{"id":"https://openalex.org/W2528531237","doi":null,"title":"Regulation of Pygopus (hPygo2) expression in prostate cancer by E74-Like factor 1 (Elf-1) transcription factor","display_name":"Regulation of Pygopus (hPygo2) expression in prostate cancer by E74-Like factor 1 (Elf-1) transcription factor","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2528531237","mag":"2528531237"},"language":"en","primary_location":{"id":"pmh:oai:research.library.mun.ca:11945","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/11945/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/48c46d24-adcb-42a5-8029-66386c76edc7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://memorial.scholaris.ca/bitstreams/48c46d24-adcb-42a5-8029-66386c76edc7/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031279490","display_name":"Paola Gonzalez Aguirre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paola Gonzalez Aguirre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031279490"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elf1","display_name":"ELF1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.8949999809265137},{"id":"https://openalex.org/keywords/22rv1","display_name":"22Rv1 cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8387176990509033},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.682711124420166},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6675156354904175},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6529265642166138},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6505364179611206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47477006912231445},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.46767815947532654},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46613284945487976},{"id":"https://openalex.org/C81350143","wikidata":"https://www.wikidata.org/wiki/Q5324485","display_name":"ETS transcription factor family","level":4,"score":0.4145585894584656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3467503786087036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33995795249938965},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3322480022907257},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.24313154816627502},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18116497993469238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12772125005722046}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:research.library.mun.ca:11945","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/11945/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/48c46d24-adcb-42a5-8029-66386c76edc7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:memorial.scholaris.ca:20.500.14783/13709","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.14783/13709","pdf_url":null,"source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Master thesis"},{"id":"mag:2528531237","doi":null,"is_oa":false,"landing_page_url":"https://research.library.mun.ca/11945/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:research.library.mun.ca:11945","doi":null,"is_oa":true,"landing_page_url":"http://research.library.mun.ca/11945/1/thesis.pdf","pdf_url":"https://memorial.scholaris.ca/bitstreams/48c46d24-adcb-42a5-8029-66386c76edc7/download","source":{"id":"https://openalex.org/S4306401319","display_name":"Memorial University Research Repository (Memorial University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130438778","host_organization_name":"Memorial University of Newfoundland","host_organization_lineage":["https://openalex.org/I130438778"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528531237.pdf","grobid_xml":"https://content.openalex.org/works/W2528531237.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W19254763","https://openalex.org/W120390722","https://openalex.org/W165062961","https://openalex.org/W190857994","https://openalex.org/W1419228847","https://openalex.org/W1486510760","https://openalex.org/W1514146345","https://openalex.org/W1516532472","https://openalex.org/W1606273823","https://openalex.org/W1866291481","https://openalex.org/W1868732334","https://openalex.org/W1911919368","https://openalex.org/W1913797671","https://openalex.org/W1922704711","https://openalex.org/W1953156003","https://openalex.org/W1967252387","https://openalex.org/W1969499006","https://openalex.org/W1982544588","https://openalex.org/W1985177466","https://openalex.org/W1990287298","https://openalex.org/W1990726951","https://openalex.org/W1995662812","https://openalex.org/W1996118868","https://openalex.org/W1996487270","https://openalex.org/W1999560120","https://openalex.org/W2000040073","https://openalex.org/W2000385281","https://openalex.org/W2003546293","https://openalex.org/W2003696158","https://openalex.org/W2005