00fcschen","orcid":"https://orcid.org/0000-0002-8355-0707","observed_orcids":["https://orcid.org/0000-0002-8355-0707"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Markus Muschen","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA","University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5035417581","https://openalex.org/A5101617358","https://openalex.org/A5103176539","https://openalex.org/A5114376003"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I201537933","https://openalex.org/I241749","https://openalex.org/I4210086780"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32124902,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"21","first_page":"513","last_page":"513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bach2","display_name":"BACH2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive acute lymphoblastic leukemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lymphoid-blast-crisis","display_name":"lymphoid blast crisis","score":0.949999988079071},{"id":"https://openalex.org/keywords/myeloid-lineage","display_name":"myeloid lineage","score":0.6179999709129333},{"id":"https://openalex.org/keywords/b-cell-lineage","display_name":"B-cell lineage","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7749999761581421},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.722000002861023},{"id":"https://openalex.org/keywords/leukemia-progression","display_name":"leukemia progression","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5913418531417847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5821361541748047},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5100448727607727},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5081565380096436},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4849262535572052},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.47925901412963867},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.42440640926361084},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2990947961807251},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2957983613014221},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26320695877075195},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15726310014724731}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v124.21.513.513","doi":"https://doi.org/10.1182/blood.v124.21.513.513","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v124.21.513.513","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2009789055","https://openalex.org/W2586736903","https://openalex.org/W2556550054","https://openalex.org/W2476136742","https://openalex.org/W2010675745","https://openalex.org/W2024028405","https://openalex.org/W173389305","https://openalex.org/W1982151423","https://openalex.org/W2014220327","https://openalex.org/W2033555686"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,5,17,29,43,48,78,87,123,130,210,223,238,241,244,344,365,431,443,458,470,495,499,512,529,568,584],"Hypothesis:":[3],"CML":[4,18,47,135,146,176,198,294,353,373,389,395,405,433,573,596,616,628],"Ph+":[6,33,49,85,121,236,245,441,493,515,554],"ALL":[7,86,122,237,442,494,516],"are":[8,51,613,624],"both":[9,338],"driven":[10,109,582],"by":[11],"the":[12,38,73,98,180,186,285,339,345,352,473,487,544,559,618],"oncogenic":[13],"BCR-ABL1":[14,108,231,475,581],"tyrosine":[15],"kinase":[16],"can":[19],"progress":[20],"into":[21],"lymphoid":[22],"blast":[23,156,633],"crisis":[24],"(LBC),":[25],"which":[26],"is":[27,126,540,564],"clinically":[28],"biologically":[30],"indistinguishable":[31],"from":[32,208,391,595],"ALL.":[34],"We":[35,216],"hypothesize":[36],"that":[37,68,101,152,170,227,332,464,504,562],"stark":[39],"differences":[40],"in":[41,84,107,116,120,142,185,196,252,266,280,288,358,363,371,386,396,403,418,429,435,479,492,509,533,543,553,580,615,627],"phenotype":[42],"clinical":[44],"outcomes":[45],"between":[46],"ALL/LBC":[50],"due":[52],"to":[53,258,262,360,420,437,455,597,641],"lineage-specific":[54,104,467,577],"transcription":[55,66],"factors.":[56],"Our":[57],"group":[58],"recently":[59],"identified":[60],"BACH2":[61,102,125,165,171,184,195,272,413,491,539,563,575,610],"as":[62,80,232,549],"a":[63,81,112,197,233,253,408,426,451,550],"B":[64,117,274,438,545],"cell-specific":[65],"factor":[67],"mediates":[69,103,576],"negative":[70],"selection":[71],"at":[72,611,617],"pre-B":[74,225],"cell":[75,118,275,439,526,546],"receptor":[76],"checkpoint":[77],"functions":[79],"tumor":[82,114,551],"suppressor":[83,115,552],"LBC":[88,444,621],"(Swaminathan":[89],"et":[90,148],"al.,":[91],"Nature":[92],"Med":[93],"2013).":[94],"Here":