{"id":"https://openalex.org/W2528397405","doi":null,"title":"Plasmid-mediated restriction evasion mechanisms","display_name":"Plasmid-mediated restriction evasion mechanisms","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2528397405","mag":"2528397405"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10165262","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","pdf_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111922782","display_name":"Nicola J. Althorpe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nicola J. Althorpe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111922782"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/incp-plasmids","display_name":"IncP plasmids","score":0.5789999961853027},{"id":"https://openalex.org/keywords/plasmid-conjugation","display_name":"plasmid conjugation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/type-i-restriction-enzymes","display_name":"type I restriction enzymes","score":0.7599999904632568},{"id":"https://openalex.org/keywords/type-ii-restriction-enzymes","display_name":"type II restriction enzymes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ecoki","display_name":"EcoKI","score":0.7080000042915344},{"id":"https://openalex.org/keywords/ecori","display_name":"EcoRI","score":0.9990000128746033},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.7448278665542603},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.7091532945632935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3559930920600891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34955835342407227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19735923409461975},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07757207751274109}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10165262","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","pdf_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/30313","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/30313","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ProQuest","raw_type":"Thesis"},{"id":"mag:2528397405","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696625","pdf_url":null,"source":{"id":"https://openalex.org/S4306478302","display_name":"ProQuest LLC eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"ProQuest eBooks","raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10165262","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","pdf_url":"https://figshare.com/articles/thesis/Plasmid-mediated_restriction_evasion_mechanisms/10165262","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528397405.pdf","grobid_xml":"https://content.openalex.org/works/W2528397405.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W2173477","https://openalex.org/W11096920","https://openalex.org/W14153436","https://openalex.org/W24924547","https://openalex.org/W1494436596","https://openalex.org/W1498106506","https://openalex.org/W1500447870","https://openalex.org/W1501928313","https://openalex.org/W1506076499","https://openalex.org/W1516660050","https://openalex.org/W1526701908","https://openalex.org/W1547227838","https://openalex.org/W1547417076","https://openalex.org/W1560827533","https://openalex.org/W1563630112","https://openalex.org/W1566339430","https://openalex.org/W1580123059","https://openalex.org/W1583470782","https://openalex.org/W1591316649","https://openalex.org/W1606511676","https://openalex.org/W1608292591","https://openalex.org/W1626003942","https://openalex.org/W1632802381","https://openalex.org/W1663543327","https://openalex.org/W1672673183","https://openalex.org/W1715057838","https://openalex.org/W1741082581","https://openalex.org/W1803661918","https://openalex.org/W1812531649","https://openalex.org/W1823547933","https://openalex.org/W1855475827","https://openalex.org/W1859453763","https://openalex.org/W1864277827","https://openalex.org/W1878286238","https://openalex.org/W1879050837","https://openalex.org/W1890597695","https://openalex.org/W1896949066","https://openalex.org/W1897176773","https://openalex.org/W1905982714","https://openalex.org/W1912451872","https://openalex.org/W1916669592","https://openalex.org/W1924027056","https://openalex.org/W1931823120","https://openalex.org/W1945265201","https://openalex.org/W1952802364","https://openalex.org/W1957929706","https://openalex.org/W1962724431","https://openalex.org/W1965301838","https://openalex.org/W1967164846","https://openalex.org/W1967359353","https://openalex.org/W1967994784","https://openalex.org/W1971403296","https://openalex.org/W1971544871","https://openalex.org/W1973232347","https://openalex.org/W1981423406","https://openalex.org/W1981501758","https://openalex.org/W1982941484","https://openalex.org/W1983407475","https://openalex.org/W1987083970","https://openalex.org/W1992033009","https://openalex.org/W1995782156","https://openalex.org/W1996696616","https://openalex.org/W2001949982","https://openalex.org/W2003798555","https://openalex.org/W2006501102","https://openalex.org/W2008841090","https://openalex.org/W2009818318","https://openalex.org/W2010618176","https://openalex.org/W2011655552","https://openalex.org/W2012434855","https://openalex.org/W2015292449","https://openalex.org/W2016456590","https://openalex.org/W2016498953","https://openalex.org/W2019410656","https://openalex.org/W2023948509","https://openalex.org/W2024168261","https://openalex.org/W2024322354","https://openalex.org/W2025104601","https://openalex.org/W2025186867","https://openalex.org/W2028073132","https://openalex.org/W2028622989","https://openalex.org/W2031726441","https://openalex.org/W2033165342","https://openalex.org/W2034079328","https://openalex.org/W2035397287","https://openalex.org/W2037530660","https://openalex.org/W2039752084","https://openalex.org/W2042843114","https://openalex.org/W2044069937","https://openalex.org/W2044152989","https://openalex.org/W2044763769","https://openalex.org/W2045659490","https://openalex.org/W2047291031","https://openalex.org/W2047521874","https://openalex.org/W2050378502","https://openalex.org/W2051689013","https://openalex.org/W2053102339","https://openalex.org/W2055043387","https://openalex.org/W2055107080","https://openalex.org/W2056865033","https://openalex.org/W2058688042","https://openalex.org/W2063564708","https://openalex.org/W2072705379","https://openalex.org/W2076614755","https://openalex.org/W2077153159","https://openalex.org/W2079254989","https://openalex.org/W2090591267","https://openalex.org/W2093267203","https://openalex.org/W2099196052","https://openalex.org/W2102752848","https://openalex.org/W2106150306","https://openalex.org/W2114213729","https://openalex.org/W2115706357","https://openalex.org/W2119978464","https://openalex.org/W2123116314","https://openalex.org/W2124458786","https://openalex.org/W2128764801","https://openalex.org/W2128884353","https://openalex.org/W2131114241","https://openalex.org/W2133440572","https://openalex.org/W2134153749","https://openalex.org/W2134378643","https://openalex.org/W2135066355","https://openalex.org/W2137500187","https://openalex.org/W2138424273","https://openalex.org/W2138987457","https://openalex.org/W2139114401","https://openalex.org/W2139536119","https://openalex.org/W2142624423","https://openalex.org/W2153360635","https://openalex.org/W2156419995","https://openalex.org/W2159293448","https://openalex.org/W2161524167","https://openalex.org/W2163997813","https://openalex.org/W2179631201","https://openalex.org/W2321041782","https://openalex.org/W2328383093","https://openalex.org/W2407876580","https://openalex.org/W2425136395","https://openalex.org/W2497771693","https://openalex.org/W2535950417","https://openalex.org/W2747853480"],"related_works":["https://openalex.org/W2535950417","https://openalex.org/W2052847804","https://openalex.org/W1916669592","https://openalex.org/W7097528510","https://openalex.org/W2041625042","https://openalex.org/W1763400538","https://openalex.org/W2159293448","https://openalex.org/W2417830088","https://openalex.org/W7096209983","https://openalex.org/W1524357749"],"abstract_inverted_index":{"Plasmid":[0],"ColIb-P9":[1],"(Incll)":[2],"encodes":[3],"mechanisms":[4,278],"which":[5,77,163,251],"allow":[6],"it":[7],"to":[8,33,65,149,173,203,280],"avoid":[9],"destruction":[10,51],"by":[11,21,52,95,120,210,303,332],"type":[12,15,81,260,263,286,299],"I":[13,82,261,287],"and":[14,56,110,212,232,262,292],"II":[16,264,300],"restriction":[17,89,257,288,301,319],"enzymes":[18,265],"during":[19,178,247],"transfer":[20,137,140],"conjugation":[22],"between":[23],"strains":[24],"of":[25,44,76,87,90,122,128,141,161,170,182,185,230,238,254,258,274,285,298,314],"Escherichia":[26],"coli.":[27],"A":[28],"genetic":[29],"system":[30,38,320],"was":[31,63,105,115],"developed":[32],"analyse":[34],"these":[35,222],"mechanisms.":[36],"The":[37,152,307],"relied":[39],"on":[40,241],"measuring":[41],"Collb-mediated":[42],"rescue":[43],"the":[45,74,108,118,133,142,147,150,158,167,171,175,194,227,242,267,318],"restriction-sensitive":[46],"plasmid":[47,172,244],"R751":[48],"(IncPp)":[49],"from":[50,146],"EcoKI":[53,88],"(type":[54,58],"I)":[55],"EcoRI":[57],"II).":[59],"One":[60],"Collb":[61,98,104,114,231],"mechanism":[62],"known":[64,71],"involve":[66],"a":[67,96,204,304],"plasmid-encoded":[68],"antirestriction":[69],"gene":[70,154],"as":[72,166,234],"ardA,":[73,255],"product":[75],"is":[78,130,155,164,219,293,302,329],"active":[79],"against":[80],"enzymes.":[83],"Tests":[84],"for":[85,236],"alleviation":[86,284,297],"R751,":[91],"showed":[92],"strong":[93],"protection":[94,102],"co-transferring":[97],"(Ard+)":[99],"plasmid,":[100],"slight":[101],"when":[103,113],"resident":[106],"in":[107,117,132,157,226,266,269,290],"recipient":[109,134,176,268],"no":[111,138],"effect":[112],"immobilised":[116],"donor":[119,148],"removal":[121],"its":[123],"nic":[124],"site.":[125],"Hence,":[126],"expression":[127],"ardA":[129,153],"activated":[131],"cell":[135,177],"following":[136],"detectable":[139],"ArdA":[143],"protein":[144],"occurs":[145,289],"recipient.":[151],"found":[156],"leading":[159],"region":[160,187,195],"Collb,":[162],"defined":[165],"first":[168],"segment":[169],"enter":[174],"conjugation.":[179,248],"Nucleotide":[180],"sequencing":[181],"11.7":[183],"kb":[184],"this":[186],"identified":[188],"ten":[189],"open":[190],"reading":[191],"frames.":[192],"Furthermore,":[193],"also":[196],"contains":[197],"three":[198],"dispersed":[199],"repeat":[200],"sequences":[201],"homologous":[202],"novel":[205],"single-stranded":[206],"DNA":[207,316],"promoter":[208],"described":[209],"Masai":[211],"Arai":[213],"(1997,":[214],"Cell":[215],"89,":[216],"897-907).":[217],"It":[218],"proposed":[220],"that":[221],"secondary":[223],"structures":[224],"form":[225],"transferring":[228],"T-strand":[229],"function":[233],"promoters":[235],"transcription":[237],"genes":[239],"encoded":[240],"unique":[243],"strand":[245],"transferred":[246,315],"Another":[249],"mechanism,":[250],"acts":[252],"independently":[253],"alleviates":[256],"both":[259],"second":[270],"or":[271],"subsequent":[272],"rounds":[273],"transfer.":[275],"Two":[276],"separate":[277],"appear":[279],"be":[281],"operating":[282],"since":[283],"trans":[291],"constitutive.":[294],"In":[295],"contrast,":[296],"czs-acting":[305],"mechanism.":[306],"'substrate":[308],"saturation'":[309],"hypothesis,":[310],"whereby":[311],"increasing":[312],"amounts":[313],"saturates":[317],"(Read":[321],"et":[322],"al.":[323],"1992,":[324],"Mol":[325],"Microbiol":[326],"6,":[327],"1933-1941)":[328],"ruled":[330],"out":[331],"data":[333],"presented.":[334]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-14T00:00:00"}
