{"id":"https://openalex.org/W2528110193","doi":null,"title":"Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure","display_name":"Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure","publication_year":2013,"publication_date":"2013-08-22","ids":{"openalex":"https://openalex.org/W2528110193","mag":"2528110193"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/45426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/45426","pdf_url":"https://www.ideals.illinois.edu/items/45408/bitstreams/134527/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/45408/bitstreams/134527/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006096975","display_name":"Wendy A. Koss","orcid":"https://orcid.org/0000-0002-2980-0672","observed_orcids":["https://orcid.org/0000-0002-2980-0672"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wendy A. Koss","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2980-0672","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006096975"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26841571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0869000032544136,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prefrontal-cortex-development","display_name":"prefrontal cortex development","score":0.8379999995231628},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9580000042915344},{"id":"https://openalex.org/keywords/adolescence","display_name":"adolescence","score":0.8059999942779541},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.9449999928474426},{"id":"https://openalex.org/keywords/alcohol-exposure","display_name":"alcohol exposure","score":0.8690000176429749},{"id":"https://openalex.org/keywords/binge-drinking","display_name":"binge drinking","score":0.878000020980835},{"id":"https://openalex.org/keywords/dendritic-spine-development","display_name":"dendritic spine development","score":0.5789999961853027},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.871999979019165},{"id":"https://openalex.org/keywords/dendritic-pruning","display_name":"dendritic pruning","score":0.7760000228881836},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/neuron-number","display_name":"neuron number","score":0.4970000088214874},{"id":"https://openalex.org/keywords/pubertal-hormones","display_name":"pubertal hormones","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8339999914169312},{"id":"https://openalex.org/keywords/rat-brain-development","display_name":"rat brain development","score":0.5120000243186951},{"id":"https://openalex.org/keywords/neurodevelopmental-disruption","display_name":"neurodevelopmental disruption","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6944360136985779},{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.6879838705062866},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5773894786834717},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5655912160873413},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4289567470550537},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.39437294006347656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32588082551956177},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2093719244003296}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/45426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/45426","pdf_url":"https://www.ideals.illinois.edu/items/45408/bitstreams/134527/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2528110193","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/45426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/45426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/45426","pdf_url":"https://www.ideals.illinois.edu/items/45408/bitstreams/134527/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2528110193.pdf","grobid_xml":"https://content.openalex.org/works/W2528110193.grobid-xml"},"referenced_works_count":168,"referenced_works":["https://openalex.org/W197001706","https://openalex.org/W1537273541","https://openalex.org/W1570708643","https://openalex.org/W1575891190","https://openalex.org/W1589353809","https://openalex.org/W1602971398","https://openalex.org/W1606879955","https://openalex.org/W1636684090","https://openalex.org/W1763496766","https://openalex.org/W1867720884","https://openalex.org/W1950026089","https://openalex.org/W1965411024","https://openalex.org/W1968037091","https://openalex.org/W1969506286","https://openalex.org/W1969662363","https://openalex.org/W1970215030","https://openalex.org/W1970585150","https://openalex.org/W1971500274","https://openalex.org/W1972490292","https://openalex.org/W1977551077","https://openalex.org/W1978275630","https://openalex.org/W1978611788","https://openalex.org/W1978689790","https://openalex.org/W1980160690","https://openalex.org/W1981284999","https://openalex.org/W1982471973","https://openalex.org/W1982508651","https://openalex.org/W1982657399","https://openalex