{"id":"https://openalex.org/W2528800307","doi":"https://doi.org/10.1038/srep32400","title":"Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine","display_name":"Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine","publication_year":2016,"publication_date":"2016-09-06","ids":{"openalex":"https://openalex.org/W2528800307","doi":"https://doi.org/10.1038/srep32400","mag":"2528800307","pmid":"https://pubmed.ncbi.nlm.nih.gov/27597117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5011655"},"language":"en","primary_location":{"id":"doi:10.1038/srep32400","doi":"https://doi.org/10.1038/srep32400","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep32400","pdf_url":"https://www.nature.com/articles/srep32400.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep32400.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109110678","display_name":"Wenjuan Zhang","orcid":"https://orcid.org/0000-0002-8815-2687","observed_orcids":["https://orcid.org/0000-0002-8815-2687"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjuan Zhang","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054912558","display_name":"Tao Qin","orcid":"https://orcid.org/0000-0002-0128-8961","observed_orcids":["https://orcid.org/0000-0002-0128-8961"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Tao","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040659626","display_name":"Zihu Guo","orcid":"https://orcid.org/0000-0003-3975-3141","observed_orcids":["https://orcid.org/0000-0003-3975-3141"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihu Guo","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014499114","display_name":"Yingxue Fu","orcid":"https://orcid.org/0000-0003-3052-4131","observed_orcids":["https://orcid.org/0000-0003-3052-4131"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingxue Fu","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019183946","display_name":"Xuetong Chen","orcid":"https://orcid.org/0000-0002-0566-0740","observed_orcids":["https://orcid.org/0000-0002-0566-0740"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuetong Chen","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006188194","display_name":"Piar Ali Shar","orcid":"https://orcid.org/0000-0002-4269-8510","observed_orcids":["https://orcid.org/0000-0002-4269-8510"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Piar Ali Shar","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086841721","display_name":"Mohamed Shahen","orcid":"https://orcid.org/0000-0003-3608-2581","observed_orcids":["https://orcid.org/0000-0003-3608-2581"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mohamed Shahen","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076878130","display_name":"Jinglin Zhu","orcid":"https://orcid.org/0000-0001-6511-1615","observed_orcids":["https://orcid.org/0000-0001-6511-1615","https://orcid.org/0000-0002-6666-0912"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinglin Zhu","raw_affiliation_strings":["College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China","College of Life Science, Northwest University, Xi'an, 710069, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"College of Life Science, Northwest University, Xi'an, 710069, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047392474","display_name":"Jun Xue","orcid":"https://orcid.org/0000-0002-0754-3812","observed_orcids":["https://orcid.org/0000-0002-0754-3812"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Xue","raw_affiliation_strings":["College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China","College of Life Science, Northwest University, Xi'an, 710069, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"College of Life Science, Northwest University, Xi'an, 710069, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026212538","display_name":"Yaofei Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaofei Bai","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009666189","display_name":"Ziyin Wu","orcid":"https://orcid.org/0000-0002-3382-2620","observed_orcids":["https://orcid.org/0000-0002-3382-2620"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyin Wu","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Center of Bioinformatics, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676554","display_name":"Zhenzhong Wang","orcid":"https://orcid.org/0000-0002-1364-3537","observed_orcids":["https://orcid.org/0000-0002-1364-3537"]},"institutions":[{"id":"https://openalex.org/I4391767800","display_name":"State Key Laboratory of New Technology of Traditional Chinese Medicine Pharmaceutical Process","ror":"https://ror.org/0216pay70","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210096033","https://openalex.org/I4391767800"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenzhong Wang","raw_affiliation_strings":["State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China","State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, 222001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China","institution_ids":["https://openalex.org/I4391767800"]},{"raw_affiliation_string":"State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, 222001, Jiangsu, China","institution_ids":["https://openalex.org/I4391767800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446383","display_name":"Wei Xiao","orcid":"https://orcid.org/0000-0001-8809-9137","observed_orcids":["https://orcid.org/0000-0001-8809-9137","https://orcid.org/0000-0002-8426-9060"]},"institutions":[{"id":"https://openalex.org/I4391767800","display_name":"State Key Laboratory of New Technology of Traditional Chinese Medicine Pharmaceutical