{"id":"https://openalex.org/W2527488564","doi":"https://doi.org/10.1007/s40262-016-0452-x","title":"Population Pharmacokinetics of Necitumumab in Cancer Patients","display_name":"Population Pharmacokinetics of Necitumumab in Cancer Patients","publication_year":2016,"publication_date":"2016-09-30","ids":{"openalex":"https://openalex.org/W2527488564","doi":"https://doi.org/10.1007/s40262-016-0452-x","mag":"2527488564","pmid":"https://pubmed.ncbi.nlm.nih.gov/27696220","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5385201"},"language":"en","primary_location":{"id":"doi:10.1007/s40262-016-0452-x","doi":"https://doi.org/10.1007/s40262-016-0452-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-016-0452-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-016-0452-x.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2527488564"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-016-0452-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055671933","display_name":"Amanda J. Long","orcid":"https://orcid.org/0009-0005-7307-3934","observed_orcids":["https://orcid.org/0009-0005-7307-3934"]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Long","raw_affiliation_strings":["Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104108481","display_name":"Emmanuel Chigutsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel Chigutsa","raw_affiliation_strings":["Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056353703","display_name":"Johan Erik Wallin","orcid":"https://orcid.org/0000-0002-4143-0096","observed_orcids":["https://orcid.org/0000-0002-4143-0096"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Johan Wallin","raw_affiliation_strings":["Lilly Sweden, Gustav III Boulevard 42, P.O box 721, SE - 169 27, Solna, Sweden. wallin_johan@lilly.com","Lilly Sweden, Gustav III Boulevard 42, P.O box 721, SE - 169 27, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Sweden, Gustav III Boulevard 42, P.O box 721, SE - 169 27, Solna, Sweden. wallin_johan@lilly.com","institution_ids":[]},{"raw_affiliation_string":"Lilly Sweden, Gustav III Boulevard 42, P.O box 721, SE - 169 27, Solna, Sweden","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056353703"],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.0034,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71530858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"56","issue":"5","first_page":"505","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.46389999985694885,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.14329999685287476,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necitumumab","display_name":"necitumumab","score":1.0},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/anti-egfr-monoclonal-antibody","display_name":"anti-EGFR monoclonal antibody","score":0.746999979019165},{"id":"https://openalex.org/keywords/target-mediated-drug-disposition","display_name":"target-mediated drug disposition","score":0.8820000290870667},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.6690000295639038},{"id":"https://openalex.org/keywords/concomitant-chemotherapy","display_name":"concomitant chemotherapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/body-surface-area-dosing","display_name":"body surface area dosing","score":0.890999972820282},{"id":"https://openalex.org/keywords/exposure-variability","display_name":"exposure variability","score":0.5630000233650208},{"id":"https://openalex.org/keywords/dosing-simulation","display_name":"dosing simulation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/effective-half-life","display_name":"effective half-life","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7979225516319275},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.635352611541748},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.629180908203125},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5770794749259949},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.568090558052063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5129256248474121},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.477083295583725},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4556056559085846},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40216419100761414},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3916383683681488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3569307327270508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22370561957359314},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s40262-016-0452-x","doi":"https://doi.org/10.1007/s40262-016-0452-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-016-0452-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-016-0452-x.