.org/W1984111997","https://openalex.org/W1984854704","https://openalex.org/W1986411584","https://openalex.org/W1989053030","https://openalex.org/W1989826158","https://openalex.org/W1989864594","https://openalex.org/W1989934484","https://openalex.org/W1991340010","https://openalex.org/W1993788286","https://openalex.org/W1995512247","https://openalex.org/W1995715564","https://openalex.org/W1995797542","https://openalex.org/W1995918704","https://openalex.org/W1998257450","https://openalex.org/W1998444616","https://openalex.org/W1999957859","https://openalex.org/W2004133350","https://openalex.org/W2004159545","https://openalex.org/W2004406968","https://openalex.org/W2006792282","https://openalex.org/W2007760226","https://openalex.org/W2007909289","https://openalex.org/W2008075970","https://openalex.org/W2008393078","https://openalex.org/W2008577142","https://openalex.org/W2009833394","https://openalex.org/W2011044541","https://openalex.org/W2011448874","https://openalex.org/W2012250372","https://openalex.org/W2012613409","https://openalex.org/W2015020129","https://openalex.org/W2017773492","https://openalex.org/W2019528658","https://openalex.org/W2022753652","https://openalex.org/W2028213326","https://openalex.org/W2028432497","https://openalex.org/W2031414482","https://openalex.org/W2031501640","https://openalex.org/W2033074601","https://openalex.org/W2033160816","https://openalex.org/W2033813843","https://openalex.org/W2033975383","https://openalex.org/W2034413450","https://openalex.org/W2034950390","https://openalex.org/W2034968517","https://openalex.org/W2036749402","https://openalex.org/W2039252406","https://openalex.org/W2039287048","https://openalex.org/W2039745954","https://openalex.org/W2041361401","https://openalex.org/W2041457323","https://openalex.org/W2041874445","https://openalex.org/W2042871946","https://openalex.org/W2045581129","https://openalex.org/W2045725858","https://openalex.org/W2046835548","https://openalex.org/W2047662887","https://openalex.org/W2047801596","https://openalex.org/W2048382344","https://openalex.org/W2049678062","https://openalex.org/W2050322513","https://openalex.org/W2050581082","https://openalex.org/W2051221143","https://openalex.org/W2052508009","https://openalex.org/W2054593173","https://openalex.org/W2054950553","https://openalex.org/W2055673325","https://openalex.org/W2056683160","https://openalex.org/W2058252306","https://openalex.org/W2058382270","https://openalex.org/W2058932154","https://openalex.org/W2058939961","https://openalex.org/W2058975031","https://openalex.org/W2059131332","https://openalex.org/W2059498859","https://openalex.org/W2061362312","https://openalex.org/W2061870960","https://openalex.org/W2062574700","https://openalex.org/W2063586313","https://openalex.org/W2068841903","https://openalex.org/W2074061123","https://openalex.org/W2075026191","https://openalex.org/W2075312117","https://openalex.org/W2076680535","https://openalex.org/W2078275073","https://openalex.org/W2078745456","https://openalex.org/W2082117755","https://openalex.org/W2083695389","https://openalex.org/W2084081279","https://openalex.org/W2084680129","https://openalex.org/W2086058847","https://openalex.org/W2086932421","https://openalex.org/W2088753284","https://openalex.org/W2090257024","https://openalex.org/W2090574733","https://openalex.org/W2095399267","https://openalex.org/W2099156854","https://openalex.org/W2099563179","https://openalex.org/W2105549490","https://openalex.org/W2113359311","https://openalex.org/W2113955611","https://openalex.org/W2117151480","https://openalex.org/W2117159943","https://openalex.org/W2119758466","https://openalex.org/W2120107945","https://openalex.org/W2120731293","https://openalex.org/W2121836282","https://openalex.org/W2124597765","https://openalex.org/W2124712820","https://openalex.org/W2125082857","https://openalex.org/W2128508619","https://openalex.org/W2130958493","https://openalex.org/W2135584693","https://openalex.org/W2136700000","https://openalex.org/W2145865543","https://openalex.org/W2145877345","https://openalex.org/W2146473511","https://openalex.org/W2147834417","https://openalex.org/W2148944193","https://openalex.org/W2152292563","https://openalex.org/W2152591277","https://openalex.org/W2154737730","https://openalex.org/W2154841219","https://openalex.org/W2158527872","https://openalex.org/W2158593571","https://openalex.org/W2160499952","https://openalex.org/W2162363996","https://openalex.org/W2162897032","https://openalex.org/W2163105100","https://openalex.org/W2163643958","https://openalex.org/W2164868462","https://openalex.org/W2166670920","https://openalex.org/W2171189029","https://openalex.org/W2171594732","https://openalex.org/W2171614525","https://openalex.org/W2192996307","https://openalex.org/W2395352673","https://openalex.org/W4233520978","https://openalex.org/W4233982723","https://openalex.org/W4234426616"],"related