{"id":"https://openalex.org/W2525940465","doi":null,"title":"Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart.","display_name":"Critical role of mitochondrial ROS is dependent on their site of production on the electron transport chain in ischemic heart.","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2525940465","mag":"2525940465","pmid":"https://pubmed.ncbi.nlm.nih.gov/27679744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5030389"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5030389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5030389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5030389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049554462","display_name":"Ngonidzashe Benson Madungwe","orcid":"https://orcid.org/0000-0002-2975-1487","observed_orcids":["https://orcid.org/0000-0002-2975-1487"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ngonidzashe B Madungwe","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Texas Health Science Center at San AntonioTX, USA; Department of Biomedical Engineering, University of Texas at San AntonioTX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Texas Health Science Center at San AntonioTX, USA; Department of Biomedical Engineering, University of Texas at San AntonioTX, USA","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067826367","display_name":"Netanel Zilberstein","orcid":"https://orcid.org/0000-0001-5409-8654","observed_orcids":["https://orcid.org/0000-0001-5409-8654"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Netanel F Zilberstein","raw_affiliation_strings":["Sackler School of Medicine, Tel Aviv University Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler School of Medicine, Tel Aviv University Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089869726","display_name":"Yansheng Feng","orcid":"https://orcid.org/0000-0002-9788-8012","observed_orcids":["https://orcid.org/0000-0002-9788-8012"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yansheng Feng","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Texas Health Science Center at San Antonio TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Texas Health Science Center at San Antonio TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031456843","display_name":"Jean C. Bopassa","orcid":"https://orcid.org/0000-0003-3667-5790","observed_orcids":["https://orcid.org/0000-0003-3667-5790"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean C Bopassa","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Texas Health Science Center at San Antonio TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Texas Health Science Center at San Antonio TX, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7189,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.97584034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"6","issue":"3","first_page":"93","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.9629999995231628},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8849999904632568},{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.984000027179718},{"id":"https://openalex.org/keywords/complex-ii","display_name":"complex II","score":0.8040000200271606},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.6660000085830688},{"id":"https://openalex.org/keywords/glutamate-malate","display_name":"glutamate-malate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sn-glycerol-3-phosphate","display_name":"sn-glycerol 3-phosphate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.8450000286102295},{"id":"https://openalex.org/keywords/antimycin-a","display_name":"antimycin A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-calcium-retention-capacity","display_name":"mitochondrial calcium retention capacity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition-pore","display_name":"mitochondrial permeability transition pore","score":0.9890000224113464},{"id":"https://openalex.org/keywords/myocardial-infarct-size","display_name":"myocardial infarct size","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cardiac-recovery","display_name":"cardiac function recovery","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.8442796468734741},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7911230325698853},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7313020825386047},{"id":"https://openalex.org/C13591479","wikidata":"https://www.wikidata.org/wiki/Q6881880","display_name":"Mitochondrial permeability transition pore","level":4,"score":0.6498245000839233},{"id":"https://openalex.org/C2779965811","wikidata":"https://www.wikidata.org/wiki/Q104708365","display_name":"Antimycin A","level":3,"score":0.6093264222145081},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.5378974676132202},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4624751806259155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4565548300743103},{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.43465790152549744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40605396032333374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3916967511177063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38759684562683105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3650445342063904},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.17646348476409912},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09492146968841553},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5030389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5030389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},{"id":"pmid:27679744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27679744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cardiovascular disease","raw_type":"Journal Article"},{"id":"mag:2525940465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27679744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5030389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5030389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cardiovasc