658600","https://openalex.org/W2011200051","https://openalex.org/W2011331611","https://openalex.org/W2018011160","https://openalex.org/W2019549684","https://openalex.org/W2019884543","https://openalex.org/W2025707029","https://openalex.org/W2027011635","https://openalex.org/W2027618137","https://openalex.org/W2030687108","https://openalex.org/W2039190435","https://openalex.org/W2041286355","https://openalex.org/W2041365664","https://openalex.org/W2041754318","https://openalex.org/W2045917414","https://openalex.org/W2046240800","https://openalex.org/W2048486094","https://openalex.org/W2049541774","https://openalex.org/W2053831552","https://openalex.org/W2055624097","https://openalex.org/W2056372829","https://openalex.org/W2062006040","https://openalex.org/W2062393124","https://openalex.org/W2063409224","https://openalex.org/W2064293531","https://openalex.org/W2069591126","https://openalex.org/W2070044201","https://openalex.org/W2070404499","https://openalex.org/W2074124897","https://openalex.org/W2076073895","https://openalex.org/W2076735703","https://openalex.org/W2077728541","https://openalex.org/W2082214219","https://openalex.org/W2082462837","https://openalex.org/W2084671890","https://openalex.org/W2086152285","https://openalex.org/W2087321474","https://openalex.org/W2089841267","https://openalex.org/W2091564367","https://openalex.org/W2092021778","https://openalex.org/W2092588668","https://openalex.org/W2093432933","https://openalex.org/W2093456791","https://openalex.org/W2094967080","https://openalex.org/W2095924422","https://openalex.org/W2096071102","https://openalex.org/W2098395472","https://openalex.org/W2101436494","https://openalex.org/W2103555733","https://openalex.org/W2105779346","https://openalex.org/W2106733257","https://openalex.org/W2121158863","https://openalex.org/W2121288046","https://openalex.org/W2123230901","https://openalex.org/W2134825260","https://openalex.org/W2137330819","https://openalex.org/W2139739677","https://openalex.org/W2141019253","https://openalex.org/W2144498681","https://openalex.org/W2145718840","https://openalex.org/W2146294552","https://openalex.org/W2148416479","https://openalex.org/W2152570672","https://openalex.org/W2154111513","https://openalex.org/W2156206743","https://openalex.org/W2156791505","https://openalex.org/W2157820793","https://openalex.org/W2161315124","https://openalex.org/W2161476839","https://openalex.org/W2162052656","https://openalex.org/W2162923066","https://openalex.org/W2171367875","https://openalex.org/W2171464509","https://openalex.org/W2188782771","https://openalex.org/W2189503017","https://openalex.org/W2208432677","https://openalex.org/W2334886854","https://openalex.org/W2417875870","https://openalex.org/W2511949746","https://openalex.org/W2520632143","https://openalex.org/W7099717845"],"related_works":["https://openalex.org/W2003058643","https://openalex.org/W7100212434","https://openalex.org/W2098395472","https://openalex.org/W2947468386","https://openalex.org/W2751921824","https://openalex.org/W1995662812","https://openalex.org/W2762877916","https://openalex.org/W4224723143","https://openalex.org/W3157844111","https://openalex.org/W1974057214"],"abstract_inverted_index":{"Prostate":[0,77],"cancer":[1,78],"is":[2,10,23,68],"a":[3],"worldwide":[4],"health":[5],"concern.":[6],"Pygopus2":[7],"(hPygo2)":[8],"protein":[9,28,85,122],"required":[11],"for":[12],"growth":[13],"in":[14,34,46,59,120,127,141,147],"breast,":[15],"ovarian,":[16],"cervical":[17,35],"and":[18,36,48,90,100],"prostate":[19,60,148],"cancer.":[20,38,61,149],"hPygo2":[21,53,66,121],"expression":[22,54,67,146],"regulated":[24,69],"by":[25,70],"the":[26,30,40,104,142],"Rb":[27],"via":[29],"ETS":[31,41,101],"factor":[32],"Elf-1":[33,71,89,99,111,135],"breast":[37],"Additionally,":[39],"family":[42],"has":[43,55],"confirmed":[44,94],"roles":[45],"carcinogenesis":[47],"proliferation.":[49],"The":[50],"mechanism":[51],"of":[52,87,98,144],"not":[56,137],"been":[57],"elucidated":[58],"My":[62],"hypothesis":[63],"proposes":[64],"that":[65,134],"bound":[72],"to":[73,83,103],"its":[74],"promoter":[75,106],"region.":[76],"cell":[79,109],"lines":[80],"were":[81,114],"used":[82],"show":[84,117,125],"levels":[86,123],"hPygo2,":[88],"ETS.":[91],"ChIP":[92],"assays":[93],"varying":[95],"binding":[96],"capability":[97],"factors":[102],"proximal":[105],"region":[107],"between":[108],"lines.":[110],"knockdown":[112],"experiments":[113],"performed,":[115],"results":[116,132],"no":[118],"change":[119],"but":[124],"reduction":[126],"22Rv1":[128],"mRNA":[129],"levels.":[130],"These":[131],"suggest":[133],"might":[136],"be":[138],"exclusively":[139],"involved":[140],"activation":[143],"Pygopus":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-14T00:00:00"}