Process","ror":"https://ror.org/0216pay70","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210096033","https://openalex.org/I4391767800"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Xiao","raw_affiliation_strings":["State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China","State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, 222001, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China","institution_ids":["https://openalex.org/I4391767800"]},{"raw_affiliation_string":"State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, 222001, Jiangsu, China","institution_ids":["https://openalex.org/I4391767800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100700947","display_name":"Yonghua Wang","orcid":"https://orcid.org/0000-0002-3060-1072","observed_orcids":["https://orcid.org/0000-0002-3060-1072"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yonghua Wang","raw_affiliation_strings":["Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Bioinformatics, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A &F University, Yangling, Shaanxi 712100, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Life Science, Northwest A & F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100446383","https://openalex.org/A5100700947"],"corresponding_institution_ids":["https://openalex.org/I4391767800","https://openalex.org/I89652312"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":17.0961,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.99341433,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"32400","last_page":"32400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.4336000084877014,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.12620000541210175,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/gastrointestinal-diseases","display_name":"gastrointestinal diseases","score":0.9959999918937683},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chinese-patent-medicine","display_name":"Chinese patent medicine","score":0.902999997138977},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/chronic-gastritis","display_name":"chronic gastritis","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.5626299381256104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5283811092376709},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.5140684843063354},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3619942367076874},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32393813133239746},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2897360026836395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22519207000732422},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10687506198883057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10282787680625916}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008516","descriptor_name":"Medicine, Chinese Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep32400","doi":"https://doi.org/10.1038/srep32400","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep32400","pdf_url":"https://www.nature.com/articles/srep32400.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3979051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5011655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5011655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5011655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:27597117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27597117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep32400","doi":"https://doi.org/10.1038/srep32400","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep32400","pdf_url":"https://www.nature.com/articles/srep32400.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5378857023","display_name":null,"funder_award_id":"81373892","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6944845745","display_name":null,"funder_award_id":"31170796","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528800307.pdf","grobid_xml":"https://content.openalex.org/works/W2528800307.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W18850067","https://openalex.org/W584073952","https://openalex.org/W1488219765","https://openalex.org/W1524425768","https://openalex.org/W1529474538","https://openalex.org/W1558848028","https://openalex.org/W1568614209","https://openalex.org/W1593511408","https://openalex.org/W1611032359","https://openalex.org/W1611522350","https://openalex.org/W1684025987","https://openalex.org/W1685675634","https://openalex.org/W1744094582","https://openalex.org/W1929009802","https://openalex.org/W1963607437","https://openalex.org/W1966330696","https://openalex.org/W1966866954","https://openalex.org/W1967239730","https://openalex.org/W1968568233","https://openalex.org/W1970477038","https://openalex.org/W1973237056","https://openalex.org/W1973677547","https://openalex.org/W1976950766","https://openalex.org/W1981714984","https://openalex.org/W1983198554","https://openalex.org/W1983248350","https://openalex.org/W1991407158","https://openalex.org/W1995731966","https://openalex.org/W1996315798","https://openalex.org/W1998086294","https://openalex.org/W1998352087","https://openalex.org/W2001514360","https://openalex.org/W2002941441","https://openalex.org/W2007452107","https://openalex.org/W2011024204","https://openalex.org/W2012175433","https://openalex.org/W2015523093","https://openalex.org/W2016513155","https://openalex.org/W2016859011","https://openalex.org/W2028246702","https://openalex.org/W2029218654","https://openalex.org/W2029236582","https://openalex.org/W2033539243","https://openalex.org/W2033591223","https://openalex.org/W2034456143","https://openalex.org/W2034657871","https://openalex.org/W2037159578","https://openalex.org/W2038876241","https://openalex.org/W2040704062","https://openalex.org/W2040724811","https