_works":["https://openalex.org/W1517665341","https://openalex.org/W2012250372","https://openalex.org/W1980451010","https://openalex.org/W7015057329","https://openalex.org/W3023223661","https://openalex.org/W2912897320","https://openalex.org/W4414169312","https://openalex.org/W4392135596","https://openalex.org/W4408845672","https://openalex.org/W3091923031"],"abstract_inverted_index":{"Human":[0],"structural":[1],"magnetic":[2],"resonance":[3],"imaging":[4],"(MRI)":[5],"studies":[6,30,111,216],"indicate":[7],"that":[8,34,78,181,183,324,357,383],"some":[9],"neural":[10],"regions":[11],"such":[12],"as":[13,67,128,130,233,235],"the":[14,19,35,38,51,61,65,86,96,101,122,125,155,165,186,200,203,240,243,254,264,292,308,314,327,338,360,372,410,413,424,428,431,438],"prefrontal":[15,157],"cortex":[16,158],"(PFC)":[17],"and":[18,43,94,107,134,145,171,202,222,227,285,296,376,392,412,430],"amygdala":[20,52,205],"continue":[21],"to":[22,56,116,163,247,279,290,353],"develop":[23],"throughout":[24],"adolescence":[25],"into":[26],"early":[27,47],"adulthood.":[28,48],"These":[29,215],"have":[31],"specifically":[32],"shown":[33,55,246],"volume":[36,59],"of":[37,70,80,88,220,242,266,273,294,311,359,374,396,427,434],"PFC":[39],"increases":[40],"until":[41,46],"puberty":[42,388],"then":[44,286],"decreases":[45],"By":[49],"contrast,":[50],"has":[53,75],"been":[54],"increase":[57],"in":[58,100,121,149,199,212,230,250,253,258,263,268,281,288,300,307,313,322,326,334,337,365,371,378,409,423],"through":[60],"adolescent":[62,98,126,425,439],"period.":[63,440],"Using":[64],"rat":[66],"a":[68,84,150,218,282,319,393],"model":[69],"these":[71,81,404],"changes,":[72],"our":[73],"laboratory":[74],"previously":[76],"found":[77,333,382],"both":[79,231,236,269],"structures":[82],"show":[83],"decreasein":[85],"number":[87,265,293,310,373,395],"neuronsbetween":[89],"postnatal":[90],"day":[91],"(P)":[92],"35":[93],"P90,":[95],"equivalent":[97],"period":[99,127,272],"rat(Markham":[102],"et":[103],"al,":[104],"2007;":[105],"Rubinow":[106],"Juraska,":[108],"2009).":[109],"The":[110],"described":[112],"here":[113],"were":[114,147,161,175,210,245,277,332,345,369],"designed":[115],"further":[117,196,406],"elucidate":[118],"neuroanatomical":[119,197,274,407],"changes":[120,198,370,408],"brain":[123],"during":[124,387],"well":[129,234],"investigate":[131],"how":[132,418],"intrinsic":[133],"extrinsic":[135],"factors":[136],"may":[137],"disrupt":[138],"this":[139,271],"development.":[140],"In":[141,340],"chapter":[142,213,301,341],"2,":[143],"adolescents":[144],"adults":[146,179],"compared":[148],"behavioral":[151],"task":[152],"dependent":[153],"on":[154,185],"medial":[156],"(mPFC).":[159],"Adolescents":[160],"able":[162],"perform":[164],"task.":[166],"On":[167],"certain":[168],"delays":[169],"(15s":[170],"30s),":[172],"however,":[173],"they":[174,416],"consistently":[176],"worse":[177],"than":[178],"indicating":[180],"behavior":[182],"depends":[184],"mPFC":[187,201,244,411,429],"is":[188],"not":[189],"yet":[190],"at":[191],"adult":[192],"levels.":[193],"To":[194],"identify":[195],"basolateral":[204],"(BLA),dendritic":[206],"arborizationsand":[207],"dendritic":[208,223],"spines":[209,224],"analyzed":[211],"3.":[214],"indicated":[217],"growth":[219],"dendrites":[221,241],"between":[225],"P20":[226],"P35":[228],"(prepuberty)":[229],"sexes":[232],"structures.":[237],"After":[238],"P35,":[239],"prune":[248],"predominately":[249],"females,":[251],"whereas":[252],"BLA,dendrites":[255],"slightly":[256],"increased":[257,262],"length":[259],"but":[260,367],"significantly":[261],"branches":[267],"sexes.During":[270],"change,adolescent":[275],"rats":[276],"exposed":[278],"alcohol":[280,435],"binge-like":[283],"manner":[284],"sacrificed":[287],"adulthood":[289],"quantify":[291],"neurons":[295,312,375,391],"glia.":[297],"Results":[298,355],"reported":[299],"4":[302],"revealed":[303],"no":[304,363],"significant":[305,320],"differences":[306,331],"total":[309],"mPFC.":[315,329],"However":[316],"there":[317,368],"was":[318,381],"decrease":[321],"glia":[323,377],"occurred":[325],"male":[328],"No":[330],"any":[335],"measure":[336],"BLA.":[339,414],"5,":[342],"pubertal":[343,419],"hormones":[344,420],"removed":[346],"by":[347],"ovariectomizing":[348],"or":[349],"castrating":[350],"animals":[351],"prior":[352],"puberty.":[354],"showed":[356],"removal":[358],"testes":[361],"caused":[362],"effects":[364,433],"males":[366],"females.":[379],"It":[380],"females":[384],"without":[385],"ovaries":[386],"had":[389],"more":[390],"greater":[394],"glia,":[397],"thus":[398],"eliminating":[399],"sex":[400],"differences.":[401],"Taken":[402],"together":[403],"experimentsreveal":[405],"Furthermore":[415],"highlight":[417],"are":[421],"involved":[422],"development":[426],"cellular":[432],"use":[436],"within":[437]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-10-14T00:00:00"}