{"id":"https://openalex.org/W2529329694","doi":"https://doi.org/10.21037/jgo.2016.09.05","title":"Next generation sequencing identifies \u2018interactome\u2019 signatures in relapsed and refractory metastatic colorectal cancer","display_name":"Next generation sequencing identifies \u2018interactome\u2019 signatures in relapsed and refractory metastatic colorectal cancer","publication_year":2017,"publication_date":"2017-02-01","ids":{"openalex":"https://openalex.org/W2529329694","doi":"https://doi.org/10.21037/jgo.2016.09.05","mag":"2529329694","pmid":"https://pubmed.ncbi.nlm.nih.gov/28280605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5334057"},"language":"en","primary_location":{"id":"doi:10.21037/jgo.2016.09.05","doi":"https://doi.org/10.21037/jgo.2016.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.09.05","pdf_url":"https://jgo.amegroups.com/article/viewFile/9460/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jgo.amegroups.com/article/viewFile/9460/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010363210","display_name":"Benny Johnson","orcid":"https://orcid.org/0000-0003-3683-8115","observed_orcids":["https://orcid.org/0000-0003-3683-8115","https://orcid.org/0000-0002-6826-6687"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Benny Johnson","raw_affiliation_strings":["Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111739536","display_name":"Laurence S. Cooke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence Cooke","raw_affiliation_strings":["The University of Arizona Cancer Center, Tucson, AZ 85719, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Cancer Center, Tucson, AZ 85719, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101638085","display_name":"Daruka Mahadevan","orcid":"https://orcid.org/0000-0002-7129-5593","observed_orcids":["https://orcid.org/0000-0002-7129-5593"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daruka Mahadevan","raw_affiliation_strings":["The University of Arizona Cancer Center, Tucson, AZ 85719, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Arizona Cancer Center, Tucson, AZ 85719, USA","institution_ids":["https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010363210"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":0.7021,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70510795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"20","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/relapsed-refractory-disease","display_name":"relapsed/refractory disease","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7039999961853027},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.5090000033378601},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.7419999837875366},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8709999918937683},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6190000176429749},{"id":"https://openalex.org/keywords/vegfr2","display_name":"VEGFR2","score":0.7599999904632568},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.7509999871253967},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4569999873638153},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5059999823570251},{"id":"https://openalex.org/keywords/drug-combination-prediction","display_name":"drug combination prediction","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9143252372741699},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.6867853999137878},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6861345171928406},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5675712823867798},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46341508626937866},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.44663378596305847},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42900484800338745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3148389458656311},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15845707058906555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06640294194221497},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/jgo.2016.09.05","doi":"https://doi.org/10.21037/jgo.2016.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.09.05","pdf_url":"https://jgo.amegroups.com/article/viewFile/9460/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5334057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5334057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:28280605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28280605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/623288","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/623288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.21037/jgo.2016.09.05","doi":"https://doi.org/10.21037/jgo.2016.09.05","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo.2016.09.05","pdf_url":"https://jgo.amegroups.com/article/viewFile/9460/pdf","source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332511","display_name":"Health Science Center, University of Tennessee","ror":"https://ror.org/0011qv509"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2529329694.pdf","grobid_xml":"https://content.openalex.org/works/W2529329694.