{"id":"https://openalex.org/W2527891752","doi":null,"title":"Comparing DNA Damage Caused by Formaldehyde, Glutaraldehye, Carnoy\u2019s and Methacarn in Cancer Tissue Fixations","display_name":"Comparing DNA Damage Caused by Formaldehyde, Glutaraldehye, Carnoy\u2019s and Methacarn in Cancer Tissue Fixations","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2527891752","mag":"2527891752"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:bgsu1161611055","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chia\u2010Jui Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157417397","display_name":"Bowling Green State University","ror":"https://ror.org/00ay7va13","country_code":"US","type":"education","lineage":["https://openalex.org/I157417397"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chia\u2010Jui Tsai","raw_affiliation_strings":["Bowling Green State Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bowling Green State Univ","institution_ids":["https://openalex.org/I157417397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157417397"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.2515000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-fixation","display_name":"tissue fixation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8579999804496765},{"id":"https://openalex.org/keywords/formaldehyde","display_name":"formaldehyde","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glutaraldehyde","display_name":"glutaraldehyde","score":0.9929999709129333},{"id":"https://openalex.org/keywords/carnoy-s-fixative","display_name":"Carnoy's fixative","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neutral-buffered-formalin","display_name":"neutral buffered formalin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dna-integrity","display_name":"DNA integrity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/small-subunit-rrna-gene","display_name":"small subunit rRNA gene","score":0.8489999771118164},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/carcinoma","display_name":"carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4777921140193939},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.464310884475708},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4402368366718292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3182496428489685}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:bgsu1161611055","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","raw_type":"text"},{"id":"mag:2527891752","doi":null,"is_oa":false,"landing_page_url":"https://etd.ohiolink.edu/!etd.send_file?accession=bgsu1161611055&disposition=inline","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:bgsu1161611055","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1161611055","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2527891752.pdf","grobid_xml":"https://content.openalex.org/works/W2527891752.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W78917068","https://openalex.org/W113957129","https://openalex.org/W1498383894","https://openalex.org/W1503393361","https://openalex.org/W1532591003","https://openalex.org/W1790066431","https://openalex.org/W1877191620","https://openalex.org/W1910522942","https://openalex.org/W1959606306","https://openalex.org/W1966286195","https://openalex.org/W1968519684","https://openalex.org/W1971707621","https://openalex.org/W1972881894","https://openalex.org/W1976831807","https://openalex.org/W1976896356","https://openalex.org/W1981567997","https://openalex.org/W1982859282","https://openalex.org/W1983308125","https://openalex.org/W1984584032","https://openalex.org/W1985804036","https://openalex.org/W1986544344","https://openalex.org/W1986612792","https://openalex.org/W1987600685","https://openalex.org/W1992651532","https://openalex.org/W1993320561","https://openalex.org/W1996382467","https://openalex.org/W1999330214","https://openalex.org/W2000119134","https://openalex.org/W2000264217","https://openalex.org/W2004771750","https://openalex.org/W2009168769","https://openalex.org/W2009383435","https://openalex.org/W2013973825","https://openalex.org/W2018762339","https://openalex.org/W2020745434","https://openalex.org/W2021013532","https://openalex.org/W2024266745","https://openalex.org/W2028187346","https://openalex.org/W2031726276","https://openalex.org/W2032542611","https://openalex.org/W2032770280","https://openalex.org/W2033791403","https://openalex.org/W2034032778","https://openalex.org/W2038682400","https://openalex.org/W2047264956","https://openalex.org/W2048511673","https://openalex.org/W2049869291","https://openalex.org/W2050105192","https://openalex.org/W2052853635","https://openalex.org/W2054356521","https://openalex.org/W2054636737","https://openalex.org/W2054760402","https://openalex.org/W2058532562","https://openalex.org/W2065130