{"id":"https://openalex.org/W2526327045","doi":"https://doi.org/10.1093/ajh/7.9.106s","title":"Mechanistic Lessons from the Save Study","display_name":"Mechanistic Lessons from the Save Study","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2526327045","doi":"https://doi.org/10.1093/ajh/7.9.106s","mag":"2526327045","pmid":"https://pubmed.ncbi.nlm.nih.gov/7818835"},"language":"en","primary_location":{"id":"doi:10.1093/ajh/7.9.106s","doi":"https://doi.org/10.1093/ajh/7.9.106s","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/7.9.106s","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031560506","display_name":"Marc Alan Pfeffer","orcid":"https://orcid.org/0000-0003-3876-7568","observed_orcids":["https://orcid.org/0000-0003-3876-7568"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc A. Pfeffer","raw_affiliation_strings":["Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115","Department of Medicine, Cardiovascular Division, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Medicine, Cardiovascular Division, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031560506"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":0.3158,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.66368953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"9_Pt_2","first_page":"106S","last_page":"111S"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.878000020980835},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ventricular-remodeling","display_name":"ventricular remodeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/left-ventricular-dilation","display_name":"left ventricular dilatation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9869999885559082},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.921999990940094},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myocardial-infarction-prevention","display_name":"myocardial infarction prevention","score":0.7200000286102295},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9344533681869507},{"id":"https://openalex.org/C2779611605","wikidata":"https://www.wikidata.org/wiki/Q288280","display_name":"ACE inhibitor","level":4,"score":0.8308535218238831},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7893142700195312},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7842838764190674},{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.7775270938873291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7262929081916809},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6970251798629761},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.46365460753440857},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.4615379273891449},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.41345033049583435},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.33583545684814453},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1121111512184143}],"mesh":[{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004452","descriptor_name":"Echocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajh/7.9.106s","doi":"https://doi.org/10.1093/ajh/7.9.106s","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajh/7.9.106s","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:7818835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7818835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W18926893","https://openalex.org/W2171772550","https://openalex.org/W2041500892","https://openalex.org/W1972123469","https://openalex.org/W2020883986","https://openalex.org/W1975064930","https://openalex.org/W2142533097","https://openalex.org/W2019448613","https://openalex.org/W2035310744","https://openalex.org/W2067630646"],"abstract_inverted_index":{"The":[0,45,64],"Survival":[1],"and":[2,40,168,187,212,232,251],"Ventricular":[3,177],"Enlargement":[4],"(SAVE)":[5],"study":[6,46,142],"was":[7,79,139],"designed":[8],"to":[9,51,96,124,137,147,154,202,258],"test":[10],"the":[11,17,52,91,98,111,141,149,159,173,182,209,213,222,264],"hypothesis":[12],"that":[13,49,67],"chronic":[14,194,233],"use":[15],"of":[16,25,37,101,113,126,131,133,151,158,162,175,215,224,263,266],"angiotensin-converting":[18],"enzyme":[19],"(ACE)":[20],"inhibitor":[21,54,76,93,164,196],"captopril":[22],"in":[23,56,74,184,228],"survivors":[24],"myocardial":[26,185,191,234,267],"infarction":[27,186,192,235],"with":[28,90,193,230],"left":[29],"ventricular":[30,38,69],"dysfunction":[31],"would":[32,71],"prevent":[33],"a":[34,156,217],"further":[35,247],"deterioration":[36],"function":[39],"thereby":[41],"improve":[42],"clinical":[43,199,252],"outcome.":[44],"did":[47],"demonstrate":[48],"randomization":[50],"ACE":[53,75,92,163,195,225],"resulted":[55],"improved":[57],"survival":[58],"and,":[59],"specifically,":[60],"lessened":[61],"cardiovascular":[62],"deaths.":[63],"prestudy":[65],"rationale":[66],"less":[68],"enlargement":[70],"be":[72],"observed":[73],"treated":[77,89],"patients":[78,88,229],"validated":[80],"by":[81,170],"an":[82,203,259],"echocardiographic":[83],"substudy.":[84],"As":[85],"anticipated,":[86],"fewer":[87,120],"went":[94],"on":[95],"manifest":[97],"prespecified":[99],"definitions":[100],"more":[102],"overt":[103],"congestive":[104,114],"heart":[105,115],"failure.":[106,127],"Importantly,":[107],"not":[108],"only":[109],"were":[110,119],"manifestations":[112],"failure":[116],"reduced,":[117],"there":[118],"fatal":[121],"events":[122],"subsequent":[123,188],"development":[125],"Although":[128,221],"this":[129],"concept":[130],"attenuation":[132],"progressive":[134],"remodeling":[135],"leading":[136],"benefits":[138],"upheld,":[140],"also":[143],"yielded":[144],"other":[145],"observations":[146,171,200],"support":[148],"generation":[150],"new":[152,240],"hypotheses":[153,242],"explain":[155],"component":[157],"overall":[160],"benefit":[161],"therapy.":[165,197],"Particularly":[166],"attractive,":[167],"supported":[169],"from":[172],"Studies":[174],"Left":[176],"Dysfunction":[178],"(SOLVD)":[179],"studies,":[180],"is":[181,236],"reduction":[183],"death":[189],"following":[190],"These":[198],"point":[201],"important":[204],"potentially":[205],"modifiable":[206],"interface":[207],"between":[208],"renin-angiotensin":[210],"system":[211],"risk":[214],"experiencing":[216],"coronary":[218],"atherosclerotic":[219],"event.":[220],"value":[223],"inhibition":[226],"therapy":[227],"acute":[231],"already":[237],"clinically":[238],"apparent,":[239],"mechanistic":[241],"generating":[243],"information":[244],"have":[245],"provided":[246],"stimulus":[248],"for":[249],"basic":[250],"research":[253],"which":[254],"will":[255],"undoubtedly":[256],"lead":[257],"even":[260],"greater":[261],"understanding":[262],"pathophysiology":[265],"infarction.":[268],"Am":[269],"J":[270],"Hypertens":[271],"1994;7:106S-111S":[272]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-10-07T00:00:00"}