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W146599603","https://openalex.org/W242040007","https://openalex.org/W1904761682","https://openalex.org/W1934094702","https://openalex.org/W1940241680","https://openalex.org/W1985199765","https://openalex.org/W1989277387","https://openalex.org/W1999659306","https://openalex.org/W2006168411","https://openalex.org/W2038141559","https://openalex.org/W2057495794","https://openalex.org/W2070050178","https://openalex.org/W2073779538","https://openalex.org/W2083831897","https://openalex.org/W2100439220","https://openalex.org/W2104347254","https://openalex.org/W2106543129","https://openalex.org/W2106789440","https://openalex.org/W2108246579","https://openalex.org/W2115735904","https://openalex.org/W2121847974","https://openalex.org/W2121869934","https://openalex.org/W2134142320","https://openalex.org/W2147834058","https://openalex.org/W2152454229","https://openalex.org/W2155311724","https://openalex.org/W2156353875","https://openalex.org/W2159187753","https://openalex.org/W2164035913","https://openalex.org/W2166084034","https://openalex.org/W2166199281","https://openalex.org/W2170552969","https://openalex.org/W2235405584","https://openalex.org/W2262414037","https://openalex.org/W2321016022","https://openalex.org/W2325087121","https://openalex.org/W2325481887","https://openalex.org/W2334157638","https://openalex.org/W2367152078","https://openalex.org/W2371259918","https://openalex.org/W2572174216","https://openalex.org/W2596696771","https://openalex.org/W2917466103","https://openalex.org/W2917668744","https://openalex.org/W3211402536","https://openalex.org/W4237335579","https://openalex.org/W4245424574","https://openalex.org/W4406414604","https://openalex.org/W6640714399"],"related_works":["https://openalex.org/W2477765711","https://openalex.org/W4394925458","https://openalex.org/W2947880701","https://openalex.org/W2807373925","https://openalex.org/W2564560842","https://openalex.org/W3145382638","https://openalex.org/W2224374599","https://openalex.org/W2810242231","https://openalex.org/W3023494706","https://openalex.org/W2890096465"],"abstract_inverted_index":{"Background:":[0],"In":[1],"the":[2,92,119,123,210,230],"management":[3],"of":[4,22,176],"metastatic":[5],"colorectal":[6],"cancer":[7],"(mCRC),":[8],"KRAS,":[9,129],"NRAS":[10],"and":[11,18,34,50,62,143,172,179,207,238,246],"BRAF":[12],"mutational":[13,40,86],"status":[14],"individualizes":[15],"therapeutic":[16],"options":[17],"identify":[19],"a":[20,48,221],"cohort":[21],"patients":[23],"(pts)":[24],"with":[25],"an":[26],"aggressive":[27],"clinical":[28,57],"course.":[29],"We":[30],"hypothesized":[31],"that":[32,42,90],"relapsed":[33,245],"refractory":[35,63,247],"mCRC":[36,64,248],"pts":[37,65,199],"develop":[38],"unique":[39,151],"signatures":[41,215],"may":[43],"guide":[44,95,240],"therapy,":[45],"predict":[46,233],"for":[47,56],"response":[49,234],"highlight":[51],"key":[52,201],"signaling":[53,157],"pathways":[54,158],"important":[55],"decision":[58],"making.":[59],"Methods:":[60],"Relapsed":[61],"(N=32)":[66],"were":[67,82],"molecularly":[68],"profiled":[69],"utilizing":[70],"commercially":[71],"available":[72],"next":[73,211],"generation":[74],"sequencing":[75],"(NGS)":[76],"platforms.":[77],"Web-based":[78],"bioinformatics":[79],"tools":[80],"(Reactome/Enrichr)":[81],"utilized":[83],"to":[84,94,190,202,224,235],"elucidate":[85],"profile":[87],"linked":[88],"pathways-networks":[89],"have":[91],"potential":[93],"therapy.":[96,213],"Results:":[97],"Pts":[98,145],"had":[99,146,149],"progressed":[100],"on":[101,147],"fluoropyrimidines,":[102],"oxaliplatin,":[103],"irinotecan,":[104],"bevacizumab,":[105],"cetuximab":[106],"and/or":[107],"panitumumab.":[108],"Most":[109],"common":[110],"histology":[111],"was":[112,122],"adenocarcinoma":[113],"(colon":[114],"N=29;":[115],"rectal":[116],"N=3).":[117],"Of":[118],"mutations":[120,185],"TP53":[121],"most":[124,154],"common,":[125],"followed":[126],"by":[127],"APC,":[128],"PIK3CA,":[130],"BRAF,":[131],"SMAD4,":[132],"SPTA1,":[133],"FAT1,":[134],"PDGFRA,":[135],"ATM,":[136],"ROS1,":[137],"ALK,":[138],"CDKN2A,":[139],"FBXW7,":[140],"TGFBR2,":[141],"NOTCH1":[142],"HER3.":[144],"average":[148],"\u22655":[150],"mutations.":[152],"The":[153],"frequent":[155],"activated":[156],"were:":[159],"HER2,":[160],"fibroblast":[161],"growth":[162],"factor":[163],"receptor":[164],"(FGFR),":[165],"p38":[166],"through":[167],"BRAF-MEK":[168],"cascade":[169],"via":[170],"RIT":[171],"RIN,":[173],"ARMS-mediated":[174],"activation":[175],"MAPK":[177],"cascade,":[178],"VEGFR2.":[180],"Conclusions:":[181],"Dominant":[182],"driver":[183],"oncogene":[184],"do":[186],"not":[187],"always":[188],"equate":[189],"oncogenic":[191],"dependence,":[192],"hence":[193],"understanding":[194],"pathogenic":[195],"\u2018interactome(s)\u2019":[196],"in":[197,208,229,244],"individual":[198],"is":[200],"both":[203],"clinically":[204],"relevant":[205],"targets":[206],"choosing":[209],"best":[212],"Mutational":[214],"derived":[216],"from":[217],"corresponding":[218],"\u2018pathway-networks\u2019":[219],"represent":[220],"meaningful":[222],"tool":[223],"(I)":[225],"evaluate":[226],"functional":[227],"investigation":[228],"laboratory;":[231],"(II)":[232],"drug":[236,242],"therapy;":[237],"(III)":[239],"rational":[241],"combinations":[243],"pts.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-14T00:00:00"}