531","https://openalex.org/W2066198989","https://openalex.org/W2068124694","https://openalex.org/W2069958185","https://openalex.org/W2071427986","https://openalex.org/W2072709573","https://openalex.org/W2074477982","https://openalex.org/W2075774689","https://openalex.org/W2077858999","https://openalex.org/W2079680569","https://openalex.org/W2081697027","https://openalex.org/W2083522386","https://openalex.org/W2087687744","https://openalex.org/W2091167042","https://openalex.org/W2092513068","https://openalex.org/W2093323851","https://openalex.org/W2095167965","https://openalex.org/W2095263949","https://openalex.org/W2095724872","https://openalex.org/W2097382368","https://openalex.org/W2097432692","https://openalex.org/W2097705418","https://openalex.org/W2099742439","https://openalex.org/W2111582326","https://openalex.org/W2123423422","https://openalex.org/W2125453837","https://openalex.org/W2128879096","https://openalex.org/W2130198345","https://openalex.org/W2133261516","https://openalex.org/W2146304428","https://openalex.org/W2146440075","https://openalex.org/W2148763006","https://openalex.org/W2152076139","https://openalex.org/W2168917479","https://openalex.org/W2324246793","https://openalex.org/W2402029145","https://openalex.org/W2406680982","https://openalex.org/W2497432837","https://openalex.org/W2886642133","https://openalex.org/W3027421332"],"related_works":["https://openalex.org/W2086400449","https://openalex.org/W2162259542","https://openalex.org/W3117661597","https://openalex.org/W2621207434","https://openalex.org/W2066198989","https://openalex.org/W4403092473","https://openalex.org/W2092814996","https://openalex.org/W7135793667","https://openalex.org/W3080311571","https://openalex.org/W2767309975"],"abstract_inverted_index":{"Many":[0],"molecular":[1,17,19],"biotechniques":[2],"are":[3,70],"useful":[4],"in":[5,73,233],"detecting":[6],"macromolecular":[7],"changes.Disease":[8],"stages":[9],"may":[10],"be":[11,25],"analyzed":[12,194],"accurately":[13],"based":[14],"on":[15],"these":[16,76],"changes.Therefore,":[18],"methods":[20,35],"have":[21],"the":[22,45,100,120,161,174,197,208,211,228,241],"potential":[23],"to":[24,99,207],"applied":[26],"as":[27],"routine":[28],"and":[29,55,67,87,112,116,147,158,166,170,189,204,239],"highly":[30],"informative":[31],"clinical":[32],"diagnostic":[33],"tools.Fixation":[34],"become":[36],"an":[37],"essential":[38],"consideration":[39],"while":[40],"preserving":[41],"tissues.This":[42],"study":[43],"investigates":[44],"frequency":[46],"of":[47,127,173,210,215],"DNA":[48,94,131,179,191,198,212,225,237,242],"change":[49,226],"caused":[50,235],"by":[51,184,195],"two":[52,56,77],"aldehyde-based":[53,101,246],"fixatives":[54],"alcohol-chloroform-acetic":[57],"acid":[58,114],"fixatives.Aldehyde-based":[59],"fixatives,":[60,78,102,232],"especially":[61],"10%":[62,153,221],"neutral":[63],"buffered":[64],"formalin":[65],"(NBF)":[66],"1%":[68,79,155],"glutaraldehyde,":[69,156],"widely":[71],"used":[72],"histological":[74],"studies.Among":[75],"glutaraldehyde":[80],"preserves":[81,93],"cellular":[82],"structure":[83],"better":[84,95,244],"than":[85,96,227,245],"formalin,":[86],"recent":[88],"studies":[89],"indicate":[90],"that":[91,220],"it":[92],"formalin.In":[97],"addition":[98],"Carnoy's,":[103],"which":[104,118],"is":[105],"made":[106],"with":[107],"ethanol":[108,128],"(60%),":[109],"chloroform":[110],"(30%)":[111],"acetic":[113],"(10%),":[115],"Methacarn,":[117],"shares":[119],"same":[121],"formula":[122],"but":[123],"uses":[124],"methanol":[125],"instead":[126],"were":[129,136,149,182,193],"tested":[130],"changes":[132,199,238],"for":[133],"each":[134],"fixation":[135],"compared":[137],"this":[138],"study.Human":[139],"tissues":[140,163],"(normal":[141],"white":[142],"blood":[143],"cells,":[144],"sarcomas,":[145],"leukemias,":[146],"carcinomas)":[148],"fixed,":[150],"separately":[151],"using":[152],"NBF,":[154],"Carnoy's":[157],"Methacarn.DNA":[159],"from":[160],"fixed":[162],"was":[164],"extracted":[165],"segments":[167],"(418":[168],"bp":[169],"597":[171],"bp)":[172],"nuclear":[175],"small":[176],"subunit":[177],"ribosomal":[178],"(SSU":[180],"rDNA)":[181],"amplified":[183],"polymerase":[185],"chain":[186],"reaction":[187],"(PCR)":[188],"sequenced.The":[190],"sequences":[192],"comparing":[196],"between":[200],"four":[201],"iii":[202],"fixative-treated":[203],"unfixed":[205],"tissues.According":[206],"results":[209],"statistical":[213],"analyses":[214],"sequence":[216],"alignments,":[217],"we":[218],"report":[219],"NBF":[222],"causes":[223],"more":[224],"other":[229],"fixatives.Alcohol-chloroform-acetic":[230],"acid-based":[231],"general,":[234],"less":[236],"maintained":[240],"integrity":[243],"fixatives.":[247]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-10-14T00:00:00"}