{"id":"https://openalex.org/W2528914818","doi":"https://doi.org/10.1177/0271678x16672482","title":"Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium","display_name":"Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium","publication_year":2016,"publication_date":"2016-10-04","ids":{"openalex":"https://openalex.org/W2528914818","doi":"https://doi.org/10.1177/0271678x16672482","mag":"2528914818","pmid":"https://pubmed.ncbi.nlm.nih.gov/27702879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5531355"},"language":"en","primary_location":{"id":"doi:10.1177/0271678x16672482","doi":"https://doi.org/10.1177/0271678x16672482","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x16672482","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X16672482","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X16672482","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073620424","display_name":"Fernando Garc\u00eda-Polite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5593406","display_name":"Universitat Ramon Llull","ror":"https://ror.org/04p9k2z50","country_code":"ES","type":"education","lineage":["https://openalex.org/I5593406"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Fernando Garcia-Polite","raw_affiliation_strings":["IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","institution_ids":["https://openalex.org/I5593406"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033204326","display_name":"Jordi Martorell","orcid":"https://orcid.org/0000-0002-2043-2762","observed_orcids":["https://orcid.org/0000-0002-2043-2762"]},"institutions":[{"id":"https://openalex.org/I5593406","display_name":"Universitat Ramon Llull","ror":"https://ror.org/04p9k2z50","country_code":"ES","type":"education","lineage":["https://openalex.org/I5593406"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jordi Martorell","raw_affiliation_strings":["IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","institution_ids":["https://openalex.org/I5593406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032824217","display_name":"Paula Del Rey-Puech","orcid":"https://orcid.org/0009-0006-0355-7404","observed_orcids":["https://orcid.org/0009-0006-0355-7404"]},"institutions":[{"id":"https://openalex.org/I5593406","display_name":"Universitat Ramon Llull","ror":"https://ror.org/04p9k2z50","country_code":"ES","type":"education","lineage":["https://openalex.org/I5593406"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Paula Del Rey-Puech","raw_affiliation_strings":["IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","institution_ids":["https://openalex.org/I5593406"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698517","display_name":"Pedro Melgar\u2010Lesmes","orcid":"https://orcid.org/0000-0002-2009-5911","observed_orcids":["https://orcid.org/0000-0002-2009-5911"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro Melgar-Lesmes","raw_affiliation_strings":["Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109163857","display_name":"Caroline C. O\u2019Brien","orcid":"https://orcid.org/0009-0009-5255-4009","observed_orcids":["https://orcid.org/0009-0009-5255-4009"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline C O\u2019Brien","raw_affiliation_strings":["Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051664900","display_name":"Jaume Roquer","orcid":"https://orcid.org/0000-0001-5992-2606","observed_orcids":["https://orcid.org/0000-0001-5992-2606"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaume Roquer","raw_affiliation_strings":["Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032952016","display_name":"\u00c1ngel Ois","orcid":"https://orcid.org/0000-0002-1375-5950","observed_orcids":["https://orcid.org/0000-0002-1375-5950"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angel Ois","raw_affiliation_strings":["Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031979984","display_name":"Alessandro Pr\u00edncipe","orcid":"https://orcid.org/0000-0002-3694-0892","observed_orcids":["https://orcid.org/0000-0002-3694-0892"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alessandro Principe","raw_affiliation_strings":["Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Servei de Neurologia, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques, Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005931821","display_name":"Elazer Reuven Edelman","orcid":"https://orcid.org/0000-0002-7832-7156","observed_orcids":["https://orcid.org/0000-0002-7832-7156"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elazer R Edelman","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066978972","display_name":"Mercedes Balcells","orcid":"https://orcid.org/0000-0002-2532-0516","observed_orcids":["https://orcid.org/0000-0002-2532-0516"]},"institutions":[{"id":"https://openalex.org/I5593406","display_name":"Universitat Ramon Llull","ror":"https://ror.org/04p9k2z50","country_code":"ES","type":"education","lineage":["https://openalex.org/I5593406"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Mercedes Balcells","raw_affiliation_strings":["IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain","institution_ids":["https://openalex.org/I5593406"]},{"raw_affiliation_string":"Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5033204326"],"corresponding_institution_ids":["https://openalex.org/I5593406"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.6782,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.89904804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"37","issue":"7","first_page":"2614","last_page":"2625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8859999775886536},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/pulsatile-flow","display_name":"pulsatile flow","score":0.7570000290870667},{"id":"https://openalex.org/keywords/high-shear-stress","display_name":"high shear stress","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9639999866485596},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.777999997138977},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9909999966621399},{"id":"https://openalex.org/keywords/src-signaling","display_name":"Src