://openalex.org/W2041542272","https://openalex.org/W2041642993","https://openalex.org/W2042281019","https://openalex.org/W2043944220","https://openalex.org/W2044002635","https://openalex.org/W2044590840","https://openalex.org/W2049421636","https://openalex.org/W2050113624","https://openalex.org/W2050394599","https://openalex.org/W2052160542","https://openalex.org/W2055874563","https://openalex.org/W2059471041","https://openalex.org/W2061390429","https://openalex.org/W2063252458","https://openalex.org/W2063664815","https://openalex.org/W2063776820","https://openalex.org/W2064822275","https://openalex.org/W2068072034","https://openalex.org/W2068950612","https://openalex.org/W2070603512","https://openalex.org/W2071524497","https://openalex.org/W2076804940","https://openalex.org/W2077987760","https://openalex.org/W2080055141","https://openalex.org/W2084616395","https://openalex.org/W2085030971","https://openalex.org/W2086005158","https://openalex.org/W2087783979","https://openalex.org/W2088114116","https://openalex.org/W2088679211","https://openalex.org/W2096011595","https://openalex.org/W2096729078","https://openalex.org/W2096912173","https://openalex.org/W2098780362","https://openalex.org/W2099530558","https://openalex.org/W2100533276","https://openalex.org/W2102304330","https://openalex.org/W2103951757","https://openalex.org/W2108172198","https://openalex.org/W2109108939","https://openalex.org/W2110543971","https://openalex.org/W2112720988","https://openalex.org/W2118374441","https://openalex.org/W2121297790","https://openalex.org/W2122353807","https://openalex.org/W2124001239","https://openalex.org/W2124023437","https://openalex.org/W2124757426","https://openalex.org/W2128921112","https://openalex.org/W2129991662","https://openalex.org/W2130034040","https://openalex.org/W2137200212","https://openalex.org/W2139243915","https://openalex.org/W2140883620","https://openalex.org/W2144393227","https://openalex.org/W2150124540","https://openalex.org/W2151155970","https://openalex.org/W2157767490","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2166444451","https://openalex.org/W2167366369","https://openalex.org/W2168129192","https://openalex.org/W2170146596","https://openalex.org/W2222010873","https://openalex.org/W2225966607","https://openalex.org/W2241011319","https://openalex.org/W2270159095","https://openalex.org/W2283632926","https://openalex.org/W2350072852","https://openalex.org/W2368235651","https://openalex.org/W2373080450","https://openalex.org/W2386526056","https://openalex.org/W2388458481","https://openalex.org/W2397818397","https://openalex.org/W2402745852","https://openalex.org/W2407041001","https://openalex.org/W2414102723","https://openalex.org/W2491614536","https://openalex.org/W2764372892","https://openalex.org/W2786581080","https://openalex.org/W3021063182","https://openalex.org/W3090972752","https://openalex.org/W4239516903","https://openalex.org/W4255564469","https://openalex.org/W4288074524","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2069370134","https://openalex.org/W562013881","https://openalex.org/W2805944259","https://openalex.org/W2076294237","https://openalex.org/W7097724597","https://openalex.org/W1529474538","https://openalex.org/W2781577643","https://openalex.org/W3006073071","https://openalex.org/W2255389592","https://openalex.org/W2800907049"],"abstract_inverted_index":{"Though":[0],"cardiovascular":[1],"diseases":[2,10,144],"(CVDs)":[3],"and":[4,58,71,73,90,96,110,164],"gastrointestinal":[5],"disorders":[6],"(GIDs)":[7],"are":[8,16,67,78],"different":[9,13,143],"associated":[11,68,194],"with":[12,69],"organs,":[14],"they":[15],"highly":[17],"correlated":[18],"clinically.":[19],"Importantly,":[20],"in":[21,32,100,161],"Traditional":[22],"Chinese":[23,101],"Medicine":[24],"(TCM),":[25],"similar":[26],"treatment":[27],"strategies":[28],"have":[29],"been":[30],"applied":[31,131],"both":[33,108,162],"diseases.":[34,195],"However,":[35],"the":[36,53,82,116,148,169,173],"etiological":[37],"mechanisms":[38,141],"underlying":[39],"them":[40],"remain":[41],"unclear.":[42],"Here,":[43],"an":[44],"integrated":[45,186],"systems":[46,181],"pharmacology":[47,182],"approach":[48],"is":[49],"presented":[50],"for":[51,177,188,192],"illustrating":[52],"molecular":[54],"correlations":[55],"between":[56,84],"CVDs":[57,70,109,163],"GIDs.":[59,165],"Firstly,":[60],"we":[61,130],"identified":[62],"pairs":[63],"of":[64,142,175],"genes":[65,77],"that":[66,75,107,139,154],"GIDs":[72,111],"found":[74],"these":[76],"functionally":[79],"related.":[80],"Then,":[81],"association":[83],"115":[85],"heart":[86],"meridian":[87,93],"(HM)":[88],"herbs":[89,95],"163":[91],"stomach":[92],"(SM)":[94],"their":[97],"combination":[98],"application":[99],"patent":[102],"medicine":[103],"was":[104],"investigated,":[105],"implying":[106],"can":[112],"be":[113],"treated":[114,146],"by":[115,120,147,172],"same":[117,149],"strategy.":[118,150],"Exemplified":[119],"a":[121,136,184],"classical":[122],"formula":[123],"Sanhe":[124],"Decoration":[125],"(SHD)":[126],"treating":[127],"chronic":[128],"gastritis,":[129],"systems-based":[132],"analysis":[133],"to":[134],"introduce":[135],"drug-target-pathway-organ":[137],"network":[138],"clarifies":[140],"being":[145],"The":[151,180],"results":[152],"indicate":[153],"SHD":[155,176],"regulated":[156],"several":[157],"pathological":[158],"processes":[159],"involved":[160],"We":[166],"experimentally":[167],"confirmed":[168],"predictions":[170],"implied":[171],"effect":[174],"myocardial":[178],"ischemia.":[179],"suggests":[183],"novel":[185],"strategy":[187],"rational":[189],"drug":[190],"development":[191],"complex":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-14T00:00:00"}