[95],"we":[96,190,204,283,330,485,556],"report":[97,557],"surprising":[99,560],"finding":[100,561],"fate":[105,468,578],"decisions":[106,469,579],"leukemia:":[110],"while":[111],"potent":[113],"lineage":[119,134,276,293,440,572,592],"LBC,":[124],"required":[127,565],"for":[128,235,566,603],"survival":[129,322,427,511,567],"self-renewal":[131,569],"of":[132,164,183,188,194,255,271,310,334,351,369,401,412,490,506,514,570,588,591,609,620,639],"myeloid":[133,292,457,523,571,632],"cells.":[136,445,461,517,574],"Results:":[137],"A":[138],"gene":[139,161],"expression":[140,162],"analysis":[141],"99":[143],"patients":[144,153,393],"with":[145,154,175,214,221,230,291,394,472],"(Radich":[147],"al,":[149],"2006)":[150],"revealed":[151],"higher":[155,160],"counts":[157],"showed":[158],"significantly":[159],"values":[163],"(P=8.88":[166],"x":[167],"10-9),":[168],"suggesting":[169],"mRNA":[172],"levels":[173],"increase":[174],"progression.":[177],"To":[178,201],"determine":[179],"mechanistic":[181],"role":[182],"progression":[187,622],"CML,":[189],"studied":[191],"genetic":[192],"deletion":[193,270,333],"mouse":[199,432],"model.":[200],"this":[202],"end,":[203],"transformed":[205,229],"Lin-kit+Sca-1+(LSK)":[206],"cells":[207,219,226,248,301,312,374,390,406,415,535],"Bach2+/+":[209,222,240],"Bach2-/-":[211,224,242,311,366,372],"bone":[212],"marrow":[213],"BCR-ABL1.":[215],"compared":[217],"these":[218],"alongside":[220],"were":[228,249,357,384],"model":[234],"LBC.":[239],"CML-like":[243,303,316],"ALL/LBC-like":[246],"leukemia":[247,265,277,583],"then":[250],"tested":[251],"series":[254],"functional":[256],"experiments":[257,290],"test":[259],"their":[260],"ability":[261,342,379],"initiate":[263],"fatal":[264],"transplant":[267,281,289],"recipients.":[268],"While":[269,538],"accelerated":[273],"(Ph+":[278],"ALL/LBC-like)":[279],"recipients,":[282],"noted":[284],"opposite":[286],"outcome":[287],"cells:":[295],"All":[296],"mice":[297],"receiving":[298],"Bach2+/+BCR-ABL1-transformed":[299],"LSK":[300],"developed":[302],"disease":[304,317],"within":[305],"60":[306],"days":[307,325],"whereas":[308],"recipients":[309],"did":[313,448],"not":[314,449,625],"develop":[315],"(Bach2+/+":[318],"vs":[319,326],"Bach2-/-,":[320],"median":[321],"time=":[323],"33":[324],"undefined;":[327],"P=0.001).":[328],"Additionally,":[329],"observed":[331,362],"Bach2":[335,370,402,424,447,465,507],"loss":[336],"reduced":[337],"colony":[340,377,500,531],"formation":[341,501,532],"(P=0.0059)":[343],"S":[346],"phase":[347,630],"proliferation":[348,513],"potential":[349],"(P=0.0075)":[350],"progenitors.":[354],"These":[355,382],"results":[356,508],"contrast":[359,436],"those":[361],"Ph+Bach2+/+":[364],"ALLs.":[367],"Reconstitution":[368],"rescued":[375],"its":[376],"forming":[378],"(P=":[380],"0.023).":[381],"findings":[383],"confirmed":[385],"primary":[387],"human":[388,430],"two":[392],"chronic":[397,629],"phase:":[398],"Inducible":[399],"overexpression":[400],"patient-derived":[404],"conferred":[407],"selective":[409,452],"proliferative":[410],"advantage":[411,454],"overexpressing":[414,483],"over":[416],"time,":[417],"comparison":[419],"empty":[421],"vector":[422],"controls.":[423],"triggered":[425],"program":[428],"cells,":[434],"Interestingly,":[446],"provide":[450],"growth":[453],"untransformed":[456],"multi-lineage":[459],"progenitor":[460],"This":[462],"demonstrates":[463],"drives":[466],"cooperates":[471],"transforming":[474],"oncogene.":[476],"Utilizing":[477],"an":[478],"vitro":[480],"lineage-switch":[481],"assay":[482],"CEBP\u03b1":[484],"characterized":[486],"opposing":[488],"roles":[489],"CML.":[496],"Cell":[497],"viability":[498],"assays":[502],"demonstrated":[503],"absence":[505],"increased":[510],"In":[518],"striking":[519],"contrast,":[520],"however,":[521],"CEBP\u03b1-induced":[522],"reprogramming":[524],"induced":[525],"cycle":[527],"arrest":[528],"suppressed":[530],"Bach2-deficient":[534],"(P=0.0001).":[536],"Conclusion:":[537],"primarily":[541],"expressed":[542],"lineage,":[547],"functioning":[548],"ALL,":[555],"here":[558],"represents":[585],"one":[586],"example":[587],"how":[589],"conversion":[590],"identity":[593],"(e.g.":[594],"LBC)":[598],"may":[599],"impact":[600],"specific":[601],"requirement":[602],"malignant":[604],"transformation.":[605],"For":[606],"instance,":[607],"deletions":[608],"6q15":[612],"common":[614],"time":[619],"but":[623],"found":[626],"or":[631],"crisis.":[634],"Disclosures":[635],"No":[636],"relevant":[637],"conflicts":[638],"interest":[640],"declare.":[642]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-10-14T00:00:00"}