{"id":"https://openalex.org/W2525976469","doi":null,"title":"Characterizing the Role of Stromal Cell Derived Factor 2 Like-1 (SDF2L1) in Pancreatic \u03b2-Cells","display_name":"Characterizing the Role of Stromal Cell Derived Factor 2 Like-1 (SDF2L1) in Pancreatic \u03b2-Cells","publication_year":2011,"publication_date":"2011-12-20","ids":{"openalex":"https://openalex.org/W2525976469","mag":"2525976469"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.470.9880","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.470.9880","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://tspace.library.utoronto.ca/bitstream/1807/31464/5/Tiwari_Akansha_201111_MSc_thesis.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091851588","display_name":"Akansha Tiwari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Akansha Tiwari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091851588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9150000214576721},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9919999837875366},{"id":"https://openalex.org/keywords/proinsulin-misfolding","display_name":"proinsulin misfolding","score":0.9909999966621399},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7310000061988831},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.9651286602020264},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.8613386154174805},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7984028458595276},{"id":"https://openalex.org/C158619295","wikidata":"https://www.wikidata.org/wiki/Q21101062","display_name":"Endoplasmic-reticulum-associated protein degradation","level":4,"score":0.5662607550621033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5475481748580933},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5159643292427063},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4778575301170349},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4387262463569641},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4322241544723511},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3903900384902954},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3822616934776306},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3504353165626526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31492704153060913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22270560264587402},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11915776133537292}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.470.9880","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.470.9880","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://tspace.library.utoronto.ca/bitstream/1807/31464/5/Tiwari_Akansha_201111_MSc_thesis.pdf","raw_type":"text"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/31464","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/31464","pdf_url":null,"source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2525976469","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/31464/5/Tiwari_Akansha_201111_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W197914185","https://openalex.org/W1493113918","https://openalex.org/W1505761263","https://openalex.org/W1516087394","https://openalex.org/W1522422264","https://openalex.org/W1546139069","https://openalex.org/W1905806846","https://openalex.org/W1964023928","https://openalex.org/W1964706050","https://openalex.org/W1965839025","https://openalex.org/W1966239691","https://openalex.org/W1967659527","https://openalex.org/W1968048626","https://openalex.org/W1971794017","https://openalex.org/W1976046875","https://openalex.org/W1976134037","https://openalex.org/W1977498240","https://openalex.org/W1978014671","https://openalex.org/W1978490927","https://openalex.org/W1980026278","https://openalex.org/W1984347348","https://openalex.org/W1984611855","https://openalex.org/W1986698508","https://openalex.org/W1986836799","https://openalex.org/W1987429899","https://openalex.org/W1991103963","https://openalex.org/W1993920746","https://openalex.org/W1994135121","https://openalex.org/W1994750562","https://openalex.org/W1997559284","https://openalex.org/W1999719904","https://openalex.org/W2000806214","https://openalex.org/W2001399725","https://openalex.org/W2010290591","https://openalex.org/W2014002820","https://openalex.org/W2018467767","https://openalex.org/W2023397454","https://openalex.org/W2027899034","https://openalex.org/W2028521534","https