{"id":"https://openalex.org/W2528166135","doi":null,"title":"THERAPEUTIC EFFECTS OF OSTEOPROTEGERIN ON A RAT OSTEOLYSIMODEL","display_name":"THERAPEUTIC EFFECTS OF OSTEOPROTEGERIN ON A RAT OSTEOLYSIMODEL","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2528166135","mag":"2528166135"},"language":"en","primary_location":{"id":"mag:2528166135","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/abs/10.1302/0301-620X.90BSUPP_I.0880171b","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078521898","display_name":"Kang-Jung Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kang-Jung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112542477","display_name":"Kenji Kaneko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenji Kaneko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062709546","display_name":"Miho Iwase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miho Iwase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014524707","display_name":"Taiki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taiki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"171","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":1.0},{"id":"https://openalex.org/keywords/periprosthetic-osteolysis","display_name":"periprosthetic osteolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polyethylene-wear-particles","display_name":"polyethylene wear particles","score":0.7559999823570251},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.675000011920929},{"id":"https://openalex.org/keywords/revision-arthroplasty","display_name":"revision arthroplasty","score":0.6470000147819519},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.942956268787384},{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.8893882036209106},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.8351526856422424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6980595588684082},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6169561147689819},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5592973232269287},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.4324350655078888},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.4276866316795349},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4144671559333801},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.36048662662506104},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3055908977985382},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.1997748613357544},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.1853432059288025},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06615826487541199},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.06443622708320618}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2528166135","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/abs/10.1302/0301-620X.90BSUPP_I.0880171b","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1641551043","https://openalex.org/W2411360890","https://openalex.org/W3089221542","https://openalex.org/W2029051823","https://openalex.org/W194340635","https://openalex.org/W1978839856","https://openalex.org/W2000647744","https://openalex.org/W2074246760","https://openalex.org/W1984389510","https://openalex.org/W2001073990"],"abstract_inverted_index":{"Osteoprotegerin":[0],"(OPG)":[1],"has":[2,167],"been":[3],"reported":[4],"to":[5,154,184],"be":[6,180],"a":[7,30,140,181,212],"novel":[8],"protein":[9],"that":[10,165,199],"can":[11],"suppress":[12],"osteoclast":[13],"differentiation":[14],"and":[15,44,118,130,207],"activation.":[16],"This":[17,196],"study":[18,163,197],"examined":[19],"the":[20,41,51,103,155,170,186,202],"therapeutic":[21],"effects":[22],"of":[23,76,83,97,100,121,124,127,204],"OPG":[24,77,84,101,166,178],"on":[25],"established":[26,61,171],"periprosthetic":[27,172,205],"osteolysis":[28,59,138,173,206],"in":[29,62,150,174,211],"rat":[31,42,213],"model.":[32,177,214],"A":[34],"bone":[35,110,115,145,187,209],"cement":[36],"prosthesis":[37],"was":[38,60,112,147],"inserted":[39],"into":[40,50,102],"femur":[43],"polyethylene":[45],"particles":[46],"were":[47,66,91,106,134],"continuously":[48],"infused":[49],"knee":[52,104],"joint":[53,105],"using":[54],"an":[55],"osmotic":[56],"pump.":[57],"After":[58],"four":[63],"weeks,":[64],"rats":[65],"intravenously":[67],"injected":[68],"with":[69,114,139],"vehicle":[70],"(control":[71],"group)":[72,79,86],"or":[73,80],"1":[74],"mg/kg":[75,82],"(OPG-1":[78],"10":[81],"(OPG-10":[85],"every":[87],"week":[88],"until":[89],"they":[90],"sacrificed":[92],"at":[93],"8":[94],"weeks.":[95],"Effects":[96],"direct":[98],"injections":[99],"also":[107],"investigated.":[108],"Periprosthetic":[109,144],"resorption":[111,146],"evaluated":[113,135],"mineral":[116],"density":[117],"histomorphometric":[119],"analysis":[120],"membranes":[122],"composed":[123],"total":[125],"area":[126],"interface":[128],"membrane":[129],"inflammatory":[131],"grading.":[132],"Radiographs":[133],"for":[136,192],"focal":[137],"blind":[141],"manner.":[142],"significantly":[148,168],"suppressed":[149],"OPG-10":[151],"group":[152],"compared":[153],"other":[156],"groups":[157],"(p":[158],"The":[161],"present":[162],"demonstrates":[164,198],"restored":[169],"our":[175],"animal":[176],"may":[179],"possible":[182],"agent":[183],"retain":[185],"stock":[188,210],"before":[189],"revision":[190],"surgery":[191],"failed":[193],"prostheses.":[194],"Conclusion:":[195],"osteoprotegerin":[200],"suppresses":[201],"progression":[203],"restores":[208]},"counts_by_year":[],"updated_date":"2026-07-23T06:02:39.697066","created_date":"2016-10-14T00:00:00"}