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4249356","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5385201","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27696220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27696220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5385201","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5385201/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Pharmacokinet","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s40262-016-0452-x","doi":"https://doi.org/10.1007/s40262-016-0452-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40262-016-0452-x","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40262-016-0452-x.pdf","source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2527488564.pdf","grobid_xml":"https://content.openalex.org/works/W2527488564.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W163850752","https://openalex.org/W1555185942","https://openalex.org/W1964594353","https://openalex.org/W1965479467","https://openalex.org/W1965987183","https://openalex.org/W1969371715","https://openalex.org/W2042553471","https://openalex.org/W2048164597","https://openalex.org/W2050427803","https://openalex.org/W2054739927","https://openalex.org/W2058734479","https://openalex.org/W2059050919","https://openalex.org/W2078908647","https://openalex.org/W2091277908","https://openalex.org/W2130357378","https://openalex.org/W2149171909","https://openalex.org/W2164977460","https://openalex.org/W2167599107","https://openalex.org/W2236409724"],"related_works":["https://openalex.org/W2149171909","https://openalex.org/W2520467315","https://openalex.org/W2360562031","https://openalex.org/W163850752","https://openalex.org/W2051363346","https://openalex.org/W2061914417","https://openalex.org/W2770681897","https://openalex.org/W2980147809","https://openalex.org/W3083793193","https://openalex.org/W2746633526"],"abstract_inverted_index":{"Necitumumab":[0,23,47,205],"is":[1],"a":[2,56,170,187,241],"second-generation,":[3],"recombinant,":[4],"human":[5],"immunoglobulin":[6],"G1,":[7],"epidermal":[8,29],"growth":[9,30],"factor":[10,31,173],"(EGFR)":[11],"receptor":[12],"antibody":[13],"that":[14,58,109,127,139,185,248],"specifically":[15],"blocks":[16],"the":[17,36,49,90,147,181,250],"ligand":[18,28],"binding":[19,60],"site":[20],"of":[21,35,51,64,83,93,116,224,231,240],"EGFR.":[22],"potentially":[24],"acts":[25],"by":[26,61,198,254],"blocking":[27],"(EGF)":[32],"binding-mediated":[33],"activation":[34],"EGFR":[37,54],"signaling":[38],"pathway,":[39],"inhibiting":[40],"tumor":[41],"growth,":[42],"angiogenesis,":[43],"and":[44,53,70,105,138,177,214,238],"anti-apoptotic":[45],"mechanisms.":[46],"inhibited":[48],"interaction":[50],"EGF":[52],"with":[55,79,100,135],"concentration":[57,118],"inhibits":[59],"50":[62],"%":[63],"approximately":[65,84,211],"0.9":[66],"nM":[67],"(0.13":[68],"mg/L)":[69],"demonstrated":[71],"antitumor":[72],"activity":[73],"during":[74],"in":[75,95,146,190,245],"vivo":[76],"experiments":[77],"associated":[78],"trough":[80],"plasma":[81],"concentrations":[82,247],"40":[85],"mg/L.":[86],"This":[87],"work":[88],"describes":[89],"population":[91],"pharmacokinetics":[92,140],"necitumumab":[94,128],"cancer":[96],"patients":[97],"when":[98,151],"administered":[99,152],"or":[101,160,200],"without":[102],"concomitant":[103,161],"chemotherapy":[104],"evaluates":[106],"patient":[107,191],"characteristics":[108],"may":[110],"guide":[111],"dosing.":[112,204],"Nonlinear":[113],"mixed-effects":[114],"modeling":[115],"serum":[117,246],"data":[119],"across":[120],"five":[121],"clinical":[122],"studies":[123],"(phases":[124],"I-III)":[125],"indicated":[126,184,253],"exhibited":[129],"target-mediated":[130],"drug":[131,192],"disposition,":[132],"commonly":[133],"observed":[134],"monoclonal":[136],"antibodies,":[137],"were":[141,164],"expected":[142],"to":[143,210,221],"be":[144,196],"linear":[145],"studied":[148],"dose":[149],"ranges":[150],"as":[153],"repeated":[154],"infusions.":[155],"No":[156],"age,":[157],"sex,":[158],"race,":[159],"medication":[162],"factors":[163],"found":[165],"influential,":[166],"while":[167],"weight":[168],"was":[169,208,217],"statistically":[171],"significant":[172],"for":[174],"both":[175],"distribution":[176],"elimination.":[178],"Simulations":[179],"from":[180],"final":[182],"model":[183],"only":[186],"limited":[188],"reduction":[189],"exposure":[193],"variability":[194],"would":[195],"achieved":[197,218],"weight-":[199],"body":[201],"surface":[202],"area-based":[203],"effective":[206],"half-life":[207],"estimated":[209],"2":[212],"weeks,":[213],"steady":[215],"state":[216],"within":[219],"three":[220],"four":[222],"cycles":[223],"treatment.":[225],"The":[226],"phase":[227],"III":[228],"dosing":[229],"schedule":[230,243],"800":[232],"mg":[233],"dosed":[234],"on":[235],"days":[236],"1":[237],"8":[239],"21-day":[242],"resulted":[244],"exceeded":[249],"40-mg/L":[251],"threshold":[252],"preclinical":[255],"experiments.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-10-07T00:00:00"}