{"id":"https://openalex.org/W2528138458","doi":null,"title":"The effect of anaesthetic and analgesic agents on glutamate uptake and release from rat neuronal preparations","display_name":"The effect of anaesthetic and analgesic agents on glutamate uptake and release from rat neuronal preparations","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2528138458","mag":"2528138458"},"language":"en","primary_location":{"id":"pmh:oai:lra.le.ac.uk:2381/29503","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/29503","pdf_url":"http://hdl.handle.net/2381/29503","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ProQuest","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2381/29503","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110035584","display_name":"Beverley Nicol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Beverley Nicol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110035584"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.9210000038146973},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anesthetic-agents","display_name":"anesthetic agents","score":0.8880000114440918},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.7549999952316284},{"id":"https://openalex.org/keywords/nociceptin","display_name":"nociceptin","score":0.7170000076293945},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.5109999775886536},{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.781000018119812},{"id":"https://openalex.org/keywords/thiopental","display_name":"thiopental","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":0.9010000228881836},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.7620000243186951},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.6290000081062317},{"id":"https://openalex.org/keywords/calcium-dependent-exocytosis","display_name":"calcium-dependent exocytosis","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.762846827507019},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6749185919761658},{"id":"https://openalex.org/C2909432430","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic agents","level":3,"score":0.6208113431930542},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5478323698043823},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5278803110122681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40482863783836365},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37927669286727905},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34893691539764404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22927376627922058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11267927289009094},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.054261237382888794}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:lra.le.ac.uk:2381/29503","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/29503","pdf_url":"http://hdl.handle.net/2381/29503","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ProQuest","raw_type":"Thesis"},{"id":"pmh:oai:figshare.com:article/10152470","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_effect_of_anaesthetic_and_analgesic_agents_on_glutamate_uptake_and_release_from_rat_neuronal_preparations/10152470","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2528138458","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696210","pdf_url":null,"source":{"id":"https://openalex.org/S4306478302","display_name":"ProQuest LLC eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"ProQuest eBooks","raw_type":null}],"best_oa_location":{"id":"pmh:oai:lra.le.ac.uk:2381/29503","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/29503","pdf_url":"http://hdl.handle.net/2381/29503","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ProQuest","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528138458.pdf","grobid_xml":"https://content.openalex.org/works/W2528138458.grobid-xml"},"referenced_works_count":166,"referenced_works":["https://openalex.org/W13617761","https://openalex.org/W20088480","https://openalex.org/W27551127","https://openalex.org/W78740994","https://openalex.org/W1514135350","https://openalex.org/W1521541843","https://openalex.org/W1563937254","https://openalex.org/W1594111906","https://openalex.org/W1686581241","https://openalex.org/W1775749144","https://openalex.org/W1810764863","https://openalex.org/W1886668162","https://openalex.org/W1900414416","https://openalex.org/W1966681799","https://openalex.org/W1968426373","https://openalex.org/W1968474308","https://openalex.org/W1969400861","https://openalex.org/W1969553615","https://openalex.org/W1971413163","https://openalex.org/W1971512819","https://openalex.org/W1972183007","https://openalex.org/W1975704905","https://openalex.org/W1975944686","https://openalex.org/W1976754780","https://openalex.org/W1976924550","https://openalex.org/W1977461780","https://openalex.org/W1977529115","https://openalex.org/W1978531717","https://openalex.org/W1979385488","https://openalex.org/W1980155257","https://openalex.org/W1980545520","https://openalex.org/W1982888478","https://openalex.org/W1983197885","https://openalex.org/W1983649348","https://openalex.org/W1987040062","https://openalex.org/W1988052349","https://openalex.org/W1988782252","https://openalex.org/W1989265581","https://openalex.org/W1990625157","https://openalex.org/W1991377640","https://openalex.org/W1991542726","https://openalex.org/W1991701465","https://openalex.org/W1992145070","https://openalex.org/W1992792869","https://openalex.org/W1998423082","https://openalex.org/W1999968276","https://openalex.org/W2000664999","https://openalex.org/W2000818039","https://openalex.org/W2001842574","https://openalex.org/W2001941537","https://openalex.org/W2002360326","https://openalex.org/W2003523284","https://openalex.org/W2003868601","https://openalex.org/W2004358441","https://openalex.org/W2005608576","https://openalex.org/W2005884659","https://openalex.org/W2008023797","https://openalex.org/W2009297045","https://openalex.org/W2010051841","https://openalex.org/W2011645297","https://openalex.org/W2012119611","https://openalex.org/W2013066565","https://openalex.org/W2013067874","https://openalex.org/W2014584100","https://openalex.org/W2014779151","https://openalex.org/W2017175377","https://openalex.org/W2019173407","https://openalex.org/W2020461481","https://openalex.org/W2021720787","https://openalex.org/W2022555327","https://openalex.org/W2024173492","https://openalex.org/W2026294888","https://openalex.org/W2026469412","https://openalex.org/W2027694520","https://openalex.org/W2027884975","https://openalex.org/W2028119807","https://openalex.org/W2028401432","https://openalex.org/W2029162796","https://openalex.org/W2034169255","https://openalex.org/W2036008979","https://openalex.org/W2036685400","https://openalex.org/W2037141564","https://openalex.org/W2038471077","https://openalex.org/W2039267613","https://openalex.org/W2039628680","https://openalex.org/W2040456704","https://openalex.org/W2042717783","https://openalex.org/W2043166209","https://openalex.org/W2043529380","https://openalex.org/W2043925885","https://openalex.org/W2045112376","https://openalex.org/W2045129357","https://openalex.org/W2047120103","https://openalex.org/W2047436200","https://openalex.org/W2049990228","https://openalex.org/W2050419480","https://openalex.org/W2051084778","https://openalex.org/W2051239584","https://openalex.org/W2051368312","https://openalex.org/W2051508663","https://openalex.org/W2052015647","https://openalex.org/W2052960183","https://openalex.org/W2053659412","https://openalex.org/W2053793579","https://openalex.org/W2054951528","https://openalex.org/W2054960438","https://openalex.org/W2055137643","https://openalex.org/W2056514859","https://openalex.org/W2058205481","https://openalex.org/W2058675779","https://openalex.org/W2058816390","https://openalex.org/W2062957466","https://openalex.org/W2065055994","https://openalex.org/W2065269605","https://openalex.org/W2066624199","https://openalex.org/W2070027885","https://openalex.org/W2070221085","https://openalex.org/W2072553414","https://openalex.org/W2073442562","https://openalex.org/W2073503112","https://openalex.org/W2075608053","https://openalex.org/W2075711087","https://openalex.org/W2075771585","https://openalex.org/W2075811628","https://openalex.org/W2077230174","https://openalex.org/W2077530921","https://openalex.org/W2082474912","https://openalex.org/W2083264485","https://openalex.org/W2083623305","https://openalex.org/W2088278912","https://openalex.org/W2092034907","https://openalex.org/W2092202094","https://openalex.org/W2094673798","https://openalex.org/W2099768625","https://openalex.org/W2102420653","https://openalex.org/W2108119444","https://openalex.org/W2113105912","https://openalex.org/W2119606784","https://openalex.org/W2123166542