{"id":"https://openalex.org/W2527844488","doi":"https://doi.org/10.1083/jcb.201603053","title":"Nuclear envelope rupture is induced by actin-based nucleus confinement","display_name":"Nuclear envelope rupture is induced by actin-based nucleus confinement","publication_year":2016,"publication_date":"2016-10-03","ids":{"openalex":"https://openalex.org/W2527844488","doi":"https://doi.org/10.1083/jcb.201603053","mag":"2527844488","pmid":"https://pubmed.ncbi.nlm.nih.gov/27697922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5057282"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.201603053","doi":"https://doi.org/10.1083/jcb.201603053","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201603053","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1083/jcb.201603053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084957989","display_name":"Emily M. Hatch","orcid":"https://orcid.org/0000-0002-3393-4075","observed_orcids":["https://orcid.org/0000-0002-3393-4075"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily M. Hatch","raw_affiliation_strings":["Department of Basic Sciences, The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, The Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011761333","display_name":"Martin W. Hetzer","orcid":"https://orcid.org/0000-0002-2111-992X","observed_orcids":["https://orcid.org/0000-0002-2111-992X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin W. Hetzer","raw_affiliation_strings":["Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 2"],"raw_orcid":"https://orcid.org/0000-0002-2111-992X","affiliations":[{"raw_affiliation_string":"Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037 2","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084957989"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":null,"apc_paid":null,"fwci":9.8036,"has_fulltext":false,"cited_by_count":260,"citation_normalized_percentile":{"value":0.98855719,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"215","issue":"1","first_page":"27","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-envelope-rupture","display_name":"nuclear envelope rupture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.593999981880188},{"id":"https://openalex.org/keywords/linc-complex","display_name":"LINC complex","score":0.8399999737739563},{"id":"https://openalex.org/keywords/actin-bundles","display_name":"actin bundles","score":0.699999988079071},{"id":"https://openalex.org/keywords/nuclear-confinement","display_name":"nuclear confinement","score":0.5740000009536743},{"id":"https://openalex.org/keywords/laminopathies","display_name":"laminopathies","score":0.734000027179718},{"id":"https://openalex.org/keywords/cancer-cells","display_name":"cancer cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/actin-depolymerization","display_name":"actin depolymerization","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.751245379447937},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.747272789478302},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.6883562803268433},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5602759122848511},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.5530164241790771},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5467322468757629},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4964211583137512},{"id":"https://openalex.org/C2777896290","wikidata":"https://www.wikidata.org/wiki/Q465608","display_name":"Nuclear membrane","level":3,"score":0.4869183301925659},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.4845227599143982},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.45139405131340027},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4341086745262146},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4279487729072571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4109492599964142},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37205034494400024},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.16284385323524475},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11250773072242737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0625942051410675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05921319127082825},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.044139713048934937},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.201603053","doi":"https://doi.org/10.1083/jcb.201603053","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201603053","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5057282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5057282","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:27697922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27697922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1083/jcb.201603053","doi":"https://doi.org/10.1083/jcb.201603053","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201603053","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1511897599","display_name":"The role of the nucleoporin Nup98 in gene regulation","funder_award_id":"R01GM098749","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G211874389","display_name":null,"funder_award_id":"P30CA014195","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G4297139916","display_name":null,"funder_award_id":"PF-12-137-01-CSM","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G4742879151","display_name":null,"funder_award_id":"P30CA014118195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8221522485","display_name":"The role of long-lived proteins in the survival of nerve cells","funder_award_id":"R01NS096786","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000880274","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320306356","display_name":"Glenn Family Foundation","ror":"https://ror.org/01bp1fj20"},{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320325162","display_name":"NOMIS Stiftung","ror":"https://ror.org/01zkd3118"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1528109689","https://openalex.org/W1934956719","https://openalex.org/W1964281587","https://openalex.org/W1995816679","https://openalex.org/W2010335932","https://openalex.org/W2015094353","https://openalex.org/W2021688302","https://openalex.org/W2025231576","https://openalex.org/W2025884506","https://openalex.org/W2035838778","https://openalex.org/W2041297088","https://openalex.org/W2042168939","https://openalex.org/W2042487912","https://openalex.org/W2043485308","https://openalex.org/W2077145482","https://openalex.org/W2097988743","https://openalex.org/W2099004980","https://openalex.org/W2101083045","https://openalex.org/W2101712721","https://openalex.org/W2114610097","https://openalex.org/W2126548279","https://openalex.org/W2135745724","https://openalex.org/W2136490523","https://openalex.org/W2138825607","https://openalex.org/W2151847364","https://openalex.org/W2153344338","https://openalex.org/W2158799849","https://openalex.org/W2161260069","https://openalex.org/W2165913063","https://openalex.org/W2167815875","https://openalex.org/W2168480092","https://openalex.org/W2169601134","https://openalex.org/W2170725518","https://openalex.org/W2180582199","https://openalex.org/W2197269124","https://openalex.org/W2302317914","https://openalex.org/W2303653884","https://openalex.org/W2311649981","https://openalex.org/W2417770086","https://openalex.org/W4211059758","https://openalex.org/W4243158166"],"related_works":["https://openalex.org/W2529749820","https://openalex.org/W4389671101","https://openalex.org/W4387570527","https://openalex.org/W2790794374","https://openalex.org/W2773239270","https://openalex.org/W7154450989","https://openalex.org/W3003769344","https://openalex.org/W1995816679","https://openalex.org/W2786777567","https://openalex.org/W2496830017"],"abstract_inverted_index":{"Repeated":[0],"rounds":[1],"of":[2,22,28,46,58,69,86,97,123,138],"nuclear":[3,79,87],"envelope":[4],"(NE)":[5],"rupture":[6,30,38,102,125,136],"and":[7,14,17,60,95],"repair":[8],"have":[9],"been":[10],"observed":[11],"in":[12,19,39,107,133,141],"laminopathy":[13],"cancer":[15,40],"cells":[16,41,108],"result":[18],"intermittent":[20],"loss":[21,68],"nucleus":[23,54,116,146],"compartmentalization.":[24],"Currently,":[25],"the":[26,44,53,56,67,73,93],"causes":[27],"NE":[29,37,101,124],"are":[31],"unclear.":[32],"Here,":[33],"we":[34],"show":[35],"that":[36,50,66],"relies":[42],"on":[43],"assembly":[45],"contractile":[47],"actin":[48,70],"bundles":[49,71],"interact":[51],"with":[52,110],"via":[55],"linker":[57],"nucleoskeleton":[59],"cytoskeleton":[61],"(LINC)":[62],"complex.":[63],"We":[64],"found":[65],"or":[72],"LINC":[74],"complex":[75],"did":[76,91],"not":[77],"rescue":[78],"lamina":[80,134],"defects,":[81],"a":[82,121],"previously":[83],"identified":[84],"determinant":[85],"membrane":[88,128],"stability,":[89],"but":[90],"decrease":[92],"number":[94],"size":[96],"chromatin":[98],"hernias.":[99],"Finally,":[100],"inhibition":[103],"could":[104],"be":[105],"rescued":[106],"treated":[109],"actin-depolymerizing":[111],"drugs":[112],"by":[113,131],"mechanically":[114],"constraining":[115],"height.":[117],"These":[118],"data":[119],"suggest":[120],"model":[122],"where":[126],"weak":[127],"areas,":[129],"caused":[130],"defects":[132],"organization,":[135],"because":[137],"an":[139],"increase":[140],"intranuclear":[142],"pressure":[143],"from":[144],"actin-based":[145],"confinement.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-10-14T00:00:00"}
