{"id":"https://openalex.org/W2527149191","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","title":"A phase I study of a novel inhibitor of protein phosphatase 2A alone and with docetaxel.","display_name":"A phase I study of a novel inhibitor of protein phosphatase 2A alone and with docetaxel.","publication_year":2015,"publication_date":"2015-05-20","ids":{"openalex":"https://openalex.org/W2527149191","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","mag":"2527149191"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2015.33.15_suppl.tps2602","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Scott Mansfield","raw_affiliation_strings":["Mayo Clinc, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinc, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022022603","display_name":"Vincent M. Chung","orcid":"https://orcid.org/0000-0001-9475-808X","observed_orcids":["https://orcid.org/0000-0001-9475-808X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Chung","raw_affiliation_strings":["City of Hope, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope, Duarte, CA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112006097","display_name":"John S. Kovach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123376","display_name":"Lixte (United States)","ror":"https://ror.org/030bhtx29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210123376"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Kovach","raw_affiliation_strings":["Lixte Biotechnology Holdings  Inc, East Setauket, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lixte Biotechnology Holdings  Inc, East Setauket, NY","institution_ids":["https://openalex.org/I4210123376"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"15_suppl","first_page":"TPS2602","last_page":"TPS2602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-2a-inhibitor","display_name":"protein phosphatase 2A inhibitor","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lb-100","display_name":"LB-100","score":0.9829999804496765},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9079999923706055},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5220000147819519},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.6299999952316284},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mitotic-exit","display_name":"mitotic exit","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cip2a","display_name":"CIP2A","score":0.746999979019165},{"id":"https://openalex.org/keywords/sets","display_name":"sets","score":0.7310000061988831},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.4909999966621399},{"id":"https://openalex.org/keywords/metastatic-solid-tumors","display_name":"metastatic solid tumors","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9091066122055054},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.7406243681907654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6355401277542114},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5536405444145203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.459597647190094},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4477064609527588},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.44478166103363037},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.4374130070209503},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.4128972291946411},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4038476347923279},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.40160760283470154},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.36037692427635193},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3492739200592041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.339118093252182},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31857067346572876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20699235796928406},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.14269345998764038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08546054363250732}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2015.33.15_suppl.tps2602","doi":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2015.33.15_suppl.tps2602","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252732887","https://openalex.org/W2408189227","https://openalex.org/W1606775748","https://openalex.org/W4308203166","https://openalex.org/W2561714923","https://openalex.org/W1988047753","https://openalex.org/W2914737396","https://openalex.org/W2065881059","https://openalex.org/W3183096025","https://openalex.org/W2110054586"],"abstract_inverted_index":{"TPS2602":[0],"Background:":[1],"Protein":[2],"phosphatase":[3],"(PP2A)":[4],"is":[5,212,261,276,285],"a":[6,23,34,98,112,174],"multifunctional":[7],"protein":[8,95],"involved":[9],"in":[10,63,84,102,121,203,207,325],"regulation":[11],"of":[12,28,33,37,51,73,87,100,182,192,228,259,320],"cell":[13,42],"cycle,":[14],"DNA-damage":[15],"response,":[16],"and":[17,39,58,76,152,161,195,206,241,281,289],"apoptosis.":[18],"In":[19,44,117,253,307],"pre-clinical":[20],"studies,":[21],"LB-100,":[22],"novel":[24],"small":[25],"molecule":[26],"inhibitor":[27],"PP2A,":[29],"inhibits":[30],"the":[31,49,137,226,245,256,316],"growth":[32],"broad":[35],"spectrum":[36],"leukemic":[38],"solid":[40],"tumor":[41],"lines.":[43],"cancer":[45,88],"xenografts,":[46],"LB100":[47,115,193,196,229,275,321],"potentiates":[48],"effectiveness":[50],"cytotoxic":[52],"drugs":[53],"(temozolomide,":[54],"docetaxel,":[55],"doxorubicin,":[56],"cisplatin)":[57],"radiation":[59],"without":[60],"significant":[61],"increases":[62],"toxicity.":[64],"The":[65],"predominant":[66],"mechanisms":[67],"responsible":[68],"for":[69,114,177,180,199,209,237],"potentiation":[70],"are":[71,130,294,311],"inhibition":[72,81],"mitotic":[74],"exit":[75],"homologous":[77],"recombination":[78],"repair.":[79],"PP2A":[80,122,134,144,149,169],"also":[82,166,312],"results":[83],"synthetic":[85],"lethality":[86],"cells":[89],"overexpressing":[90],"Mad2":[91],"(mitotic":[92],"arrest":[93],"deficiency":[94],"2)":[96],"as":[97,127],"result":[99],"mutations":[101],"Rb":[103],"and/or":[104],"p53":[105],"pathways,":[106],"suggesting":[107],"that":[108,139],"Mad2-overexpression":[109],"may":[110,165],"be":[111,167],"biomarker":[113],"responsiveness.":[116],"addition,":[118],"cancers":[119,141,163,208],"deficient":[120],"by":[123],"somatic":[124],"mutation":[125],"such":[126],"(del)5q":[128,204],"MDS":[129,205],"vulnerable":[131],"to":[132,188,224,278,287],"further":[133],"inhibition,":[135],"raising":[136],"possibility":[138],"other":[140],"with":[142,248,271,298],"decreased":[143],"resulting":[145],"from":[146],"increased":[147,286],"endogenous":[148],"inhibitors,":[150],"CIP2A":[151],"SET,":[153],"which":[154,210],"include":[155],"blast":[156],"crisis":[157],"CML,":[158],"NSCLC":[159],"(40%)":[160],"prostate":[162],"(60%),":[164],"vulnerable.":[168],"has":[170],"not":[171],"been":[172],"considered":[173],"practical":[175],"target":[176],"anti-cancer":[178],"therapy":[179],"concern":[181],"off-target":[183],"effects.":[184],"This":[185,218],"trial":[186,332],"seeks":[187],"determine":[189,225],"appropriate":[190,213],"doses":[191],"alone":[194,230,322],"plus":[197],"docetaxel":[198,211,249,272,284],"phase":[200,220],"II":[201],"studies":[202],"2nd":[214],"line":[215],"treatment.":[216,306],"Methods:":[217],"two-part":[219],"I":[221],"study":[222],"aims":[223],"MTD":[227,269],"given":[231,243],"intravenously":[232],"over":[233],"15":[234],"minutes":[235],"daily":[236],"3":[238],"days":[239],"q3w":[240],"when":[242],"on":[244,250],"same":[246],"schedule":[247],"day":[251],"2.":[252],"part":[254,308],"2,":[255,309],"starting":[257],"dose":[258,318],"LB-100":[260,290],"two":[262],"levels":[263],"lower":[264],"than":[265],"its":[266,279],"single":[267],"agent":[268],"combined":[270],"at":[273],"60mg/m2.":[274],"escalated":[277],"MTD,":[280],"if":[282],"tolerated,":[283],"75mg/m2":[288],"re-escalated.":[291],"Eligible":[292],"patients":[293,310],"\u2265":[295],"18":[296],"y":[297],"progressive":[299],"or":[300],"metastatic":[301],"tumors":[302],"having":[303],"failed":[304],"standard":[305],"docetaxel-naive.":[313],"Enrollment":[314],"through":[315],"5th":[317],"level":[319],"was":[323],"completed":[324],"January":[326],"2015.":[327],"Clinical":[328,331],"trial:":[329],"NCTO1837667.":[330,334],"information:":[333]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-10-07T00:00:00"}