{"id":"https://openalex.org/W2529112655","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","title":"Outcome with total therapy 3 (TT3) compared to total therapy 2 (TT2): Role of GEP70-defined high-risk disease with trisomy of 1q21 and activation of the proteasome gene PSMD4.","display_name":"Outcome with total therapy 3 (TT3) compared to total therapy 2 (TT2): Role of GEP70-defined high-risk disease with trisomy of 1q21 and activation of the proteasome gene PSMD4.","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2529112655","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","mag":"2529112655"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.8027","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027806317","display_name":"John D. Shaughnessy","orcid":"https://orcid.org/0000-0002-2017-6236","observed_orcids":["https://orcid.org/0000-0002-2017-6236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. D. Shaughnessy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082141323","display_name":"Pingping Qu","orcid":"https://orcid.org/0000-0003-2487-5402","observed_orcids":["https://orcid.org/0000-0003-2487-5402"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Qu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113884256","display_name":"E Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Edmondson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Edmondson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112041795","display_name":"Bijay P. Nair","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. P. Nair","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111921085","display_name":"Sarah Waheed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Waheed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085052","display_name":"Yazan M. Alsayed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Alsayed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090044223","display_name":"Frits van Rhee","orcid":"https://orcid.org/0000-0001-9959-1282","observed_orcids":["https://orcid.org/0000-0001-9959-1282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Van Rhee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111026806","display_name":"Jeff Haessler","orcid":"https://orcid.org/0000-0002-2756-4370","observed_orcids":["https://orcid.org/0000-0002-2756-4370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Haessler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408877","display_name":"John J. Crowley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Crowley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000879635","display_name":"Bart Barlogie","orcid":"https://orcid.org/0000-0001-6116-1017","observed_orcids":["https://orcid.org/0000-0001-6116-1017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Barlogie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"8027","last_page":"8027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9049999713897705},{"id":"https://openalex.org/keywords/psmd4","display_name":"PSMD4","score":0.8399999737739563},{"id":"https://openalex.org/keywords/proteasome-genes","display_name":"proteasome genes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7699999809265137},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/copy-number","display_name":"copy number","score":0.46700000762939453},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4320000112056732},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.746999979019165},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9610000252723694},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5987168550491333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5450373888015747},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.5121190547943115},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.48094815015792847},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.4720096290111542},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.45761221647262573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4572018086910248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4400389492511749},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4171791970729828},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41261014342308044},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3269308805465698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2919121980667114},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.08821842074394226}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.8027","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.8027","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2579417230","https://openalex.org/W2045010580","https://openalex.org/W2278098528","https://openalex.org/W2572704867","https://openalex.org/W4200488638","https://openalex.org/W2261973104","https://openalex.org/W2573074943","https://openalex.org/W2419653255","https://openalex.org/W2535220291","https://openalex.org/W4310125635"],"abstract_inverted_index":{"8027":[0],"Background:":[1],"A":[2],"GEP-based":[3],"risk":[4,43,170,185,189],"model":[5,68],"(GEP70)":[6],"defines":[7],"15%":[8],"of":[9,17,29,37,51,56,61,80,92,200,215,231,237,243,250,258,306,313,323,345],"newly":[10],"diagnosed":[11],"MM":[12,81,318],"with":[13,48,118,212,220,234,255,310,320,342],"a":[14,195,268,276,289],"median":[15],"survival":[16,340],"2yr":[18],"compared":[19],"to":[20,46,71,83,100,141,208,253,316,336,351],"10+yr":[21],"others.":[22],"GEP70":[23,174,201],"is":[24,59,275,294],"driven":[25,90],"by":[26,151,172,296],"elevated":[27,137],"expression":[28,138,230],"genes":[30,64,130,134,147,233],"from":[31],"chromosome":[32],"1q":[33],"and":[34,102,107,115,126,145,175,180,245],"FISH-defined":[35],"gains":[36],"1q21.":[38,52,324,346],"In":[39,95],"serial":[40],"studies,":[41],"low":[42],"frequently":[44],"evolves":[45],"high-risk":[47],"increased":[49],"amplification":[50,344],"PSMD4,":[53,251,267],"regulatory":[54],"subunit":[55],"the":[57,66,72,78,173,184,235,311,338],"proteasome,":[58],"one":[60],"only":[62],"two":[63],"in":[65,120,178,198,205,264,280,284,292,298],"70GEP":[67],"that":[69,77,157,247,302],"map":[70],"1q21":[73,116,244],"amplicon.":[74],"We":[75,112,182,228,300],"hypothesized":[76],"sensitivity":[79],"cells":[82,319],"BOR-induced":[84],"apoptosis":[85],"might":[86],"depend":[87],"on":[88],"copy-number":[89],"activity":[91],"PSMD4.":[93],"Methods:":[94],"TT3,":[96],"we":[97],"added":[98],"BOR":[99,297,307,331],"TT2":[101,179,293],"performed":[103],"GEP":[104,114],"at":[105,273],"baseline":[106],"48hr":[108],"after":[109],"1.0mg/m2":[110],"BOR.":[111],"correlated":[113,229],"FISH":[117],"outcomes":[119,199,263],"over":[121,328],"600":[122],"cases.":[123],"Results:":[124],"PSMD4":[125,144,285],"14":[127],"other":[128],"proteasome":[129,146],"were":[131,148],"among":[132],"80":[133],"whose":[135],"post-BOR":[136],"was":[139,160,163,260],"related":[140],"poor":[142,290],"outcome.":[143],"not":[149,166,218],"activated":[150],"thalidomide,":[152],"dexamethasone":[153],"or":[154,222,240],"lenalidomide":[155],"suggesting":[156],"this":[158,314,330],"effect":[159],"BOR-specific.":[161],"There":[162],"strong":[164,277],"but":[165,217],"complete":[167],"overlap":[168],"between":[169],"designations":[171],"GEP80":[176],"models":[177],"TT3.":[181,265,299],"combined":[183],"predictions":[186],"creating":[187],"four":[188],"catagories.":[190],"Kaplan":[191],"Meier":[192],"analysis":[193],"revealed":[194],"dramatic":[196],"improvement":[197],"high-risk/GEP80":[202],"low-risk":[203],"cases":[204],"TT3":[206],"relative":[207],"TT2.":[209],"Similarly,":[210],"disease":[211,219,254],"3":[213,239,256],"copies":[214,224,242,257,322],"1q21,":[216,259,274],"2":[221],"4+":[223,241,321],"experienced":[225],"improved":[226,262],"outcomes.":[227],"candidate":[232],"presence":[236],"2,":[238],"found":[246],"intermediate":[248],"levels":[249],"corresponding":[252],"associated":[261,341],"Conclusions:":[266],"copy":[269],"number":[270],"dependent":[271],"gene":[272,286],"prognostic":[278],"biomarker":[279],"MM.":[281],"Modest":[282],"increases":[283],"expression,":[287],"conferring":[288],"prognosis":[291],"overcome":[295],"speculate":[301],"dose":[303],"limiting":[304],"toxicities":[305],"may":[308,333],"interfere":[309],"ability":[312],"drug":[315],"kill":[317],"Novel":[325],"therapeutic":[326],"strategies":[327],"coming":[329],"limitation":[332],"be":[334],"needed":[335],"improve":[337],"dismal":[339],"high-level":[343],"No":[347],"significant":[348],"financial":[349],"relationships":[350],"disclose.":[352]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-10-14T00:00:00"}