://openalex.org/W2029353544","https://openalex.org/W2032487852","https://openalex.org/W2033133173","https://openalex.org/W2033619275","https://openalex.org/W2034213169","https://openalex.org/W2034264764","https://openalex.org/W2038203729","https://openalex.org/W2038708830","https://openalex.org/W2040666005","https://openalex.org/W2041158925","https://openalex.org/W2046061359","https://openalex.org/W2046153858","https://openalex.org/W2047455709","https://openalex.org/W2051881845","https://openalex.org/W2054772758","https://openalex.org/W2055591486","https://openalex.org/W2058511356","https://openalex.org/W2062985112","https://openalex.org/W2064609154","https://openalex.org/W2065022563","https://openalex.org/W2065278356","https://openalex.org/W2070750261","https://openalex.org/W2072881240","https://openalex.org/W2079118456","https://openalex.org/W2080707414","https://openalex.org/W2080901528","https://openalex.org/W2081104776","https://openalex.org/W2083278580","https://openalex.org/W2084498285","https://openalex.org/W2085580153","https://openalex.org/W2086868506","https://openalex.org/W2089198803","https://openalex.org/W2089894176","https://openalex.org/W2092709351","https://openalex.org/W2093158584","https://openalex.org/W2097164847","https://openalex.org/W2098466228","https://openalex.org/W2101758144","https://openalex.org/W2104622496","https://openalex.org/W2104734239","https://openalex.org/W2105393355","https://openalex.org/W2105628355","https://openalex.org/W2107601804","https://openalex.org/W2108412187","https://openalex.org/W2111587627","https://openalex.org/W2114366341","https://openalex.org/W2117313136","https://openalex.org/W2120103843","https://openalex.org/W2123174753","https://openalex.org/W2124368774","https://openalex.org/W2125231550","https://openalex.org/W2125841023","https://openalex.org/W2126042384","https://openalex.org/W2128347862","https://openalex.org/W2128588842","https://openalex.org/W2131632095","https://openalex.org/W2131879548","https://openalex.org/W2135845161","https://openalex.org/W2141018705","https://openalex.org/W2144065739","https://openalex.org/W2144482148","https://openalex.org/W2145869245","https://openalex.org/W2152656461","https://openalex.org/W2155112391","https://openalex.org/W2155163967","https://openalex.org/W2155945227","https://openalex.org/W2158959097","https://openalex.org/W2159641975","https://openalex.org/W2163323666","https://openalex.org/W2169409747","https://openalex.org/W2171862076"],"related_works":["https://openalex.org/W2151935021","https://openalex.org/W2890120255","https://openalex.org/W3209570315","https://openalex.org/W4399868389","https://openalex.org/W2472189914","https://openalex.org/W3158921277","https://openalex.org/W1627109034","https://openalex.org/W2144482148","https://openalex.org/W2025682280","https://openalex.org/W2112728838"],"abstract_inverted_index":{"Type":[0],"2":[1,101],"diabetes":[2],"is":[3,106],"characterized":[4],"by":[5,56],"insulin":[6,17],"resistance":[7,13],"and":[8,67],"pancreatic":[9,48,75,129],"\u03b2-cell":[10,49,76],"failure.":[11],"Insulin":[12],"leads":[14],"to":[15,22,47,53],"increased":[16,23],"demand,":[18],"which":[19,44,62],"can":[20,40,45],"lead":[21,46],"proinsulin":[24,81],"misfolding":[25],"in":[26,37,128,131],"the":[27,34,38,57,92,123],"endoplasmic":[28],"reticulum":[29],"(ER).":[30],"The":[31],"accumulation":[32],"of":[33,70,78,91,126],"misfolded":[35,71,80],"proteins":[36],"ER":[39,42,54,108,132],"cause":[41],"stress,":[43],"dysfunction.":[50],"Cells":[51],"respond":[52],"stress":[55,133],"unfolded":[58],"protein":[59,64,111],"response":[60],"(UPR),":[61],"increases":[63],"folding":[65],"capacity":[66],"causes":[68],"degradation":[69],"proteins.":[72],"Using":[73],"a":[74],"model":[77],"induced":[79,95],"expression":[82],"(proinsulin-C96Y":[83],"tagged":[84],"with":[85,112],"GFP)":[86],"we":[87],"discovered":[88],"that":[89],"one":[90],"most":[93],"highly":[94],"genes":[96],"was":[97],"stromal":[98],"cell-derived":[99],"factor":[100],"like":[102],"1":[103],"(SDF2L1).":[104],"SDF2L1":[105,127],"an":[107,113],"localized":[109],"soluble":[110],"as":[114],"yet":[115],"unknown":[116],"function.":[117],"In":[118],"this":[119],"thesis":[120],"I":[121],"examined":[122],"potential":[124],"role":[125],"\u03b2-cells":[130],"conditions.":[134]},"counts_by_year":[],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2016-10-07T00:00:00"}