","https://openalex.org/W2131024077","https://openalex.org/W2132768644","https://openalex.org/W2141260882","https://openalex.org/W2143968827","https://openalex.org/W2147107991","https://openalex.org/W2147730134","https://openalex.org/W2148527746","https://openalex.org/W2148980073","https://openalex.org/W2149201522","https://openalex.org/W2152985670","https://openalex.org/W2153779246","https://openalex.org/W2157853053","https://openalex.org/W2161525508","https://openalex.org/W2164293375","https://openalex.org/W2165224523","https://openalex.org/W2166644295","https://openalex.org/W2166959286","https://openalex.org/W2172403866","https://openalex.org/W2180941170","https://openalex.org/W2227531958","https://openalex.org/W2275009642","https://openalex.org/W2288581753","https://openalex.org/W2294485621","https://openalex.org/W2399465001","https://openalex.org/W2403466950","https://openalex.org/W2463031614","https://openalex.org/W4406968089"],"related_works":["https://openalex.org/W2086611016","https://openalex.org/W2315398444","https://openalex.org/W2079453253","https://openalex.org/W1988782252","https://openalex.org/W2460851068","https://openalex.org/W2131547697","https://openalex.org/W2156798177","https://openalex.org/W2134644363","https://openalex.org/W1709778104","https://openalex.org/W2011185729"],"abstract_inverted_index":{"In":[0,20],"rat":[1,33],"cerebrocortical":[2,34],"and":[3,13,17,44,73,110,125,167,177,193,211,216,249],"cerebellar":[4],"synaptosomes":[5],"the":[6,22,114,184,199,228,245],"uptake":[7,23],"of":[8,31,40,49,56,72,81,97,102,117,121,180,190,201,207,221,232,247],"[3H]L-glutamate":[9],"was":[10,25,145],"time-,":[11],"concentration-(Km=-8.6":[12],"~2.2M":[14],"respectively),":[15],"Na+-dependent":[16],"L-trans-PDC":[18],"sensitive.":[19],"general":[21],"mechanism":[24,246],"insensitive":[26,95],"to":[27,161],"clinically":[28],"relevant":[29],"concentrations":[30],"anaesthetics.;Perfused":[32],"slices":[35],"depolarised":[36],"with":[37,52,119,186,203],"2x2min":[38],"pulses":[39],"46mM":[41],"K+":[42],"(S1":[43],"S2)":[45],"evoked":[46,63,79,98,115,233],"monophasic":[47],"releases":[48],"endogenous":[50],"glutamate":[51,82,99,118,151,234],"an":[53,204],"S2/S1":[54],"ratio":[55],"~1.07.":[57],"0.1mM":[58],"EGTA":[59],"pre-treatment":[60],"significantly":[61,137,182,197],"inhibited":[62,78,113,138],"release,":[64],"confirming":[65],"a":[66,92,155,165,239],"Ca2+":[67],"regulated":[68],"exocytotic":[69],"process.;A":[70],"range":[71],",":[74],"but":[75],"not":[76],"ligands":[77],"release":[80,100,116,152],"(e.g.":[83],"morphine":[84,217],"IC50":[85],"71nM).":[86],"A":[87,140],"novel":[88],"heptadecapeptide,":[89],"nociceptin":[90],"produced":[91],"dose-dependent":[93],"naloxone":[94],"inhibition":[96,231],"(IC50":[101],"51nM).":[103],"The":[104,173],"anaesthetic":[105,158],"agents":[106,253],"propofol,":[107],"thiopentone,":[108],"ketamine":[109,181],"halothane,":[111],"dose-dependently":[112],"IC50s":[120],"~20,":[122],"10,":[123],"18":[124],"132M":[126],"respectively.":[127,195],"At":[128],"single":[129],"doses":[130],"1M":[131],"MK-801,":[132],"100M":[133],"pentobarbital":[134],"435M":[135],"isoflurane":[136],"release.":[139],"non-anaesthetic":[141],"barbiturate,":[142],"barbituric":[143,213],"acid":[144],"ineffective.":[146,219],"These":[147],"data":[148,237],"suggest":[149],"that":[150],"may":[153,250],"be":[154],"target":[156],"for":[157,241],"agents.;[3H]MK-801":[159],"bound":[160],"NMDA":[162,223],"receptors":[163,224],"in":[164,244],"time-":[166],"concentration-dependent":[168],"manner":[169],"(KD=~3nM,":[170],"Bmax=~900fmoles/mg":[171],"protein).":[172],"racemic":[174],"mixture,":[175],"R-":[176],"S+":[178],"isomers":[179],"displaced":[183,198],"binding":[185,200],"estimated":[187,205],"Ki":[188,206],"values":[189],"~638,":[191],"2703":[192],"568nM":[194],"Etomidate":[196],"[3H]MK-801":[202],"4M.":[208],"Propofol,":[209],"thiopentone":[210],"pentobarbital,":[212],"acid,":[214],"halothane":[215],"were":[218],"Block":[220],"pre-synaptic":[222],"alone":[225],"cannot":[226],"explain":[227],"observed":[229],"anaesthetic/analgesic":[230,252],"release.;Collectively":[235],"these":[236],"support":[238],"role":[240],"glutamatergic":[242],"neurotransmission":[243],"anaesthesia/analgesia":[248],"implicate":[251],"as":[254],"neuroprotectants.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-14T00:00:00"}