signaling","score":0.4300000071525574},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7250000238418579},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6885539293289185},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.6556329727172852},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.5795235633850098},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.55887770652771},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5325303077697754},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5228053331375122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4982762336730957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4960399568080902},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4574313759803772},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.43670883774757385},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3378371000289917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24183142185211182},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23077449202537537},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1823682188987732},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10219350457191467},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09406530857086182},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06781858205795288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06280407309532166},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011673","descriptor_name":"Pulsatile Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D033081","descriptor_name":"Shear Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D062507","descriptor_name":"Claudin-5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062507","descriptor_name":"Claudin-5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/0271678x16672482","doi":"https://doi.org/10.1177/0271678x16672482","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x16672482","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X16672482","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4974978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5531355","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5531355","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5531355","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cereb Blood Flow Metab","raw_type":"Text"},{"id":"pmid:27702879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27702879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/0271678x16672482","doi":"https://doi.org/10.1177/0271678x16672482","is_oa":true,"landing_page_url":"https://doi.org/10.1177/0271678x16672482","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/0271678X16672482","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3406280980","display_name":"Endovascular Devices and Vascular Repair","funder_award_id":"R01GM049039","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528914818.pdf"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W58419149","https://openalex.org/W1147956078","https://openalex.org/W1561858733","https://openalex.org/W1684804860","https://openalex.org/W1963535811","https://openalex.org/W1968150858","https://openalex.org/W1970263371","https://openalex.org/W1983595498","https://openalex.org/W1985038074","https://openalex.org/W1995627194","https://openalex.org/W2004723568","https://openalex.org/W2009344769","https://openalex.org/W2009842133","https://openalex.org/W2020946741","https://openalex.org/W2028507273","https://openalex.org/W2030588597","https://openalex.org/W2037426713","https://openalex.org/W2037481900","https://openalex.org/W2040490831","https://openalex.org/W2050537391","https://openalex.org/W2058794464","https://openalex.org/W2070114011","https://openalex.org/W2081135553","https://openalex.org/W2082121172","https://openalex.org/W2093491806","https://openalex.org/W2095298843","https://openalex.org/W2102801765","https://openalex.org/W2106468847","https://openalex.org/W2110885875","https://openalex.org/W2116383251","https://openalex.org/W2117691576","https://openalex.org/W2120206472","https://openalex.org/W2121636548","https://openalex.org/W2138465150","https://openalex.org/W2138852525","https://openalex.org/W2139671059","https://openalex.org/W2148910661","https://openalex.org/W2157454176","https://openalex.org/W2163808515","https://openalex.org/W2167279371","https://openalex.org/W2196906371","https://openalex.org/W2246007286"],"related_works":["https://openalex.org/W2740294724","https://openalex.org/W2162913942","https://openalex.org/W1976439848","https://openalex.org/W1973651527","https://openalex.org/W4281753424","https://openalex.org/W3167221900","https://openalex.org/W2081135553","https://openalex.org/W2727207578","https://openalex.org/W7096669787","https://openalex.org/W4412419246"],"abstract_inverted_index":{"Microvascular":[0],"endothelial":[1,53,64,76],"cells":[2,65,77,128],"at":[3,30],"the":[4,143],"blood\u2013brain":[5],"barrier":[6,152,191],"exhibit":[7],"a":[8,60],"protective":[9],"phenotype,":[10],"which":[11,193],"is":[12,48],"highly":[13],"induced":[14],"by":[15,135,197],"biochemical":[16],"and":[17,27,102,122,176],"biomechanical":[18],"stimuli.":[19],"Amongst":[20],"them,":[21],"shear":[22,87,108,131,175,182],"stress":[23,109,132,183],"enhances":[24],"junctional":[25,124,156],"tightness":[26],"limits":[28],"transport":[29],"capillary-like":[31,136],"levels.":[32],"Abnormal":[33],"flow":[34,71,84],"patterns":[35,133],"can":[36],"reduce":[37],"functional":[38],"features":[39],"of":[40,63,94,145,151],"macrovascular":[41],"endothelium.":[42],"We":[43,55,126],"now":[44],"examine":[45],"if":[46],"this":[47,58],"true":[49],"in":[50,57],"brain":[51,74],"microvascular":[52,75],"cells.":[54],"suggest":[56],"paper":[59],"complex":[61],"response":[62],"to":[66,80,119,129,166,185,190],"aberrant":[67],"forces":[68],"under":[69,173],"different":[70],"domains.":[72],"Human":[73],"were":[78],"exposed":[79,127],"physiological":[81],"or":[82],"abnormal":[83,181],"patterns.":[85],"Physiologic":[86],"(10\u201320":[88],"dyn/cm":[89,111],"2":[90,112],")":[91,113],"upregulates":[92],"expression":[93,118,144],"tight":[95,146],"junction":[96,147],"markers":[97],"Zona":[98],"Occludens":[99],"1":[100],"(1.7-fold)":[101],"Claudin-5":[103],"(more":[104],"than":[105],"2-fold).":[106],"High":[107],"(40":[110],"and/or":[114],"pulsatility":[115],"decreased":[116],"their":[117],"basal":[120],"levels":[121],"altered":[123],"morphology.":[125],"pathological":[130],"followed":[134],"conditions.":[137,168],"Results":[138],"showed":[139],"reversible":[140],"recovery":[141],"on":[142],"markers.":[148],"Flow":[149],"protection":[150],"phenotype":[153],"commensurate":[154],"with":[155],"signaling":[157],"pathways":[158],"decrease":[159,170],"(Src,":[160],"0.25-fold,":[161],"ERK,":[162],"0.77-fold)":[163],"when":[164],"compared":[165],"static":[167],"This":[169],"was":[171],"lost":[172],"high":[174],"pulsatile":[177],"flow.":[178],"In":[179],"conclusion,":[180],"inherent":[184],"systemic":[186],"vascular":[187],"disease":[188],"leads":[189],"impairment,":[192],"could":[194],"be":[195],"reverted":[196],"hemodynamic":[198],"interventions.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-14T00:00:00"}