{"id":"https://openalex.org/W2525245272","doi":null,"title":"(coronary arteries/thromboxane synthetase/platelet aggregation/s","display_name":"(coronary arteries/thromboxane synthetase/platelet aggregation/s","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2525245272","mag":"2525245272"},"language":"en","primary_location":{"id":"mag:2525245272","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/8528","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103399336","display_name":"Edward F. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward F. Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017672217","display_name":"Ronald L. Magolda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald L. Magolda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022757808","display_name":"James Bryan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Bryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06115224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.039400000125169754,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-vasoconstriction","display_name":"coronary vasoconstriction","score":0.921999990940094},{"id":"https://openalex.org/keywords/platelet-inhibition","display_name":"platelet aggregation inhibition","score":0.8379999995231628},{"id":"https://openalex.org/keywords/thromboxane-synthase","display_name":"thromboxane synthase","score":0.7839999794960022},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sudden-death","display_name":"sudden death","score":0.890999972820282},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.8224886655807495},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.7780654430389404},{"id":"https://openalex.org/C173202427","wikidata":"https://www.wikidata.org/wiki/Q408575","display_name":"Thromboxane-A synthase","level":4,"score":0.6743066906929016},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6471229791641235},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.618018627166748},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5606050491333008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.552717924118042},{"id":"https://openalex.org/C2780978440","wikidata":"https://www.wikidata.org/wiki/Q416567","display_name":"Prostaglandin H2","level":4,"score":0.47545310854911804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46491748094558716},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.46313053369522095},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.4602234959602356},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.4525451362133026},{"id":"https://openalex.org/C51603380","wikidata":"https://www.wikidata.org/wiki/Q411978","display_name":"Thromboxane receptor","level":4,"score":0.4142584204673767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34200775623321533},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3376152515411377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2883312702178955},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14154309034347534}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2525245272","doi":null,"is_oa":false,"landing_page_url":"https://www.jstor.org/stable/8528","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070088449","https://openalex.org/W2068591642","https://openalex.org/W1974207043","https://openalex.org/W2399350127","https://openalex.org/W324056768","https://openalex.org/W2020066385","https://openalex.org/W7099012378","https://openalex.org/W2001718725","https://openalex.org/W4248418362","https://openalex.org/W2072722254"],"abstract_inverted_index":{"Carbocyclic":[0,20],"thromboxane":[1,11,21,75,93,100,116],"A2":[2,22,117,140],"(2f3(Z),3a-":[3],"(1E,3R*)-3-3-hydroxy(l-octenyl)bicyclo(3.1.1)hept-2-yl-5-hepte-":[4],"noic":[5],"acid),":[6],"a":[7,24,95],"stable":[8],"analog":[9],"of":[10,48,54,63,70,85,133],"A2,":[12,94,101],"has":[13],"been":[14],"tested":[15],"for":[16],"its":[17],"physiologic":[18],"properties.":[19],"is":[23,44,142],"potent":[25],"coronary":[26,29,103,119,137],"vasoconstrictor,":[27],"stimulating":[28],"vascular":[30],"smooth":[31],"muscle":[32],"at":[33],"concentrations":[34],"as":[35,37],"low":[36],"29":[38],"pM.":[39],"At":[40,56],"1-5":[41],"AM":[42],"it":[43,59,80],"also":[45],"an":[46,143],"inhibitor":[47],"arachidonic-acid-":[49],"and":[50,125],"endoperoxide-":[51],"induced":[52],"aggregation":[53],"platelets.":[55],"200":[57],"nM":[58],"stimulated":[60],"the":[61,131],"release":[62],"lysosomal":[64],"hydrolases":[65],"from":[66,105],"large":[67],"granule":[68],"fractions":[69],"liver":[71],"homogenate.":[72],"It":[73],"inhibited":[74],"synthesis":[76,84],"in":[77,87,113,128,130],"platelets,":[78],"although":[79],"did":[81],"not":[82],"inhibit":[83],"prostacyclin":[86],"ram":[88],"seminal":[89],"vesicles.":[90],"Thus,":[91],"carbocyclic":[92,115],"molecule":[96],"closely":[97],"related":[98],"to":[99,122],"separates":[102],"vasoconstrictor":[104],"platelet-aggregating":[106],"activity.":[107],"The":[108],"con-":[109],"strictor":[110],"activity":[111],"predominates":[112],"vivo;":[114],"induces":[118],"vasoconstriction":[120],"leading":[121],"myocardial":[123],"ischemia":[124],"sudden":[126],"death":[127],"rabbits":[129],"absence":[132],"pul-":[134],"monary":[135],"or":[136],"thrombosis.":[138],"Thromboxane":[139],"(TA2)":[141],"unstable":[144],"substance":[145],"(half-life":[146],"m30":[147]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-10-07T00:00:00"}