{"id":"https://openalex.org/W2526572306","doi":null,"title":"The cyclophilin inhibitor Debio 025 is highly efficient in clearing HCV replicon containing cells, alone or when combined with STAT-C inhibitors and has a unique resistance profile","display_name":"The cyclophilin inhibitor Debio 025 is highly efficient in clearing HCV replicon containing cells, alone or when combined with STAT-C inhibitors and has a unique resistance profile","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2526572306","mag":"2526572306"},"language":"en","primary_location":{"id":"mag:2526572306","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/268499","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008713330","display_name":"Lotte Coelmont","orcid":"https://orcid.org/0000-0002-7888-4534","observed_orcids":["https://orcid.org/0000-0002-7888-4534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lotte Coelmont","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7888-4534","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037045273","display_name":"Suzanne J. F. Kaptein","orcid":"https://orcid.org/0000-0002-7935-0219","observed_orcids":["https://orcid.org/0000-0002-7935-0219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne J. F. Kaptein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7935-0219","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056476810","display_name":"Jan Paeshuyse","orcid":"https://orcid.org/0000-0003-2396-354X","observed_orcids":["https://orcid.org/0000-0003-2396-354X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Paeshuyse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052667034","display_name":"Inge Vliegen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inge Vliegen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904841","display_name":"Gr\u00e9goire Vuagniaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Vuagniaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan Neyts","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0033-7514","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44352901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophilin-inhibitors","display_name":"cyclophilin inhibitors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hcv-replicon","display_name":"HCV replicon","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.7429999709129333},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.46674424409866333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39214882254600525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3607408404350281},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3562237620353699},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.346038281917572},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3391258120536804},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.2064218521118164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15073540806770325},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1028115451335907}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2526572306","doi":null,"is_oa":false,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/268499","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2526065026","https://openalex.org/W2018339055","https://openalex.org/W2048367442","https://openalex.org/W1985394717","https://openalex.org/W2095563205","https://openalex.org/W4242342797","https://openalex.org/W2519586090","https://openalex.org/W2062153657","https://openalex.org/W6981392808","https://openalex.org/W2005874413"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-10-07T00:00:00"}