Dis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W10006180","https://openalex.org/W194541936","https://openalex.org/W1120735632","https://openalex.org/W1512824421","https://openalex.org/W1520350491","https://openalex.org/W1530946604","https://openalex.org/W1922087192","https://openalex.org/W1944912191","https://openalex.org/W1964826110","https://openalex.org/W1965091767","https://openalex.org/W1966038248","https://openalex.org/W1966621383","https://openalex.org/W1968183669","https://openalex.org/W1970094644","https://openalex.org/W1977326576","https://openalex.org/W1978631786","https://openalex.org/W1978631832","https://openalex.org/W1981932198","https://openalex.org/W1982085892","https://openalex.org/W1982330633","https://openalex.org/W1983078193","https://openalex.org/W1984156662","https://openalex.org/W1986956461","https://openalex.org/W1992736786","https://openalex.org/W1995246710","https://openalex.org/W1997242730","https://openalex.org/W2002439304","https://openalex.org/W2006084919","https://openalex.org/W2008757109","https://openalex.org/W2013805538","https://openalex.org/W2013968205","https://openalex.org/W2020585998","https://openalex.org/W2021615423","https://openalex.org/W2024024691","https://openalex.org/W2029176648","https://openalex.org/W2035127779","https://openalex.org/W2036127346","https://openalex.org/W2043227348","https://openalex.org/W2050352784","https://openalex.org/W2050365720","https://openalex.org/W2052252788","https://openalex.org/W2057099146","https://openalex.org/W2062609826","https://openalex.org/W2068063220","https://openalex.org/W2072420639","https://openalex.org/W2073331259","https://openalex.org/W2075941546","https://openalex.org/W2079100436","https://openalex.org/W2084933852","https://openalex.org/W2085939309","https://openalex.org/W2087561593","https://openalex.org/W2094062327","https://openalex.org/W2097133939","https://openalex.org/W2098689751","https://openalex.org/W2099829545","https://openalex.org/W2101147253","https://openalex.org/W2106056969","https://openalex.org/W2109698138","https://openalex.org/W2110481067","https://openalex.org/W2111542355","https://openalex.org/W2120888944","https://openalex.org/W2121075670","https://openalex.org/W2122091775","https://openalex.org/W2124709834","https://openalex.org/W2126960465","https://openalex.org/W2134704000","https://openalex.org/W2135791951","https://openalex.org/W2137182040","https://openalex.org/W2139200038","https://openalex.org/W2148546947","https://openalex.org/W2150509483","https://openalex.org/W2151524159","https://openalex.org/W2154566486","https://openalex.org/W2168975002","https://openalex.org/W2169052274","https://openalex.org/W2395716490"],"related_works":["https://openalex.org/W1990618231","https://openalex.org/W2117929483","https://openalex.org/W2169052274","https://openalex.org/W2026525843","https://openalex.org/W2124709834","https://openalex.org/W7160085829","https://openalex.org/W4249032922","https://openalex.org/W2610150050","https://openalex.org/W2986171963","https://openalex.org/W2004803969"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"generation":[4],"has":[5,238],"been":[6,33],"implicated":[7],"in":[8,46,61,66,125,155,244,251,269],"many":[9],"pathologies":[10],"including":[11],"ischemia/reperfusion":[12,273],"(I/R)":[13],"injury.":[14,274],"This":[15],"led":[16],"to":[17,23,85,131,173,190,202,221],"multiple":[18],"studies":[19],"on":[20,76],"antioxidant":[21],"therapies":[22],"treat":[24],"cardiovascular":[25],"diseases":[26],"but":[27],"paradoxically,":[28],"results":[29],"have":[30],"so":[31],"far":[32],"mixed":[34],"as":[35,41,63,65],"ROS":[36,60,87,100,124,147,159,227,258],"production":[37,75,148,160,228],"can":[38],"be":[39,69,191],"beneficial":[40],"a":[42,266],"signaling":[43],"mechanism":[44,255],"and":[45,117,141,151,187,199,215,236,247],"cardiac":[47,212],"protection":[48,67],"via":[49],"preconditioning":[50],"interventions.":[51],"We":[52],"investigated":[53],"whether":[54],"the":[55,77,111,162,230,260,263],"differential":[56],"impact":[57],"of":[58,74,113,137,256,262],"increased":[59,146,216],"injury":[62],"well":[64],"could":[68],"explained":[70],"by":[71,229],"their":[72],"site":[73],"mitochondrial":[78,175],"electron":[79],"transport":[80],"chain.":[81],"Using":[82],"amplex":[83],"red":[84],"measure":[86],"production,":[88],"we":[89],"found":[90,189],"that":[91],"mitochondria":[92,126,194],"isolated":[93],"from":[94,127],"hearts":[95,129,206,222],"after":[96],"I/R":[97,128],"produced":[98,122,243,250],"more":[99],"than":[101],"non-ischemic":[102],"when":[103,149,161,193,242,249],"complex":[104,114,138,142,163,245,252],"I":[105,139,235,246],"substrate":[106,165],"(glutamate/malate)":[107],"was":[108,166,181,188],"used.":[109,167],"Interestingly,":[110],"substrates":[112],"II":[115,164],"(succinate)":[116],"ubiquinone":[118],"(sn-glycerol":[119],"3-phosphate,":[120],"G3P)":[121],"less":[123],"compared":[130,201,220],"normal":[132],"healthy":[133],"hearts.":[134],"The":[135,254],"inhibitors":[136],"(rotenone)":[140],"III":[143,237],"(antimycin":[144],"A)":[145],"glutamate/malate":[150,209],"G3P":[152,198],"were":[153,195],"used;":[154],"contrast,":[156],"they":[157],"reduced":[158,211],"Mitochondrial":[168],"calcium":[169,184],"retention":[170],"capacity":[171],"required":[172],"induce":[174],"permeability":[176],"transition":[177],"pore":[178],"(mPTP)":[179],"opening":[180],"measured":[182],"using":[183],"green":[185],"fluorescence":[186],"higher":[192],"treated":[196,207,223],"with":[197,208,224],"succinate":[200],"glutamate/malate.":[203],"Furthermore,":[204],"Langendorff":[205],"exhibited":[210],"functional":[213],"recovery":[214],"myocardial":[217],"infarct":[218],"size":[219],"G3P.":[225],"Thus,":[226],"stimulated":[231],"respiratory":[232],"chain":[233],"complexes":[234],"opposite":[239],"roles:":[240],"cardio-deleterious":[241],"cardio-protective":[248],"III.":[253],"these":[257],"involves":[259],"inhibition":[261],"mPTP":[264],"opening,":[265],"key":[267],"event":[268],"cell":[270],"death":[271],"following":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-10-07T00:00:00"}